Fund HoldingsORBIMED ADVISORS LLC

Total Portfolio Value
$4.59B
Total Bought
$1.16B
Total Sold
$1.34B
Net Transaction
-$178.35M
Filing Period:
Securities
SharesValue ($K)
Q4 2025
Q1 2026
Change
Q4 2025
Q1 2026
Weight (%)
Change
MDXHEALTH SA(Call)0124,306,000+124,306,0000285,904+285,904
ENLIVEN THERAPEUTICS INC07,959,538+7,959,5380312,0146.80%+312,014
AVITA MEDICAL INC(Call)040,966,100+40,966,1000154,442+154,442
ASTRAZENECA PLC(AZN)0670,200+670,2000132,1772.88%+132,177
MYRIAD GENETICS INC0000122,8752.68%+122,875
EDGEWISE THERAPEUTICS INC(EWTX)15,518,49215,518,4920385,091488,83210.66%+103,741
MERCK & CO INC(MRK)0663,400+663,400079,8001.74%+79,800
CORVUS PHARMACEUTICALS INC(CRVS)7,165,0067,165,006055,171104,8242.29%+49,653
AVITA MEDICAL INC0544,895+544,895042,5160.93%+42,516
XENON PHARMACEUTICALS INC(XENE)447,2001,059,971+612,77120,04461,6371.34%+41,594
GUARDANT HEALTH INC(GH)0435,200+435,200040,1990.88%+40,199
PRAXIS PRECISION MEDICINES I(PRAX)94,500172,500+78,00027,85355,5781.21%+27,725
SYNDAX PHARMACEUTICALS INC(SNDX)0962,300+962,300022,4790.49%+22,479
RELMADA THERAPEUTICS INC2,610,6004,715,864+2,105,26412,60932,8220.72%+20,213
MINERALYS THERAPEUTICS INC(MLYS)02,052,900+2,052,900055,6131.21%+55,613
SUTRO BIOPHARMA INC0801,144+801,144019,9560.44%+19,956
NEKTAR THERAPEUTICS(NKTR)0275,000+275,000019,7860.43%+19,786
SHATTUCK LABS INC6,306,1276,306,127023,01740,5480.88%+17,531
UNIQURE NV(QURE)02,136,149+2,136,149034,9260.76%+34,926
PALVELLA THERAPEUTICS INC NE(PVLA)0134,600+134,600016,7780.37%+16,778
DEFINIUM THERAPEUTICS INC(DFTX)0804,000+804,000015,1960.33%+15,196
BRISTOL-MYERS SQUIBB CO(BMY)775,000925,000+150,00041,80456,1011.22%+14,298
AMGEN INC(AMGN)039,900+39,900014,0390.31%+14,039
ALIGNMENT HEALTHCARE INC(ALHC)0791,000+791,000013,9370.30%+13,937
PFIZER INC(PFE)1,652,9001,946,500+293,60041,15754,6581.19%+13,501
REGENERON PHARMACEUTICALS(REGN)014,700+14,700011,3580.25%+11,358
BIOGEN INC(BIIB)061,600+61,600011,2930.25%+11,293
QIAGEN NV(QGEN)(Call)0250,000+250,000010,010+10,010
DYNE THERAPEUTICS INC(DYN)2,202,1842,917,884+715,70043,07552,9011.15%+9,827
BICARA THERAPEUTICS INC209,100667,300+458,2003,51913,2730.29%+9,753
ARRIVENT BIOPHARMA INC(AVBP)3,027,3283,027,328060,91069,8401.52%+8,931
GILEAD SCIENCES INC(GILD)059,600+59,60008,3060.18%+8,306
HERON THERAPEUTICS INC09,816,940+9,816,94007,8550.17%+7,855
Q32 BIO INC2,252,9872,252,98707,48014,4640.32%+6,984
ESPERION THERAPEUTICS INC NE(ESPR)5,965,49810,570,300+4,604,80222,07228,9630.63%+6,890
COMPASS PATHWAYS PLC(CMPS)01,150,646+1,150,64606,3630.14%+6,363
PALVELLA THERAPEUTICS INC NE(PVLA)(Call)050,000+50,00006,233+6,233
ALX ONCOLOGY HLDGS INC02,866,256+2,866,25605,7470.13%+5,747
PRELUDE THERAPEUTICS INC10,909,25610,909,256031,63737,3100.81%+5,673
ARTIVION INC(AORT)0151,000+151,00005,5300.12%+5,530
ASCENDIS PHARMA A/S(ASND)171,977181,977+10,00036,67241,6240.91%+4,951
ORIC PHARMACEUTICALS INC(ORIC)02,693,929+2,693,929034,1320.74%+34,132
WHITEHAWK THERAPEUTICS INC4,166,0004,166,000010,08214,3730.31%+4,291
SAVARA INC(SVRA)0635,000+635,00003,4670.08%+3,467
SOLENO THERAPEUTICS INC(Call)0100,000+100,00003,348+3,348
CORBUS PHARMACEUTICALS HLDGS1,597,2871,737,287+140,00013,00216,3130.36%+3,311
LIFESTANCE HEALTH GROUP INC(LFST)0500,000+500,00003,1850.07%+3,185
REVOLUTION MEDICINES INC(RVMD)25,90052,000+26,1002,0635,0570.11%+2,994
BRIGHT MINDS BIOSCIENCES INC040,000+40,00002,9190.06%+2,919
BRIGHTSPRING HEALTH SVCS INC(BTSG)488,500497,800+9,30018,29421,2110.46%+2,917
PROTAGONIST THERAPEUTICS INC21,70042,100+20,4001,8954,4370.10%+2,542
ABIVAX SA(ABVX)367,900465,700+97,80049,61351,8561.13%+2,243
BIOAGE LABS INC(BIOA)790,901711,811-79,09010,46412,4500.27%+1,986
IMAGENEBIO INC6,210,8996,210,899020,13422,0800.48%+1,945
RHYTHM PHARMACEUTICALS INC(RYTM)239,800314,100+74,30025,66827,3170.60%+1,649
PTC THERAPEUTICS INC(PTCT)23,20049,100+25,9001,7623,3450.07%+1,583
ALTO NEUROSCIENCE INC(ANRO)125,000167,500+42,5002,2253,7650.08%+1,540
ALUMIS INC1,102,730548,163-554,56710,76312,0760.26%+1,313
ATAIBECKLEY INC(ATAI)0347,000+347,00001,2280.03%+1,228
CG ONCOLOGY INC(CGON)0948,267+948,267064,1791.40%+64,179
KINIKSA PHARMACEUTICALS INTL(KNSA)187,199180,599-6,6007,7228,6960.19%+974
CULLINAN THERAPEUTICS INC(CGEM)0243,006+243,00603,4530.08%+3,453
TRAWS PHARMA INC605,531605,53106841,1080.02%+424
PHARVARIS N V
COM
205,400205,40005,7005,8030.13%+103
COGENT BIOSCIENCES INC(COGT)0001,1741,2200.03%+46
SINOVAC BIOTECH LTD(SVA)2,718,7352,718,7350184,466184,4664.02%0
BIOCRYST PHARMACEUTICALS INC(BCRX)1,741,8001,425,200-316,60013,58613,5680.30%-18
VISTAGEN THERAPEUTICS INC(Call)45,2000-45,200300-30
VISTAGEN THERAPEUTICS INC03,060,000+3,060,00001,7490.04%+1,749
PALISADE BIO INC1,871,4202,333,000+461,5804,3984,0830.09%-315
LEXEO THERAPEUTICS INC2,125,0003,602,450+1,477,45021,10120,6780.45%-423
C4 THERAPEUTICS INC0856,353+856,35302,2520.05%+2,252
INSPIREMD INC3,133,4053,133,40505,5775,1070.11%-470
IMAGENEBIO INC378,556378,55602,6121,8930.04%-719
COGENT BIOSCIENCES INC(COGT)371,000322,100-48,90013,17812,3980.27%-780
MAPLIGHT THERAPEUTICS INC(MPLT)56,0000-56,0009520-952
ELEVANCE HEALTH INC FORMERLY(ELV)99,100114,700+15,60034,74033,5780.73%-1,161
COMPASS THERAPEUTICS INC15,219,99415,219,994081,73180,5141.76%-1,218
FORTE BIOSCIENCES INC(FBRX)1,196,9551,196,955032,64131,0010.68%-1,640
ADICET BIO INC1,027,9441,027,94408,6557,0000.15%-1,655
OCULAR THERAPEUTIX INC(OCUL)157,3000-157,3001,9100-1,910
VERA THERAPEUTICS INC(VERA)353,500369,596+16,09617,90114,8690.32%-3,032
THERMO FISHER SCIENTIFIC INC(TMO)46,50046,500026,94422,8560.50%-4,088
CARLSMED INC1,252,6001,252,600015,47011,3360.25%-4,134
KALVISTA PHARMACEUTICALS INC382,40094,400-288,0006,1761,9000.04%-4,275
INSMED INC(INSM)25,4000-25,4004,4210-4,421
UROGEN PHARMA LTD(URGN)875,487875,487020,50415,7410.34%-4,763
SIONNA THERAPEUTICS INC(SION)3,561,6553,530,702-30,953146,526141,5463.09%-4,981
TECTONIC THERAPEUTIC INC574,600226,600-348,00011,9867,0040.15%-4,982
JADE BIOSCIENCES INC531,163185,011-346,1528,1962,5990.06%-5,596
PMV PHARMACEUTICALS INC4,975,2910-4,975,2916,2190-6,219
KEROS THERAPEUTICS INC804,212759,155-45,05716,3748,3810.18%-7,993
CELCUITY INC(CELC)85,6640-85,6648,5440-8,544
REPARE THERAPEUTICS INC3,322,4880-3,322,4888,6380-8,638
NEUROPACE INC2,406,3352,096,527-309,80837,15427,5690.60%-9,584
STRUCTURE THERAPEUTICS INC1,161,8031,475,403+313,60080,80371,1141.55%-9,689
AXSOME THERAPEUTICS INC.(AXSM)0213,921+213,921036,1570.79%+36,157
CRINETICS PHARMACEUTICALS IN(CRNX)999,000999,000046,50336,2840.79%-10,220
AMICUS THERAPEUTICS INC
COM
729,9000-729,90010,3940-10,394
TREVI THERAPEUTICS INC(TRVI)3,190,7002,454,400-736,30039,94829,2810.64%-10,667
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