Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2023 ▲▼ | Q1 2024 ▲▼ | Change ▲▼ | Q4 2023 ▲▼ | Q1 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| JANUX THERAPEUTICS INC(JANX) | 3,317,927 | 4,275,553 | +957,626 | 35,601 | 160,975 | 2.96% | +125,373 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 14,567,176 | 15,021,721 | +454,545 | 159,365 | 273,996 | 5.03% | +114,631 |
| ELI LILLY & CO(LLY) | 365,400 | 360,800 | -4,600 | 212,999 | 280,688 | 5.15% | +67,689 |
| MERCK & CO INC(MRK) | 1,055,000 | 1,316,000 | +261,000 | 115,016 | 173,646 | 3.19% | +58,630 |
| ALPINE IMMUNE SCIENCES INC | 2,535,245 | 2,680,496 | +145,251 | 48,322 | 106,255 | 1.95% | +57,933 |
| ARRIVENT BIOPHARMA INC(AVBP) | 0 | 3,027,328 | +3,027,328 | 0 | 54,068 | 0.99% | +54,068 |
| CYTOKINETICS INC(CYTK) | 0 | 682,700 | +682,700 | 0 | 47,864 | 0.88% | +47,864 |
| ARS PHARMACEUTICALS INC(SPRY) | 9,240,887 | 9,240,887 | 0 | 50,640 | 94,442 | 1.73% | +43,802 |
| GERON CORP(GERN) | 485,000 | 12,893,611 | +12,408,611 | 1,023 | 42,549 | 0.78% | +41,526 |
| Q32 BIO INC(FIXX) | 0 | 2,252,987 | +2,252,987 | 0 | 38,391 | 0.70% | +38,391 |
| ESPERION THERAPEUTICS INC NE | 0 | 13,708,731 | +13,708,731 | 0 | 36,739 | 0.67% | +36,739 |
| ENLIVEN THERAPEUTICS INC | 8,998,338 | 8,998,338 | 0 | 124,537 | 158,281 | 2.91% | +33,744 |
| KEROS THERAPEUTICS INC(KROS) | 1,268,734 | 1,268,734 | 0 | 50,445 | 83,990 | 1.54% | +33,545 |
| BOSTON SCIENTIFIC CORP(BSX) | 3,306,800 | 3,273,000 | -33,800 | 191,166 | 224,168 | 4.12% | +33,002 |
| TENET HEALTHCARE CORP(THC) | 1,224,400 | 1,173,300 | -51,100 | 92,528 | 123,326 | 2.26% | +30,798 |
| INTUITIVE SURGICAL INC | 499,000 | 493,100 | -5,900 | 168,343 | 196,791 | 3.61% | +28,449 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 0 | 460,512 | +460,512 | 0 | 28,100 | 0.52% | +28,100 |
| ARGENX SE(ARGX) | 84,600 | 151,600 | +67,000 | 32,184 | 59,688 | 1.10% | +27,504 |
| MINERALYS THERAPEUTICS INC(MLYS) | 0 | 2,021,424 | +2,021,424 | 0 | 26,097 | 0.48% | +26,097 |
| AVIDITY BIOSCIENCES INC | 0 | 994,100 | +994,100 | 0 | 25,369 | 0.47% | +25,369 |
| SAREPTA THERAPEUTICS INC(SRPT) | 697,500 | 697,500 | 0 | 67,260 | 90,298 | 1.66% | +23,038 |
| NATERA INC(NTRA) | 954,481 | 899,431 | -55,050 | 59,789 | 82,262 | 1.51% | +22,473 |
| APELLIS PHARMACEUTICALS INC COM | 922,200 | 1,297,800 | +375,600 | 55,203 | 76,285 | 1.40% | +21,082 |
| ICON PLC(ICLR) | 132,200 | 174,100 | +41,900 | 37,422 | 58,489 | 1.07% | +21,067 |
| ELEVANCE HEALTH INC(ELV) | 141,500 | 168,100 | +26,600 | 66,726 | 87,167 | 1.60% | +20,441 |
| DYNE THERAPEUTICS INC(DYN) | 0 | 708,400 | +708,400 | 0 | 20,111 | 0.37% | +20,111 |
| HERON THERAPEUTICS INC(HRTX) | 5,928,591 | 10,111,550 | +4,182,959 | 10,079 | 28,009 | 0.51% | +17,930 |
| STRYKER CORPORATION(SYK) | 269,000 | 269,000 | 0 | 80,555 | 96,267 | 1.77% | +15,712 |
| TYRA BIOSCIENCES INC(TYRA) | 0 | 768,638 | +768,638 | 0 | 12,606 | 0.23% | +12,606 |
| APOGEE THERAPEUTICS INC(APGE) | 1,277,901 | 718,901 | -559,000 | 35,705 | 47,771 | 0.88% | +12,066 |
| MORPHIC HLDG INC | 273,400 | 558,500 | +285,100 | 7,896 | 19,659 | 0.36% | +11,763 |
| NEUROPACE INC(NPCE) | 4,003,967 | 4,003,967 | 0 | 41,281 | 52,852 | 0.97% | +11,571 |
| ARROWHEAD PHARMACEUTICALS IN(ARWR) | 319,651 | 739,651 | +420,000 | 9,781 | 21,154 | 0.39% | +11,373 |
| ADICET BIO INC | 8,322,140 | 11,447,140 | +3,125,000 | 15,729 | 26,901 | 0.49% | +11,172 |
| DEXCOM INC(DXCM) | 73,200 | 140,300 | +67,100 | 9,083 | 19,460 | 0.36% | +10,376 |
| VENTYX BIOSCIENCES INC | 0 | 1,870,456 | +1,870,456 | 0 | 10,288 | 0.19% | +10,288 |
| REGENERON PHARMACEUTICALS(REGN) | 13,500 | 22,800 | +9,300 | 11,857 | 21,945 | 0.40% | +10,088 |
| EXACT SCIENCES CORP(EXK) | 0 | 140,400 | +140,400 | 0 | 9,696 | 0.18% | +9,696 |
| COMPASS THERAPEUTICS INC(CMPX) | 22,362,850 | 22,362,850 | 0 | 34,886 | 44,278 | 0.81% | +9,392 |
| NKARTA INC(NKTX) | 0 | 800,000 | +800,000 | 0 | 8,648 | 0.16% | +8,648 |
| LEXICON PHARMACEUTICALS INC(LXRX) | 0 | 3,542,000 | +3,542,000 | 0 | 8,501 | 0.16% | +8,501 |
| FATE THERAPEUTICS INC(FATE) | 528,080 | 1,355,352 | +827,272 | 1,975 | 9,948 | 0.18% | +7,973 |
| PERSPECTIVE THERAPEUTICS INC(CATX) | 0 | 6,505,800 | +6,505,800 | 0 | 7,742 | 0.14% | +7,742 |
| CYTOMX THERAPEUTICS INC(CTMX) | 0 | 3,544,578 | +3,544,578 | 0 | 7,727 | 0.14% | +7,727 |
| DISC MEDICINE INC(IRON) | 1,702,237 | 1,702,237 | 0 | 98,321 | 105,981 | 1.95% | +7,660 |
| 10X GENOMICS INC(TXG) | 39,800 | 225,200 | +185,400 | 2,227 | 8,452 | 0.16% | +6,225 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 536,642 | 704,842 | +168,200 | 24,669 | 30,541 | 0.56% | +5,871 |
| VERA THERAPEUTICS INC(VERA) | 1,518,115 | 675,872 | -842,243 | 23,349 | 29,144 | 0.54% | +5,795 |
| VERASTEM INC(VSTM) | 1,529,115 | 1,529,115 | 0 | 12,447 | 18,044 | 0.33% | +5,597 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 1,667,360 | 1,385,000 | -282,360 | 59,325 | 64,832 | 1.19% | +5,507 |
| VIR BIOTECHNOLOGY INC(VIR) | 101,000 | 640,000 | +539,000 | 1,016 | 6,483 | 0.12% | +5,467 |
| PRELUDE THERAPEUTICS INC(PRLD) | 10,909,256 | 10,909,256 | 0 | 46,583 | 51,710 | 0.95% | +5,127 |
| PROGYNY INC | 0 | 113,300 | +113,300 | 0 | 4,322 | 0.08% | +4,322 |
| ELEVATION ONCOLOGY INC | 1,500,000 | 941,275 | -558,725 | 806 | 4,829 | 0.09% | +4,023 |
| X4 PHARMACEUTICALS INC(XFOR) | 7,133,515 | 7,133,515 | 0 | 5,981 | 9,916 | 0.18% | +3,934 |
| SI-BONE INC(SIBN) | 2,292,531 | 3,174,521 | +881,990 | 48,120 | 51,967 | 0.95% | +3,847 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 1,749,000 | 1,749,000 | 0 | 37,796 | 41,626 | 0.76% | +3,830 |
| MILESTONE PHARMACEUTICALS IN(MIST) | 0 | 2,000,000 | +2,000,000 | 0 | 3,580 | 0.07% | +3,580 |
| PASSAGE BIO INC(PASG) | 10,124,576 | 10,124,576 | 0 | 10,226 | 13,668 | 0.25% | +3,442 |
| CULLINAN ONCOLOGY INC(CGEM) | 544,848 | 517,606 | -27,242 | 5,552 | 8,820 | 0.16% | +3,268 |
| XTANT MED HLDGS INC(XTNT) | 73,114,592 | 73,114,592 | 0 | 82,619 | 85,544 | 1.57% | +2,925 |
| IMMATICS N.V(IMTX) | 1,543,407 | 1,769,708 | +226,301 | 16,252 | 18,600 | 0.34% | +2,348 |
| KINNATE BIOPHARMA INC | 8,009,729 | 8,009,729 | 0 | 18,983 | 21,306 | 0.39% | +2,323 |
| DYNAVAX TECHNOLOGIES CORP | 0 | 113,500 | +113,500 | 0 | 1,409 | 0.03% | +1,409 |
| BIOMX INC(PHGE) | 4,517,589 | 4,517,589 | 0 | 1,265 | 2,033 | 0.04% | +768 |
| CHEMOMAB THERAPEUTICS LTD | 2,241,274 | 2,241,274 | 0 | 1,143 | 1,746 | 0.03% | +603 |
| TERNS PHARMACEUTICALS INC | 7,619,135 | 7,619,135 | 0 | 49,448 | 49,982 | 0.92% | +533 |
| LYELL IMMUNOPHARMA INC(LYEL) | 0 | 199,500 | +199,500 | 0 | 445 | 0.01% | +445 |
| BOLT BIOTHERAPEUTICS INC | 1,541,000 | 1,541,000 | 0 | 1,726 | 2,157 | 0.04% | +431 |
| VAXCYTE INC(PCVX) | 1,153,091 | 1,066,131 | -86,960 | 72,414 | 72,827 | 1.34% | +413 |
| THERMO FISHER SCIENTIFIC INC(TMO) | 143,800 | 132,000 | -11,800 | 76,328 | 76,720 | 1.41% | +392 |
| CALCIMEDICA INC(CALC) | 297,380 | 297,380 | 0 | 851 | 1,237 | 0.02% | +387 |
| TURNSTONE BIOLOGICS CORP | 3,099,265 | 3,099,265 | 0 | 7,888 | 8,120 | 0.15% | +232 |
| XERIS BIOPHARMA HOLDINGS INC | 0 | 80,420 | +80,420 | 0 | 178 | 0.00% | +178 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 6,943,654 | 6,943,654 | 0 | 12,221 | 12,360 | 0.23% | +139 |
| SINGULAR GENOMICS SYSTEMS IN | 540,697 | 540,697 | 0 | 249 | 278 | 0.01% | +29 |
| VIGIL NEUROSCIENCE INC | 448,891 | 448,891 | 0 | 1,517 | 1,531 | 0.03% | +13 |
| SINOVAC BIOTECH LTD(SVA) | 2,718,735 | 2,718,735 | 0 | 340,000 | 340,000 | 6.24% | 0 |
| ACUTUS MED INC | 2,648,386 | 2,648,386 | 0 | 535 | 498 | 0.01% | -37 |
| KEZAR LIFE SCIENCES INC | 1,927,000 | 1,927,000 | 0 | 1,826 | 1,737 | 0.03% | -88 |
| AEROVATE THERAPEUTICS INC | 756,930 | 565,374 | -191,556 | 17,129 | 16,718 | 0.31% | -411 |
| NEXTCURE INC | 2,711,013 | 1,141,200 | -1,569,813 | 3,091 | 2,545 | 0.05% | -546 |
| YS BIOPHARMA CO LTD | 3,236,311 | 1,534,430 | -1,701,881 | 1,654 | 1,105 | 0.02% | -549 |
| ORIC PHARMACEUTICALS INC(ORIC) | 522,968 | 287,100 | -235,868 | 4,811 | 3,948 | 0.07% | -864 |
| INSPIREMD INC(NSPR) | 2,133,405 | 2,133,405 | 0 | 5,995 | 5,056 | 0.09% | -938 |
| AGIOS PHARMACEUTICALS INC(AGIO) | 45,000 | 0 | -45,000 | 1,002 | 0 | — | -1,002 |
| XENON PHARMACEUTICALS INC(XENE) | 550,000 | 550,000 | 0 | 25,333 | 23,678 | 0.43% | -1,655 |
| APOLLOMICS INC(APLM) | 8,565,456 | 8,565,456 | 0 | 8,266 | 6,424 | 0.12% | -1,842 |
| IKENA ONCOLOGY INC | 3,539,358 | 3,539,358 | 0 | 6,973 | 5,026 | 0.09% | -1,947 |
| UNITEDHEALTH GROUP INC(UNH) | 70,000 | 70,000 | 0 | 36,853 | 34,629 | 0.64% | -2,224 |
| ARCUS BIOSCIENCES INC(RCUS) | 117,000 | 0 | -117,000 | 2,235 | 0 | — | -2,235 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 58,800 | 0 | -58,800 | 2,332 | 0 | — | -2,332 |
| TELA BIO INC(TELA) | 2,835,542 | 2,835,542 | 0 | 18,771 | 16,078 | 0.30% | -2,694 |
| ACELYRIN INC | 4,001,711 | 4,001,711 | 0 | 29,853 | 27,012 | 0.50% | -2,841 |
| AMBRX BIOPHARMA INC | 296,000 | 0 | -296,000 | 4,215 | 0 | — | -4,215 |
| ILLUMINA INC(ILMN) | 30,300 | 0 | -30,300 | 4,219 | 0 | — | -4,219 |
| INVIVYD INC(IVVD) | 4,127,565 | 2,690,300 | -1,437,265 | 16,263 | 11,945 | 0.22% | -4,318 |
| AMICUS THERAPEUTICS INC COM | 806,000 | 570,300 | -235,700 | 11,437 | 6,718 | 0.12% | -4,719 |
| ABCELLERA BIOLOGICS INC(ABCL) | 4,180,768 | 4,180,768 | 0 | 23,872 | 18,939 | 0.35% | -4,933 |
| NEUMORA THERAPEUTICS INC.(NMRA) | 1,500,000 | 1,500,000 | 0 | 25,575 | 20,625 | 0.38% | -4,950 |