Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2023 ▲▼ | Q1 2024 ▲▼ | Change ▲▼ | Q4 2023 ▲▼ | Q1 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| IOVANCE BIOTHERAPEUTICS INC(IOVA) | 11,979,415 | 19,272,991 | +7,293,576 | 97,393 | 285,626 | 5.03% | +188,233 |
| FUSION PHARMACEUTICALS INC | 2,751,395 | 6,825,395 | +4,074,000 | 26,441 | 145,517 | 2.56% | +119,077 |
| APOGEE THERAPEUTICS INC(APGE) | 1,827,901 | 2,060,395 | +232,494 | 51,072 | 136,913 | 2.41% | +85,842 |
| VIKING THERAPEUTICS INC(VKTX) | 0 | 994,098 | +994,098 | 0 | 81,516 | 1.44% | +81,516 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 151,151 | 429,953 | +278,802 | 34,973 | 114,815 | 2.02% | +79,841 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 270,794 | 804,409 | +533,615 | 35,680 | 110,944 | 1.96% | +75,264 |
| SOLID BIOSCIENCES INC | 3,495,933 | 6,906,646 | +3,410,713 | 21,465 | 91,997 | 1.62% | +70,531 |
| INTRA-CELLULAR THERAPIES INC | 108,000 | 1,055,355 | +947,355 | 7,735 | 73,031 | 1.29% | +65,296 |
| VAXCYTE INC(PCVX) | 1,088,486 | 1,932,759 | +844,273 | 68,357 | 132,027 | 2.33% | +63,670 |
| ASTRIA THERAPEUTICS INC | 4,004,070 | 6,485,420 | +2,481,350 | 30,751 | 91,250 | 1.61% | +60,499 |
| CG ONCOLOGY INC(CGON) | 0 | 1,304,105 | +1,304,105 | 0 | 57,250 | 1.01% | +57,250 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 0 | 821,589 | +821,589 | 0 | 50,133 | 0.88% | +50,133 |
| MEDTRONIC PLC(MDT) | 976,652 | 1,429,563 | +452,911 | 80,457 | 124,586 | 2.20% | +44,130 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 2,154,110 | 3,268,579 | +1,114,469 | 99,024 | 141,628 | 2.50% | +42,603 |
| SPYRE THERAPEUTICS INC(SYRE) | 2,606,679 | 2,556,679 | -50,000 | 56,096 | 96,975 | 1.71% | +40,879 |
| APPLIED THERAPEUTICS INC | 4,080,249 | 8,005,000 | +3,924,751 | 13,669 | 54,434 | 0.96% | +40,765 |
| SPRINGWORKS THERAPEUTICS INC | 1,957,246 | 2,262,462 | +305,216 | 71,439 | 111,358 | 1.96% | +39,919 |
| ARTIVION INC(AORT) | 931,352 | 2,668,978 | +1,737,626 | 16,653 | 56,476 | 1.00% | +39,823 |
| EVOLUS INC(EOLS) | 3,963,424 | 5,753,798 | +1,790,374 | 41,735 | 80,553 | 1.42% | +38,818 |
| ARVINAS INC(ARVN) | 354,082 | 1,236,603 | +882,521 | 14,574 | 51,047 | 0.90% | +36,473 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 555,555 | 2,319,646 | +1,764,091 | 6,078 | 42,310 | 0.75% | +36,233 |
| CENTESSA PHARMACEUTICALS PLC | 0 | 3,083,307 | +3,083,307 | 0 | 34,841 | 0.61% | +34,841 |
| OCULAR THERAPEUTIX INC(OCUL) | 0 | 3,324,468 | +3,324,468 | 0 | 30,253 | 0.53% | +30,253 |
| CELCUITY INC(CELC) | 1,481,300 | 2,362,279 | +880,979 | 21,583 | 51,025 | 0.90% | +29,443 |
| IRHYTHM TECHNOLOGIES INC(IRTC) | 0 | 245,205 | +245,205 | 0 | 28,444 | 0.50% | +28,444 |
| LANDOS BIOPHARMA INC | 1,486,991 | 1,486,991 | 0 | 5,442 | 31,941 | 0.56% | +26,498 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 1,730,212 | 3,657,099 | +1,926,887 | 37,684 | 64,036 | 1.13% | +26,352 |
| SAREPTA THERAPEUTICS INC(SRPT) | 451,873 | 525,683 | +73,810 | 43,574 | 68,055 | 1.20% | +24,481 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 1,255,512 | 1,476,203 | +220,691 | 44,671 | 69,101 | 1.22% | +24,430 |
| INTUITIVE SURGICAL INC | 55,000 | 101,800 | +46,800 | 18,555 | 40,627 | 0.72% | +22,073 |
| ARCELLX INC COMMON STOCK | 4,544,809 | 3,933,556 | -611,253 | 252,237 | 273,579 | 4.82% | +21,342 |
| TARSUS PHARMACEUTICALS INC(TARS) | 1,296,416 | 1,296,416 | 0 | 26,252 | 47,125 | 0.83% | +20,872 |
| PEPGEN INC(PEPG) | 0 | 1,410,438 | +1,410,438 | 0 | 20,733 | 0.37% | +20,733 |
| BIOHAVEN LTD(BHVN) | 1,725,047 | 1,725,047 | 0 | 73,832 | 94,343 | 1.66% | +20,511 |
| PROTAGONIST THERAPEUTICS INC | 383,260 | 994,323 | +611,063 | 8,788 | 28,766 | 0.51% | +19,978 |
| ENGENE HOLDINGS INC COM | 0 | 998,888 | +998,888 | 0 | 16,931 | 0.30% | +16,931 |
| LIVANOVA PLC(LIVN) | 0 | 299,000 | +299,000 | 0 | 16,726 | 0.29% | +16,726 |
| NATERA INC(NTRA) | 850,225 | 757,225 | -93,000 | 53,258 | 69,256 | 1.22% | +15,998 |
| AUTOLUS THERAPEUTICS PLC(AUTL) | 1,831,167 | 4,330,745 | +2,499,578 | 11,793 | 27,630 | 0.49% | +15,837 |
| TREACE MED CONCEPTS INC(TMCI) | 1,250,405 | 2,304,954 | +1,054,549 | 15,943 | 30,080 | 0.53% | +14,137 |
| ADMA BIOLOGICS INC | 6,433,369 | 6,433,369 | 0 | 29,079 | 42,460 | 0.75% | +13,381 |
| LYRA THERAPEUTICS INC | 12,757,562 | 12,757,562 | 0 | 66,850 | 79,352 | 1.40% | +12,502 |
| AKERO THERAPEUTICS INC | 967,775 | 1,387,471 | +419,696 | 22,598 | 35,048 | 0.62% | +12,450 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 82,398 | 339,012 | +256,614 | 4,976 | 17,029 | 0.30% | +12,053 |
| IMMATICS N.V(IMTX) | 3,491,500 | 4,582,409 | +1,090,909 | 36,765 | 48,161 | 0.85% | +11,396 |
| PROCEPT BIOROBOTICS CORP(PRCT) | 0 | 210,659 | +210,659 | 0 | 10,411 | 0.18% | +10,411 |
| ARS PHARMACEUTICALS INC(SPRY) | 0 | 867,319 | +867,319 | 0 | 8,864 | 0.16% | +8,864 |
| MORPHIC HLDG INC | 56,980 | 288,221 | +231,241 | 1,646 | 10,145 | 0.18% | +8,500 |
| SOLENO THERAPEUTICS INC | 3,074,542 | 3,074,542 | 0 | 123,750 | 131,590 | 2.32% | +7,840 |
| ARCUTIS BIOTHERAPEUTICS INC(ARQT) | 0 | 750,000 | +750,000 | 0 | 7,433 | 0.13% | +7,433 |
| ARRIVENT BIOPHARMA INC(AVBP) | 0 | 415,000 | +415,000 | 0 | 7,412 | 0.13% | +7,412 |
| AXOGEN INC(AXGN) | 808,380 | 1,553,929 | +745,549 | 5,521 | 12,540 | 0.22% | +7,019 |
| ACRIVON THERAPEUTICS INC | 3,007,858 | 3,007,858 | 0 | 14,799 | 21,506 | 0.38% | +6,708 |
| PRECISION BIOSCIENCES INC(DTIL) | 0 | 480,483 | +480,483 | 0 | 6,515 | 0.11% | +6,515 |
| TYRA BIOSCIENCES INC(TYRA) | 360,000 | 669,159 | +309,159 | 4,986 | 10,974 | 0.19% | +5,988 |
| KALVISTA PHARMACEUTICALS INC | 0 | 500,000 | +500,000 | 0 | 5,930 | 0.10% | +5,930 |
| IMMUNITYBIO INC(IBRX) | 0 | 1,052,887 | +1,052,887 | 0 | 5,654 | 0.10% | +5,654 |
| AXSOME THERAPEUTICS INC(AXSM) | 1,038,019 | 1,105,341 | +67,322 | 82,616 | 88,206 | 1.55% | +5,590 |
| HELIX ACQUISITION CORP II | 0 | 500,000 | +500,000 | 0 | 5,200 | 0.09% | +5,200 |
| TACTILE SYS TECHNOLOGY INC(TCMD) | 707,159 | 903,085 | +195,926 | 10,112 | 14,675 | 0.26% | +4,563 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 0 | 175,000 | +175,000 | 0 | 4,139 | 0.07% | +4,139 |
| ABSCI CORPORATION | 0 | 700,000 | +700,000 | 0 | 3,976 | 0.07% | +3,976 |
| KYVERNA THERAPEUTICS INC(KYTX) | 0 | 150,000 | +150,000 | 0 | 3,726 | 0.07% | +3,726 |
| TRINITY BIOTECH PLC(TRIB) | 0 | 1,800,000 | +1,800,000 | 0 | 3,672 | 0.06% | +3,672 |
| REVANCE THERAPEUTICS INC | 0 | 600,000 | +600,000 | 0 | 2,952 | 0.05% | +2,952 |
| ESTABLISHMENT LABS HLDGS INC(ESTA) | 82,299 | 82,299 | 0 | 2,131 | 4,189 | 0.07% | +2,058 |
| X4 PHARMACEUTICALS INC(XFOR) | 3,545,454 | 3,545,454 | 0 | 2,973 | 4,928 | 0.09% | +1,955 |
| ATHIRA PHARMA INC | 5,402,964 | 5,402,964 | 0 | 13,129 | 14,804 | 0.26% | +1,675 |
| KURA ONCOLOGY INC(KURA) | 0 | 48,200 | +48,200 | 0 | 1,028 | 0.02% | +1,028 |
| SYROS PHARMACEUTICALS INC | 0 | 116,754 | +116,754 | 0 | 625 | 0.01% | +625 |
| CAREMAX INC | 0 | 122,643 | +122,643 | 0 | 591 | 0.01% | +591 |
| ENVVENO MEDICAL CORPORATION(NVNO) | 623,315 | 623,315 | 0 | 3,204 | 3,391 | 0.06% | +187 |
| ZYMEWORKS INC(ZYME) | 1,074,807 | 1,074,807 | 0 | 11,167 | 11,307 | 0.20% | +140 |
| SINGULAR GENOMICS SYSTEMS IN | 2,126,893 | 2,126,893 | 0 | 979 | 1,094 | 0.02% | +115 |
| SURROZEN INC(SRZN) | 166,666 | 166,666 | 0 | 3 | 5 | 0.00% | +2 |
| CAREMAX INC | 60,000 | 60,000 | 0 | 0 | 1 | 0.00% | +1 |
| REVOLUTION MEDICINES INC(RVMD) | 250,000 | 250,000 | 0 | 83 | 46 | 0.00% | -37 |
| VBI VACCINES INC CDA | 1,381,355 | 1,261,710 | -119,645 | 815 | 757 | 0.01% | -58 |
| VERU INC(VERU) | 5,584,699 | 5,584,699 | 0 | 4,021 | 3,910 | 0.07% | -111 |
| BIOATLA INC(BCAB) | 73,000 | 0 | -73,000 | 180 | 0 | — | -180 |
| LEAP THERAPEUTICS INC(CYPH) | 44,971 | 0 | -44,971 | 186 | 0 | — | -186 |
| MACROGENICS INC(MGNX) | 611,932 | 378,327 | -233,605 | 5,887 | 5,569 | 0.10% | -318 |
| FORTE BIOSCIENCES INC | 3,265,359 | 3,265,359 | 0 | 2,683 | 2,273 | 0.04% | -410 |
| NANOBIOTIX(NBTX) | 555,066 | 555,066 | 0 | 4,041 | 3,608 | 0.06% | -433 |
| DISC MEDICINE INC(IRON) | 1,023,045 | 939,866 | -83,179 | 59,091 | 58,516 | 1.03% | -575 |
| NAUTILUS BIOTECHNOLOGY INC(NAUT) | 12,594,211 | 12,594,211 | 0 | 37,657 | 37,027 | 0.65% | -630 |
| COGENT BIOSCIENCES INC(COGT) | 1,122,958 | 883,333 | -239,625 | 6,603 | 5,936 | 0.10% | -667 |
| AMBRX BIOPHARMA INC | 78,811 | 0 | -78,811 | 1,122 | 0 | — | -1,122 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 589,646 | 589,646 | 0 | 13,627 | 12,188 | 0.21% | -1,439 |
| CAREMAX INC | 3,679,284 | 0 | -3,679,284 | 1,832 | 0 | — | -1,832 |
| ALDEYRA THERAPEUTICS INC(ALDX) | 8,593,586 | 8,593,586 | 0 | 30,163 | 28,101 | 0.50% | -2,062 |
| KRONOS BIO INC | 1,752,745 | 0 | -1,752,745 | 2,191 | 0 | — | -2,191 |
| IMMUNOVANT INC(IMVT) | 2,328,082 | 2,963,212 | +635,130 | 98,082 | 95,741 | 1.69% | -2,341 |
| CYTOKINETICS INC(CYTK) | 30,317 | 0 | -30,317 | 2,531 | 0 | — | -2,531 |
| CARGO THERAPEUTICS INC | 3,436,600 | 3,448,004 | +11,404 | 79,557 | 76,959 | 1.36% | -2,598 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 1,707,398 | 1,801,068 | +93,670 | 51,171 | 48,521 | 0.86% | -2,650 |
| ACADIA PHARMACEUTICALS INC | 101,000 | 0 | -101,000 | 3,162 | 0 | — | -3,162 |
| REVOLUTION MEDICINES INC(RVMD) | 818,882 | 618,885 | -199,997 | 23,486 | 19,947 | 0.35% | -3,539 |
| TRAVERE THERAPEUTICS INC(TVTX) | 400,000 | 0 | -400,000 | 3,596 | 0 | — | -3,596 |
| NUVALENT INC | 2,917,991 | 2,783,454 | -134,537 | 214,735 | 209,010 | 3.68% | -5,725 |