Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2024 ▲▼ | Q4 2024 ▲▼ | Change ▲▼ | Q3 2024 ▲▼ | Q4 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| UPSTREAM BIO INC(UPB) | 0 | 5,693,589 | +5,693,589 | 0 | 93,603 | 1.94% | +93,603 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 302,220 | 938,120 | +635,900 | 34,822 | 128,053 | 2.66% | +93,232 |
| EDWARDS LIFESCIENCES CORP | 0 | 1,145,302 | +1,145,302 | 0 | 84,787 | 1.76% | +84,787 |
| CYTOKINETICS INC(CYTK) | 766,906 | 1,584,005 | +817,099 | 40,493 | 74,512 | 1.55% | +34,019 |
| SPDR SER TR ST STR SP BIOT | 0 | 372,000 | +372,000 | 0 | 33,502 | 0.70% | +33,502 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 250,300 | 415,600 | +165,300 | 68,840 | 97,795 | 2.03% | +28,955 |
| DISC MEDICINE INC(IRON) | 1,785,571 | 1,785,571 | 0 | 87,743 | 113,205 | 2.35% | +25,462 |
| RAPT THERAPEUTICS INC | 0 | 13,135,260 | +13,135,260 | 0 | 20,754 | 0.43% | +20,754 |
| AMICUS THERAPEUTICS INC COM | 570,300 | 2,285,400 | +1,715,100 | 6,091 | 21,528 | 0.45% | +15,438 |
| CG ONCOLOGY INC(CGON) | 691,114 | 1,431,114 | +740,000 | 26,076 | 41,044 | 0.85% | +14,969 |
| NEUROPACE INC(NPCE) | 3,406,335 | 3,406,335 | 0 | 23,742 | 38,117 | 0.79% | +14,375 |
| FORTE BIOSCIENCES INC(FBRX) | 0 | 600,000 | +600,000 | 0 | 13,626 | 0.28% | +13,626 |
| INTRA-CELLULAR THERAPIES INC | 0 | 163,000 | +163,000 | 0 | 13,614 | 0.28% | +13,614 |
| UNIVERSAL HLTH SVCS INC(UHS) | 156,000 | 269,300 | +113,300 | 35,726 | 48,318 | 1.00% | +12,592 |
| GILEAD SCIENCES INC(GILD) | 151,700 | 245,600 | +93,900 | 12,719 | 22,686 | 0.47% | +9,968 |
| ARRIVENT BIOPHARMA INC(AVBP) | 3,027,328 | 3,027,328 | 0 | 71,142 | 80,648 | 1.67% | +9,506 |
| BOSTON SCIENTIFIC CORP(BSX) | 3,273,000 | 3,160,300 | -112,700 | 274,277 | 282,278 | 5.86% | +8,001 |
| GERON CORP(GERN) | 0 | 2,168,000 | +2,168,000 | 0 | 7,675 | 0.16% | +7,675 |
| CARDIFF ONCOLOGY INC(CRDF) | 0 | 1,538,462 | +1,538,462 | 0 | 6,677 | 0.14% | +6,677 |
| INSMED INC(INSM) | 0 | 94,559 | +94,559 | 0 | 6,528 | 0.14% | +6,528 |
| VERASTEM INC(VSTM) | 2,862,448 | 2,862,448 | 0 | 8,559 | 14,799 | 0.31% | +6,240 |
| ENGENE HOLDINGS INC COM | 0 | 920,339 | +920,339 | 0 | 6,120 | 0.13% | +6,120 |
| ARGENX SE(ARGX) | 204,500 | 189,700 | -14,800 | 110,855 | 116,666 | 2.42% | +5,810 |
| CULLINAN THERAPEUTICS INC(CGEM) | 1,070,055 | 1,942,555 | +872,500 | 17,913 | 23,660 | 0.49% | +5,748 |
| IONIS PHARMACEUTICALS INC(IONS) | 2,324,447 | 2,817,347 | +492,900 | 93,117 | 98,494 | 2.05% | +5,377 |
| DYNE THERAPEUTICS INC(DYN) | 708,400 | 1,227,080 | +518,680 | 25,446 | 28,910 | 0.60% | +3,464 |
| CERIBELL INC(CBLL) | 0 | 112,500 | +112,500 | 0 | 2,912 | 0.06% | +2,912 |
| TYRA BIOSCIENCES INC(TYRA) | 768,638 | 1,470,086 | +701,448 | 18,071 | 20,434 | 0.42% | +2,364 |
| SI-BONE INC(SIBN) | 3,305,801 | 3,442,853 | +137,052 | 46,215 | 48,269 | 1.00% | +2,054 |
| IMMUNOVANT INC(IMVT) | 0 | 78,500 | +78,500 | 0 | 1,944 | 0.04% | +1,944 |
| AKERO THERAPEUTICS INC | 0 | 66,000 | +66,000 | 0 | 1,836 | 0.04% | +1,836 |
| TRAWS PHARMA INC(TRAW) | 605,531 | 605,531 | 0 | 3,561 | 5,377 | 0.11% | +1,817 |
| TANGO THERAPEUTICS INC(TNGX) | 0 | 550,000 | +550,000 | 0 | 1,700 | 0.04% | +1,700 |
| MILESTONE PHARMACEUTICALS IN(MIST) | 2,000,000 | 2,000,000 | 0 | 3,040 | 4,720 | 0.10% | +1,680 |
| VERA THERAPEUTICS INC(VERA) | 675,872 | 742,572 | +66,700 | 29,874 | 31,403 | 0.65% | +1,530 |
| INTEGER HLDGS CORP(ITGR) | 575,000 | 575,000 | 0 | 74,750 | 76,199 | 1.58% | +1,449 |
| ABCELLERA BIOLOGICS INC(ABCL) | 4,180,768 | 4,180,768 | 0 | 10,870 | 12,250 | 0.25% | +1,380 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 0 | 348,000 | +348,000 | 0 | 1,315 | 0.03% | +1,315 |
| KEZAR LIFE SCIENCES INC COM NEW | 0 | 192,700 | +192,700 | 0 | 1,295 | 0.03% | +1,295 |
| XENON PHARMACEUTICALS INC(XENE) | 911,420 | 947,877 | +36,457 | 35,883 | 37,157 | 0.77% | +1,274 |
| KORRO BIO INC(KRRO) | 0 | 32,400 | +32,400 | 0 | 1,233 | 0.03% | +1,233 |
| ALTO NEUROSCIENCE INC(ANRO) | 0 | 250,000 | +250,000 | 0 | 1,058 | 0.02% | +1,058 |
| AGIOS PHARMACEUTICALS INC(AGIO) | 0 | 26,700 | +26,700 | 0 | 877 | 0.02% | +877 |
| STRUCTURE THERAPEUTICS INC | 383,705 | 652,028 | +268,323 | 16,841 | 17,683 | 0.37% | +842 |
| SPRINGWORKS THERAPEUTICS INC | 1,390,631 | 1,255,031 | -135,600 | 44,556 | 45,344 | 0.94% | +788 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 742,300 | 151,800 | -590,500 | 5,946 | 6,561 | 0.14% | +615 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 6,943,654 | 6,943,654 | 0 | 36,662 | 37,149 | 0.77% | +486 |
| LAKESHORE BIOPHARMA CO LTD | 0 | 140,428 | +140,428 | 0 | 486 | 0.01% | +486 |
| X4 PHARMACEUTICALS INC(XFOR) | 7,133,515 | 7,133,515 | 0 | 4,774 | 5,233 | 0.11% | +459 |
| CHEMOMAB THERAPEUTICS LTD | 1,741,273 | 1,741,273 | 0 | 2,734 | 3,152 | 0.07% | +418 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 15,021,721 | 15,021,721 | 0 | 400,930 | 401,080 | 8.33% | +150 |
| PMV PHARMACEUTICALS INC(PMVP) | 6,475,291 | 6,475,291 | 0 | 9,648 | 9,778 | 0.20% | +130 |
| XERIS BIOPHARMA HOLDINGS INC | 80,420 | 80,420 | 0 | 229 | 273 | 0.01% | +43 |
| ELEVATION ONCOLOGY INC | 941,275 | 941,275 | 0 | 565 | 530 | 0.01% | -35 |
| INSTIL BIO INC(TIL) | 33,700 | 116,785 | +83,085 | 2,269 | 2,229 | 0.05% | -39 |
| MEDPACE HLDGS INC(MEDP) | 44,900 | 44,900 | 0 | 14,988 | 14,917 | 0.31% | -70 |
| INSPIREMD INC(NSPR) | 2,133,405 | 2,133,405 | 0 | 5,718 | 5,611 | 0.12% | -107 |
| TURNSTONE BIOLOGICS CORP | 3,099,265 | 3,099,265 | 0 | 1,727 | 1,540 | 0.03% | -187 |
| ARDENT HEALTH PARTNERS INC(ARDT) | 206,000 | 206,000 | 0 | 3,786 | 3,518 | 0.07% | -268 |
| IKENA ONCOLOGY INC | 3,539,358 | 3,539,358 | 0 | 6,123 | 5,805 | 0.12% | -319 |
| STRYKER CORPORATION(SYK) | 344,400 | 344,400 | 0 | 124,418 | 124,001 | 2.57% | -417 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 435,900 | 400,000 | -35,900 | 22,837 | 22,392 | 0.46% | -445 |
| BIOMX INC(PHGE) | 1,787,767 | 1,787,767 | 0 | 1,824 | 1,305 | 0.03% | -518 |
| KRYSTAL BIOTECH INC(KRYS) | 23,500 | 23,500 | 0 | 4,278 | 3,682 | 0.08% | -596 |
| NEXTCURE INC | 1,141,200 | 1,141,200 | 0 | 1,563 | 880 | 0.02% | -684 |
| IMMATICS N.V(IMTX) | 2,006,381 | 3,087,462 | +1,081,081 | 22,893 | 21,952 | 0.46% | -941 |
| INVIVYD INC(IVVD) | 1,728,300 | 1,149,300 | -579,000 | 1,763 | 509 | 0.01% | -1,254 |
| KEZAR LIFE SCIENCES INC | 1,927,000 | 0 | -1,927,000 | 1,490 | 0 | — | -1,490 |
| VIGIL NEUROSCIENCE INC | 448,891 | 0 | -448,891 | 1,526 | 0 | — | -1,526 |
| BICARA THERAPEUTICS INC | 271,910 | 298,301 | +26,391 | 6,926 | 5,196 | 0.11% | -1,729 |
| AVALO THERAPEUTICS INC(AVTX) | 967,000 | 967,000 | 0 | 9,187 | 7,185 | 0.15% | -2,002 |
| SAREPTA THERAPEUTICS INC(SRPT) | 954,500 | 963,400 | +8,900 | 119,208 | 117,140 | 2.43% | -2,068 |
| ADC THERAPEUTICS SA(ADCT) | 4,533,801 | 5,968,451 | +1,434,650 | 14,281 | 11,877 | 0.25% | -2,404 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 1,050,055 | 999,000 | -51,055 | 53,658 | 51,079 | 1.06% | -2,579 |
| PASSAGE BIO INC(PASG) | 9,822,876 | 7,404,869 | -2,418,007 | 6,876 | 4,199 | 0.09% | -2,677 |
| FATE THERAPEUTICS INC(FATE) | 1,680,580 | 1,680,580 | 0 | 5,882 | 2,773 | 0.06% | -3,109 |
| VIR BIOTECHNOLOGY INC(VIR) | 3,573,000 | 3,218,617 | -354,383 | 26,762 | 23,625 | 0.49% | -3,137 |
| INTUITIVE SURGICAL INC | 433,800 | 401,700 | -32,100 | 213,113 | 209,671 | 4.35% | -3,442 |
| PEPGEN INC(PEPG) | 797,358 | 653,016 | -144,342 | 6,817 | 2,475 | 0.05% | -4,342 |
| MINERALYS THERAPEUTICS INC(MLYS) | 2,002,939 | 1,611,637 | -391,302 | 24,256 | 19,839 | 0.41% | -4,416 |
| NKARTA INC(NKTX) | 1,480,600 | 821,400 | -659,200 | 6,692 | 2,045 | 0.04% | -4,647 |
| CORBUS PHARMACEUTICALS HLDGS(CRBP) | 912,552 | 1,172,287 | +259,735 | 18,826 | 13,833 | 0.29% | -4,993 |
| TELA BIO INC(TELA) | 2,161,185 | 0 | -2,161,185 | 5,468 | 0 | — | -5,468 |
| ADICET BIO INC | 11,447,140 | 11,447,140 | 0 | 16,484 | 11,012 | 0.23% | -5,472 |
| LONGBOARD PHARMACEUTICALS IN | 170,000 | 0 | -170,000 | 5,666 | 0 | — | -5,666 |
| SINOVAC BIOTECH LTD(SVA) | 2,718,735 | 2,718,735 | 0 | 340,000 | 333,997 | 6.94% | -6,003 |
| SCPHARMACEUTICALS INC | 6,059,528 | 6,059,528 | 0 | 27,631 | 21,451 | 0.45% | -6,181 |
| LYELL IMMUNOPHARMA INC(LYEL) | 6,086,001 | 3,103,623 | -2,982,378 | 8,399 | 1,986 | 0.04% | -6,412 |
| REPARE THERAPEUTICS INC | 3,322,488 | 3,322,488 | 0 | 11,429 | 4,352 | 0.09% | -7,077 |
| ACELYRIN INC | 4,001,711 | 4,001,711 | 0 | 19,728 | 12,565 | 0.26% | -7,163 |
| OSCAR HEALTH INC(OSCR) | 351,618 | 0 | -351,618 | 7,458 | 0 | — | -7,458 |
| EXACT SCIENCES CORP(EXK) | 679,816 | 679,816 | 0 | 46,309 | 38,199 | 0.79% | -8,110 |
| THERMO FISHER SCIENTIFIC INC(TMO) | 84,400 | 84,400 | 0 | 52,207 | 43,907 | 0.91% | -8,300 |
| PRELUDE THERAPEUTICS INC(PRLD) | 10,909,256 | 10,909,256 | 0 | 22,582 | 13,909 | 0.29% | -8,673 |
| COMPASS THERAPEUTICS INC(CMPX) | 22,362,850 | 22,362,850 | 0 | 41,148 | 32,426 | 0.67% | -8,722 |
| C4 THERAPEUTICS INC(CCCC) | 4,377,900 | 4,377,900 | 0 | 24,954 | 15,760 | 0.33% | -9,194 |
| VERTEX PHARMACEUTICALS INC(VRTX) | 151,000 | 151,000 | 0 | 70,227 | 60,808 | 1.26% | -9,419 |
| NEUMORA THERAPEUTICS INC.(NMRA) | 1,500,000 | 804,996 | -695,004 | 19,815 | 8,533 | 0.18% | -11,282 |
| ACADIA PHARMACEUTICALS INC | 764,600 | 0 | -764,600 | 11,760 | 0 | — | -11,760 |
| BIONTECH SE(BNTX) | 103,000 | 0 | -103,000 | 12,233 | 0 | — | -12,233 |