Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Edgewise Therapeutics, Inc.(EWTX) | 15,518,492 | 15,518,492 | 0 | $251.71M | $385.09M | 7.88% | +$133.38M |
| Eli Lilly and Company(LLY) | 301,200 | 301,200 | 0 | $229.82M | $323.69M | 6.62% | +$93.88M |
| Boston Scientific Corporation(BSX) | 2,429,300 | 2,419,300 | -10,000 | $237.17M | $230.68M | 4.72% | -$6.49M |
| Sinovac Biotech, Ltd.SHS(SVA) | 2,718,735 | 2,718,735 | 0 | $184.47M | $184.47M | 3.77% | $0 |
| Edwards Lifesciences Corp | 1,684,000 | 1,842,900 | +158,900 | $130.96M | $157.11M | 3.22% | +$26.14M |
| Upstream Bio, Inc.(UPB) | 5,693,589 | 5,693,589 | 0 | $107.10M | $154.58M | 3.16% | +$47.48M |
| Intuitive Surgical, Inc.(ISRG) | 287,200 | 263,400 | -23,800 | $128.44M | $149.18M | 3.05% | +$20.73M |
| Sionna Therapeutics, Inc.(SION) | 3,704,959 | 3,561,655 | -143,304 | $108.96M | $146.53M | 3.00% | +$37.56M |
| MBX Biosciences, Inc.(MBX) | 4,002,887 | 3,935,203 | -67,684 | $70.05M | $124.12M | 2.54% | +$54.07M |
| argenx SEADR(ARGX) | 172,300 | 146,000 | -26,300 | $127.08M | $122.78M | 2.51% | -$4.30M |
| Enliven Therapeutics Inc | 7,959,538 | 7,959,538 | 0 | $162.93M | $122.58M | 2.51% | -$40.35M |
| Alnylam Pharmaceuticals, Inc.(ALNY) | 301,600 | 288,800 | -12,800 | $137.53M | $114.84M | 2.35% | -$22.69M |
| Stryker Corporation(SYK) | 359,200 | 325,000 | -34,200 | $132.79M | $114.23M | 2.34% | -$18.56M |
| ARS Pharmaceuticals, Inc.(SPRY) | 8,288,510 | 8,288,510 | 0 | $83.30M | $96.56M | 1.98% | +$13.26M |
| Terns Pharmaceuticals Inc | 7,562,971 | 2,153,300 | -5,409,671 | $56.80M | $86.99M | 1.78% | +$30.20M |
| Disc Medicine, Inc.(IRON) | 1,415,020 | 1,067,550 | -347,470 | $93.50M | $84.77M | 1.73% | -$8.73M |
| Caris Life Sciences, Inc.(CAI) | 3,034,858 | 3,116,011 | +81,153 | $91.80M | $84.07M | 1.72% | -$7.73M |
| Natera, Inc.(NTRA) | 429,300 | 365,800 | -63,500 | $69.10M | $83.80M | 1.71% | +$14.70M |
| Compass Therapeutics, Inc.(CMPX) | 15,219,994 | 15,219,994 | 0 | $53.27M | $81.73M | 1.67% | +$28.46M |
| Structure Therapeutics IncADS | 1,139,300 | 1,161,803 | +22,503 | $31.90M | $80.80M | 1.65% | +$48.90M |
| Danaher Corporation(DHR) | 263,100 | 299,800 | +36,700 | $52.16M | $68.63M | 1.40% | +$16.47M |
| CG Oncology, Inc.(CGON) | 1,726,850 | 1,516,550 | -210,300 | $69.56M | $62.97M | 1.29% | -$6.59M |
| Apellis Pharmaceuticals Inc COM | 2,323,368 | 2,429,868 | +106,500 | $52.58M | $61.04M | 1.25% | +$8.46M |
| ArriVent BioPharma, Inc.(AVBP) | 3,027,328 | 3,027,328 | 0 | $55.85M | $60.91M | 1.25% | +$5.06M |
| The Cigna Group(CI) | 162,800 | 205,000 | +42,200 | $46.93M | $56.42M | 1.15% | +$9.50M |
| Rapt Therapeutics Inc | 1,086,618 | 1,642,891 | +556,273 | $28.02M | $55.64M | 1.14% | +$27.62M |
| Corvus Pharmaceuticals, Inc.(CRVS) | 7,165,006 | 7,165,006 | 0 | $52.81M | $55.17M | 1.13% | +$2.36M |
| United Therapeutics Corporation(UTHR) | 114,900 | 105,200 | -9,700 | $48.17M | $51.26M | 1.05% | +$3.09M |
| ABIVAX Société AnonymeADS(ABVX) | 380,000 | 367,900 | -12,100 | $32.26M | $49.61M | 1.02% | +$17.35M |
| Roivant Sciences Ltd.SHS(ROIV) | 2,714,798 | 2,190,907 | -523,891 | $41.07M | $47.54M | 0.97% | +$6.47M |
| Crinetics Pharmaceuticals In | 1,099,000 | 999,000 | -100,000 | $45.77M | $46.50M | 0.95% | +$730.1K |
| Axsome Therapeutics, Inc.(AXSM) | 531,800 | 253,121 | -278,679 | $64.59M | $46.23M | 0.95% | -$18.36M |
| EyePoint, Inc.(EYPT) | 1,796,000 | 2,468,314 | +672,314 | $25.58M | $45.10M | 0.92% | +$19.52M |
| Avidity Biosciences Inc | 1,638,886 | 619,530 | -1,019,356 | $71.41M | $44.69M | 0.91% | -$26.72M |
| Neurocrine Biosciences, Inc.(NBIX) | 353,640 | 314,240 | -39,400 | $49.64M | $44.57M | 0.91% | -$5.08M |
| Dyne Therapeutics, Inc.(DYN) | 2,314,184 | 2,202,184 | -112,000 | $29.27M | $43.07M | 0.88% | +$13.80M |
| Bristol-Myers Squibb Company(BMY) | 0 | 775,000 | +775,000 | $0 | $41.80M | 0.86% | +$41.80M |
| Pfizer Inc.(PFE) | 0 | 1,652,900 | +1,652,900 | $0 | $41.16M | 0.84% | +$41.16M |
| Trevi Therapeutics, Inc.(TRVI) | 3,308,400 | 3,190,700 | -117,700 | $30.27M | $39.95M | 0.82% | +$9.68M |
| NeuroPace, Inc.(NPCE) | 2,614,184 | 2,406,335 | -207,849 | $26.95M | $37.15M | 0.76% | +$10.20M |
| Ascendis Pharma A/SADR(ASND) | 191,905 | 171,977 | -19,928 | $38.15M | $36.67M | 0.75% | -$1.48M |
| Endeavour Silver Corp.(EXK) | 994,616 | 351,716 | -642,900 | $54.42M | $35.72M | 0.73% | -$18.70M |
| Mineralys Therapeutics, Inc.(MLYS) | 1,469,494 | 980,400 | -489,094 | $55.72M | $35.58M | 0.73% | -$20.14M |
| Elevance Health, Inc.(ELV) | 0 | 99,100 | +99,100 | $0 | $34.74M | 0.71% | +$34.74M |
| Forte Biosciences Inc | 1,196,955 | 1,196,955 | 0 | $17.95M | $32.64M | 0.67% | +$14.69M |
| Prelude Therapeutics Incorporated(PRLD) | 10,909,256 | 10,909,256 | 0 | $15.71M | $31.64M | 0.65% | +$15.93M |
| Cybin D/B/A Helus Pharma(HELP) | 0 | 3,840,500 | +3,840,500 | $0 | $31.42M | 0.64% | +$31.42M |
| ORIC Pharmaceuticals, Inc.(ORIC) | 3,641,756 | 3,641,756 | 0 | $43.70M | $29.79M | 0.61% | -$13.91M |
| Krystal Biotech, Inc.(KRYS) | 102,745 | 119,800 | +17,055 | $18.14M | $29.54M | 0.60% | +$11.40M |
| Praxis Precision Medicines, Inc.(PRAX) | 0 | 94,500 | +94,500 | $0 | $27.85M | 0.57% | +$27.85M |
| Janux Therapeutics, Inc.(JANX) | 1,766,100 | 1,954,426 | +188,326 | $43.16M | $26.97M | 0.55% | -$16.19M |
| Thermo Fisher Scientific Inc.(TMO) | 46,500 | 46,500 | 0 | $22.55M | $26.94M | 0.55% | +$4.39M |
| Bruker Corporation(BRKR) | 0 | 555,789 | +555,789 | $0 | $26.18M | 0.54% | +$26.18M |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 215,152 | 239,800 | +24,648 | $21.73M | $25.67M | 0.53% | +$3.94M |
| Shattuck Labs, Inc.(STTK) | 6,306,127 | 6,306,127 | 0 | $15.07M | $23.02M | 0.47% | +$7.95M |
| Esperion Therapeutics Inc Ne | 0 | 5,965,498 | +5,965,498 | $0 | $22.07M | 0.45% | +$22.07M |
| Avalo Therapeutics, Inc.(AVTX) | 1,349,300 | 1,187,300 | -162,000 | $17.15M | $21.56M | 0.44% | +$4.41M |
| Lexeo Therapeutics, Inc.(LXEO) | 0 | 2,125,000 | +2,125,000 | $0 | $21.10M | 0.43% | +$21.10M |
| ADC Therapeutics SASHS(ADCT) | 5,907,351 | 5,822,854 | -84,497 | $23.63M | $20.55M | 0.42% | -$3.07M |
| UroGen Pharma Ltd.(URGN) | 689,000 | 875,487 | +186,487 | $13.75M | $20.50M | 0.42% | +$6.76M |
| Imagenebio IncNONVOTING | 6,210,899 | 6,210,899 | 0 | $12.50M | $20.13M | 0.41% | +$7.63M |
| Xenon Pharmaceuticals Inc.(XENE) | 419,600 | 447,200 | +27,600 | $16.85M | $20.04M | 0.41% | +$3.20M |
| BrightSpring Health Services, Inc.(BTSG) | 263,800 | 488,500 | +224,700 | $7.80M | $18.29M | 0.37% | +$10.50M |
| Vera Therapeutics, Inc.CL A(VERA) | 0 | 353,500 | +353,500 | $0 | $17.90M | 0.37% | +$17.90M |
| uniQure N.V.SHS(QURE) | 458,500 | 737,400 | +278,900 | $26.76M | $17.65M | 0.36% | -$9.12M |
| Mind Medicine Mindmed Inc | 367,824 | 1,226,700 | +858,876 | $4.34M | $16.43M | 0.34% | +$12.09M |
| Keros Therapeutics, Inc.(KROS) | 1,018,734 | 804,212 | -214,522 | $16.12M | $16.37M | 0.34% | +$257.4K |
| Carlsmed, Inc.(CARL) | 1,252,600 | 1,252,600 | 0 | $16.77M | $15.47M | 0.32% | -$1.30M |
| CytomX Therapeutics, Inc.(CTMX) | 8,461,500 | 3,525,650 | -4,935,850 | $26.99M | $15.02M | 0.31% | -$11.97M |
| Vir Biotechnology, Inc.(VIR) | 2,380,715 | 2,380,715 | 0 | $13.59M | $14.36M | 0.29% | +$761.8K |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 901,500 | 1,741,800 | +840,300 | $6.84M | $13.59M | 0.28% | +$6.74M |
| Cogent Biosciences, Inc.(COGT) | 0 | 371,000 | +371,000 | $0 | $13.18M | 0.27% | +$13.18M |
| Corbus Pharmaceuticals Holdings, Inc.(CRBP) | 1,172,287 | 1,597,287 | +425,000 | $14.83M | $13.00M | 0.27% | -$1.83M |
| Tarsus Pharmaceuticals, Inc.(TARS) | 197,900 | 154,400 | -43,500 | $11.76M | $12.64M | 0.26% | +$881.1K |
| Relmada Therapeutics, Inc.(RLMD) | 0 | 2,610,600 | +2,610,600 | $0 | $12.61M | 0.26% | +$12.61M |
| Tectonic Therapeutic, Inc.(TECX) | 0 | 574,600 | +574,600 | $0 | $11.99M | 0.25% | +$11.99M |
| Alumis Inc | 1,926,423 | 1,102,730 | -823,693 | $7.69M | $10.76M | 0.22% | +$3.08M |
| BioAge Labs, Inc.(BIOA) | 790,901 | 790,901 | 0 | $4.65M | $10.46M | 0.21% | +$5.81M |
| Amicus Therapeutics Inc COM | 1,645,400 | 729,900 | -915,500 | $12.97M | $10.39M | 0.21% | -$2.57M |
| Whitehawk Therapeutics, Inc.(WHWK) | 4,166,000 | 4,166,000 | 0 | $7.92M | $10.08M | 0.21% | +$2.17M |
| Adicet Bio Inc | 0 | 1,027,944 | +1,027,944 | $0 | $8.66M | 0.18% | +$8.66M |
| Repare Therapeutics Inc | 3,322,488 | 3,322,488 | 0 | $5.85M | $8.64M | 0.18% | +$2.79M |
| Celcuity Inc.(CELC) | 84,020 | 85,664 | +1,644 | $4.15M | $8.54M | 0.17% | +$4.39M |
| Jade Biosciences Inc | 531,163 | 531,163 | 0 | $4.58M | $8.20M | 0.17% | +$3.61M |
| Kiniksa Pharmaceuticals International, plcCL A(KNSA) | 0 | 187,199 | +187,199 | $0 | $7.72M | 0.16% | +$7.72M |
| Q32 Bio Inc.(QTTB) | 2,252,987 | 2,252,987 | 0 | $4.46M | $7.48M | 0.15% | +$3.02M |
| PMV Pharmaceuticals, Inc.(PMVP) | 5,975,291 | 4,975,291 | -1,000,000 | $8.37M | $6.22M | 0.13% | -$2.15M |
| Kalvista Pharmaceuticals Inc | 0 | 382,400 | +382,400 | $0 | $6.18M | 0.13% | +$6.18M |
| Pharvaris N V COM | 0 | 205,400 | +205,400 | $0 | $5.70M | 0.12% | +$5.70M |
| InspireMD, Inc.(NSPR) | 2,133,405 | 3,133,405 | +1,000,000 | $5.14M | $5.58M | 0.11% | +$436.0K |
| Insmed Incorporated(INSM) | 13,459 | 25,400 | +11,941 | $1.94M | $4.42M | 0.09% | +$2.48M |
| Palisade Bio, Inc.(PALI) | 0 | 1,871,420 | +1,871,420 | $0 | $4.40M | 0.09% | +$4.40M |
| Bicara Therapeutics Inc | 0 | 209,100 | +209,100 | $0 | $3.52M | 0.07% | +$3.52M |
| Cullinan Therapeutics, Inc.(CGEM) | 1,923,855 | 270,006 | -1,653,849 | $11.41M | $2.79M | 0.06% | -$8.61M |
| C4 Therapeutics, Inc.(CCCC) | 5,235,146 | 1,404,902 | -3,830,244 | $11.62M | $2.68M | 0.05% | -$8.94M |
| ImageneBio, Inc.(IMA) | 378,556 | 378,556 | 0 | $3.09M | $2.61M | 0.05% | -$473.2K |
| Alto Neuroscience, Inc.(ANRO) | 250,000 | 125,000 | -125,000 | $1.00M | $2.23M | 0.05% | +$1.22M |
| Revolution Medicines, Inc.(RVMD) | 0 | 25,900 | +25,900 | $0 | $2.06M | 0.04% | +$2.06M |
| Vistagen Therapeutics, Inc.(VTGN) | 3,060,000 | 3,060,000 | 0 | $10.86M | $2.03M | 0.04% | -$8.84M |
| Ocular Therapeutix, Inc.(OCUL) | 0 | 157,300 | +157,300 | $0 | $1.91M | 0.04% | +$1.91M |