Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q1 2025 ▲▼ | Q2 2025 ▲▼ | Change ▲▼ | Q1 2025 ▲▼ | Q2 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| CARIS LIFE SCIENCES INC(CAI) | 0 | 3,034,858 | +3,034,858 | 0 | 81,091 | 2.04% | +81,091 |
| ARS PHARMACEUTICALS INC(SPRY) | 8,288,510 | 8,288,510 | 0 | 104,269 | 144,635 | 3.64% | +40,365 |
| ROIVANT SCIENCES LTD(ROIV) | 0 | 2,779,427 | +2,779,427 | 0 | 31,324 | 0.79% | +31,324 |
| UPSTREAM BIO INC(UPB) | 5,693,589 | 5,693,589 | 0 | 34,845 | 62,516 | 1.57% | +27,671 |
| SIONNA THERAPEUTICS INC(SION) | 3,704,959 | 3,704,959 | 0 | 38,754 | 64,281 | 1.62% | +25,527 |
| NATERA INC(NTRA) | 547,000 | 593,434 | +46,434 | 77,351 | 100,255 | 2.52% | +22,903 |
| EDWARDS LIFESCIENCES CORP | 1,532,000 | 1,708,000 | +176,000 | 111,039 | 133,583 | 3.36% | +22,543 |
| TENET HEALTHCARE CORP(THC) | 465,000 | 465,000 | 0 | 62,543 | 81,840 | 2.06% | +19,298 |
| CYTOMX THERAPEUTICS INC(CTMX) | 0 | 8,461,500 | +8,461,500 | 0 | 19,208 | 0.48% | +19,208 |
| BOSTON SCIENTIFIC CORP(BSX) | 2,813,200 | 2,813,200 | 0 | 283,796 | 302,166 | 7.60% | +18,370 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 346,100 | 341,900 | -4,200 | 93,454 | 111,490 | 2.80% | +18,036 |
| MBX BIOSCIENCES INC(MBX) | 4,002,887 | 4,002,887 | 0 | 29,541 | 45,673 | 1.15% | +16,132 |
| VERTEX PHARMACEUTICALS INC(VRTX) | 159,900 | 210,287 | +50,387 | 77,523 | 93,620 | 2.35% | +16,097 |
| INTUITIVE SURGICAL INC | 291,000 | 291,000 | 0 | 144,124 | 158,132 | 3.98% | +14,009 |
| STRUCTURE THERAPEUTICS INC | 652,028 | 1,199,300 | +547,272 | 11,287 | 24,873 | 0.63% | +13,587 |
| RAPT THERAPEUTICS INC | 0 | 1,641,906 | +1,641,906 | 0 | 13,135 | 0.33% | +13,135 |
| THIRD HARMONIC BIO INC | 5,779,071 | 5,779,071 | 0 | 20,053 | 31,380 | 0.79% | +11,327 |
| TREVI THERAPEUTICS INC(TRVI) | 1,120,000 | 3,308,400 | +2,188,400 | 7,045 | 18,097 | 0.46% | +11,052 |
| FORTE BIOSCIENCES INC(FBRX) | 593,088 | 1,196,955 | +603,867 | 4,602 | 15,477 | 0.39% | +10,874 |
| MINERALYS THERAPEUTICS INC(MLYS) | 0 | 760,351 | +760,351 | 0 | 10,288 | 0.26% | +10,288 |
| ARRIVENT BIOPHARMA INC(AVBP) | 3,027,328 | 3,027,328 | 0 | 55,975 | 65,905 | 1.66% | +9,930 |
| CATALYST PHARMACEUTICALS INC | 0 | 416,900 | +416,900 | 0 | 9,047 | 0.23% | +9,047 |
| AGIOS PHARMACEUTICALS INC(AGIO) | 325,500 | 557,900 | +232,400 | 9,537 | 18,556 | 0.47% | +9,019 |
| STRYKER CORPORATION(SYK) | 359,200 | 359,200 | 0 | 133,712 | 142,110 | 3.57% | +8,398 |
| ZAI LAB LTD(ZLAB) | 0 | 231,000 | +231,000 | 0 | 8,078 | 0.20% | +8,078 |
| JANUX THERAPEUTICS INC(JANX) | 758,566 | 1,210,300 | +451,734 | 20,481 | 27,958 | 0.70% | +7,477 |
| ADC THERAPEUTICS SA(ADCT) | 5,968,451 | 5,907,351 | -61,100 | 8,416 | 15,832 | 0.40% | +7,416 |
| TERNS PHARMACEUTICALS INC | 7,562,971 | 7,562,971 | 0 | 20,874 | 28,210 | 0.71% | +7,336 |
| SCPHARMACEUTICALS INC | 6,059,528 | 6,059,528 | 0 | 15,937 | 23,087 | 0.58% | +7,150 |
| ITEOS THERAPEUTICS INC | 0 | 700,000 | +700,000 | 0 | 6,979 | 0.18% | +6,979 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 6,943,654 | 7,165,006 | +221,352 | 22,081 | 28,660 | 0.72% | +6,579 |
| UROGEN PHARMA LTD(URGN) | 0 | 478,400 | +478,400 | 0 | 6,554 | 0.16% | +6,554 |
| ASCENDIS PHARMA A/S(ASND) | 0 | 34,400 | +34,400 | 0 | 5,937 | 0.15% | +5,937 |
| ALUMIS INC | 0 | 1,926,423 | +1,926,423 | 0 | 5,779 | 0.15% | +5,779 |
| JADE BIOSCIENCES INC | 0 | 531,163 | +531,163 | 0 | 5,306 | 0.13% | +5,306 |
| ORIC PHARMACEUTICALS INC(ORIC) | 700,000 | 899,281 | +199,281 | 3,906 | 9,128 | 0.23% | +5,222 |
| DISC MEDICINE INC(IRON) | 1,415,020 | 1,415,020 | 0 | 70,242 | 74,939 | 1.88% | +4,698 |
| AKERO THERAPEUTICS INC | 179,900 | 211,300 | +31,400 | 7,282 | 11,275 | 0.28% | +3,993 |
| KEROS THERAPEUTICS INC(KROS) | 1,018,734 | 1,018,734 | 0 | 10,381 | 13,600 | 0.34% | +3,219 |
| ENLIVEN THERAPEUTICS INC | 7,959,538 | 7,959,538 | 0 | 156,644 | 159,668 | 4.02% | +3,025 |
| EXACT SCIENCES CORP(EXK) | 679,816 | 607,316 | -72,500 | 29,429 | 32,273 | 0.81% | +2,844 |
| ABCELLERA BIOLOGICS INC(ABCL) | 4,180,768 | 3,344,568 | -836,200 | 9,323 | 11,472 | 0.29% | +2,149 |
| CORBUS PHARMACEUTICALS HLDGS(CRBP) | 1,172,287 | 1,172,287 | 0 | 6,225 | 8,089 | 0.20% | +1,864 |
| MURAL ONCOLOGY PUB LTD CO | 0 | 588,800 | +588,800 | 0 | 1,454 | 0.04% | +1,454 |
| REPARE THERAPEUTICS INC | 3,322,488 | 3,322,488 | 0 | 3,276 | 4,618 | 0.12% | +1,343 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 348,000 | 313,200 | -34,800 | 1,232 | 2,008 | 0.05% | +776 |
| LYELL IMMUNOPHARMA INC(LYEL) | 0 | 51,727 | +51,727 | 0 | 457 | 0.01% | +457 |
| PRELUDE THERAPEUTICS INC(PRLD) | 10,909,256 | 10,909,256 | 0 | 8,378 | 8,830 | 0.22% | +452 |
| WHITEHAWK THERAPEUTICS INC(WHWK) | 4,166,000 | 4,166,000 | 0 | 7,415 | 7,790 | 0.20% | +375 |
| BIOAGE LABS INC(BIOA) | 921,959 | 921,959 | 0 | 3,467 | 3,808 | 0.10% | +341 |
| SI-BONE INC(SIBN) | 3,442,853 | 2,578,979 | -863,874 | 48,303 | 48,536 | 1.22% | +233 |
| IKENA ONCOLOGY INC | 3,539,358 | 3,539,358 | 0 | 4,530 | 4,743 | 0.12% | +212 |
| DIH HLDG US INC | 1,915,000 | 1,915,000 | 0 | 443 | 469 | 0.01% | +26 |
| ALTO NEUROSCIENCE INC(ANRO) | 250,000 | 250,000 | 0 | 540 | 550 | 0.01% | +10 |
| SINOVAC BIOTECH LTD(SVA) | 2,718,735 | 2,718,735 | 0 | 333,997 | 333,997 | 8.40% | 0 |
| KEZAR LIFE SCIENCES INC COM NEW | 192,700 | 192,700 | 0 | 940 | 883 | 0.02% | -58 |
| PASSAGE BIO INC(PASG) | 7,034,626 | 6,055,300 | -979,326 | 2,484 | 2,424 | 0.06% | -60 |
| XERIS BIOPHARMA HOLDINGS INC | 80,420 | 80,420 | 0 | 442 | 376 | 0.01% | -66 |
| CULLINAN THERAPEUTICS INC(CGEM) | 1,923,855 | 1,923,855 | 0 | 14,564 | 14,487 | 0.36% | -77 |
| TURNSTONE BIOLOGICS CORP | 3,099,265 | 3,099,265 | 0 | 1,271 | 1,113 | 0.03% | -158 |
| KORRO BIO INC(KRRO) | 32,400 | 32,400 | 0 | 564 | 405 | 0.01% | -159 |
| PMV PHARMACEUTICALS INC(PMVP) | 6,475,291 | 6,475,291 | 0 | 7,058 | 6,864 | 0.17% | -194 |
| LAKESHORE BIOPHARMA CO LTD | 140,428 | 54,799 | -85,629 | 344 | 56 | 0.00% | -288 |
| Q32 BIO INC(FIXX) | 2,252,987 | 2,252,987 | 0 | 3,717 | 3,357 | 0.08% | -360 |
| AXSOME THERAPEUTICS INC(AXSM) | 386,700 | 427,900 | +41,200 | 45,101 | 44,668 | 1.12% | -432 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 999,000 | 1,149,000 | +150,000 | 33,506 | 33,045 | 0.83% | -461 |
| UNITEDHEALTH GROUP INC(UNH) | 201,200 | 336,300 | +135,100 | 105,379 | 104,916 | 2.64% | -463 |
| TRAWS PHARMA INC(TRAW) | 605,531 | 605,531 | 0 | 1,393 | 896 | 0.02% | -497 |
| NEXTCURE INC | 1,141,200 | 0 | -1,141,200 | 548 | 0 | — | -548 |
| INVIVYD INC(IVVD) | 933,500 | 0 | -933,500 | 565 | 0 | — | -565 |
| TANGO THERAPEUTICS INC(TNGX) | 550,000 | 0 | -550,000 | 754 | 0 | — | -753 |
| DYNE THERAPEUTICS INC(DYN) | 1,014,611 | 1,031,400 | +16,789 | 10,613 | 9,819 | 0.25% | -794 |
| CHEMOMAB THERAPEUTICS LTD | 1,741,273 | 940,990 | -800,283 | 1,898 | 1,092 | 0.03% | -806 |
| INSMED INC(INSM) | 28,659 | 13,459 | -15,200 | 2,186 | 1,355 | 0.03% | -832 |
| INSPIREMD INC(NSPR) | 2,133,405 | 2,133,405 | 0 | 5,739 | 4,843 | 0.12% | -896 |
| BIOMX INC(PHGE) | 1,787,767 | 0 | -1,787,767 | 993 | 0 | — | -993 |
| C4 THERAPEUTICS INC(CCCC) | 6,830,300 | 6,830,300 | 0 | 10,928 | 9,767 | 0.25% | -1,161 |
| FATE THERAPEUTICS INC(FATE) | 1,680,580 | 0 | -1,680,580 | 1,328 | 0 | — | -1,328 |
| NKARTA INC(NKTX) | 821,400 | 0 | -821,400 | 1,511 | 0 | — | -1,511 |
| ENGENE HOLDINGS INC COM | 891,616 | 677,977 | -213,639 | 3,994 | 2,468 | 0.06% | -1,527 |
| X4 PHARMACEUTICALS INC(XFOR) | 6,776,515 | 0 | -6,776,515 | 1,602 | 0 | — | -1,602 |
| ADICET BIO INC | 11,447,140 | 11,447,140 | 0 | 8,643 | 6,983 | 0.18% | -1,660 |
| CARDIFF ONCOLOGY INC(CRDF) | 573,884 | 0 | -573,884 | 1,802 | 0 | — | -1,802 |
| INSTIL BIO INC(TIL) | 116,785 | 0 | -116,785 | 2,027 | 0 | — | -2,027 |
| AVIDITY BIOSCIENCES INC | 1,812,886 | 1,812,886 | 0 | 53,516 | 51,486 | 1.29% | -2,030 |
| XENON PHARMACEUTICALS INC(XENE) | 947,877 | 947,877 | 0 | 31,801 | 29,669 | 0.75% | -2,133 |
| CERIBELL INC(CBLL) | 112,500 | 0 | -112,500 | 2,161 | 0 | — | -2,161 |
| VIR BIOTECHNOLOGY INC(VIR) | 2,248,249 | 2,380,715 | +132,466 | 14,569 | 11,999 | 0.30% | -2,570 |
| COMPASS THERAPEUTICS INC(CMPX) | 22,362,850 | 15,219,994 | -7,142,856 | 42,489 | 39,572 | 1.00% | -2,917 |
| AVALO THERAPEUTICS INC(AVTX) | 967,000 | 967,000 | 0 | 7,746 | 4,825 | 0.12% | -2,920 |
| KRYSTAL BIOTECH INC(KRYS) | 23,500 | 9,200 | -14,300 | 4,237 | 1,265 | 0.03% | -2,972 |
| BICARA THERAPEUTICS INC | 298,301 | 0 | -298,301 | 3,887 | 0 | — | -3,887 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 380,000 | 248,512 | -131,488 | 20,129 | 15,703 | 0.39% | -4,425 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 151,800 | 0 | -151,800 | 4,880 | 0 | — | -4,880 |
| AMICUS THERAPEUTICS INC COM | 2,285,400 | 2,285,400 | 0 | 18,649 | 13,095 | 0.33% | -5,554 |
| APELLIS PHARMACEUTICALS INC COM | 1,432,300 | 1,482,300 | +50,000 | 31,324 | 25,659 | 0.65% | -5,666 |
| KESTRA MED TECHNOLOGIES LTD SHS | 250,000 | 0 | -250,000 | 6,230 | 0 | — | -6,230 |
| ARGENX SE(ARGX) | 206,700 | 208,000 | +1,300 | 122,338 | 114,654 | 2.88% | -7,685 |
| TYRA BIOSCIENCES INC(TYRA) | 1,752,831 | 804,603 | -948,228 | 16,301 | 7,700 | 0.19% | -8,601 |
| ACELYRIN INC | 4,001,711 | 0 | -4,001,711 | 9,884 | 0 | — | -9,884 |