Fund Holdings

ORBIMED ADVISORS LLC

Filing Period:
Securities
SharesValue ($K)
Q4 2025
Q1 2026
Change
Q4 2025
Q1 2026
Weight (%)
Change
MDXHEALTH SA(Call)0124,306,000+124,306,0000285,903,800+285,903,800
ENLIVEN THERAPEUTICS INC07,959,538+7,959,5380312,013,890+312,013,890
AVITA MEDICAL INC(Call)040,966,100+40,966,1000154,442,197+154,442,197
ASTRAZENECA PLC0670,200+670,2000132,176,844+132,176,844
MYRIAD GENETICS INC0000122,875,000+122,875,000
EDGEWISE THERAPEUTICS INC015,518,492+15,518,4920488,832,498+488,832,498
MERCK & CO INC0663,400+663,400079,800,386+79,800,386
CORVUS PHARMACEUTICALS INC07,165,006+7,165,0060104,824,038+104,824,038
AVITA MEDICAL INC0544,895+544,895042,516,112+42,516,112
XENON PHARMACEUTICALS INC01,059,971+1,059,971061,637,314+61,637,314
GUARDANT HEALTH INC0435,200+435,200040,199,424+40,199,424
PRAXIS PRECISION MEDICINES I0172,500+172,500055,577,775+55,577,775
SYNDAX PHARMACEUTICALS INC0962,300+962,300022,479,328+22,479,328
RELMADA THERAPEUTICS INC04,715,864+4,715,864032,822,413+32,822,413
MINERALYS THERAPEUTICS INC02,052,900+2,052,900055,613,061+55,613,061
SUTRO BIOPHARMA INC0801,144+801,144019,956,497+19,956,497
NEKTAR THERAPEUTICS0275,000+275,000019,786,250+19,786,250
SHATTUCK LABS INC06,306,127+6,306,127040,548,397+40,548,397
UNIQURE NV02,136,149+2,136,149034,926,036+34,926,036
PALVELLA THERAPEUTICS INC NE0134,600+134,600016,777,890+16,777,890
DEFINIUM THERAPEUTICS INC0804,000+804,000015,195,600+15,195,600
BRISTOL-MYERS SQUIBB CO0925,000+925,000056,101,250+56,101,250
AMGEN INC039,900+39,900014,038,815+14,038,815
ALIGNMENT HEALTHCARE INC0791,000+791,000013,937,420+13,937,420
PFIZER INC01,946,500+1,946,500054,657,720+54,657,720
REGENERON PHARMACEUTICALS014,700+14,700011,357,808+11,357,808
BIOGEN INC061,600+61,600011,293,128+11,293,128
QIAGEN NV(Call)0250,000+250,000010,010,000+10,010,000
DYNE THERAPEUTICS INC02,917,884+2,917,884052,901,237+52,901,237
BICARA THERAPEUTICS INC0667,300+667,300013,272,597+13,272,597
ARRIVENT BIOPHARMA INC03,027,328+3,027,328069,840,457+69,840,457
GILEAD SCIENCES INC059,600+59,60008,306,452+8,306,452
HERON THERAPEUTICS INC09,816,940+9,816,94007,854,534+7,854,534
Q32 BIO INC02,252,987+2,252,987014,464,177+14,464,177
ESPERION THERAPEUTICS INC NE010,570,300+10,570,300028,962,622+28,962,622
COMPASS PATHWAYS PLC01,150,646+1,150,64606,363,072+6,363,072
PALVELLA THERAPEUTICS INC NE(Call)050,000+50,00006,232,500+6,232,500
ALX ONCOLOGY HLDGS INC02,866,256+2,866,25605,746,843+5,746,843
PRELUDE THERAPEUTICS INC010,909,256+10,909,256037,309,656+37,309,656
ARTIVION INC0151,000+151,00005,529,620+5,529,620
ASCENDIS PHARMA A/S0181,977+181,977041,623,599+41,623,599
ORIC PHARMACEUTICALS INC02,693,929+2,693,929034,132,080+34,132,080
WHITEHAWK THERAPEUTICS INC04,166,000+4,166,000014,372,700+14,372,700
SAVARA INC0635,000+635,00003,467,100+3,467,100
SOLENO THERAPEUTICS INC(Call)0100,000+100,00003,348,000+3,348,000
CORBUS PHARMACEUTICALS HLDGS01,737,287+1,737,287016,313,125+16,313,125
LIFESTANCE HEALTH GROUP INC0500,000+500,00003,185,000+3,185,000
REVOLUTION MEDICINES INC052,000+52,00005,057,000+5,057,000
BRIGHT MINDS BIOSCIENCES INC040,000+40,00002,918,800+2,918,800
BRIGHTSPRING HEALTH SVCS INC0497,800+497,800021,211,258+21,211,258
PROTAGONIST THERAPEUTICS INC042,100+42,10004,437,340+4,437,340
ABIVAX SA0465,700+465,700051,855,695+51,855,695
BIOAGE LABS INC0711,811+711,811012,449,574+12,449,574
IMAGENEBIO INC06,210,899+6,210,899022,079,801+22,079,801
RHYTHM PHARMACEUTICALS INC0314,100+314,100027,317,277+27,317,277
PTC THERAPEUTICS INC049,100+49,10003,345,183+3,345,183
ALTO NEUROSCIENCE INC0167,500+167,50003,765,400+3,765,400
ALUMIS INC0548,163+548,163012,076,031+12,076,031
ATAIBECKLEY INC0347,000+347,00001,228,380+1,228,380
CG ONCOLOGY INC0948,267+948,267064,178,711+64,178,711
KINIKSA PHARMACEUTICALS INTL0180,599+180,59908,695,842+8,695,842
CULLINAN THERAPEUTICS INC0243,006+243,00603,453,115+3,453,115
TRAWS PHARMA INC0605,531+605,53101,108,122+1,108,122
PHARVARIS N V0205,400+205,40005,802,550+5,802,550
COGENT BIOSCIENCES INC00001,220,000+1,220,000
SINOVAC BIOTECH LTD02,718,735+2,718,7350184,466,170+184,466,170
BIOCRYST PHARMACEUTICALS INC01,425,200+1,425,200013,567,904+13,567,904
VISTAGEN THERAPEUTICS INC(Call)000000
VISTAGEN THERAPEUTICS INC03,060,000+3,060,00001,748,790+1,748,790
PALISADE BIO INC02,333,000+2,333,00004,082,750+4,082,750
LEXEO THERAPEUTICS INC03,602,450+3,602,450020,678,063+20,678,063
C4 THERAPEUTICS INC0856,353+856,35302,252,208+2,252,208
INSPIREMD INC03,133,405+3,133,40505,107,450+5,107,450
IMAGENEBIO INC0378,556+378,55601,892,780+1,892,780
COGENT BIOSCIENCES INC0322,100+322,100012,397,629+12,397,629
MAPLIGHT THERAPEUTICS INC000000
ELEVANCE HEALTH INC FORMERLY0114,700+114,700033,578,425+33,578,425
COMPASS THERAPEUTICS INC015,219,994+15,219,994080,513,768+80,513,768
FORTE BIOSCIENCES INC01,196,955+1,196,955031,001,135+31,001,135
ADICET BIO INC01,027,944+1,027,94407,000,299+7,000,299
OCULAR THERAPEUTIX INC000000
VERA THERAPEUTICS INC0369,596+369,596014,868,847+14,868,847
THERMO FISHER SCIENTIFIC INC046,500+46,500022,856,145+22,856,145
CARLSMED INC01,252,600+1,252,600011,336,030+11,336,030
KALVISTA PHARMACEUTICALS INC094,400+94,40001,900,272+1,900,272
INSMED INC000000
UROGEN PHARMA LTD0875,487+875,487015,741,256+15,741,256
SIONNA THERAPEUTICS INC03,530,702+3,530,7020141,545,843+141,545,843
TECTONIC THERAPEUTIC INC0226,600+226,60007,004,206+7,004,206
JADE BIOSCIENCES INC0185,011+185,01102,599,405+2,599,405
PMV PHARMACEUTICALS INC000000
KEROS THERAPEUTICS INC0759,155+759,15508,381,071+8,381,071
CELCUITY INC000000
REPARE THERAPEUTICS INC000000
NEUROPACE INC02,096,527+2,096,527027,569,330+27,569,330
STRUCTURE THERAPEUTICS INC01,475,403+1,475,403071,114,425+71,114,425
AXSOME THERAPEUTICS INC.0213,921+213,921036,156,927+36,156,927
CRINETICS PHARMACEUTICALS IN0999,000+999,000036,283,680+36,283,680
AMICUS THERAPEUTICS INC000000
TREVI THERAPEUTICS INC02,454,400+2,454,400029,280,992+29,280,992
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