Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| EDGEWISE THERAPEUTICS INC(EWTX) | 15,518,492 | 15,518,492 | 0 | 251,710 | 385,091 | 7.88% | +133,381 |
| ELI LILLY & CO(LLY) | 301,200 | 301,200 | 0 | 229,816 | 323,694 | 6.62% | +93,878 |
| MBX BIOSCIENCES INC(MBX) | 4,002,887 | 3,935,203 | -67,684 | 70,051 | 124,116 | 2.54% | +54,066 |
| STRUCTURE THERAPEUTICS INC | 1,139,300 | 1,161,803 | +22,503 | 31,900 | 80,803 | 1.65% | +48,903 |
| UPSTREAM BIO INC(UPB) | 5,693,589 | 5,693,589 | 0 | 107,096 | 154,581 | 3.16% | +47,485 |
| BRISTOL-MYERS SQUIBB CO(BMY) | 0 | 775,000 | +775,000 | 0 | 41,804 | 0.86% | +41,804 |
| PFIZER INC(PFE) | 0 | 1,652,900 | +1,652,900 | 0 | 41,157 | 0.84% | +41,157 |
| SIONNA THERAPEUTICS INC(SION) | 3,704,959 | 3,561,655 | -143,304 | 108,963 | 146,526 | 3.00% | +37,564 |
| ELEVANCE HEALTH INC FORMERLY(ELV) | 0 | 99,100 | +99,100 | 0 | 34,740 | 0.71% | +34,740 |
| CYBIN INC(HELP) | 0 | 3,840,500 | +3,840,500 | 0 | 31,415 | 0.64% | +31,415 |
| TERNS PHARMACEUTICALS INC | 7,562,971 | 2,153,300 | -5,409,671 | 56,798 | 86,993 | 1.78% | +30,195 |
| COMPASS THERAPEUTICS INC(CMPX) | 15,219,994 | 15,219,994 | 0 | 53,270 | 81,731 | 1.67% | +28,461 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 0 | 94,500 | +94,500 | 0 | 27,853 | 0.57% | +27,853 |
| RAPT THERAPEUTICS INC | 1,086,618 | 1,642,891 | +556,273 | 28,024 | 55,645 | 1.14% | +27,621 |
| BRUKER CORP(BRKR) | 0 | 555,789 | +555,789 | 0 | 26,183 | 0.54% | +26,183 |
| EDWARDS LIFESCIENCES CORP | 1,684,000 | 1,842,900 | +158,900 | 130,965 | 157,107 | 3.22% | +26,143 |
| ESPERION THERAPEUTICS INC NE | 0 | 5,965,498 | +5,965,498 | 0 | 22,072 | 0.45% | +22,072 |
| LEXEO THERAPEUTICS INC(LXEO) | 0 | 2,125,000 | +2,125,000 | 0 | 21,101 | 0.43% | +21,101 |
| INTUITIVE SURGICAL INC | 287,200 | 263,400 | -23,800 | 128,444 | 149,179 | 3.05% | +20,735 |
| EYEPOINT INC(EYPT) | 1,796,000 | 2,468,314 | +672,314 | 25,575 | 45,096 | 0.92% | +19,521 |
| VERA THERAPEUTICS INC(VERA) | 0 | 353,500 | +353,500 | 0 | 17,901 | 0.37% | +17,901 |
| ABIVAX SA(ABVX) | 380,000 | 367,900 | -12,100 | 32,262 | 49,613 | 1.02% | +17,351 |
| DANAHER CORPORATION(DHR) | 263,100 | 299,800 | +36,700 | 52,162 | 68,630 | 1.40% | +16,468 |
| PRELUDE THERAPEUTICS INC(PRLD) | 10,909,256 | 10,909,256 | 0 | 15,709 | 31,637 | 0.65% | +15,928 |
| NATERA INC(NTRA) | 429,300 | 365,800 | -63,500 | 69,104 | 83,801 | 1.71% | +14,697 |
| FORTE BIOSCIENCES INC(FBRX) | 1,196,955 | 1,196,955 | 0 | 17,954 | 32,641 | 0.67% | +14,687 |
| DYNE THERAPEUTICS INC(DYN) | 2,314,184 | 2,202,184 | -112,000 | 29,274 | 43,075 | 0.88% | +13,800 |
| ARS PHARMACEUTICALS INC(SPRY) | 8,288,510 | 8,288,510 | 0 | 83,300 | 96,561 | 1.98% | +13,262 |
| COGENT BIOSCIENCES INC(COGT) | 0 | 371,000 | +371,000 | 0 | 13,178 | 0.27% | +13,178 |
| RELMADA THERAPEUTICS INC(RLMD) | 0 | 2,610,600 | +2,610,600 | 0 | 12,609 | 0.26% | +12,609 |
| MIND MEDICINE MINDMED INC | 367,824 | 1,226,700 | +858,876 | 4,337 | 16,426 | 0.34% | +12,089 |
| TECTONIC THERAPEUTIC INC(TECX) | 0 | 574,600 | +574,600 | 0 | 11,986 | 0.25% | +11,986 |
| KRYSTAL BIOTECH INC(KRYS) | 102,745 | 119,800 | +17,055 | 18,138 | 29,535 | 0.60% | +11,398 |
| BRIGHTSPRING HEALTH SVCS INC(BTSG) | 263,800 | 488,500 | +224,700 | 7,798 | 18,294 | 0.37% | +10,496 |
| NEUROPACE INC(NPCE) | 2,614,184 | 2,406,335 | -207,849 | 26,952 | 37,154 | 0.76% | +10,202 |
| TREVI THERAPEUTICS INC(TRVI) | 3,308,400 | 3,190,700 | -117,700 | 30,272 | 39,948 | 0.82% | +9,676 |
| THE CIGNA GROUP(CI) | 162,800 | 205,000 | +42,200 | 46,927 | 56,422 | 1.15% | +9,495 |
| ADICET BIO INC | 0 | 1,027,944 | +1,027,944 | 0 | 8,655 | 0.18% | +8,655 |
| APELLIS PHARMACEUTICALS INC COM | 2,323,368 | 2,429,868 | +106,500 | 52,578 | 61,038 | 1.25% | +8,460 |
| SHATTUCK LABS INC(STTK) | 6,306,127 | 6,306,127 | 0 | 15,072 | 23,017 | 0.47% | +7,946 |
| KINIKSA PHARMACEUTICALS INTL(KNSA) | 0 | 187,199 | +187,199 | 0 | 7,722 | 0.16% | +7,722 |
| UROGEN PHARMA LTD(URGN) | 689,000 | 875,487 | +186,487 | 13,746 | 20,504 | 0.42% | +6,758 |
| BIOCRYST PHARMACEUTICALS INC(BCRX) | 901,500 | 1,741,800 | +840,300 | 6,842 | 13,586 | 0.28% | +6,744 |
| ROIVANT SCIENCES LTD(ROIV) | 2,714,798 | 2,190,907 | -523,891 | 41,075 | 47,543 | 0.97% | +6,468 |
| KALVISTA PHARMACEUTICALS INC | 0 | 382,400 | +382,400 | 0 | 6,176 | 0.13% | +6,176 |
| BIOAGE LABS INC(BIOA) | 790,901 | 790,901 | 0 | 4,650 | 10,464 | 0.21% | +5,813 |
| PHARVARIS N V COM | 0 | 205,400 | +205,400 | 0 | 5,700 | 0.12% | +5,700 |
| ARRIVENT BIOPHARMA INC(AVBP) | 3,027,328 | 3,027,328 | 0 | 55,854 | 60,910 | 1.25% | +5,056 |
| AVALO THERAPEUTICS INC(AVTX) | 1,349,300 | 1,187,300 | -162,000 | 17,150 | 21,561 | 0.44% | +4,412 |
| PALISADE BIO INC(PALI) | 0 | 1,871,420 | +1,871,420 | 0 | 4,398 | 0.09% | +4,398 |
| CELCUITY INC(CELC) | 84,020 | 85,664 | +1,644 | 4,151 | 8,544 | 0.17% | +4,394 |
| THERMO FISHER SCIENTIFIC INC(TMO) | 46,500 | 46,500 | 0 | 22,553 | 26,944 | 0.55% | +4,391 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 215,152 | 239,800 | +24,648 | 21,728 | 25,668 | 0.53% | +3,940 |
| JADE BIOSCIENCES INC | 531,163 | 531,163 | 0 | 4,584 | 8,196 | 0.17% | +3,612 |
| BICARA THERAPEUTICS INC | 0 | 209,100 | +209,100 | 0 | 3,519 | 0.07% | +3,519 |
| XENON PHARMACEUTICALS INC(XENE) | 419,600 | 447,200 | +27,600 | 16,847 | 20,044 | 0.41% | +3,197 |
| UNITED THERAPEUTICS CORP DEL(UTHR) | 114,900 | 105,200 | -9,700 | 48,167 | 51,259 | 1.05% | +3,091 |
| ALUMIS INC | 1,926,423 | 1,102,730 | -823,693 | 7,686 | 10,763 | 0.22% | +3,076 |
| Q32 BIO INC(FIXX) | 2,252,987 | 2,252,987 | 0 | 4,461 | 7,480 | 0.15% | +3,019 |
| REPARE THERAPEUTICS INC | 3,322,488 | 3,322,488 | 0 | 5,848 | 8,638 | 0.18% | +2,791 |
| INSMED INC(INSM) | 13,459 | 25,400 | +11,941 | 1,938 | 4,421 | 0.09% | +2,482 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 7,165,006 | 7,165,006 | 0 | 52,806 | 55,171 | 1.13% | +2,364 |
| WHITEHAWK THERAPEUTICS INC(WHWK) | 4,166,000 | 4,166,000 | 0 | 7,915 | 10,082 | 0.21% | +2,166 |
| REVOLUTION MEDICINES INC(RVMD) | 0 | 25,900 | +25,900 | 0 | 2,063 | 0.04% | +2,063 |
| OCULAR THERAPEUTIX INC(OCUL) | 0 | 157,300 | +157,300 | 0 | 1,910 | 0.04% | +1,910 |
| PROTAGONIST THERAPEUTICS INC | 0 | 21,700 | +21,700 | 0 | 1,895 | 0.04% | +1,895 |
| PTC THERAPEUTICS INC(PTCT) | 0 | 23,200 | +23,200 | 0 | 1,762 | 0.04% | +1,762 |
| ALTO NEUROSCIENCE INC(ANRO) | 250,000 | 125,000 | -125,000 | 1,005 | 2,225 | 0.05% | +1,220 |
| COGENT BIOSCIENCES INC(COGT) | 0 | 0 | 0 | 0 | 1,174 | 0.02% | +1,174 |
| MAPLIGHT THERAPEUTICS INC(MPLT) | 0 | 56,000 | +56,000 | 0 | 952 | 0.02% | +952 |
| TARSUS PHARMACEUTICALS INC(TARS) | 197,900 | 154,400 | -43,500 | 11,761 | 12,642 | 0.26% | +881 |
| VIR BIOTECHNOLOGY INC(VIR) | 2,380,715 | 2,380,715 | 0 | 13,594 | 14,356 | 0.29% | +762 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 1,099,000 | 999,000 | -100,000 | 45,773 | 46,503 | 0.95% | +730 |
| INSPIREMD INC(NSPR) | 2,133,405 | 3,133,405 | +1,000,000 | 5,142 | 5,577 | 0.11% | +436 |
| KEROS THERAPEUTICS INC(KROS) | 1,018,734 | 804,212 | -214,522 | 16,116 | 16,374 | 0.34% | +257 |
| SINOVAC BIOTECH LTD(SVA) | 2,718,735 | 2,718,735 | 0 | 184,466 | 184,466 | 3.77% | 0 |
| DIH HLDG US INC | 1,915,000 | 0 | -1,915,000 | 358 | 0 | — | -358 |
| TRAWS PHARMA INC(TRAW) | 605,531 | 605,531 | 0 | 1,120 | 684 | 0.01% | -436 |
| IMAGENEBIO INC(IMA) | 378,556 | 378,556 | 0 | 3,085 | 2,612 | 0.05% | -473 |
| PASSAGE BIO INC(PASG) | 59,046 | 0 | -59,046 | 474 | 0 | — | -474 |
| XERIS BIOPHARMA HOLDINGS INC | 80,420 | 0 | -80,420 | 655 | 0 | — | -655 |
| KEZAR LIFE SCIENCES INC COM NEW | 192,700 | 0 | -192,700 | 752 | 0 | — | -752 |
| LYELL IMMUNOPHARMA INC(LYEL) | 51,727 | 0 | -51,727 | 840 | 0 | — | -840 |
| MURAL ONCOLOGY PUB LTD CO | 588,800 | 0 | -588,800 | 1,219 | 0 | — | -1,219 |
| CARLSMED INC(CARL) | 1,252,600 | 1,252,600 | 0 | 16,772 | 15,470 | 0.32% | -1,303 |
| ASCENDIS PHARMA A/S(ASND) | 191,905 | 171,977 | -19,928 | 38,153 | 36,672 | 0.75% | -1,480 |
| KORRO BIO INC(KRRO) | 32,400 | 0 | -32,400 | 1,552 | 0 | — | -1,552 |
| CORBUS PHARMACEUTICALS HLDGS(CRBP) | 1,172,287 | 1,597,287 | +425,000 | 14,829 | 13,002 | 0.27% | -1,828 |
| ATAI LIFE SCIENCES NV | 347,000 | 0 | -347,000 | 1,836 | 0 | — | -1,836 |
| PMV PHARMACEUTICALS INC(PMVP) | 5,975,291 | 4,975,291 | -1,000,000 | 8,365 | 6,219 | 0.13% | -2,146 |
| AMICUS THERAPEUTICS INC COM | 1,645,400 | 729,900 | -915,500 | 12,966 | 10,394 | 0.21% | -2,572 |
| CELCUITY INC(CELC) | 0 | 0 | 0 | 2,684 | 0 | — | -2,684 |
| ADC THERAPEUTICS SA(ADCT) | 5,907,351 | 5,822,854 | -84,497 | 23,629 | 20,555 | 0.42% | -3,075 |
| IMMATICS N.V(IMTX) | 466,601 | 0 | -466,601 | 3,975 | 0 | — | -3,975 |
| ARGENX SE(ARGX) | 172,300 | 146,000 | -26,300 | 127,082 | 122,779 | 2.51% | -4,303 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 353,640 | 314,240 | -39,400 | 49,644 | 44,569 | 0.91% | -5,075 |
| MILESTONE PHARMACEUTICALS IN(MIST) | 3,221,828 | 0 | -3,221,828 | 6,444 | 0 | — | -6,444 |
| BOSTON SCIENTIFIC CORP(BSX) | 2,429,300 | 2,419,300 | -10,000 | 237,173 | 230,680 | 4.72% | -6,492 |
| CG ONCOLOGY INC(CGON) | 1,726,850 | 1,516,550 | -210,300 | 69,558 | 62,967 | 1.29% | -6,590 |
| CARIS LIFE SCIENCES INC(CAI) | 3,034,858 | 3,116,011 | +81,153 | 91,804 | 84,070 | 1.72% | -7,734 |