Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2023 ▲▼ | Q4 2023 ▲▼ | Change ▲▼ | Q3 2023 ▲▼ | Q4 2023 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ELI LILLY & CO(LLY) | 186,000 | 365,400 | +179,400 | 99,906 | 212,999 | 4.27% | +113,093 |
| RAYZEBIO INC | 2,622,909 | 2,365,213 | -257,696 | 58,229 | 147,045 | 2.95% | +88,817 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 14,567,176 | 14,567,176 | 0 | 83,470 | 159,365 | 3.19% | +75,895 |
| BIOGEN INC(BIIB) | 556,800 | 827,600 | +270,800 | 143,103 | 214,158 | 4.29% | +71,055 |
| ELEVANCE HEALTH INC(ELV) | 0 | 141,500 | +141,500 | 0 | 66,726 | 1.34% | +66,726 |
| GRACELL BIOTECHNOLOGIES INC | 9,308,726 | 9,308,726 | 0 | 26,809 | 93,460 | 1.87% | +66,650 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 2,033,789 | 4,245,000 | +2,211,211 | 14,440 | 79,806 | 1.60% | +65,366 |
| ALX ONCOLOGY HLDGS INC(ALXO) | 2,871,000 | 3,095,000 | +224,000 | 13,781 | 46,085 | 0.92% | +32,304 |
| THIRD HARMONIC BIO INC | 5,779,071 | 5,779,071 | 0 | 36,928 | 63,396 | 1.27% | +26,468 |
| SPRINGWORKS THERAPEUTICS INC | 3,968,588 | 3,219,359 | -749,229 | 91,754 | 117,507 | 2.35% | +25,753 |
| THESEUS PHARMACEUTICALS INC | 17,713,600 | 17,713,600 | 0 | 47,650 | 71,740 | 1.44% | +24,090 |
| INTUITIVE SURGICAL INC | 499,000 | 499,000 | 0 | 145,853 | 168,343 | 3.37% | +22,490 |
| FUSION PHARMACEUTICALS INC | 3,122,770 | 3,122,770 | 0 | 8,119 | 30,010 | 0.60% | +21,891 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 415,900 | 519,279 | +103,379 | 46,789 | 68,420 | 1.37% | +21,631 |
| VAXCYTE INC(PCVX) | 1,007,148 | 1,153,091 | +145,943 | 51,344 | 72,414 | 1.45% | +21,070 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 1,284,000 | 1,749,000 | +465,000 | 18,644 | 37,796 | 0.76% | +19,152 |
| NATERA INC(NTRA) | 920,581 | 954,481 | +33,900 | 40,736 | 59,789 | 1.20% | +19,053 |
| IOVANCE BIOTHERAPEUTICS INC(IOVA) | 4,707,458 | 4,707,458 | 0 | 21,419 | 38,272 | 0.77% | +16,853 |
| BOSTON SCIENTIFIC CORP(BSX) | 3,306,800 | 3,306,800 | 0 | 174,599 | 191,166 | 3.83% | +16,567 |
| ARGENX SE(ARGX) | 32,600 | 84,600 | +52,000 | 16,027 | 32,184 | 0.64% | +16,157 |
| ARS PHARMACEUTICALS INC(SPRY) | 9,240,887 | 9,240,887 | 0 | 34,931 | 50,640 | 1.01% | +15,710 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 0 | 79,400 | +79,400 | 0 | 15,198 | 0.30% | +15,198 |
| VERTEX PHARMACEUTICALS INC(VRTX) | 165,400 | 175,200 | +9,800 | 57,516 | 71,287 | 1.43% | +13,771 |
| VERONA PHARMA PLC | 3,777,778 | 3,777,778 | 0 | 61,578 | 75,102 | 1.50% | +13,524 |
| PRELUDE THERAPEUTICS INC(PRLD) | 10,909,256 | 10,909,256 | 0 | 33,710 | 46,583 | 0.93% | +12,873 |
| KRYSTAL BIOTECH INC(KRYS) | 0 | 103,700 | +103,700 | 0 | 12,865 | 0.26% | +12,865 |
| EVOLENT HEALTH INC(EVH) | 2,895,632 | 2,746,532 | -149,100 | 78,848 | 90,718 | 1.82% | +11,870 |
| TENET HEALTHCARE CORP(THC) | 1,224,400 | 1,224,400 | 0 | 80,676 | 92,528 | 1.85% | +11,852 |
| AMICUS THERAPEUTICS INC COM | 0 | 806,000 | +806,000 | 0 | 11,437 | 0.23% | +11,437 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 583,642 | 536,642 | -47,000 | 13,380 | 24,669 | 0.49% | +11,289 |
| TERNS PHARMACEUTICALS INC | 7,619,135 | 7,619,135 | 0 | 38,324 | 49,448 | 0.99% | +11,124 |
| HERON THERAPEUTICS INC(HRTX) | 802,700 | 5,928,591 | +5,125,891 | 827 | 10,079 | 0.20% | +9,252 |
| DEXCOM INC(DXCM) | 0 | 73,200 | +73,200 | 0 | 9,083 | 0.18% | +9,083 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 1,615,210 | 1,571,410 | -43,800 | 142,914 | 151,515 | 3.03% | +8,602 |
| KINNATE BIOPHARMA INC | 8,009,729 | 8,009,729 | 0 | 11,214 | 18,983 | 0.38% | +7,769 |
| INVIVYD INC(IVVD) | 5,270,400 | 4,127,565 | -1,142,835 | 8,960 | 16,263 | 0.33% | +7,303 |
| APELLIS PHARMACEUTICALS INC COM | 1,260,500 | 922,200 | -338,300 | 47,949 | 55,203 | 1.11% | +7,253 |
| STRYKER CORPORATION(SYK) | 269,000 | 269,000 | 0 | 73,510 | 80,555 | 1.61% | +7,045 |
| AEROVATE THERAPEUTICS INC | 756,930 | 756,930 | 0 | 10,272 | 17,129 | 0.34% | +6,858 |
| MERCK & CO INC(MRK) | 1,055,000 | 1,055,000 | 0 | 108,612 | 115,016 | 2.30% | +6,404 |
| IONIS PHARMACEUTICALS INC(IONS) | 2,169,500 | 2,064,797 | -104,703 | 98,409 | 104,458 | 2.09% | +6,050 |
| APOGEE THERAPEUTICS INC(APGE) | 1,427,901 | 1,277,901 | -150,000 | 30,414 | 35,705 | 0.72% | +5,290 |
| ICON PLC(ICLR) | 132,200 | 132,200 | 0 | 32,554 | 37,422 | 0.75% | +4,868 |
| ABCELLERA BIOLOGICS INC(ABCL) | 4,180,768 | 4,180,768 | 0 | 19,232 | 23,872 | 0.48% | +4,641 |
| NEUMORA THERAPEUTICS INC.(NMRA) | 1,500,000 | 1,500,000 | 0 | 21,165 | 25,575 | 0.51% | +4,410 |
| ADICET BIO INC | 8,322,140 | 8,322,140 | 0 | 11,401 | 15,729 | 0.32% | +4,328 |
| ILLUMINA INC(ILMN) | 0 | 30,300 | +30,300 | 0 | 4,219 | 0.08% | +4,219 |
| AMBRX BIOPHARMA INC | 0 | 296,000 | +296,000 | 0 | 4,215 | 0.08% | +4,215 |
| IMMATICS N.V(IMTX) | 1,050,200 | 1,543,407 | +493,207 | 12,161 | 16,252 | 0.33% | +4,091 |
| PASSAGE BIO INC(PASG) | 10,124,576 | 10,124,576 | 0 | 6,662 | 10,226 | 0.20% | +3,564 |
| THERMO FISHER SCIENTIFIC INC(TMO) | 143,800 | 143,800 | 0 | 72,787 | 76,328 | 1.53% | +3,540 |
| MORPHIC HLDG INC | 208,500 | 273,400 | +64,900 | 4,777 | 7,896 | 0.16% | +3,119 |
| SAREPTA THERAPEUTICS INC(SRPT) | 529,200 | 697,500 | +168,300 | 64,150 | 67,260 | 1.35% | +3,110 |
| VERA THERAPEUTICS INC(VERA) | 1,518,115 | 1,518,115 | 0 | 20,813 | 23,349 | 0.47% | +2,535 |
| AMGEN INC(AMGN) | 127,300 | 127,300 | 0 | 34,213 | 36,665 | 0.73% | +2,452 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 0 | 58,800 | +58,800 | 0 | 2,332 | 0.05% | +2,332 |
| NEUROPACE INC(NPCE) | 4,012,281 | 4,003,967 | -8,314 | 39,039 | 41,281 | 0.83% | +2,241 |
| ARCUS BIOSCIENCES INC(RCUS) | 0 | 117,000 | +117,000 | 0 | 2,235 | 0.04% | +2,235 |
| 10X GENOMICS INC(TXG) | 0 | 39,800 | +39,800 | 0 | 2,227 | 0.04% | +2,227 |
| XTANT MED HLDGS INC(XTNT) | 73,114,592 | 73,114,592 | 0 | 80,426 | 82,619 | 1.65% | +2,193 |
| JANUX THERAPEUTICS INC(JANX) | 3,317,927 | 3,317,927 | 0 | 33,445 | 35,601 | 0.71% | +2,157 |
| KEROS THERAPEUTICS INC(KROS) | 1,514,734 | 1,268,734 | -246,000 | 48,290 | 50,445 | 1.01% | +2,155 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 6,943,654 | 6,943,654 | 0 | 10,138 | 12,221 | 0.24% | +2,083 |
| FATE THERAPEUTICS INC(FATE) | 0 | 528,080 | +528,080 | 0 | 1,975 | 0.04% | +1,975 |
| ENLIVEN THERAPEUTICS INC | 8,998,338 | 8,998,338 | 0 | 122,917 | 124,537 | 2.49% | +1,620 |
| ALPINE IMMUNE SCIENCES INC | 4,081,592 | 2,535,245 | -1,546,347 | 46,734 | 48,322 | 0.97% | +1,588 |
| UNITEDHEALTH GROUP INC(UNH) | 70,000 | 70,000 | 0 | 35,293 | 36,853 | 0.74% | +1,560 |
| GERON CORP(GERN) | 0 | 485,000 | +485,000 | 0 | 1,023 | 0.02% | +1,023 |
| VIR BIOTECHNOLOGY INC(VIR) | 0 | 101,000 | +101,000 | 0 | 1,016 | 0.02% | +1,016 |
| AGIOS PHARMACEUTICALS INC(AGIO) | 0 | 45,000 | +45,000 | 0 | 1,002 | 0.02% | +1,002 |
| REGENERON PHARMACEUTICALS(REGN) | 13,500 | 13,500 | 0 | 11,110 | 11,857 | 0.24% | +747 |
| CULLINAN ONCOLOGY INC(CGEM) | 544,848 | 544,848 | 0 | 4,931 | 5,552 | 0.11% | +621 |
| GILEAD SCIENCES INC(GILD) | 100,000 | 100,000 | 0 | 7,494 | 8,101 | 0.16% | +607 |
| BOLT BIOTHERAPEUTICS INC | 1,541,000 | 1,541,000 | 0 | 1,603 | 1,726 | 0.03% | +123 |
| CALCIMEDICA INC(CALC) | 297,380 | 297,380 | 0 | 791 | 851 | 0.02% | +60 |
| SINGULAR GENOMICS SYSTEMS IN | 540,697 | 540,697 | 0 | 206 | 249 | 0.00% | +43 |
| VERASTEM INC(VSTM) | 1,529,115 | 1,529,115 | 0 | 12,432 | 12,447 | 0.25% | +15 |
| SINOVAC BIOTECH LTD(SVA) | 2,718,735 | 2,718,735 | 0 | 340,000 | 340,000 | 6.81% | 0 |
| INSPIREMD INC(NSPR) | 1,860,405 | 2,133,405 | +273,000 | 6,084 | 5,995 | 0.12% | -89 |
| ELEVATION ONCOLOGY INC | 1,500,000 | 1,500,000 | 0 | 994 | 806 | 0.02% | -188 |
| HARPOON THERAPEUTICS INC | 62,121 | 0 | -62,121 | 250 | 0 | — | -250 |
| ALTIMMUNE INC(ALT) | 100,000 | 0 | -100,000 | 260 | 0 | — | -260 |
| BIOMX INC(PHGE) | 4,553,489 | 4,517,589 | -35,900 | 1,603 | 1,265 | 0.03% | -338 |
| XENCOR INC(XNCR) | 19,142 | 0 | -19,142 | 386 | 0 | — | -386 |
| NEXTCURE INC | 2,711,013 | 2,711,013 | 0 | 3,497 | 3,091 | 0.06% | -407 |
| SI-BONE INC(SIBN) | 2,292,531 | 2,292,531 | 0 | 48,693 | 48,120 | 0.96% | -573 |
| ORIC PHARMACEUTICALS INC(ORIC) | 893,668 | 522,968 | -370,700 | 5,407 | 4,811 | 0.10% | -595 |
| GALECTO INC | 924,788 | 0 | -924,788 | 665 | 0 | — | -665 |
| CHEMOMAB THERAPEUTICS LTD | 2,241,274 | 2,241,274 | 0 | 2,006 | 1,143 | 0.02% | -863 |
| VIGIL NEUROSCIENCE INC | 448,891 | 448,891 | 0 | 2,420 | 1,517 | 0.03% | -902 |
| R1 RCM INC | 3,441,000 | 4,803,200 | +1,362,200 | 51,856 | 50,770 | 1.02% | -1,086 |
| SYNLOGIC INC(SYBX) | 401,998 | 0 | -401,998 | 1,130 | 0 | — | -1,130 |
| PROTARA THERAPEUTICS INC(TARA) | 772,584 | 0 | -772,584 | 1,290 | 0 | — | -1,290 |
| ACUTUS MED INC | 2,648,386 | 2,648,386 | 0 | 1,845 | 535 | 0.01% | -1,310 |
| BIOATLA INC(BCAB) | 1,009,279 | 0 | -1,009,279 | 1,716 | 0 | — | -1,716 |
| X4 PHARMACEUTICALS INC(XFOR) | 7,133,515 | 7,133,515 | 0 | 7,776 | 5,981 | 0.12% | -1,794 |
| ARROWHEAD PHARMACEUTICALS IN(ARWR) | 433,651 | 319,651 | -114,000 | 11,652 | 9,781 | 0.20% | -1,871 |
| YS BIOPHARMA CO LTD | 4,541,422 | 3,236,311 | -1,305,111 | 3,633 | 1,654 | 0.03% | -1,979 |
| TELADOC HEALTH INC(TDOC) | 110,000 | 0 | -110,000 | 2,045 | 0 | — | -2,045 |
| KARUNA THERAPEUTICS INC | 14,000 | 0 | -14,000 | 2,367 | 0 | — | -2,367 |