Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ENLIVEN THERAPEUTICS INC | 7,959,538 | 7,959,538 | 0 | 122,577 | 312,014 | 6.80% | +189,437 |
| ASTRAZENECA PLC(AZN) | 0 | 670,200 | +670,200 | 0 | 132,177 | 2.88% | +132,177 |
| MYRIAD GENETICS INC(MYGN) | 0 | 0 | 0 | 0 | 122,875 | 2.68% | +122,875 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 15,518,492 | 15,518,492 | 0 | 385,091 | 488,832 | 10.66% | +103,741 |
| MERCK & CO INC(MRK) | 0 | 663,400 | +663,400 | 0 | 79,800 | 1.74% | +79,800 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 7,165,006 | 7,165,006 | 0 | 55,171 | 104,824 | 2.29% | +49,653 |
| AVITA MEDICAL INC(RCEL) | 0 | 544,895 | +544,895 | 0 | 42,516 | 0.93% | +42,516 |
| XENON PHARMACEUTICALS INC(XENE) | 447,200 | 1,059,971 | +612,771 | 20,044 | 61,637 | 1.34% | +41,594 |
| GUARDANT HEALTH INC(GH) | 0 | 435,200 | +435,200 | 0 | 40,199 | 0.88% | +40,199 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 94,500 | 172,500 | +78,000 | 27,853 | 55,578 | 1.21% | +27,725 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 0 | 962,300 | +962,300 | 0 | 22,479 | 0.49% | +22,479 |
| RELMADA THERAPEUTICS INC(RLMD) | 2,610,600 | 4,715,864 | +2,105,264 | 12,609 | 32,822 | 0.72% | +20,213 |
| MINERALYS THERAPEUTICS INC(MLYS) | 980,400 | 2,052,900 | +1,072,500 | 35,579 | 55,613 | 1.21% | +20,034 |
| SUTRO BIOPHARMA INC(STRO) | 0 | 801,144 | +801,144 | 0 | 19,956 | 0.44% | +19,956 |
| NEKTAR THERAPEUTICS(NKTR) | 0 | 275,000 | +275,000 | 0 | 19,786 | 0.43% | +19,786 |
| SHATTUCK LABS INC(STTK) | 6,306,127 | 6,306,127 | 0 | 23,017 | 40,548 | 0.88% | +17,531 |
| UNIQURE NV(QURE) | 737,400 | 2,136,149 | +1,398,749 | 17,646 | 34,926 | 0.76% | +17,280 |
| PALVELLA THERAPEUTICS INC NE(PVLA) | 0 | 134,600 | +134,600 | 0 | 16,778 | 0.37% | +16,778 |
| DEFINIUM THERAPEUTICS INC(DFTX) | 0 | 804,000 | +804,000 | 0 | 15,196 | 0.33% | +15,196 |
| BRISTOL-MYERS SQUIBB CO(BMY) | 775,000 | 925,000 | +150,000 | 41,804 | 56,101 | 1.22% | +14,298 |
| AMGEN INC(AMGN) | 0 | 39,900 | +39,900 | 0 | 14,039 | 0.31% | +14,039 |
| ALIGNMENT HEALTHCARE INC(ALHC) | 0 | 791,000 | +791,000 | 0 | 13,937 | 0.30% | +13,937 |
| PFIZER INC(PFE) | 1,652,900 | 1,946,500 | +293,600 | 41,157 | 54,658 | 1.19% | +13,501 |
| REGENERON PHARMACEUTICALS(REGN) | 0 | 14,700 | +14,700 | 0 | 11,358 | 0.25% | +11,358 |
| BIOGEN INC(BIIB) | 0 | 61,600 | +61,600 | 0 | 11,293 | 0.25% | +11,293 |
| DYNE THERAPEUTICS INC(DYN) | 2,202,184 | 2,917,884 | +715,700 | 43,075 | 52,901 | 1.15% | +9,827 |
| BICARA THERAPEUTICS INC | 209,100 | 667,300 | +458,200 | 3,519 | 13,273 | 0.29% | +9,753 |
| ARRIVENT BIOPHARMA INC(AVBP) | 3,027,328 | 3,027,328 | 0 | 60,910 | 69,840 | 1.52% | +8,931 |
| GILEAD SCIENCES INC(GILD) | 0 | 59,600 | +59,600 | 0 | 8,306 | 0.18% | +8,306 |
| HERON THERAPEUTICS INC(HRTX) | 0 | 9,816,940 | +9,816,940 | 0 | 7,855 | 0.17% | +7,855 |
| Q32 BIO INC(FIXX) | 2,252,987 | 2,252,987 | 0 | 7,480 | 14,464 | 0.32% | +6,984 |
| ESPERION THERAPEUTICS INC NE | 5,965,498 | 10,570,300 | +4,604,802 | 22,072 | 28,963 | 0.63% | +6,890 |
| COMPASS PATHWAYS PLC(CMPS) | 0 | 1,150,646 | +1,150,646 | 0 | 6,363 | 0.14% | +6,363 |
| ALX ONCOLOGY HLDGS INC(ALXO) | 0 | 2,866,256 | +2,866,256 | 0 | 5,747 | 0.13% | +5,747 |
| PRELUDE THERAPEUTICS INC(PRLD) | 10,909,256 | 10,909,256 | 0 | 31,637 | 37,310 | 0.81% | +5,673 |
| ARTIVION INC(AORT) | 0 | 151,000 | +151,000 | 0 | 5,530 | 0.12% | +5,530 |
| ASCENDIS PHARMA A/S(ASND) | 171,977 | 181,977 | +10,000 | 36,672 | 41,624 | 0.91% | +4,951 |
| ORIC PHARMACEUTICALS INC(ORIC) | 3,641,756 | 2,693,929 | -947,827 | 29,790 | 34,132 | 0.74% | +4,343 |
| WHITEHAWK THERAPEUTICS INC(WHWK) | 4,166,000 | 4,166,000 | 0 | 10,082 | 14,373 | 0.31% | +4,291 |
| SAVARA INC(SVRA) | 0 | 635,000 | +635,000 | 0 | 3,467 | 0.08% | +3,467 |
| CORBUS PHARMACEUTICALS HLDGS(CRBP) | 1,597,287 | 1,737,287 | +140,000 | 13,002 | 16,313 | 0.36% | +3,311 |
| LIFESTANCE HEALTH GROUP INC(LFST) | 0 | 500,000 | +500,000 | 0 | 3,185 | 0.07% | +3,185 |
| REVOLUTION MEDICINES INC(RVMD) | 25,900 | 52,000 | +26,100 | 2,063 | 5,057 | 0.11% | +2,994 |
| BRIGHT MINDS BIOSCIENCES INC(DRUG) | 0 | 40,000 | +40,000 | 0 | 2,919 | 0.06% | +2,919 |
| BRIGHTSPRING HEALTH SVCS INC(BTSG) | 488,500 | 497,800 | +9,300 | 18,294 | 21,211 | 0.46% | +2,917 |
| PROTAGONIST THERAPEUTICS INC | 21,700 | 42,100 | +20,400 | 1,895 | 4,437 | 0.10% | +2,542 |
| ABIVAX SA(ABVX) | 367,900 | 465,700 | +97,800 | 49,613 | 51,856 | 1.13% | +2,243 |
| BIOAGE LABS INC(BIOA) | 790,901 | 711,811 | -79,090 | 10,464 | 12,450 | 0.27% | +1,986 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 239,800 | 314,100 | +74,300 | 25,668 | 27,317 | 0.60% | +1,649 |
| PTC THERAPEUTICS INC(PTCT) | 23,200 | 49,100 | +25,900 | 1,762 | 3,345 | 0.07% | +1,583 |
| ALTO NEUROSCIENCE INC(ANRO) | 125,000 | 167,500 | +42,500 | 2,225 | 3,765 | 0.08% | +1,540 |
| ALUMIS INC | 1,102,730 | 548,163 | -554,567 | 10,763 | 12,076 | 0.26% | +1,313 |
| ATAIBECKLEY INC(ATAI) | 0 | 347,000 | +347,000 | 0 | 1,228 | 0.03% | +1,228 |
| CG ONCOLOGY INC(CGON) | 1,516,550 | 948,267 | -568,283 | 62,967 | 64,179 | 1.40% | +1,212 |
| KINIKSA PHARMACEUTICALS INTL(KNSA) | 187,199 | 180,599 | -6,600 | 7,722 | 8,696 | 0.19% | +974 |
| CULLINAN THERAPEUTICS INC(CGEM) | 270,006 | 243,006 | -27,000 | 2,795 | 3,453 | 0.08% | +659 |
| TRAWS PHARMA INC(TRAW) | 605,531 | 605,531 | 0 | 684 | 1,108 | 0.02% | +424 |
| PHARVARIS N V COM | 205,400 | 205,400 | 0 | 5,700 | 5,803 | 0.13% | +103 |
| COGENT BIOSCIENCES INC(COGT) | 0 | 0 | 0 | 1,174 | 1,220 | 0.03% | +46 |
| SINOVAC BIOTECH LTD(SVA) | 2,718,735 | 2,718,735 | 0 | 184,466 | 184,466 | 4.02% | 0 |
| BIOCRYST PHARMACEUTICALS INC(BCRX) | 1,741,800 | 1,425,200 | -316,600 | 13,586 | 13,568 | 0.30% | -18 |
| VISTAGEN THERAPEUTICS INC(VTGN) | 3,060,000 | 3,060,000 | 0 | 2,025 | 1,749 | 0.04% | -277 |
| PALISADE BIO INC(PALI) | 1,871,420 | 2,333,000 | +461,580 | 4,398 | 4,083 | 0.09% | -315 |
| LEXEO THERAPEUTICS INC(LXEO) | 2,125,000 | 3,602,450 | +1,477,450 | 21,101 | 20,678 | 0.45% | -423 |
| C4 THERAPEUTICS INC(CCCC) | 1,404,902 | 856,353 | -548,549 | 2,683 | 2,252 | 0.05% | -431 |
| INSPIREMD INC(NSPR) | 3,133,405 | 3,133,405 | 0 | 5,577 | 5,107 | 0.11% | -470 |
| IMAGENEBIO INC(IMA) | 378,556 | 378,556 | 0 | 2,612 | 1,893 | 0.04% | -719 |
| COGENT BIOSCIENCES INC(COGT) | 371,000 | 322,100 | -48,900 | 13,178 | 12,398 | 0.27% | -780 |
| MAPLIGHT THERAPEUTICS INC(MPLT) | 56,000 | 0 | -56,000 | 952 | 0 | — | -952 |
| ELEVANCE HEALTH INC FORMERLY(ELV) | 99,100 | 114,700 | +15,600 | 34,740 | 33,578 | 0.73% | -1,161 |
| COMPASS THERAPEUTICS INC(CMPX) | 15,219,994 | 15,219,994 | 0 | 81,731 | 80,514 | 1.76% | -1,218 |
| FORTE BIOSCIENCES INC(FBRX) | 1,196,955 | 1,196,955 | 0 | 32,641 | 31,001 | 0.68% | -1,640 |
| ADICET BIO INC | 1,027,944 | 1,027,944 | 0 | 8,655 | 7,000 | 0.15% | -1,655 |
| OCULAR THERAPEUTIX INC(OCUL) | 157,300 | 0 | -157,300 | 1,910 | 0 | — | -1,910 |
| VERA THERAPEUTICS INC(VERA) | 353,500 | 369,596 | +16,096 | 17,901 | 14,869 | 0.32% | -3,032 |
| THERMO FISHER SCIENTIFIC INC(TMO) | 46,500 | 46,500 | 0 | 26,944 | 22,856 | 0.50% | -4,088 |
| CARLSMED INC(CARL) | 1,252,600 | 1,252,600 | 0 | 15,470 | 11,336 | 0.25% | -4,134 |
| KALVISTA PHARMACEUTICALS INC | 382,400 | 94,400 | -288,000 | 6,176 | 1,900 | 0.04% | -4,275 |
| INSMED INC(INSM) | 25,400 | 0 | -25,400 | 4,421 | 0 | — | -4,421 |
| UROGEN PHARMA LTD(URGN) | 875,487 | 875,487 | 0 | 20,504 | 15,741 | 0.34% | -4,763 |
| SIONNA THERAPEUTICS INC(SION) | 3,561,655 | 3,530,702 | -30,953 | 146,526 | 141,546 | 3.09% | -4,981 |
| TECTONIC THERAPEUTIC INC(TECX) | 574,600 | 226,600 | -348,000 | 11,986 | 7,004 | 0.15% | -4,982 |
| JADE BIOSCIENCES INC | 531,163 | 185,011 | -346,152 | 8,196 | 2,599 | 0.06% | -5,596 |
| PMV PHARMACEUTICALS INC(PMVP) | 4,975,291 | 0 | -4,975,291 | 6,219 | 0 | — | -6,219 |
| KEROS THERAPEUTICS INC(KROS) | 804,212 | 759,155 | -45,057 | 16,374 | 8,381 | 0.18% | -7,993 |
| CELCUITY INC(CELC) | 85,664 | 0 | -85,664 | 8,544 | 0 | — | -8,544 |
| REPARE THERAPEUTICS INC | 3,322,488 | 0 | -3,322,488 | 8,638 | 0 | — | -8,638 |
| NEUROPACE INC(NPCE) | 2,406,335 | 2,096,527 | -309,808 | 37,154 | 27,569 | 0.60% | -9,584 |
| STRUCTURE THERAPEUTICS INC | 1,161,803 | 1,475,403 | +313,600 | 80,803 | 71,114 | 1.55% | -9,689 |
| AXSOME THERAPEUTICS INC.(AXSM) | 253,121 | 213,921 | -39,200 | 46,230 | 36,157 | 0.79% | -10,073 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 999,000 | 999,000 | 0 | 46,503 | 36,284 | 0.79% | -10,220 |
| AMICUS THERAPEUTICS INC COM | 729,900 | 0 | -729,900 | 10,394 | 0 | — | -10,394 |
| TREVI THERAPEUTICS INC(TRVI) | 3,190,700 | 2,454,400 | -736,300 | 39,948 | 29,281 | 0.64% | -10,667 |
| KRYSTAL BIOTECH INC(KRYS) | 119,800 | 69,100 | -50,700 | 29,535 | 17,850 | 0.39% | -11,686 |
| TARSUS PHARMACEUTICALS INC(TARS) | 154,400 | 0 | -154,400 | 12,642 | 0 | — | -12,642 |
| CYBIN INC(HELP) | 3,840,500 | 3,832,843 | -7,657 | 31,415 | 18,398 | 0.40% | -13,018 |
| JANUX THERAPEUTICS INC(JANX) | 1,954,426 | 983,600 | -970,826 | 26,971 | 13,672 | 0.30% | -13,299 |
| VIR BIOTECHNOLOGY INC(VIR) | 2,380,715 | 0 | -2,380,715 | 14,356 | 0 | — | -14,356 |
| AVALO THERAPEUTICS INC(AVTX) | 1,187,300 | 475,165 | -712,135 | 21,561 | 7,094 | 0.15% | -14,467 |
| CYTOMX THERAPEUTICS INC(CTMX) | 3,525,650 | 0 | -3,525,650 | 15,019 | 0 | — | -15,019 |