Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Edgewise Therapeutics, Inc.(EWTX) | 15,518,492 | 15,518,492 | 0 | $385.09M | $488.83M | 10.66% | +$103.74M |
| Enliven Therapeutics Inc | 7,959,538 | 7,959,538 | 0 | $122.58M | $312.01M | 6.80% | +$189.44M |
| Eli Lilly and Company(LLY) | 301,200 | 236,800 | -64,400 | $323.69M | $217.80M | 4.75% | -$105.89M |
| Sinovac Biotech, Ltd.SHS(SVA) | 2,718,735 | 2,718,735 | 0 | $184.47M | $184.47M | 4.02% | $0 |
| Boston Scientific Corporation(BSX) | 2,419,300 | 2,382,100 | -37,200 | $230.68M | $149.48M | 3.26% | -$81.20M |
| Sionna Therapeutics, Inc.(SION) | 3,561,655 | 3,530,702 | -30,953 | $146.53M | $141.55M | 3.09% | -$4.98M |
| AstraZeneca PLC(AZN) | 0 | 670,200 | +670,200 | $0 | $132.18M | 2.88% | +$132.18M |
| Myriad Genetics, Inc.(MYGN) | 0 | 0 | 0 | $0 | $122.88M | 2.68% | +$122.88M |
| MBX Biosciences, Inc.(MBX) | 3,935,203 | 3,637,887 | -297,316 | $124.12M | $108.59M | 2.37% | -$15.53M |
| Corvus Pharmaceuticals, Inc.(CRVS) | 7,165,006 | 7,165,006 | 0 | $55.17M | $104.82M | 2.29% | +$49.65M |
| argenx SEADR(ARGX) | 146,000 | 136,900 | -9,100 | $122.78M | $99.97M | 2.18% | -$22.81M |
| Edwards Lifesciences Corp | 1,842,900 | 1,230,600 | -612,300 | $157.11M | $98.55M | 2.15% | -$58.56M |
| Intuitive Surgical, Inc.(ISRG) | 263,400 | 208,700 | -54,700 | $149.18M | $96.21M | 2.10% | -$52.97M |
| Compass Therapeutics, Inc.(CMPX) | 15,219,994 | 15,219,994 | 0 | $81.73M | $80.51M | 1.76% | -$1.22M |
| Merck & Co., Inc.(MRK) | 0 | 663,400 | +663,400 | $0 | $79.80M | 1.74% | +$79.80M |
| Structure Therapeutics IncADS | 1,161,803 | 1,475,403 | +313,600 | $80.80M | $71.11M | 1.55% | -$9.69M |
| ArriVent BioPharma, Inc.(AVBP) | 3,027,328 | 3,027,328 | 0 | $60.91M | $69.84M | 1.52% | +$8.93M |
| Disc Medicine, Inc.(IRON) | 1,067,550 | 1,067,550 | 0 | $84.77M | $68.26M | 1.49% | -$16.51M |
| ARS Pharmaceuticals, Inc.(SPRY) | 8,288,510 | 8,288,510 | 0 | $96.56M | $66.56M | 1.45% | -$30.00M |
| CG Oncology, Inc.(CGON) | 1,516,550 | 948,267 | -568,283 | $62.97M | $64.18M | 1.40% | +$1.21M |
| Xenon Pharmaceuticals Inc.(XENE) | 447,200 | 1,059,971 | +612,771 | $20.04M | $61.64M | 1.34% | +$41.59M |
| Stryker Corporation(SYK) | 325,000 | 182,500 | -142,500 | $114.23M | $59.97M | 1.31% | -$54.26M |
| Bristol-Myers Squibb Company(BMY) | 775,000 | 925,000 | +150,000 | $41.80M | $56.10M | 1.22% | +$14.30M |
| Mineralys Therapeutics, Inc.(MLYS) | 980,400 | 2,052,900 | +1,072,500 | $35.58M | $55.61M | 1.21% | +$20.03M |
| Praxis Precision Medicines, Inc.(PRAX) | 94,500 | 172,500 | +78,000 | $27.85M | $55.58M | 1.21% | +$27.72M |
| Pfizer Inc.(PFE) | 1,652,900 | 1,946,500 | +293,600 | $41.16M | $54.66M | 1.19% | +$13.50M |
| Dyne Therapeutics, Inc.(DYN) | 2,202,184 | 2,917,884 | +715,700 | $43.07M | $52.90M | 1.15% | +$9.83M |
| Natera, Inc.(NTRA) | 365,800 | 262,000 | -103,800 | $83.80M | $52.40M | 1.14% | -$31.40M |
| ABIVAX Société AnonymeADS(ABVX) | 367,900 | 465,700 | +97,800 | $49.61M | $51.86M | 1.13% | +$2.24M |
| Upstream Bio, Inc.(UPB) | 5,693,589 | 5,693,589 | 0 | $154.58M | $51.24M | 1.12% | -$103.34M |
| Danaher Corporation(DHR) | 299,800 | 265,800 | -34,000 | $68.63M | $50.40M | 1.10% | -$18.23M |
| Caris Life Sciences, Inc.(CAI) | 3,116,011 | 2,806,811 | -309,200 | $84.07M | $50.19M | 1.09% | -$33.88M |
| AVITA Medical, Inc.(RCEL) | 0 | 544,895 | +544,895 | $0 | $42.52M | 0.93% | +$42.52M |
| Ascendis Pharma A/SADR(ASND) | 171,977 | 181,977 | +10,000 | $36.67M | $41.62M | 0.91% | +$4.95M |
| Shattuck Labs, Inc.(STTK) | 6,306,127 | 6,306,127 | 0 | $23.02M | $40.55M | 0.88% | +$17.53M |
| Guardant Health, Inc.(GH) | 0 | 435,200 | +435,200 | $0 | $40.20M | 0.88% | +$40.20M |
| Alnylam Pharmaceuticals, Inc.(ALNY) | 288,800 | 119,000 | -169,800 | $114.84M | $39.37M | 0.86% | -$75.47M |
| Prelude Therapeutics Incorporated(PRLD) | 10,909,256 | 10,909,256 | 0 | $31.64M | $37.31M | 0.81% | +$5.67M |
| Crinetics Pharmaceuticals In | 999,000 | 999,000 | 0 | $46.50M | $36.28M | 0.79% | -$10.22M |
| Axsome Therapeutics, Inc.(AXSM) | 253,121 | 213,921 | -39,200 | $46.23M | $36.16M | 0.79% | -$10.07M |
| uniQure N.V.SHS(QURE) | 737,400 | 2,136,149 | +1,398,749 | $17.65M | $34.93M | 0.76% | +$17.28M |
| ORIC Pharmaceuticals, Inc.(ORIC) | 3,641,756 | 2,693,929 | -947,827 | $29.79M | $34.13M | 0.74% | +$4.34M |
| Elevance Health, Inc.(ELV) | 99,100 | 114,700 | +15,600 | $34.74M | $33.58M | 0.73% | -$1.16M |
| Relmada Therapeutics, Inc.(RLMD) | 2,610,600 | 4,715,864 | +2,105,264 | $12.61M | $32.82M | 0.72% | +$20.21M |
| Forte Biosciences Inc | 1,196,955 | 1,196,955 | 0 | $32.64M | $31.00M | 0.68% | -$1.64M |
| Trevi Therapeutics, Inc.(TRVI) | 3,190,700 | 2,454,400 | -736,300 | $39.95M | $29.28M | 0.64% | -$10.67M |
| Esperion Therapeutics Inc Ne | 5,965,498 | 10,570,300 | +4,604,802 | $22.07M | $28.96M | 0.63% | +$6.89M |
| NeuroPace, Inc.(NPCE) | 2,406,335 | 2,096,527 | -309,808 | $37.15M | $27.57M | 0.60% | -$9.58M |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 239,800 | 314,100 | +74,300 | $25.67M | $27.32M | 0.60% | +$1.65M |
| Thermo Fisher Scientific Inc.(TMO) | 46,500 | 46,500 | 0 | $26.94M | $22.86M | 0.50% | -$4.09M |
| Syndax Pharmaceuticals, Inc.(SNDX) | 0 | 962,300 | +962,300 | $0 | $22.48M | 0.49% | +$22.48M |
| Imagenebio IncNONVOTING | 6,210,899 | 6,210,899 | 0 | $20.13M | $22.08M | 0.48% | +$1.95M |
| BrightSpring Health Services, Inc.(BTSG) | 488,500 | 497,800 | +9,300 | $18.29M | $21.21M | 0.46% | +$2.92M |
| Lexeo Therapeutics, Inc.(LXEO) | 2,125,000 | 3,602,450 | +1,477,450 | $21.10M | $20.68M | 0.45% | -$423.2K |
| Sutro Biopharma, Inc.(STRO) | 0 | 801,144 | +801,144 | $0 | $19.96M | 0.44% | +$19.96M |
| Nektar Therapeutics(NKTR) | 0 | 275,000 | +275,000 | $0 | $19.79M | 0.43% | +$19.79M |
| Cybin D/B/A Helus Pharma(HELP) | 3,840,500 | 3,832,843 | -7,657 | $31.42M | $18.40M | 0.40% | -$13.02M |
| Krystal Biotech, Inc.(KRYS) | 119,800 | 69,100 | -50,700 | $29.54M | $17.85M | 0.39% | -$11.69M |
| Palvella Therapeutics, Inc.(PVLA) | 0 | 134,600 | +134,600 | $0 | $16.78M | 0.37% | +$16.78M |
| Corbus Pharmaceuticals Holdings, Inc.(CRBP) | 1,597,287 | 1,737,287 | +140,000 | $13.00M | $16.31M | 0.36% | +$3.31M |
| UroGen Pharma Ltd.(URGN) | 875,487 | 875,487 | 0 | $20.50M | $15.74M | 0.34% | -$4.76M |
| Definium Therapeutics, Inc.(DFTX) | 0 | 804,000 | +804,000 | $0 | $15.20M | 0.33% | +$15.20M |
| Vera Therapeutics, Inc.CL A(VERA) | 353,500 | 369,596 | +16,096 | $17.90M | $14.87M | 0.32% | -$3.03M |
| Q32 Bio Inc.(QTTB) | 2,252,987 | 2,252,987 | 0 | $7.48M | $14.46M | 0.32% | +$6.98M |
| Whitehawk Therapeutics, Inc.(WHWK) | 4,166,000 | 4,166,000 | 0 | $10.08M | $14.37M | 0.31% | +$4.29M |
| Amgen Inc.(AMGN) | 0 | 39,900 | +39,900 | $0 | $14.04M | 0.31% | +$14.04M |
| Alignment Healthcare, Inc.(ALHC) | 0 | 791,000 | +791,000 | $0 | $13.94M | 0.30% | +$13.94M |
| EyePoint, Inc.(EYPT) | 2,468,314 | 1,069,147 | -1,399,167 | $45.10M | $13.78M | 0.30% | -$31.31M |
| Janux Therapeutics, Inc.(JANX) | 1,954,426 | 983,600 | -970,826 | $26.97M | $13.67M | 0.30% | -$13.30M |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 1,741,800 | 1,425,200 | -316,600 | $13.59M | $13.57M | 0.30% | -$18.1K |
| Bicara Therapeutics Inc | 209,100 | 667,300 | +458,200 | $3.52M | $13.27M | 0.29% | +$9.75M |
| BioAge Labs, Inc.(BIOA) | 790,901 | 711,811 | -79,090 | $10.46M | $12.45M | 0.27% | +$1.99M |
| Cogent Biosciences, Inc.(COGT) | 371,000 | 322,100 | -48,900 | $13.18M | $12.40M | 0.27% | -$780.3K |
| Alumis Inc | 1,102,730 | 548,163 | -554,567 | $10.76M | $12.08M | 0.26% | +$1.31M |
| Regeneron Pharmaceuticals, Inc.(REGN) | 0 | 14,700 | +14,700 | $0 | $11.36M | 0.25% | +$11.36M |
| Carlsmed, Inc.(CARL) | 1,252,600 | 1,252,600 | 0 | $15.47M | $11.34M | 0.25% | -$4.13M |
| Biogen Inc.(BIIB) | 0 | 61,600 | +61,600 | $0 | $11.29M | 0.25% | +$11.29M |
| Kiniksa Pharmaceuticals International, plcCL A(KNSA) | 187,199 | 180,599 | -6,600 | $7.72M | $8.70M | 0.19% | +$973.9K |
| Keros Therapeutics, Inc.(KROS) | 804,212 | 759,155 | -45,057 | $16.37M | $8.38M | 0.18% | -$7.99M |
| Gilead Sciences, Inc.(GILD) | 0 | 59,600 | +59,600 | $0 | $8.31M | 0.18% | +$8.31M |
| Heron Therapeutics, Inc.(HRTX) | 0 | 9,816,940 | +9,816,940 | $0 | $7.85M | 0.17% | +$7.85M |
| Avalo Therapeutics, Inc.(AVTX) | 1,187,300 | 475,165 | -712,135 | $21.56M | $7.09M | 0.15% | -$14.47M |
| Tectonic Therapeutic, Inc.(TECX) | 574,600 | 226,600 | -348,000 | $11.99M | $7.00M | 0.15% | -$4.98M |
| Adicet Bio Inc | 1,027,944 | 1,027,944 | 0 | $8.66M | $7.00M | 0.15% | -$1.65M |
| COMPASS Pathways plcADS(CMPS) | 0 | 1,150,646 | +1,150,646 | $0 | $6.36M | 0.14% | +$6.36M |
| Pharvaris N V COM | 205,400 | 205,400 | 0 | $5.70M | $5.80M | 0.13% | +$102.7K |
| ALX Oncology Holdings Inc.(ALXO) | 0 | 2,866,256 | +2,866,256 | $0 | $5.75M | 0.13% | +$5.75M |
| Artivion, Inc.(AORT) | 0 | 151,000 | +151,000 | $0 | $5.53M | 0.12% | +$5.53M |
| InspireMD, Inc.(NSPR) | 3,133,405 | 3,133,405 | 0 | $5.58M | $5.11M | 0.11% | -$470.0K |
| Revolution Medicines, Inc.(RVMD) | 25,900 | 52,000 | +26,100 | $2.06M | $5.06M | 0.11% | +$2.99M |
| ADC Therapeutics SASHS(ADCT) | 5,822,854 | 1,318,026 | -4,504,828 | $20.55M | $4.94M | 0.11% | -$15.61M |
| Protagonist Therapeutics Inc | 21,700 | 42,100 | +20,400 | $1.90M | $4.44M | 0.10% | +$2.54M |
| Palisade Bio, Inc.(PALI) | 1,871,420 | 2,333,000 | +461,580 | $4.40M | $4.08M | 0.09% | -$315.1K |
| Alto Neuroscience, Inc.(ANRO) | 125,000 | 167,500 | +42,500 | $2.23M | $3.77M | 0.08% | +$1.54M |
| Savara Inc.(SVRA) | 0 | 635,000 | +635,000 | $0 | $3.47M | 0.08% | +$3.47M |
| Cullinan Therapeutics, Inc.(CGEM) | 270,006 | 243,006 | -27,000 | $2.79M | $3.45M | 0.08% | +$658.6K |
| PTC Therapeutics, Inc.(PTCT) | 23,200 | 49,100 | +25,900 | $1.76M | $3.35M | 0.07% | +$1.58M |
| LifeStance Health Group, Inc.(LFST) | 0 | 500,000 | +500,000 | $0 | $3.19M | 0.07% | +$3.19M |
| Bright Minds Biosciences Inc.(DRUG) | 0 | 40,000 | +40,000 | $0 | $2.92M | 0.06% | +$2.92M |
| Jade Biosciences Inc | 531,163 | 185,011 | -346,152 | $8.20M | $2.60M | 0.06% | -$5.60M |