Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2023 ▲▼ | Q4 2023 ▲▼ | Change ▲▼ | Q3 2023 ▲▼ | Q4 2023 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| CAVA GROUP INC(CAVA) | 32,007,990 | 32,007,990 | 0 | 980 | 1,376 | 46.90% | +395 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 9,059,507 | 11,259,438 | +2,199,931 | 64 | 212 | 7.22% | +147 |
| CYTOKINETICS INC(CYTK) | 1,518,831 | 1,214,284 | -304,547 | 45 | 101 | 3.46% | +57 |
| LEXICON PHARMACEUTICALS INC(LXRX) | 117,553,284 | 117,553,284 | 0 | 128 | 180 | 6.13% | +52 |
| ARGENX SE(ARGX) | 0 | 116,388 | +116,388 | 0 | 44 | 1.51% | +44 |
| KYMERA THERAPEUTICS INC(KYMR) | 1,805,346 | 2,530,735 | +725,389 | 25 | 64 | 2.20% | +39 |
| ARROWHEAD PHARMACEUTICALS IN(ARWR) | 5,440 | 1,028,255 | +1,022,815 | 0 | 31 | 1.07% | +31 |
| SILENCE THERAPEUTICS PLC(SLN) | 2,500,000 | 3,000,000 | +500,000 | 25 | 52 | 1.78% | +28 |
| APELLIS PHARMACEUTICALS INC COM | 1,664,572 | 1,421,346 | -243,226 | 63 | 85 | 2.90% | +22 |
| KORRO BIO INC(KRRO) | 0 | 418,605 | +418,605 | 0 | 20 | 0.68% | +20 |
| PROTHENA CORP PLC SHS | 0 | 501,360 | +501,360 | 0 | 18 | 0.62% | +18 |
| SPRINGWORKS THERAPEUTICS INC | 1,816,620 | 1,615,348 | -201,272 | 42 | 59 | 2.01% | +17 |
| HARPOON THERAPEUTICS INC | 100,000 | 1,304,127 | +1,204,127 | 0 | 15 | 0.51% | +14 |
| SYROS PHARMACEUTICALS INC | 1,475,744 | 2,505,013 | +1,029,269 | 6 | 20 | 0.67% | +14 |
| MORPHIC HLDG INC | 2,138,188 | 2,138,188 | 0 | 49 | 62 | 2.11% | +13 |
| DYNE THERAPEUTICS INC(DYN) | 815,085 | 1,217,960 | +402,875 | 7 | 16 | 0.55% | +9 |
| LEXEO THERAPEUTICS INC(LXEO) | 0 | 603,435 | +603,435 | 0 | 8 | 0.28% | +8 |
| CENTESSA PHARMACEUTICALS PLC | 0 | 1,012,500 | +1,012,500 | 0 | 8 | 0.27% | +8 |
| GLYCOMIMETICS INC | 8,589,064 | 8,589,064 | 0 | 13 | 20 | 0.69% | +7 |
| CYMABAY THERAPEUTICS INC | 0 | 303,600 | +303,600 | 0 | 7 | 0.24% | +7 |
| KURA ONCOLOGY INC(KURA) | 2,018,056 | 1,768,056 | -250,000 | 18 | 25 | 0.87% | +7 |
| GOSSAMER BIO INC(GOSS) | 6,399,819 | 12,058,968 | +5,659,149 | 5 | 11 | 0.38% | +6 |
| FUSION PHARMACEUTICALS INC | 1,725,000 | 1,005,500 | -719,500 | 4 | 10 | 0.33% | +5 |
| PDD HOLDINGS INC(PDD) | 0 | 32,500 | +32,500 | 0 | 5 | 0.16% | +5 |
| IGM BIOSCIENCES INC | 2,522,244 | 3,100,422 | +578,178 | 21 | 26 | 0.88% | +5 |
| NEUMORA THERAPEUTICS INC(NMRA) | 2,802,702 | 2,552,702 | -250,000 | 40 | 44 | 1.48% | +4 |
| WAVE LIFE SCIENCES LTD(WVE) | 2,000,000 | 3,007,400 | +1,007,400 | 12 | 15 | 0.52% | +4 |
| NATERA INC(NTRA) | 200,000 | 200,000 | 0 | 9 | 13 | 0.43% | +4 |
| STRUCTURE THERAPEUTICS INC | 0 | 86,600 | +86,600 | 0 | 4 | 0.12% | +4 |
| SOLID BIOSCIENCES INC | 909,219 | 909,219 | 0 | 2 | 6 | 0.19% | +3 |
| TOURMALINE BIO INC | 0 | 91,426 | +91,426 | 0 | 2 | 0.08% | +2 |
| HOOKIPA PHARMA INC | 5,666,410 | 5,666,410 | 0 | 3 | 5 | 0.16% | +1 |
| ERASCA INC(ERAS) | 4,721,194 | 4,721,194 | 0 | 9 | 10 | 0.34% | +1 |
| DENALI THERAPEUTICS INC(DNLI) | 802,899 | 802,899 | 0 | 17 | 17 | 0.59% | +1 |
| CURIS INC(CRIS) | 105,000 | 105,000 | 0 | 1 | 1 | 0.05% | +1 |
| ELI LILLY & CO(LLY) | 0 | 1,000 | +1,000 | 0 | 1 | 0.02% | +1 |
| REMITLY GLOBAL INC(RELY) | 0 | 25,000 | +25,000 | 0 | 0 | 0.02% | 0 |
| CONFLUENT INC | 0 | 19,000 | +19,000 | 0 | 0 | 0.02% | 0 |
| MONGODB INC(MDB) | 0 | 1,000 | +1,000 | 0 | 0 | 0.01% | 0 |
| ADAGENE INC | 1,000,000 | 1,000,000 | 0 | 2 | 2 | 0.07% | 0 |
| CLEARWATER ANALYTICS HLDGS I | 0 | 20,000 | +20,000 | 0 | 0 | 0.01% | 0 |
| ALPHABET INC(GOOG) | 5,500 | 7,800 | +2,300 | 1 | 1 | 0.04% | 0 |
| PROCORE TECHNOLOGIES INC(PCOR) | 4,500 | 9,500 | +5,000 | 0 | 1 | 0.02% | 0 |
| DLOCAL LTD(DLO) | 0 | 20,000 | +20,000 | 0 | 0 | 0.01% | 0 |
| INTAPP INC(INTA) | 10,000 | 17,500 | +7,500 | 0 | 1 | 0.02% | 0 |
| AMAZON COM INC(AMZN) | 12,000 | 12,000 | 0 | 2 | 2 | 0.06% | 0 |
| BEIGENE LTD(ONC) | 403,934 | 404,480 | +546 | 73 | 73 | 2.49% | 0 |
| PEGASYSTEMS INC(PEGA) | 7,500 | 11,500 | +4,000 | 0 | 1 | 0.02% | 0 |
| IRONWOOD PHARMACEUTICALS INC(IRWD) | 110,532 | 110,532 | 0 | 1 | 1 | 0.04% | 0 |
| CARIBOU BIOSCIENCES INC(CRBU) | 105,347 | 105,347 | 0 | 1 | 1 | 0.02% | 0 |
| HIPPO HLDGS INC(HIPO) | 24,000 | 24,000 | 0 | 0 | 0 | 0.01% | 0 |
| PAYPAL HLDGS INC(PYPL) | 5,000 | 5,000 | 0 | 0 | 0 | 0.01% | 0 |
| SENTI BIOSCIENCES INC | 55,555 | 55,555 | 0 | 0 | 0 | 0.00% | 0 |
| ITEOS THERAPEUTICS INC | 400,000 | 400,000 | 0 | 4 | 4 | 0.15% | 0 |
| MINK THERAPEUTICS INC | 1,916 | 1,916 | 0 | 0 | 0 | 0.00% | 0 |
| CYCLERION THERAPEUTICS INC | 552 | 0 | -552 | 0 | 0 | — | -0 |
| CYCLERION THERAPEUTICS INC(CYCN) | 138,403 | 138,955 | +552 | 0 | 0 | 0.02% | -0 |
| PLIANT THERAPEUTICS INC(PLRX) | 1,490 | 0 | -1,490 | 0 | 0 | — | -0 |
| 23ANDME HOLDING CO | 661,009 | 661,009 | 0 | 1 | 1 | 0.02% | -0 |
| ACHILLES THERAPEUTICS PLC | 2,255,375 | 2,255,375 | 0 | 2 | 2 | 0.07% | -0 |
| KINETA INC | 31,055 | 0 | -31,055 | 0 | 0 | — | -0 |
| BLACK DIAMOND THERAPEUTICS I | 2,046,517 | 2,046,517 | 0 | 6 | 6 | 0.20% | -0 |
| SQZ BIOTECHNOLOGIES CO | 1,606,309 | 0 | -1,606,309 | 0 | 0 | — | -0 |
| DATADOG INC(DDOG) | 11,500 | 7,500 | -4,000 | 1 | 1 | 0.03% | -0 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 936 | 0 | -936 | 0 | 0 | — | -0 |
| KE HLDGS INC(BEKE) | 275,000 | 250,000 | -25,000 | 4 | 4 | 0.14% | -0 |
| ADVANCED MICRO DEVICES INC(AMD) | 6,000 | 2,500 | -3,500 | 1 | 0 | 0.01% | -0 |
| BEAM THERAPEUTICS INC(BEAM) | 10,975 | 0 | -10,975 | 0 | 0 | — | -0 |
| LAVA THERAPEUTICS NV | 200,000 | 0 | -200,000 | 0 | 0 | — | -0 |
| CROWDSTRIKE HLDGS INC(CRWD) | 2,000 | 0 | -2,000 | 0 | 0 | — | -0 |
| VOR BIOPHARMA INC(VOR) | 2,688,015 | 2,347,424 | -340,591 | 6 | 5 | 0.18% | -0 |
| ROIVANT SCIENCES LTD(ROIV) | 1,000,000 | 1,000,000 | 0 | 12 | 11 | 0.38% | -0 |
| NETFLIX INC(NFLX) | 1,285 | 0 | -1,285 | 0 | 0 | — | -0 |
| BLOCK INC(XYZ) | 15,500 | 0 | -15,500 | 1 | 0 | — | -1 |
| XILIO THERAPEUTICS INC(XLO) | 450,000 | 450,000 | 0 | 1 | 0 | 0.01% | -1 |
| MICROSOFT CORP(MSFT) | 5,500 | 2,500 | -3,000 | 2 | 1 | 0.03% | -1 |
| ADAPTIMMUNE THERAPEUTICS PLC(ADAPY) | 1,133,775 | 0 | -1,133,775 | 1 | 0 | — | -1 |
| KRONOS BIO INC | 1,542,954 | 842,954 | -700,000 | 2 | 1 | 0.04% | -1 |
| VISA INC(V) | 7,500 | 2,500 | -5,000 | 2 | 1 | 0.02% | -1 |
| I MAB(NBP) | 850,000 | 0 | -850,000 | 1 | 0 | — | -1 |
| SEER INC(SEER) | 4,750,000 | 4,750,000 | 0 | 10 | 9 | 0.31% | -1 |
| OMEGA THERAPEUTICS INC | 2,533,045 | 1,323,530 | -1,209,515 | 5 | 4 | 0.14% | -1 |
| OVID THERAPEUTICS INC(OVID) | 2,500,000 | 2,500,000 | 0 | 10 | 8 | 0.27% | -2 |
| KANZHUN LIMITED(BZ) | 220,000 | 100,000 | -120,000 | 3 | 2 | 0.06% | -2 |
| TAIWAN SEMICONDUCTOR MFG LTD(TSM) | 102,699 | 67,999 | -34,700 | 9 | 7 | 0.24% | -2 |
| AVIDITY BIOSCIENCES INC | 300,000 | 0 | -300,000 | 2 | 0 | — | -2 |
| SEA LTD(SE) | 397,000 | 372,000 | -25,000 | 17 | 15 | 0.51% | -2 |
| ACELYRIN INC | 2,469,279 | 3,035,888 | +566,609 | 25 | 23 | 0.77% | -2 |
| TALARIS THERAPEUTICS INC | 914,262 | 0 | -914,262 | 3 | 0 | — | -3 |
| SAGIMET BIOSCIENCES INC(SGMT) | 924,771 | 924,771 | 0 | 8 | 5 | 0.17% | -3 |
| REPARE THERAPEUTICS INC | 700,000 | 700,000 | 0 | 8 | 5 | 0.17% | -3 |
| CARTESIAN THERAPEUTICS INC | 9,136,635 | 9,136,635 | 0 | 10 | 6 | 0.21% | -3 |
| SCHRODINGER INC(SDGR) | 500,000 | 300,000 | -200,000 | 14 | 11 | 0.37% | -3 |
| FOGHORN THERAPEUTICS INC(FHTX) | 1,720,720 | 720,720 | -1,000,000 | 9 | 5 | 0.16% | -4 |
| VERVE THERAPEUTICS INC | 300,000 | 0 | -300,000 | 4 | 0 | — | -4 |
| VIGIL NEUROSCIENCE INC | 1,908,135 | 1,811,191 | -96,944 | 10 | 6 | 0.21% | -4 |
| REPLIMUNE GROUP INC(REPL) | 500,000 | 500,000 | 0 | 9 | 4 | 0.14% | -4 |
| AGENUS INC(AGEN) | 15,631,235 | 15,631,235 | 0 | 18 | 13 | 0.44% | -5 |
| TAYSHA GENE THERAPIES INC(TSHA) | 3,663,104 | 3,663,104 | 0 | 12 | 6 | 0.22% | -5 |
| GENERATION BIO CO | 2,814,191 | 2,814,191 | 0 | 11 | 5 | 0.16% | -6 |