Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| DANAHER CORPORATION(DHR) | 0 | 263,100 | +263,100 | 0 | 52,162 | 1.25% | +52,162 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 15,518,492 | 15,518,492 | 0 | 203,447 | 251,710 | 6.04% | +48,263 |
| UNITED THERAPEUTICS CORP DEL(UTHR) | 0 | 114,900 | +114,900 | 0 | 48,167 | 1.16% | +48,167 |
| THE CIGNA GROUP(CI) | 0 | 162,800 | +162,800 | 0 | 46,927 | 1.13% | +46,927 |
| MINERALYS THERAPEUTICS INC(MLYS) | 760,351 | 1,469,494 | +709,143 | 10,288 | 55,723 | 1.34% | +45,436 |
| SIONNA THERAPEUTICS INC(SION) | 3,704,959 | 3,704,959 | 0 | 64,281 | 108,963 | 2.61% | +44,682 |
| UPSTREAM BIO INC(UPB) | 5,693,589 | 5,693,589 | 0 | 62,516 | 107,096 | 2.57% | +44,581 |
| ORIC PHARMACEUTICALS INC(ORIC) | 899,281 | 3,641,756 | +2,742,475 | 9,128 | 43,701 | 1.05% | +34,573 |
| ABIVAX SA(ABVX) | 0 | 380,000 | +380,000 | 0 | 32,262 | 0.77% | +32,262 |
| ASCENDIS PHARMA A/S(ASND) | 34,400 | 191,905 | +157,505 | 5,937 | 38,153 | 0.91% | +32,215 |
| TERNS PHARMACEUTICALS INC | 7,562,971 | 7,562,971 | 0 | 28,210 | 56,798 | 1.36% | +28,588 |
| APELLIS PHARMACEUTICALS INC COM | 1,482,300 | 2,323,368 | +841,068 | 25,659 | 52,578 | 1.26% | +26,919 |
| UNIQURE NV(QURE) | 0 | 458,500 | +458,500 | 0 | 26,763 | 0.64% | +26,763 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 341,900 | 301,600 | -40,300 | 111,490 | 137,530 | 3.30% | +26,039 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 0 | 1,796,000 | +1,796,000 | 0 | 25,575 | 0.61% | +25,575 |
| MBX BIOSCIENCES INC(MBX) | 4,002,887 | 4,002,887 | 0 | 45,673 | 70,051 | 1.68% | +24,378 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 7,165,006 | 7,165,006 | 0 | 28,660 | 52,806 | 1.27% | +24,146 |
| EXACT SCIENCES CORP(EXK) | 607,316 | 994,616 | +387,300 | 32,273 | 54,415 | 1.31% | +22,143 |
| CG ONCOLOGY INC(CGON) | 1,877,850 | 1,726,850 | -151,000 | 48,824 | 69,558 | 1.67% | +20,733 |
| AVIDITY BIOSCIENCES INC | 1,812,886 | 1,638,886 | -174,000 | 51,486 | 71,406 | 1.71% | +19,920 |
| AXSOME THERAPEUTICS INC(AXSM) | 427,900 | 531,800 | +103,900 | 44,668 | 64,587 | 1.55% | +19,919 |
| DYNE THERAPEUTICS INC(DYN) | 1,031,400 | 2,314,184 | +1,282,784 | 9,819 | 29,274 | 0.70% | +19,456 |
| DISC MEDICINE INC(IRON) | 1,415,020 | 1,415,020 | 0 | 74,939 | 93,505 | 2.24% | +18,565 |
| KRYSTAL BIOTECH INC(KRYS) | 9,200 | 102,745 | +93,545 | 1,265 | 18,138 | 0.43% | +16,873 |
| CARLSMED INC(CARL) | 0 | 1,252,600 | +1,252,600 | 0 | 16,772 | 0.40% | +16,772 |
| JANUX THERAPEUTICS INC(JANX) | 1,210,300 | 1,766,100 | +555,800 | 27,958 | 43,163 | 1.04% | +15,206 |
| SHATTUCK LABS INC(STTK) | 0 | 6,306,127 | +6,306,127 | 0 | 15,072 | 0.36% | +15,072 |
| RAPT THERAPEUTICS INC | 1,641,906 | 1,086,618 | -555,288 | 13,135 | 28,024 | 0.67% | +14,889 |
| AKERO THERAPEUTICS INC | 211,300 | 526,200 | +314,900 | 11,275 | 24,984 | 0.60% | +13,709 |
| COMPASS THERAPEUTICS INC(CMPX) | 15,219,994 | 15,219,994 | 0 | 39,572 | 53,270 | 1.28% | +13,698 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 1,149,000 | 1,099,000 | -50,000 | 33,045 | 45,773 | 1.10% | +12,728 |
| ARGENX SE(ARGX) | 208,000 | 172,300 | -35,700 | 114,654 | 127,082 | 3.05% | +12,428 |
| AVALO THERAPEUTICS INC(AVTX) | 967,000 | 1,349,300 | +382,300 | 4,825 | 17,150 | 0.41% | +12,324 |
| TREVI THERAPEUTICS INC(TRVI) | 3,308,400 | 3,308,400 | 0 | 18,097 | 30,272 | 0.73% | +12,175 |
| SCPHARMACEUTICALS INC | 6,059,528 | 6,059,528 | 0 | 23,087 | 34,358 | 0.82% | +11,271 |
| VISTAGEN THERAPEUTICS INC(VTGN) | 0 | 3,060,000 | +3,060,000 | 0 | 10,863 | 0.26% | +10,863 |
| CARIS LIFE SCIENCES INC(CAI) | 3,034,858 | 3,034,858 | 0 | 81,091 | 91,804 | 2.20% | +10,713 |
| ROIVANT SCIENCES LTD(ROIV) | 2,779,427 | 2,714,798 | -64,629 | 31,324 | 41,075 | 0.99% | +9,751 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 313,200 | 750,600 | +437,400 | 2,008 | 10,201 | 0.24% | +8,193 |
| VERASTEM INC(VSTM) | 0 | 887,561 | +887,561 | 0 | 7,837 | 0.19% | +7,837 |
| BRIGHTSPRING HEALTH SVCS INC(BTSG) | 0 | 263,800 | +263,800 | 0 | 7,798 | 0.19% | +7,798 |
| ADC THERAPEUTICS SA(ADCT) | 5,907,351 | 5,907,351 | 0 | 15,832 | 23,629 | 0.57% | +7,798 |
| CYTOMX THERAPEUTICS INC(CTMX) | 8,461,500 | 8,461,500 | 0 | 19,208 | 26,992 | 0.65% | +7,785 |
| UROGEN PHARMA LTD(URGN) | 478,400 | 689,000 | +210,600 | 6,554 | 13,746 | 0.33% | +7,191 |
| STRUCTURE THERAPEUTICS INC | 1,199,300 | 1,139,300 | -60,000 | 24,873 | 31,900 | 0.77% | +7,027 |
| PRELUDE THERAPEUTICS INC(PRLD) | 10,909,256 | 10,909,256 | 0 | 8,830 | 15,709 | 0.38% | +6,879 |
| BIOCRYST PHARMACEUTICALS INC(BCRX) | 0 | 901,500 | +901,500 | 0 | 6,842 | 0.16% | +6,842 |
| CORBUS PHARMACEUTICALS HLDGS(CRBP) | 1,172,287 | 1,172,287 | 0 | 8,089 | 14,829 | 0.36% | +6,741 |
| MILESTONE PHARMACEUTICALS IN(MIST) | 0 | 3,221,828 | +3,221,828 | 0 | 6,444 | 0.15% | +6,444 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 248,512 | 215,152 | -33,360 | 15,703 | 21,728 | 0.52% | +6,025 |
| MIND MEDICINE MINDMED INC | 0 | 367,824 | +367,824 | 0 | 4,337 | 0.10% | +4,337 |
| CELCUITY INC(CELC) | 0 | 84,020 | +84,020 | 0 | 4,151 | 0.10% | +4,151 |
| TARSUS PHARMACEUTICALS INC(TARS) | 197,900 | 197,900 | 0 | 8,017 | 11,761 | 0.28% | +3,744 |
| THERMO FISHER SCIENTIFIC INC(TMO) | 46,500 | 46,500 | 0 | 18,854 | 22,553 | 0.54% | +3,700 |
| ENLIVEN THERAPEUTICS INC | 7,959,538 | 7,959,538 | 0 | 159,668 | 162,932 | 3.91% | +3,263 |
| IMAGENEBIO INC(IMA) | 0 | 378,556 | +378,556 | 0 | 3,085 | 0.07% | +3,085 |
| CELCUITY INC(CELC) | 0 | 0 | 0 | 0 | 2,684 | 0.06% | +2,684 |
| KEROS THERAPEUTICS INC(KROS) | 1,018,734 | 1,018,734 | 0 | 13,600 | 16,116 | 0.39% | +2,516 |
| FORTE BIOSCIENCES INC(FBRX) | 1,196,955 | 1,196,955 | 0 | 15,477 | 17,954 | 0.43% | +2,478 |
| ADICET BIO INC | 11,447,140 | 11,447,140 | 0 | 6,983 | 9,274 | 0.22% | +2,292 |
| ALUMIS INC | 1,926,423 | 1,926,423 | 0 | 5,779 | 7,686 | 0.18% | +1,907 |
| C4 THERAPEUTICS INC(CCCC) | 6,830,300 | 5,235,146 | -1,595,154 | 9,767 | 11,622 | 0.28% | +1,855 |
| ATAI LIFE SCIENCES NV | 0 | 347,000 | +347,000 | 0 | 1,836 | 0.04% | +1,836 |
| VIR BIOTECHNOLOGY INC(VIR) | 2,380,715 | 2,380,715 | 0 | 11,999 | 13,594 | 0.33% | +1,595 |
| PMV PHARMACEUTICALS INC(PMVP) | 6,475,291 | 5,975,291 | -500,000 | 6,864 | 8,365 | 0.20% | +1,502 |
| REPARE THERAPEUTICS INC | 3,322,488 | 3,322,488 | 0 | 4,618 | 5,848 | 0.14% | +1,229 |
| KORRO BIO INC(KRRO) | 32,400 | 32,400 | 0 | 405 | 1,552 | 0.04% | +1,147 |
| Q32 BIO INC(FIXX) | 2,252,987 | 2,252,987 | 0 | 3,357 | 4,461 | 0.11% | +1,104 |
| BIOAGE LABS INC(BIOA) | 921,959 | 790,901 | -131,058 | 3,808 | 4,650 | 0.11% | +843 |
| INSMED INC(INSM) | 13,459 | 13,459 | 0 | 1,355 | 1,938 | 0.05% | +584 |
| PASSAGE BIO INC(PASG) | 0 | 59,046 | +59,046 | 0 | 474 | 0.01% | +474 |
| ALTO NEUROSCIENCE INC(ANRO) | 250,000 | 250,000 | 0 | 550 | 1,005 | 0.02% | +455 |
| LYELL IMMUNOPHARMA INC(LYEL) | 51,727 | 51,727 | 0 | 457 | 840 | 0.02% | +383 |
| INSPIREMD INC(NSPR) | 2,133,405 | 2,133,405 | 0 | 4,843 | 5,142 | 0.12% | +299 |
| XERIS BIOPHARMA HOLDINGS INC | 80,420 | 80,420 | 0 | 376 | 655 | 0.02% | +279 |
| TRAWS PHARMA INC(TRAW) | 605,531 | 605,531 | 0 | 896 | 1,120 | 0.03% | +224 |
| WHITEHAWK THERAPEUTICS INC(WHWK) | 4,166,000 | 4,166,000 | 0 | 7,790 | 7,915 | 0.19% | +125 |
| IMMATICS N.V(IMTX) | 719,901 | 466,601 | -253,300 | 3,873 | 3,975 | 0.10% | +102 |
| LAKESHORE BIOPHARMA CO LTD | 54,799 | 0 | -54,799 | 56 | 0 | — | -56 |
| DIH HLDG US INC | 1,915,000 | 1,915,000 | 0 | 469 | 358 | 0.01% | -111 |
| AMICUS THERAPEUTICS INC COM | 2,285,400 | 1,645,400 | -640,000 | 13,095 | 12,966 | 0.31% | -130 |
| KEZAR LIFE SCIENCES INC COM NEW | 192,700 | 192,700 | 0 | 883 | 752 | 0.02% | -131 |
| MURAL ONCOLOGY PUB LTD CO | 588,800 | 588,800 | 0 | 1,454 | 1,219 | 0.03% | -236 |
| JADE BIOSCIENCES INC | 531,163 | 531,163 | 0 | 5,306 | 4,584 | 0.11% | -722 |
| CHEMOMAB THERAPEUTICS LTD | 940,990 | 0 | -940,990 | 1,092 | 0 | — | -1,092 |
| TURNSTONE BIOLOGICS CORP | 3,099,265 | 0 | -3,099,265 | 1,113 | 0 | — | -1,113 |
| NEUROPACE INC(NPCE) | 2,614,184 | 2,614,184 | 0 | 29,122 | 26,952 | 0.65% | -2,170 |
| PASSAGE BIO INC(PASG) | 6,055,300 | 0 | -6,055,300 | 2,424 | 0 | — | -2,424 |
| ENGENE HOLDINGS INC COM | 677,977 | 0 | -677,977 | 2,468 | 0 | — | -2,468 |
| EDWARDS LIFESCIENCES CORP | 1,708,000 | 1,684,000 | -24,000 | 133,583 | 130,965 | 3.14% | -2,618 |
| CULLINAN THERAPEUTICS INC(CGEM) | 1,923,855 | 1,923,855 | 0 | 14,487 | 11,408 | 0.27% | -3,078 |
| IKENA ONCOLOGY INC | 3,539,358 | 0 | -3,539,358 | 4,743 | 0 | — | -4,743 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 438,540 | 353,640 | -84,900 | 55,120 | 49,644 | 1.19% | -5,476 |
| ITEOS THERAPEUTICS INC | 700,000 | 0 | -700,000 | 6,979 | 0 | — | -6,979 |
| TYRA BIOSCIENCES INC(TYRA) | 804,603 | 0 | -804,603 | 7,700 | 0 | — | -7,700 |
| ZAI LAB LTD(ZLAB) | 231,000 | 0 | -231,000 | 8,078 | 0 | — | -8,078 |
| CATALYST PHARMACEUTICALS INC | 416,900 | 0 | -416,900 | 9,047 | 0 | — | -9,047 |
| STRYKER CORPORATION(SYK) | 359,200 | 359,200 | 0 | 142,110 | 132,785 | 3.18% | -9,325 |
| ARRIVENT BIOPHARMA INC(AVBP) | 3,027,328 | 3,027,328 | 0 | 65,905 | 55,854 | 1.34% | -10,051 |
| SI-BONE INC(SIBN) | 2,578,979 | 2,578,979 | 0 | 48,536 | 37,963 | 0.91% | -10,574 |