Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q1 2025 ▲▼ | Q2 2025 ▲▼ | Change ▲▼ | Q1 2025 ▲▼ | Q2 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Sinovac Biotech, Ltd.SHS(SVA) | 2,718,735 | 2,718,735 | 0 | $334.00M | $334.00M | 8.40% | $0 |
| Boston Scientific Corporation(BSX) | 2,813,200 | 2,813,200 | 0 | $283.80M | $302.17M | 7.60% | +$18.37M |
| Eli Lilly and Company(LLY) | 337,600 | 337,600 | 0 | $278.83M | $263.17M | 6.62% | -$15.66M |
| Edgewise Therapeutics, Inc.(EWTX) | 15,021,721 | 15,518,492 | +496,771 | $330.48M | $203.45M | 5.12% | -$127.03M |
| Enliven Therapeutics Inc | 7,959,538 | 7,959,538 | 0 | $156.64M | $159.67M | 4.02% | +$3.02M |
| Intuitive Surgical, Inc.(ISRG) | 291,000 | 291,000 | 0 | $144.12M | $158.13M | 3.98% | +$14.01M |
| ARS Pharmaceuticals, Inc.(SPRY) | 8,288,510 | 8,288,510 | 0 | $104.27M | $144.63M | 3.64% | +$40.37M |
| Stryker Corporation(SYK) | 359,200 | 359,200 | 0 | $133.71M | $142.11M | 3.57% | +$8.40M |
| Edwards Lifesciences Corp | 1,532,000 | 1,708,000 | +176,000 | $111.04M | $133.58M | 3.36% | +$22.54M |
| argenx SEADR(ARGX) | 206,700 | 208,000 | +1,300 | $122.34M | $114.65M | 2.88% | -$7.68M |
| Alnylam Pharmaceuticals, Inc.(ALNY) | 346,100 | 341,900 | -4,200 | $93.45M | $111.49M | 2.80% | +$18.04M |
| UnitedHealth Group Incorporated(UNH) | 201,200 | 336,300 | +135,100 | $105.38M | $104.92M | 2.64% | -$463.0K |
| Natera, Inc.(NTRA) | 547,000 | 593,434 | +46,434 | $77.35M | $100.25M | 2.52% | +$22.90M |
| Vertex Pharmaceuticals Incorporated(VRTX) | 159,900 | 210,287 | +50,387 | $77.52M | $93.62M | 2.35% | +$16.10M |
| Tenet Healthcare Corporation(THC) | 465,000 | 465,000 | 0 | $62.54M | $81.84M | 2.06% | +$19.30M |
| Caris Life Sciences, Inc.(CAI) | 0 | 3,034,858 | +3,034,858 | $0 | $81.09M | 2.04% | +$81.09M |
| Disc Medicine, Inc.(IRON) | 1,415,020 | 1,415,020 | 0 | $70.24M | $74.94M | 1.88% | +$4.70M |
| ArriVent BioPharma, Inc.(AVBP) | 3,027,328 | 3,027,328 | 0 | $55.98M | $65.90M | 1.66% | +$9.93M |
| Sionna Therapeutics, Inc.(SION) | 3,704,959 | 3,704,959 | 0 | $38.75M | $64.28M | 1.62% | +$25.53M |
| Upstream Bio, Inc.(UPB) | 5,693,589 | 5,693,589 | 0 | $34.84M | $62.52M | 1.57% | +$27.67M |
| Neurocrine Biosciences, Inc.(NBIX) | 934,640 | 438,540 | -496,100 | $103.37M | $55.12M | 1.39% | -$48.25M |
| Integer Holdings Corporation(ITGR) | 662,500 | 433,400 | -229,100 | $78.18M | $53.30M | 1.34% | -$24.89M |
| Avidity Biosciences Inc | 1,812,886 | 1,812,886 | 0 | $53.52M | $51.49M | 1.29% | -$2.03M |
| CG Oncology, Inc.(CGON) | 2,471,994 | 1,877,850 | -594,144 | $60.54M | $48.82M | 1.23% | -$11.72M |
| SI-BONE, Inc.(SIBN) | 3,442,853 | 2,578,979 | -863,874 | $48.30M | $48.54M | 1.22% | +$233.2K |
| MBX Biosciences, Inc.(MBX) | 4,002,887 | 4,002,887 | 0 | $29.54M | $45.67M | 1.15% | +$16.13M |
| Axsome Therapeutics, Inc.(AXSM) | 386,700 | 427,900 | +41,200 | $45.10M | $44.67M | 1.12% | -$432.3K |
| Compass Therapeutics, Inc.(CMPX) | 22,362,850 | 15,219,994 | -7,142,856 | $42.49M | $39.57M | 1.00% | -$2.92M |
| Cytokinetics, Incorporated(CYTK) | 1,509,205 | 1,077,000 | -432,205 | $60.65M | $35.58M | 0.89% | -$25.07M |
| Crinetics Pharmaceuticals In | 999,000 | 1,149,000 | +150,000 | $33.51M | $33.05M | 0.83% | -$461.2K |
| Endeavour Silver Corp.(EXK) | 679,816 | 607,316 | -72,500 | $29.43M | $32.27M | 0.81% | +$2.84M |
| Third Harmonic Bio Inc | 5,779,071 | 5,779,071 | 0 | $20.05M | $31.38M | 0.79% | +$11.33M |
| Roivant Sciences Ltd.SHS(ROIV) | 0 | 2,779,427 | +2,779,427 | $0 | $31.32M | 0.79% | +$31.32M |
| Xenon Pharmaceuticals Inc.(XENE) | 947,877 | 947,877 | 0 | $31.80M | $29.67M | 0.75% | -$2.13M |
| NeuroPace, Inc.(NPCE) | 3,406,335 | 2,614,184 | -792,151 | $41.86M | $29.12M | 0.73% | -$12.74M |
| Corvus Pharmaceuticals, Inc.(CRVS) | 6,943,654 | 7,165,006 | +221,352 | $22.08M | $28.66M | 0.72% | +$6.58M |
| Terns Pharmaceuticals Inc | 7,562,971 | 7,562,971 | 0 | $20.87M | $28.21M | 0.71% | +$7.34M |
| Janux Therapeutics, Inc.(JANX) | 758,566 | 1,210,300 | +451,734 | $20.48M | $27.96M | 0.70% | +$7.48M |
| Apellis Pharmaceuticals Inc COM | 1,432,300 | 1,482,300 | +50,000 | $31.32M | $25.66M | 0.65% | -$5.67M |
| Structure Therapeutics IncADS | 652,028 | 1,199,300 | +547,272 | $11.29M | $24.87M | 0.63% | +$13.59M |
| Scpharmaceuticals Inc | 6,059,528 | 6,059,528 | 0 | $15.94M | $23.09M | 0.58% | +$7.15M |
| CytomX Therapeutics, Inc.(CTMX) | 0 | 8,461,500 | +8,461,500 | $0 | $19.21M | 0.48% | +$19.21M |
| Thermo Fisher Scientific Inc.(TMO) | 129,000 | 46,500 | -82,500 | $64.19M | $18.85M | 0.47% | -$45.34M |
| Agios Pharmaceuticals, Inc.(AGIO) | 325,500 | 557,900 | +232,400 | $9.54M | $18.56M | 0.47% | +$9.02M |
| Trevi Therapeutics, Inc.(TRVI) | 1,120,000 | 3,308,400 | +2,188,400 | $7.04M | $18.10M | 0.46% | +$11.05M |
| ADC Therapeutics SASHS(ADCT) | 5,968,451 | 5,907,351 | -61,100 | $8.42M | $15.83M | 0.40% | +$7.42M |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 380,000 | 248,512 | -131,488 | $20.13M | $15.70M | 0.39% | -$4.43M |
| Forte Biosciences Inc | 593,088 | 1,196,955 | +603,867 | $4.60M | $15.48M | 0.39% | +$10.87M |
| Cullinan Therapeutics, Inc.(CGEM) | 1,923,855 | 1,923,855 | 0 | $14.56M | $14.49M | 0.36% | -$77.0K |
| Keros Therapeutics, Inc.(KROS) | 1,018,734 | 1,018,734 | 0 | $10.38M | $13.60M | 0.34% | +$3.22M |
| Rapt Therapeutics Inc | 0 | 1,641,906 | +1,641,906 | $0 | $13.14M | 0.33% | +$13.14M |
| Ikena Oncology IncNONVOTING | 12,048,773 | 12,048,773 | 0 | $12.51M | $13.13M | 0.33% | +$617.3K |
| Amicus Therapeutics Inc COM | 2,285,400 | 2,285,400 | 0 | $18.65M | $13.10M | 0.33% | -$5.55M |
| Vir Biotechnology, Inc.(VIR) | 2,248,249 | 2,380,715 | +132,466 | $14.57M | $12.00M | 0.30% | -$2.57M |
| AbCellera Biologics Inc.(ABCL) | 4,180,768 | 3,344,568 | -836,200 | $9.32M | $11.47M | 0.29% | +$2.15M |
| Akero Therapeutics Inc | 179,900 | 211,300 | +31,400 | $7.28M | $11.27M | 0.28% | +$3.99M |
| Mineralys Therapeutics, Inc.(MLYS) | 0 | 760,351 | +760,351 | $0 | $10.29M | 0.26% | +$10.29M |
| Dyne Therapeutics, Inc.(DYN) | 1,014,611 | 1,031,400 | +16,789 | $10.61M | $9.82M | 0.25% | -$793.9K |
| C4 Therapeutics, Inc.(CCCC) | 6,830,300 | 6,830,300 | 0 | $10.93M | $9.77M | 0.25% | -$1.16M |
| ORIC Pharmaceuticals, Inc.(ORIC) | 700,000 | 899,281 | +199,281 | $3.91M | $9.13M | 0.23% | +$5.22M |
| Catalyst Pharmaceuticals Inc | 0 | 416,900 | +416,900 | $0 | $9.05M | 0.23% | +$9.05M |
| Prelude Therapeutics Incorporated(PRLD) | 10,909,256 | 10,909,256 | 0 | $8.38M | $8.83M | 0.22% | +$451.6K |
| Corbus Pharmaceuticals Holdings, Inc.(CRBP) | 1,172,287 | 1,172,287 | 0 | $6.22M | $8.09M | 0.20% | +$1.86M |
| Zai Lab LimitedADR(ZLAB) | 0 | 231,000 | +231,000 | $0 | $8.08M | 0.20% | +$8.08M |
| Tarsus Pharmaceuticals, Inc.(TARS) | 653,743 | 197,900 | -455,843 | $33.58M | $8.02M | 0.20% | -$25.57M |
| Whitehawk Therapeutics, Inc.(WHWK) | 4,166,000 | 4,166,000 | 0 | $7.42M | $7.79M | 0.20% | +$374.9K |
| Tyra Biosciences, Inc.(TYRA) | 1,752,831 | 804,603 | -948,228 | $16.30M | $7.70M | 0.19% | -$8.60M |
| Adicet Bio Inc | 11,447,140 | 11,447,140 | 0 | $8.64M | $6.98M | 0.18% | -$1.66M |
| Iteos Therapeutics Inc | 0 | 700,000 | +700,000 | $0 | $6.98M | 0.18% | +$6.98M |
| PMV Pharmaceuticals, Inc.(PMVP) | 6,475,291 | 6,475,291 | 0 | $7.06M | $6.86M | 0.17% | -$194.3K |
| UroGen Pharma Ltd.(URGN) | 0 | 478,400 | +478,400 | $0 | $6.55M | 0.16% | +$6.55M |
| Ascendis Pharma A/SADR(ASND) | 0 | 34,400 | +34,400 | $0 | $5.94M | 0.15% | +$5.94M |
| Alumis Inc | 0 | 1,926,423 | +1,926,423 | $0 | $5.78M | 0.15% | +$5.78M |
| Jade Biosciences Inc | 0 | 531,163 | +531,163 | $0 | $5.31M | 0.13% | +$5.31M |
| InspireMD, Inc.(NSPR) | 2,133,405 | 2,133,405 | 0 | $5.74M | $4.84M | 0.12% | -$896.0K |
| Avalo Therapeutics, Inc.(AVTX) | 967,000 | 967,000 | 0 | $7.75M | $4.83M | 0.12% | -$2.92M |
| Ikena Oncology Inc | 3,539,358 | 3,539,358 | 0 | $4.53M | $4.74M | 0.12% | +$212.4K |
| Repare Therapeutics Inc | 3,322,488 | 3,322,488 | 0 | $3.28M | $4.62M | 0.12% | +$1.34M |
| Immatics N.V.SHS(IMTX) | 3,087,462 | 719,901 | -2,367,561 | $13.92M | $3.87M | 0.10% | -$10.05M |
| BioAge Labs, Inc.(BIOA) | 921,959 | 921,959 | 0 | $3.47M | $3.81M | 0.10% | +$341.1K |
| Q32 Bio Inc.(QTTB) | 2,252,987 | 2,252,987 | 0 | $3.72M | $3.36M | 0.08% | -$360.5K |
| Engene Holdings Inc COM | 891,616 | 677,977 | -213,639 | $3.99M | $2.47M | 0.06% | -$1.53M |
| Passage Bio, Inc.(PASG) | 7,034,626 | 6,055,300 | -979,326 | $2.48M | $2.42M | 0.06% | -$60.0K |
| Amylyx Pharmaceuticals, Inc.(AMLX) | 348,000 | 313,200 | -34,800 | $1.23M | $2.01M | 0.05% | +$775.7K |
| Mural Oncology Pub Ltd Co | 0 | 588,800 | +588,800 | $0 | $1.45M | 0.04% | +$1.45M |
| Insmed Incorporated(INSM) | 28,659 | 13,459 | -15,200 | $2.19M | $1.35M | 0.03% | -$831.9K |
| Krystal Biotech, Inc.(KRYS) | 23,500 | 9,200 | -14,300 | $4.24M | $1.26M | 0.03% | -$2.97M |
| Turnstone Biologics Corp | 3,099,265 | 3,099,265 | 0 | $1.27M | $1.11M | 0.03% | -$158.1K |
| Chemomab Therapeutics LtdADS | 1,741,273 | 940,990 | -800,283 | $1.90M | $1.09M | 0.03% | -$806.4K |
| Traws Pharma, Inc.(TRAW) | 605,531 | 605,531 | 0 | $1.39M | $896.2K | 0.02% | -$496.5K |
| Kezar Life Sciences Inc COM NEW | 192,700 | 192,700 | 0 | $940.4K | $882.6K | 0.02% | -$57.8K |
| Alto Neuroscience, Inc.(ANRO) | 250,000 | 250,000 | 0 | $540.0K | $550.0K | 0.01% | +$10.0K |
| Dih Hldg Us IncCL A | 1,915,000 | 1,915,000 | 0 | $442.9K | $469.0K | 0.01% | +$26.0K |
| Lyell Immunopharma, Inc.(LYEL) | 0 | 51,727 | +51,727 | $0 | $457.3K | 0.01% | +$457.3K |
| Korro Bio, Inc.(KRRO) | 32,400 | 32,400 | 0 | $564.1K | $404.7K | 0.01% | -$159.4K |
| Xeris Biopharma Holdings Inc | 80,420 | 80,420 | 0 | $441.5K | $375.6K | 0.01% | -$65.9K |
| Lakeshore Biopharma Co Ltd | 140,428 | 54,799 | -85,629 | $344.0K | $55.9K | 0.00% | -$288.2K |
| Acelyrin Inc | 4,001,711 | 0 | -4,001,711 | $9.88M | $0 | — | -$9.88M |
| Amgen Inc.(AMGN) | 44,200 | 0 | -44,200 | $13.77M | $0 | — | -$13.77M |
| Bicara Therapeutics Inc | 298,301 | 0 | -298,301 | $3.89M | $0 | — | -$3.89M |