Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2024 ▲▼ | Q1 2025 ▲▼ | Change ▲▼ | Q4 2024 ▲▼ | Q1 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| PFIZER INC(PFE) | 0 | 3,850,200 | +3,850,200 | 0 | 97,564 | 2.34% | +97,564 |
| AXSOME THERAPEUTICS INC(AXSM) | 0 | 386,700 | +386,700 | 0 | 45,101 | 1.08% | +45,101 |
| UNITEDHEALTH GROUP INC(UNH) | 130,900 | 201,200 | +70,300 | 66,217 | 105,379 | 2.53% | +39,161 |
| SIONNA THERAPEUTICS INC(SION) | 0 | 3,704,959 | +3,704,959 | 0 | 38,754 | 0.93% | +38,754 |
| TARSUS PHARMACEUTICALS INC(TARS) | 0 | 653,743 | +653,743 | 0 | 33,583 | 0.81% | +33,583 |
| APELLIS PHARMACEUTICALS INC COM | 0 | 1,432,300 | +1,432,300 | 0 | 31,324 | 0.75% | +31,324 |
| EDWARDS LIFESCIENCES CORP | 1,145,302 | 1,532,000 | +386,698 | 84,787 | 111,039 | 2.67% | +26,253 |
| AVIDITY BIOSCIENCES INC | 1,112,886 | 1,812,886 | +700,000 | 32,363 | 53,516 | 1.29% | +21,154 |
| THERMO FISHER SCIENTIFIC INC(TMO) | 84,400 | 129,000 | +44,600 | 43,907 | 64,190 | 1.54% | +20,283 |
| CG ONCOLOGY INC(CGON) | 1,431,114 | 2,471,994 | +1,040,880 | 41,044 | 60,539 | 1.45% | +19,495 |
| ELI LILLY & CO(LLY) | 337,600 | 337,600 | 0 | 260,627 | 278,827 | 6.70% | +18,200 |
| ARS PHARMACEUTICALS INC(SPRY) | 8,288,510 | 8,288,510 | 0 | 87,444 | 104,269 | 2.50% | +16,826 |
| VERTEX PHARMACEUTICALS INC(VRTX) | 151,000 | 159,900 | +8,900 | 60,808 | 77,523 | 1.86% | +16,715 |
| AMGEN INC(AMGN) | 0 | 44,200 | +44,200 | 0 | 13,771 | 0.33% | +13,771 |
| NATERA INC(NTRA) | 413,000 | 547,000 | +134,000 | 65,378 | 77,351 | 1.86% | +11,973 |
| COMPASS THERAPEUTICS INC(CMPX) | 22,362,850 | 22,362,850 | 0 | 32,426 | 42,489 | 1.02% | +10,063 |
| STRYKER CORPORATION(SYK) | 344,400 | 359,200 | +14,800 | 124,001 | 133,712 | 3.21% | +9,711 |
| AGIOS PHARMACEUTICALS INC(AGIO) | 26,700 | 325,500 | +298,800 | 877 | 9,537 | 0.23% | +8,660 |
| WHITEHAWK THERAPEUTICS INC(WHWK) | 0 | 4,166,000 | +4,166,000 | 0 | 7,415 | 0.18% | +7,415 |
| TREVI THERAPEUTICS INC(TRVI) | 0 | 1,120,000 | +1,120,000 | 0 | 7,045 | 0.17% | +7,045 |
| KESTRA MED TECHNOLOGIES LTD SHS | 0 | 250,000 | +250,000 | 0 | 6,230 | 0.15% | +6,230 |
| ARGENX SE(ARGX) | 189,700 | 206,700 | +17,000 | 116,666 | 122,338 | 2.94% | +5,673 |
| AKERO THERAPEUTICS INC | 66,000 | 179,900 | +113,900 | 1,836 | 7,282 | 0.17% | +5,446 |
| ORIC PHARMACEUTICALS INC(ORIC) | 0 | 700,000 | +700,000 | 0 | 3,906 | 0.09% | +3,906 |
| NEUROPACE INC(NPCE) | 3,406,335 | 3,406,335 | 0 | 38,117 | 41,864 | 1.01% | +3,747 |
| VERASTEM INC(VSTM) | 2,862,448 | 2,862,448 | 0 | 14,799 | 17,261 | 0.41% | +2,462 |
| INTEGER HLDGS CORP(ITGR) | 575,000 | 662,500 | +87,500 | 76,199 | 78,182 | 1.88% | +1,983 |
| XTANT MED HLDGS INC(XTNT) | 73,114,592 | 73,114,592 | 0 | 32,390 | 34,364 | 0.83% | +1,974 |
| BOSTON SCIENTIFIC CORP(BSX) | 3,160,300 | 2,813,200 | -347,100 | 282,278 | 283,796 | 6.82% | +1,518 |
| AVALO THERAPEUTICS INC(AVTX) | 967,000 | 967,000 | 0 | 7,185 | 7,746 | 0.19% | +561 |
| KRYSTAL BIOTECH INC(KRYS) | 23,500 | 23,500 | 0 | 3,682 | 4,237 | 0.10% | +556 |
| DIH HLDG US INC | 0 | 1,915,000 | +1,915,000 | 0 | 443 | 0.01% | +443 |
| XERIS BIOPHARMA HOLDINGS INC | 80,420 | 80,420 | 0 | 273 | 442 | 0.01% | +169 |
| INSPIREMD INC(NSPR) | 2,133,405 | 2,133,405 | 0 | 5,611 | 5,739 | 0.14% | +128 |
| INVIVYD INC(IVVD) | 1,149,300 | 933,500 | -215,800 | 509 | 565 | 0.01% | +56 |
| SI-BONE INC(SIBN) | 3,442,853 | 3,442,853 | 0 | 48,269 | 48,303 | 1.16% | +34 |
| SINOVAC BIOTECH LTD(SVA) | 2,718,735 | 2,718,735 | 0 | 333,997 | 333,997 | 8.02% | 0 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 348,000 | 348,000 | 0 | 1,315 | 1,232 | 0.03% | -84 |
| LAKESHORE BIOPHARMA CO LTD | 140,428 | 140,428 | 0 | 486 | 344 | 0.01% | -142 |
| INSTIL BIO INC(TIL) | 116,785 | 116,785 | 0 | 2,229 | 2,027 | 0.05% | -202 |
| TURNSTONE BIOLOGICS CORP | 3,099,265 | 3,099,265 | 0 | 1,540 | 1,271 | 0.03% | -269 |
| BIOMX INC(PHGE) | 1,787,767 | 1,787,767 | 0 | 1,305 | 993 | 0.02% | -312 |
| NEXTCURE INC | 1,141,200 | 1,141,200 | 0 | 880 | 548 | 0.01% | -332 |
| KEZAR LIFE SCIENCES INC COM NEW | 192,700 | 192,700 | 0 | 1,295 | 940 | 0.02% | -355 |
| ALTO NEUROSCIENCE INC(ANRO) | 250,000 | 250,000 | 0 | 1,058 | 540 | 0.01% | -517 |
| ELEVATION ONCOLOGY INC | 941,275 | 0 | -941,275 | 530 | 0 | — | -530 |
| NKARTA INC(NKTX) | 821,400 | 821,400 | 0 | 2,045 | 1,511 | 0.04% | -534 |
| GILEAD SCIENCES INC(GILD) | 245,600 | 197,500 | -48,100 | 22,686 | 22,130 | 0.53% | -556 |
| KORRO BIO INC(KRRO) | 32,400 | 32,400 | 0 | 1,233 | 564 | 0.01% | -669 |
| CERIBELL INC(CBLL) | 112,500 | 112,500 | 0 | 2,912 | 2,161 | 0.05% | -750 |
| TANGO THERAPEUTICS INC(TNGX) | 550,000 | 550,000 | 0 | 1,700 | 754 | 0.02% | -946 |
| REPARE THERAPEUTICS INC | 3,322,488 | 3,322,488 | 0 | 4,352 | 3,276 | 0.08% | -1,077 |
| CHEMOMAB THERAPEUTICS LTD | 1,741,273 | 1,741,273 | 0 | 3,152 | 1,898 | 0.05% | -1,254 |
| IKENA ONCOLOGY INC | 3,539,358 | 3,539,358 | 0 | 5,805 | 4,530 | 0.11% | -1,274 |
| BICARA THERAPEUTICS INC | 298,301 | 298,301 | 0 | 5,196 | 3,887 | 0.09% | -1,310 |
| FATE THERAPEUTICS INC(FATE) | 1,680,580 | 1,680,580 | 0 | 2,773 | 1,328 | 0.03% | -1,445 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 151,800 | 151,800 | 0 | 6,561 | 4,880 | 0.12% | -1,680 |
| PASSAGE BIO INC(PASG) | 7,404,869 | 7,034,626 | -370,243 | 4,199 | 2,484 | 0.06% | -1,715 |
| BIOAGE LABS INC(BIOA) | 921,959 | 921,959 | 0 | 5,338 | 3,467 | 0.08% | -1,872 |
| IMMUNOVANT INC(IMVT) | 78,500 | 0 | -78,500 | 1,944 | 0 | — | -1,944 |
| LYELL IMMUNOPHARMA INC(LYEL) | 3,103,623 | 0 | -3,103,623 | 1,986 | 0 | — | -1,986 |
| ENGENE HOLDINGS INC COM | 920,339 | 891,616 | -28,723 | 6,120 | 3,994 | 0.10% | -2,126 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 400,000 | 380,000 | -20,000 | 22,392 | 20,129 | 0.48% | -2,263 |
| ADICET BIO INC | 11,447,140 | 11,447,140 | 0 | 11,012 | 8,643 | 0.21% | -2,370 |
| PEPGEN INC(PEPG) | 653,016 | 0 | -653,016 | 2,475 | 0 | — | -2,475 |
| ACELYRIN INC | 4,001,711 | 4,001,711 | 0 | 12,565 | 9,884 | 0.24% | -2,681 |
| PMV PHARMACEUTICALS INC(PMVP) | 6,475,291 | 6,475,291 | 0 | 9,778 | 7,058 | 0.17% | -2,720 |
| AMICUS THERAPEUTICS INC COM | 2,285,400 | 2,285,400 | 0 | 21,528 | 18,649 | 0.45% | -2,880 |
| ABCELLERA BIOLOGICS INC(ABCL) | 4,180,768 | 4,180,768 | 0 | 12,250 | 9,323 | 0.22% | -2,927 |
| SPRINGWORKS THERAPEUTICS INC | 1,255,031 | 950,200 | -304,831 | 45,344 | 41,932 | 1.01% | -3,412 |
| ADC THERAPEUTICS SA(ADCT) | 5,968,451 | 5,968,451 | 0 | 11,877 | 8,416 | 0.20% | -3,462 |
| ARDENT HEALTH PARTNERS INC(ARDT) | 206,000 | 0 | -206,000 | 3,518 | 0 | — | -3,518 |
| X4 PHARMACEUTICALS INC(XFOR) | 7,133,515 | 6,776,515 | -357,000 | 5,233 | 1,602 | 0.04% | -3,631 |
| TRAWS PHARMA INC(TRAW) | 605,531 | 605,531 | 0 | 5,377 | 1,393 | 0.03% | -3,984 |
| Q32 BIO INC(FIXX) | 2,252,987 | 2,252,987 | 0 | 7,750 | 3,717 | 0.09% | -4,033 |
| TYRA BIOSCIENCES INC(TYRA) | 1,470,086 | 1,752,831 | +282,745 | 20,434 | 16,301 | 0.39% | -4,133 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 415,600 | 346,100 | -69,500 | 97,795 | 93,454 | 2.24% | -4,341 |
| INSMED INC(INSM) | 94,559 | 28,659 | -65,900 | 6,528 | 2,186 | 0.05% | -4,342 |
| MILESTONE PHARMACEUTICALS IN(MIST) | 2,000,000 | 0 | -2,000,000 | 4,720 | 0 | — | -4,720 |
| RAPT THERAPEUTICS INC | 13,135,260 | 13,135,260 | 0 | 20,754 | 16,025 | 0.38% | -4,729 |
| C4 THERAPEUTICS INC(CCCC) | 4,377,900 | 6,830,300 | +2,452,400 | 15,760 | 10,928 | 0.26% | -4,832 |
| CARDIFF ONCOLOGY INC(CRDF) | 1,538,462 | 573,884 | -964,578 | 6,677 | 1,802 | 0.04% | -4,875 |
| XENON PHARMACEUTICALS INC(XENE) | 947,877 | 947,877 | 0 | 37,157 | 31,801 | 0.76% | -5,356 |
| SCPHARMACEUTICALS INC | 6,059,528 | 6,059,528 | 0 | 21,451 | 15,937 | 0.38% | -5,514 |
| PRELUDE THERAPEUTICS INC(PRLD) | 10,909,256 | 10,909,256 | 0 | 13,909 | 8,378 | 0.20% | -5,531 |
| KEROS THERAPEUTICS INC(KROS) | 1,018,734 | 1,018,734 | 0 | 16,127 | 10,381 | 0.25% | -5,746 |
| STRUCTURE THERAPEUTICS INC | 652,028 | 652,028 | 0 | 17,683 | 11,287 | 0.27% | -6,396 |
| CORBUS PHARMACEUTICALS HLDGS(CRBP) | 1,172,287 | 1,172,287 | 0 | 13,833 | 6,225 | 0.15% | -7,608 |
| GERON CORP(GERN) | 2,168,000 | 0 | -2,168,000 | 7,675 | 0 | — | -7,675 |
| IMMATICS N.V(IMTX) | 3,087,462 | 3,087,462 | 0 | 21,952 | 13,924 | 0.33% | -8,027 |
| NEUMORA THERAPEUTICS INC.(NMRA) | 804,996 | 0 | -804,996 | 8,533 | 0 | — | -8,533 |
| EXACT SCIENCES CORP(EXK) | 679,816 | 679,816 | 0 | 38,199 | 29,429 | 0.71% | -8,770 |
| FORTE BIOSCIENCES INC(FBRX) | 600,000 | 593,088 | -6,912 | 13,626 | 4,602 | 0.11% | -9,024 |
| VIR BIOTECHNOLOGY INC(VIR) | 3,218,617 | 2,248,249 | -970,368 | 23,625 | 14,569 | 0.35% | -9,056 |
| CULLINAN THERAPEUTICS INC(CGEM) | 1,942,555 | 1,923,855 | -18,700 | 23,660 | 14,564 | 0.35% | -9,097 |
| INTRA-CELLULAR THERAPIES INC | 163,000 | 0 | -163,000 | 13,614 | 0 | — | -13,614 |
| CYTOKINETICS INC(CYTK) | 1,584,005 | 1,509,205 | -74,800 | 74,512 | 60,655 | 1.46% | -13,857 |
| MEDPACE HLDGS INC(MEDP) | 44,900 | 0 | -44,900 | 14,917 | 0 | — | -14,917 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 6,943,654 | 6,943,654 | 0 | 37,149 | 22,081 | 0.53% | -15,068 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 999,000 | 999,000 | 0 | 51,079 | 33,506 | 0.80% | -17,572 |