Fund HoldingsORBIMED ADVISORS LLC

Total Portfolio Value
$3.98B
Total Bought
$506.55M
Total Sold
$657.91M
Net Transaction
-$151.35M
Filing Period:
Securities
SharesValue ($K)
Q1 2025
Q2 2025
Change
Q1 2025
Q2 2025
Weight (%)
Change
CARIS LIFE SCIENCES INC(CAI)03,034,858+3,034,858081,0912.04%+81,091
ARS PHARMACEUTICALS INC8,288,5108,288,5100104,269144,6353.64%+40,365
ROIVANT SCIENCES LTD(ROIV)02,779,427+2,779,427031,3240.79%+31,324
UPSTREAM BIO INC05,693,589+5,693,589062,5161.57%+62,516
SIONNA THERAPEUTICS INC(SION)3,704,9593,704,959038,75464,2811.62%+25,527
NATERA INC(NTRA)547,000593,434+46,43477,351100,2552.52%+22,903
EDWARDS LIFESCIENCES CORP1,532,0001,708,000+176,000111,039133,5833.36%+22,543
TENET HEALTHCARE CORP(THC)0465,000+465,000081,8402.06%+81,840
CYTOMX THERAPEUTICS INC08,461,500+8,461,500019,2080.48%+19,208
BOSTON SCIENTIFIC CORP(BSX)2,813,2002,813,2000283,796302,1667.60%+18,370
ALNYLAM PHARMACEUTICALS INC(ALNY)346,100341,900-4,20093,454111,4902.80%+18,036
MBX BIOSCIENCES INC(MBX)04,002,887+4,002,887045,6731.15%+45,673
VERTEX PHARMACEUTICALS INC(VRTX)159,900210,287+50,38777,52393,6202.35%+16,097
UNITEDHEALTH GROUP INC(UNH)(Call)050,000+50,000015,599+15,599
INTUITIVE SURGICAL INC0291,000+291,0000158,1323.98%+158,132
STRUCTURE THERAPEUTICS INC652,0281,199,300+547,27211,28724,8730.63%+13,587
RAPT THERAPEUTICS INC01,641,906+1,641,906013,1350.33%+13,135
THIRD HARMONIC BIO INC05,779,071+5,779,071031,3800.79%+31,380
TREVI THERAPEUTICS INC(TRVI)1,120,0003,308,400+2,188,4007,04518,0970.46%+11,052
FORTE BIOSCIENCES INC(FBRX)01,196,955+1,196,955015,4770.39%+15,477
MINERALYS THERAPEUTICS INC(MLYS)0760,351+760,351010,2880.26%+10,288
ARRIVENT BIOPHARMA INC(AVBP)03,027,328+3,027,328065,9051.66%+65,905
CATALYST PHARMACEUTICALS INC(CPRX)0416,900+416,90009,0470.23%+9,047
AGIOS PHARMACEUTICALS INC(AGIO)325,500557,900+232,4009,53718,5560.47%+9,019
STRYKER CORPORATION(SYK)359,200359,2000133,712142,1103.57%+8,398
ZAI LAB LTD(ZLAB)0231,000+231,00008,0780.20%+8,078
JANUX THERAPEUTICS INC(JANX)01,210,300+1,210,300027,9580.70%+27,958
ADC THERAPEUTICS SA5,968,4515,907,351-61,1008,41615,8320.40%+7,416
TERNS PHARMACEUTICALS INC07,562,971+7,562,971028,2100.71%+28,210
SCPHARMACEUTICALS INC6,059,5286,059,528015,93723,0870.58%+7,150
ASTRAZENECA PLC(AZN)(Call)0100,000+100,00006,988+6,988
ITEOS THERAPEUTICS INC0700,000+700,00006,9790.18%+6,979
CORVUS PHARMACEUTICALS INC(CRVS)07,165,006+7,165,006028,6600.72%+28,660
UROGEN PHARMA LTD(URGN)0478,400+478,40006,5540.16%+6,554
ASCENDIS PHARMA A/S(ASND)034,400+34,40005,9370.15%+5,937
ALUMIS INC01,926,423+1,926,42305,7790.15%+5,779
JADE BIOSCIENCES INC0531,163+531,16305,3060.13%+5,306
ORIC PHARMACEUTICALS INC(ORIC)700,000899,281+199,2813,9069,1280.23%+5,222
DISC MEDICINE INC(IRON)01,415,020+1,415,020074,9391.88%+74,939
AKERO THERAPEUTICS INC179,900211,300+31,4007,28211,2750.28%+3,993
CG ONCOLOGY INC(CGON)(Call)0150,000+150,00003,900+3,900
KEROS THERAPEUTICS INC1,018,7341,018,734010,38113,6000.34%+3,219
ENLIVEN THERAPEUTICS INC07,959,538+7,959,5380159,6684.02%+159,668
EXACT SCIENCES CORP(EXK)679,816607,316-72,50029,42932,2730.81%+2,844
ABCELLERA BIOLOGICS INC(ABCL)4,180,7683,344,568-836,2009,32311,4720.29%+2,149
CORBUS PHARMACEUTICALS HLDGS1,172,2871,172,28706,2258,0890.20%+1,864
MURAL ONCOLOGY PUB LTD CO0588,800+588,80001,4540.04%+1,454
REPARE THERAPEUTICS INC3,322,4883,322,48803,2764,6180.12%+1,343
APELLIS PHARMACEUTICALS INC(Call)
COM
050,000+50,0000866+866
AMYLYX PHARMACEUTICALS INC(AMLX)348,000313,200-34,8001,2322,0080.05%+776
IKENA ONCOLOGY INC12,048,77312,048,773012,51413,1310.33%+617
LYELL IMMUNOPHARMA INC051,727+51,72704570.01%+457
PRELUDE THERAPEUTICS INC10,909,25610,909,25608,3788,8300.22%+452
WHITEHAWK THERAPEUTICS INC4,166,0004,166,00007,4157,7900.20%+375
BIOAGE LABS INC(BIOA)921,959921,95903,4673,8080.10%+341
SI-BONE INC3,442,8532,578,979-863,87448,30348,5361.22%+233
IKENA ONCOLOGY INC3,539,3583,539,35804,5304,7430.12%+212
INMUNE BIO INC(Put)050,000+50,0000116+116
DIH HLDG US INC1,915,0001,915,00004434690.01%+26
ALTO NEUROSCIENCE INC(ANRO)250,000250,00005405500.01%+10
SINOVAC BIOTECH LTD(SVA)2,718,7352,718,7350333,997333,9978.40%0
KEZAR LIFE SCIENCES INC
COM NEW
192,700192,70009408830.02%-58
PASSAGE BIO INC7,034,6266,055,300-979,3262,4842,4240.06%-60
XERIS BIOPHARMA HOLDINGS INC80,42080,42004423760.01%-66
CULLINAN THERAPEUTICS INC(CGEM)01,923,855+1,923,855014,4870.36%+14,487
TURNSTONE BIOLOGICS CORP3,099,2653,099,26501,2711,1130.03%-158
KORRO BIO INC32,40032,40005644050.01%-159
PMV PHARMACEUTICALS INC6,475,2916,475,29107,0586,8640.17%-194
LAKESHORE BIOPHARMA CO LTD140,42854,799-85,629344560.00%-288
Q32 BIO INC2,252,9872,252,98703,7173,3570.08%-360
AXSOME THERAPEUTICS INC(AXSM)386,700427,900+41,20045,10144,6681.12%-432
CRINETICS PHARMACEUTICALS IN(CRNX)01,149,000+1,149,000033,0450.83%+33,045
UNITEDHEALTH GROUP INC(UNH)201,200336,300+135,100105,379104,9162.64%-463
TRAWS PHARMA INC605,531605,53101,3938960.02%-497
NEXTCURE INC1,141,2000-1,141,2005480-548
INVIVYD INC933,5000-933,5005650-565
TANGO THERAPEUTICS INC(TNGX)550,0000-550,0007540-753
DYNE THERAPEUTICS INC(DYN)01,031,400+1,031,40009,8190.25%+9,819
CHEMOMAB THERAPEUTICS LTD1,741,273940,990-800,2831,8981,0920.03%-806
INSMED INC(INSM)28,65913,459-15,2002,1861,3550.03%-832
INSPIREMD INC2,133,4052,133,40505,7394,8430.12%-896
BIOMX INC1,787,7670-1,787,7679930-993
C4 THERAPEUTICS INC6,830,3006,830,300010,9289,7670.25%-1,161
FATE THERAPEUTICS INC1,680,5800-1,680,5801,3280-1,328
NKARTA INC821,4000-821,4001,5110-1,511
ENGENE HOLDINGS INC
COM
891,616677,977-213,6393,9942,4680.06%-1,527
X4 PHARMACEUTICALS INC6,776,5150-6,776,5151,6020-1,602
ADICET BIO INC11,447,14011,447,14008,6436,9830.18%-1,660
CARDIFF ONCOLOGY INC573,8840-573,8841,8020-1,802
INSTIL BIO INC116,7850-116,7852,0270-2,027
AVIDITY BIOSCIENCES INC1,812,8861,812,886053,51651,4861.29%-2,030
XENON PHARMACEUTICALS INC(XENE)947,877947,877031,80129,6690.75%-2,133
CERIBELL INC112,5000-112,5002,1610-2,161
VIR BIOTECHNOLOGY INC(VIR)02,380,715+2,380,715011,9990.30%+11,999
STRUCTURE THERAPEUTICS INC(Call)150,0000-150,0002,5970-2,596
COMPASS THERAPEUTICS INC22,362,85015,219,994-7,142,85642,48939,5721.00%-2,917
AVALO THERAPEUTICS INC(AVTX)967,000967,00007,7464,8250.12%-2,920
KRYSTAL BIOTECH INC(KRYS)23,5009,200-14,3004,2371,2650.03%-2,972
BICARA THERAPEUTICS INC298,3010-298,3013,8870-3,887
RHYTHM PHARMACEUTICALS INC(RYTM)380,000248,512-131,48820,12915,7030.39%-4,425
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