Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q1 2026 ▲▼ | Q2 2026 ▲▼ | Change ▲▼ | Q1 2026 ▲▼ | Q2 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ASCENDIS PHARMA A/S(ASND) | 0 | 1,163,721 | +1,163,721 | 0 | 310,388 | 4.66% | +310,388 |
| KARDIGAN INC | 0 | 8,200,662 | +8,200,662 | 0 | 195,586 | 2.94% | +195,586 |
| SPYRE THERAPEUTICS INC(SYRE) | 3,783,225 | 4,319,496 | +536,271 | 190,826 | 383,485 | 5.76% | +192,659 |
| RELAY THERAPEUTICS INC(RLAY) | 9,751,141 | 14,106,187 | +4,355,046 | 97,024 | 263,927 | 3.96% | +166,903 |
| TRAVERE THERAPEUTICS INC(TVTX) | 0 | 3,752,574 | +3,752,574 | 0 | 213,184 | 3.20% | +213,184 |
| TANGO THERAPEUTICS INC(TNGX) | 808,153 | 3,377,000 | +2,568,847 | 16,907 | 105,565 | 1.58% | +88,658 |
| AVALYN PHARMACEUTICALS INC | 0 | 2,675,296 | +2,675,296 | 0 | 88,071 | 1.32% | +88,071 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 0 | 2,586,295 | +2,586,295 | 0 | 287,156 | 4.31% | +287,156 |
| REVOLUTION MEDICINES INC(RVMD) | 258,600 | 527,600 | +269,000 | 25,149 | 98,809 | 1.48% | +73,660 |
| BIOGEN INC(BIIB) | 0 | 276,173 | +276,173 | 0 | 59,670 | 0.90% | +59,670 |
| ORUKA THERAPEUTICS INC(ORKA) | 1,395,501 | 1,345,063 | -50,438 | 68,449 | 128,010 | 1.92% | +59,560 |
| ROIVANT SCIENCES LTD(ROIV) | 8,285,461 | 8,085,461 | -200,000 | 229,507 | 286,144 | 4.30% | +56,637 |
| MEIRAGTX HLDGS PLC(MGTX) | 10,326,103 | 10,786,658 | +460,555 | 89,313 | 145,728 | 2.19% | +56,415 |
| UNITEDHEALTH GROUP INC(UNH) | 0 | 116,806 | +116,806 | 0 | 48,548 | 0.73% | +48,548 |
| SPDR SERIES TRUST(Put) ST STR SP BIOT | 0 | 300,000 | +300,000 | 0 | 47,475 | — | +47,475 |
| NURIX THERAPEUTICS INC(NRIX) | 3,710,877 | 4,320,422 | +609,545 | 57,519 | 104,813 | 1.57% | +47,295 |
| APOGEE THERAPEUTICS INC(APGE) | 0 | 1,308,113 | +1,308,113 | 0 | 173,626 | 2.61% | +173,626 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 4,423,974 | 4,373,974 | -50,000 | 139,355 | 177,715 | 2.67% | +38,359 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 8,284,882 | 8,334,882 | +50,000 | 115,160 | 149,694 | 2.25% | +34,535 |
| NUVALENT INC | 1,580,505 | 1,580,505 | 0 | 161,923 | 195,192 | 2.93% | +33,270 |
| SOLID BIOSCIENCES INC | 11,906,646 | 11,906,646 | 0 | 85,728 | 118,947 | 1.79% | +33,220 |
| CORCEPT THERAPEUTICS INC(CORT) | 50,000 | 398,385 | +348,385 | 2,016 | 34,640 | 0.52% | +32,624 |
| BIOCRYST PHARMACEUTICALS INC(BCRX) | 7,434,033 | 10,308,888 | +2,874,855 | 70,772 | 103,089 | 1.55% | +32,317 |
| CHARLES RIV LABS INTL INC(CRL) | 0 | 140,000 | +140,000 | 0 | 31,751 | 0.48% | +31,751 |
| EYEPOINT INC(EYPT)(Put) | 0 | 2,000,000 | +2,000,000 | 0 | 28,600 | — | +28,600 |
| INHIBRX BIOSCIENCES INC(INBX) | 0 | 1,297,763 | +1,297,763 | 0 | 122,963 | 1.85% | +122,963 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 2,035,986 | 2,035,986 | 0 | 655,974 | 681,628 | 10.23% | +25,653 |
| SUTRO BIOPHARMA INC | 715,307 | 1,304,846 | +589,539 | 17,818 | 43,321 | 0.65% | +25,503 |
| DANAHER CORP DEL(DHR) | 0 | 130,000 | +130,000 | 0 | 24,762 | 0.37% | +24,762 |
| CAPRICOR THERAPEUTICS INC(Call) | 0 | 1,000,000 | +1,000,000 | 0 | 24,080 | — | +24,080 |
| ADAPTIVE BIOTECHNOLOGIES COR(ADPT) | 152,500 | 1,217,325 | +1,064,825 | 2,117 | 26,112 | 0.39% | +23,995 |
| SELLAS LIFE SCIENCES GROUP I(SLS)(Put) | 0 | 1,500,000 | +1,500,000 | 0 | 22,140 | — | +22,140 |
| ZYMEWORKS INC(ZYME) | 3,510,078 | 4,182,953 | +672,875 | 87,892 | 109,342 | 1.64% | +21,450 |
| ADLAI NORTYE LTD(ANL) | 0 | 1,793,190 | +1,793,190 | 0 | 20,622 | 0.31% | +20,622 |
| MODERNA INC(MRNA)(Put) | 1,000,000 | 1,000,000 | 0 | 50,800 | 70,030 | — | +19,230 |
| NUVECTIS PHARMA INC | 0 | 1,000,000 | +1,000,000 | 0 | 18,390 | 0.28% | +18,390 |
| NEWAMSTERDAM PHARMA COMPANY(Put) ORDINARY SHARES | 0 | 500,000 | +500,000 | 0 | 16,945 | — | +16,945 |
| ANTERIS TECHNOLOGIES GLOBAL(AVR) | 3,425,476 | 3,425,476 | 0 | 19,011 | 33,741 | 0.51% | +14,730 |
| IRHYTHM HOLDINGS INC(IRTC) | 105,026 | 223,766 | +118,740 | 12,395 | 26,617 | 0.40% | +14,222 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 0 | 115,391 | +115,391 | 0 | 13,509 | 0.20% | +13,509 |
| SIONNA THERAPEUTICS INC | 0 | 905,000 | +905,000 | 0 | 39,811 | 0.60% | +39,811 |
| IMMUNOVANT INC(IMVT) | 1,597,383 | 1,357,383 | -240,000 | 39,679 | 52,300 | 0.79% | +12,621 |
| CAPRICOR THERAPEUTICS INC(Put) | 0 | 500,000 | +500,000 | 0 | 12,040 | — | +12,040 |
| EVOLUS INC | 1,286,862 | 2,459,285 | +1,172,423 | 5,289 | 17,067 | 0.26% | +11,778 |
| OSCAR HEALTH INC(OSCR) | 0 | 400,000 | +400,000 | 0 | 11,408 | 0.17% | +11,408 |
| RAPPORT THERAPEUTICS INC(RAPP) | 673,923 | 773,342 | +99,419 | 21,087 | 32,225 | 0.48% | +11,138 |
| SEAPORT THERAPEUTICS INC | 0 | 500,000 | +500,000 | 0 | 10,860 | 0.16% | +10,860 |
| BOSTON SCIENTIFIC CORP(BSX) | 0 | 250,000 | +250,000 | 0 | 10,670 | 0.16% | +10,670 |
| NATERA INC(NTRA) | 0 | 34,689 | +34,689 | 0 | 9,416 | 0.14% | +9,416 |
| X4 PHARMACEUTICALS INC | 6,737,648 | 7,933,491 | +1,195,843 | 27,826 | 37,049 | 0.56% | +9,223 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 170,000 | 170,000 | 0 | 32,139 | 40,965 | 0.61% | +8,826 |
| ENGENE THERAPEUTICS INC | 0 | 4,822,169 | +4,822,169 | 0 | 8,342 | 0.13% | +8,342 |
| RESEARCH ALLIANCE CORP III | 0 | 750,000 | +750,000 | 0 | 8,025 | 0.12% | +8,025 |
| CULLINAN THERAPEUTICS INC(CGEM) | 0 | 426,478 | +426,478 | 0 | 7,766 | 0.12% | +7,766 |
| UNIQURE NV(QURE) | 0 | 168,000 | +168,000 | 0 | 7,738 | 0.12% | +7,738 |
| OMADA HEALTH INC(OMDA) | 0 | 786,330 | +786,330 | 0 | 17,260 | 0.26% | +17,260 |
| IONIS PHARMACEUTICALS INC(IONS) | 504,000 | 566,000 | +62,000 | 37,845 | 44,878 | 0.67% | +7,033 |
| MOBIA MED INC | 0 | 523,654 | +523,654 | 0 | 7,017 | 0.11% | +7,017 |
| DBV TECHNOLOGIES S A(DBVT) | 964,391 | 1,653,350 | +688,959 | 20,146 | 27,115 | 0.41% | +6,969 |
| SURROZEN INC | 229,393 | 503,985 | +274,592 | 6,682 | 13,078 | 0.20% | +6,396 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 2,292,441 | 2,667,441 | +375,000 | 33,538 | 39,852 | 0.60% | +6,313 |
| OUTLOOK THERAPEUTICS INC | 0 | 3,139,216 | +3,139,216 | 0 | 4,991 | 0.07% | +4,991 |
| BETA BIONICS INC | 842,944 | 832,944 | -10,000 | 8,446 | 13,052 | 0.20% | +4,606 |
| CONTINEUM THERAPEUTICS INC | 1,255,592 | 1,255,592 | 0 | 16,398 | 20,579 | 0.31% | +4,181 |
| XERIS BIOPHARMA HOLDINGS INC | 0 | 467,013 | +467,013 | 0 | 3,699 | 0.06% | +3,699 |
| AXSOME THERAPEUTICS INC.(AXSM) | 149,950 | 118,450 | -31,500 | 25,345 | 28,993 | 0.44% | +3,648 |
| BILLIONTOONE INC | 91,812 | 86,812 | -5,000 | 7,248 | 10,416 | 0.16% | +3,168 |
| IMMATICS N.V(IMTX) | 10,383,456 | 10,383,456 | 0 | 102,173 | 105,184 | 1.58% | +3,011 |
| BIODESIX INC | 0 | 108,694 | +108,694 | 0 | 2,451 | 0.04% | +2,451 |
| PALISADE BIO INC | 8,928,149 | 8,425,065 | -503,084 | 15,624 | 17,608 | 0.26% | +1,984 |
| AVALO THERAPEUTICS INC(AVTX) | 139,667 | 219,813 | +80,146 | 2,085 | 4,062 | 0.06% | +1,977 |
| REVOLUTION MEDICINES INC(RVMD) | 250,000 | 250,000 | 0 | 448 | 2,345 | 0.04% | +1,897 |
| EDESA BIOTECH INC(EDSA) | 563,239 | 563,239 | 0 | 2,946 | 4,579 | 0.07% | +1,633 |
| TENAX THERAPEUTICS INC | 1,447,782 | 1,700,000 | +252,218 | 23,150 | 24,735 | 0.37% | +1,585 |
| AGOMAB THERAPEUTICS NV | 600,000 | 600,000 | 0 | 6,294 | 7,788 | 0.12% | +1,494 |
| SAB BIOTHERAPEUTICS INC | 6,431,743 | 6,627,501 | +195,758 | 24,634 | 25,847 | 0.39% | +1,214 |
| KIORA PHARMACEUTICALS INC | 0 | 438,471 | +438,471 | 0 | 1,153 | 0.02% | +1,153 |
| REPLIGEN CORP(RGEN) | 0 | 248,212 | +248,212 | 0 | 33,866 | 0.51% | +33,866 |
| OUTSET MED INC | 833,333 | 833,333 | 0 | 3,200 | 3,600 | 0.05% | +400 |
| ORCHESTRA BIOMED HLDGS INC | 5,037,906 | 5,037,906 | 0 | 21,411 | 21,739 | 0.33% | +327 |
| EXAGEN INC | 114,893 | 114,893 | 0 | 345 | 534 | 0.01% | +190 |
| DAMORA THERAPEUTICS INC(DMRA) | 1,223,000 | 1,223,000 | 0 | 31,676 | 31,810 | 0.48% | +135 |
| COGENT BIOSCIENCES INC(COGT) | 121,082 | 121,082 | 0 | 4,660 | 4,686 | 0.07% | +25 |
| SURROZEN INC | 166,666 | 166,666 | 0 | 3 | 3 | 0.00% | 0 |
| CUMBERLAND PHARMACEUTICALS I | 196,978 | 96,982 | -99,996 | 640 | 628 | 0.01% | -12 |
| ENSYSCE BIOSCIENCES INC | 86,666 | 86,666 | 0 | 47 | 25 | 0.00% | -22 |
| CRESCENT BIOPHARMA INC. | 206,942 | 206,942 | 0 | 3,802 | 3,725 | 0.06% | -77 |
| MEDLINE INC(MDLN) | 28,000 | 28,000 | 0 | 1,246 | 1,104 | 0.02% | -142 |
| CONNECT BIOPHARMA HLDGS LTD | 792,696 | 792,696 | 0 | 2,077 | 1,887 | 0.03% | -190 |
| PALATIN TECHNOLOGIES INC | 61,945 | 0 | -61,945 | 1,079 | 0 | — | -1,079 |
| CELCUITY INC(CELC) | 0 | 0 | 0 | 15,876 | 14,629 | 0.22% | -1,246 |
| OCULIS HOLDING AG | 493,827 | 808,827 | +315,000 | 13,131 | 11,218 | 0.17% | -1,912 |
| LEONABIO INC | 1,859,322 | 1,859,322 | 0 | 19,114 | 17,087 | 0.26% | -2,027 |
| ALTO NEUROSCIENCE INC(ANRO) | 2,009,893 | 1,609,893 | -400,000 | 45,182 | 42,485 | 0.64% | -2,697 |
| APELLIS PHARMACEUTICALS INC COM | 80,956 | 0 | -80,956 | 3,257 | 0 | — | -3,257 |
| ADMA BIOLOGICS INC | 467,233 | 113,765 | -353,468 | 4,210 | 952 | 0.01% | -3,258 |
| TWIST BIOSCIENCE CORP(TWST) | 150,000 | 36,812 | -113,188 | 7,128 | 3,787 | 0.06% | -3,341 |
| INHIBIKASE THERAPEUTICS INC | 2,315,000 | 0 | -2,315,000 | 3,889 | 0 | — | -3,889 |
| OCULAR THERAPEUTIX INC(OCUL)(Call) | 500,000 | 0 | -500,000 | 4,235 | 0 | — | -4,235 |
| PHATHOM PHARMACEUTICALS INC | 925,000 | 532,000 | -393,000 | 10,277 | 5,772 | 0.09% | -4,505 |