Fund HoldingsORBIMED ADVISORS LLC

Total Portfolio Value
$4.16B
Total Bought
$543.09M
Total Sold
$774.26M
Net Transaction
-$231.18M
Filing Period:
Securities
SharesValue ($K)
Q4 2024
Q1 2025
Change
Q4 2024
Q1 2025
Weight (%)
Change
PFIZER INC(PFE)03,850,200+3,850,200097,5642.34%+97,564
AXSOME THERAPEUTICS INC(AXSM)0386,700+386,700045,1011.08%+45,101
UNITEDHEALTH GROUP INC(UNH)0201,200+201,2000105,3792.53%+105,379
SIONNA THERAPEUTICS INC(SION)03,704,959+3,704,959038,7540.93%+38,754
TARSUS PHARMACEUTICALS INC(TARS)0653,743+653,743033,5830.81%+33,583
APELLIS PHARMACEUTICALS INC
COM
01,432,300+1,432,300031,3240.75%+31,324
EDWARDS LIFESCIENCES CORP1,145,3021,532,000+386,69884,787111,0392.67%+26,253
AVIDITY BIOSCIENCES INC01,812,886+1,812,886053,5161.29%+53,516
THERMO FISHER SCIENTIFIC INC(TMO)0129,000+129,000064,1901.54%+64,190
CG ONCOLOGY INC(CGON)1,431,1142,471,994+1,040,88041,04460,5391.45%+19,495
ELI LILLY & CO(LLY)0337,600+337,6000278,8276.70%+278,827
ARS PHARMACEUTICALS INC08,288,510+8,288,5100104,2692.50%+104,269
VERTEX PHARMACEUTICALS INC(VRTX)0159,900+159,900077,5231.86%+77,523
AMGEN INC(AMGN)044,200+44,200013,7710.33%+13,771
NATERA INC(NTRA)0547,000+547,000077,3511.86%+77,351
COMPASS THERAPEUTICS INC022,362,850+22,362,850042,4891.02%+42,489
STRYKER CORPORATION(SYK)344,400359,200+14,800124,001133,7123.21%+9,711
AGIOS PHARMACEUTICALS INC(AGIO)26,700325,500+298,8008779,5370.23%+8,660
SPDR SER TR(Call)
ST STR SP BIOT
0100,000+100,00008,110+8,110
SPRINGWORKS THERAPEUTICS INC(Call)0172,600+172,60007,617+7,617
WHITEHAWK THERAPEUTICS INC04,166,000+4,166,00007,4150.18%+7,415
TREVI THERAPEUTICS INC(TRVI)01,120,000+1,120,00007,0450.17%+7,045
KESTRA MED TECHNOLOGIES LTD
SHS
0250,000+250,00006,2300.15%+6,230
PFIZER INC(PFE)(Call)250,000500,000+250,0006,63312,670+6,038
ARGENX SE(ARGX)189,700206,700+17,000116,666122,3382.94%+5,673
AKERO THERAPEUTICS INC66,000179,900+113,9001,8367,2820.17%+5,446
ORIC PHARMACEUTICALS INC(ORIC)0700,000+700,00003,9060.09%+3,906
NEUROPACE INC3,406,3353,406,335038,11741,8641.01%+3,747
VERASTEM INC2,862,4482,862,448014,79917,2610.41%+2,462
INTEGER HLDGS CORP(ITGR)575,000662,500+87,50076,19978,1821.88%+1,983
XTANT MED HLDGS INC073,114,592+73,114,592034,3640.83%+34,364
BOSTON SCIENTIFIC CORP(BSX)3,160,3002,813,200-347,100282,278283,7966.82%+1,518
AVALO THERAPEUTICS INC(AVTX)967,000967,00007,1857,7460.19%+561
KRYSTAL BIOTECH INC(KRYS)23,50023,50003,6824,2370.10%+556
DIH HLDG US INC01,915,000+1,915,00004430.01%+443
XERIS BIOPHARMA HOLDINGS INC80,42080,42002734420.01%+169
INSPIREMD INC2,133,4052,133,40505,6115,7390.14%+128
INVIVYD INC1,149,300933,500-215,8005095650.01%+56
SI-BONE INC3,442,8533,442,853048,26948,3031.16%+34
SINOVAC BIOTECH LTD(SVA)2,718,7352,718,7350333,997333,9978.02%0
AMYLYX PHARMACEUTICALS INC(AMLX)348,000348,00001,3151,2320.03%-84
LAKESHORE BIOPHARMA CO LTD140,428140,42804863440.01%-142
INSTIL BIO INC116,785116,78502,2292,0270.05%-202
TURNSTONE BIOLOGICS CORP3,099,2653,099,26501,5401,2710.03%-269
BIOMX INC1,787,7671,787,76701,3059930.02%-312
NEXTCURE INC1,141,2001,141,20008805480.01%-332
KEZAR LIFE SCIENCES INC
COM NEW
192,700192,70001,2959400.02%-355
ALTO NEUROSCIENCE INC(ANRO)250,000250,00001,0585400.01%-517
ELEVATION ONCOLOGY INC941,2750-941,2755300-530
NKARTA INC821,400821,40002,0451,5110.04%-534
C4 THERAPEUTICS INC(Call)150,0000-150,0005400-540
GILEAD SCIENCES INC(GILD)245,600197,500-48,10022,68622,1300.53%-556
KORRO BIO INC32,40032,40001,2335640.01%-669
CERIBELL INC112,500112,50002,9122,1610.05%-750
TANGO THERAPEUTICS INC(TNGX)550,000550,00001,7007540.02%-946
REPARE THERAPEUTICS INC03,322,488+3,322,48803,2760.08%+3,276
CHEMOMAB THERAPEUTICS LTD1,741,2731,741,27303,1521,8980.05%-1,254
IKENA ONCOLOGY INC3,539,3583,539,35805,8054,5300.11%-1,274
BICARA THERAPEUTICS INC298,301298,30105,1963,8870.09%-1,310
FATE THERAPEUTICS INC1,680,5801,680,58002,7731,3280.03%-1,445
STRUCTURE THERAPEUTICS INC(Call)150,000150,00004,0682,597-1,471
SCHOLAR ROCK HLDG CORP(SRRK)151,800151,80006,5614,8800.12%-1,680
PASSAGE BIO INC7,404,8697,034,626-370,2434,1992,4840.06%-1,715
BIOAGE LABS INC(BIOA)0921,959+921,95903,4670.08%+3,467
IMMUNOVANT INC(IMVT)78,5000-78,5001,9440-1,944
LYELL IMMUNOPHARMA INC000000
ENGENE HOLDINGS INC
COM
920,339891,616-28,7236,1203,9940.10%-2,126
RHYTHM PHARMACEUTICALS INC(RYTM)400,000380,000-20,00022,39220,1290.48%-2,263
ADICET BIO INC11,447,14011,447,140011,0128,6430.21%-2,370
PEPGEN INC653,0160-653,0162,4750-2,475
ACELYRIN INC04,001,711+4,001,71109,8840.24%+9,884
PMV PHARMACEUTICALS INC6,475,2916,475,29109,7787,0580.17%-2,720
AMICUS THERAPEUTICS INC
COM
2,285,4002,285,400021,52818,6490.45%-2,880
ABCELLERA BIOLOGICS INC(ABCL)4,180,7684,180,768012,2509,3230.22%-2,927
TENET HEALTHCARE CORP(THC)(Call)25,0000-25,0003,1560-3,156
SPRINGWORKS THERAPEUTICS INC1,255,031950,200-304,83145,34441,9321.01%-3,412
ADC THERAPEUTICS SA5,968,4515,968,451011,8778,4160.20%-3,462
SI-BONE INC(Call)250,0000-250,0003,5050-3,505
ARDENT HEALTH PARTNERS INC(ARDT)206,0000-206,0003,5180-3,518
X4 PHARMACEUTICALS INC7,133,5156,776,515-357,0005,2331,6020.04%-3,631
TRAWS PHARMA INC605,531605,53105,3771,3930.03%-3,984
Q32 BIO INC02,252,987+2,252,98703,7170.09%+3,717
TYRA BIOSCIENCES INC(TYRA)1,470,0861,752,831+282,74520,43416,3010.39%-4,133
ALNYLAM PHARMACEUTICALS INC(ALNY)415,600346,100-69,50097,79593,4542.24%-4,341
INSMED INC(INSM)94,55928,659-65,9006,5282,1860.05%-4,342
MILESTONE PHARMACEUTICALS IN2,000,0000-2,000,0004,7200-4,720
RAPT THERAPEUTICS INC13,135,26013,135,260020,75416,0250.38%-4,729
C4 THERAPEUTICS INC06,830,300+6,830,300010,9280.26%+10,928
CARDIFF ONCOLOGY INC1,538,462573,884-964,5786,6771,8020.04%-4,875
IKENA ONCOLOGY INC12,048,77312,048,773017,68712,5140.30%-5,173
XENON PHARMACEUTICALS INC(XENE)947,877947,877037,15731,8010.76%-5,356
SCPHARMACEUTICALS INC6,059,5286,059,528021,45115,9370.38%-5,514
PRELUDE THERAPEUTICS INC010,909,256+10,909,25608,3780.20%+8,378
KEROS THERAPEUTICS INC01,018,734+1,018,734010,3810.25%+10,381
STRUCTURE THERAPEUTICS INC652,028652,028017,68311,2870.27%-6,396
CORBUS PHARMACEUTICALS HLDGS1,172,2871,172,287013,8336,2250.15%-7,608
GERON CORP(GERN)2,168,0000-2,168,0007,6750-7,675
IMMATICS N.V(IMTX)3,087,4623,087,462021,95213,9240.33%-8,027
NEUMORA THERAPEUTICS INC.000000
EXACT SCIENCES CORP(EXK)0679,816+679,816029,4290.71%+29,429
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