Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2024 ▲▼ | Q1 2025 ▲▼ | Change ▲▼ | Q4 2024 ▲▼ | Q1 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| VERONA PHARMA PLC | 6,392,106 | 6,563,340 | +171,234 | 296,849 | 416,706 | 14.78% | +119,857 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 2,685,537 | 6,547,328 | +3,861,791 | 71,704 | 144,041 | 5.11% | +72,337 |
| SOLENO THERAPEUTICS INC | 1,501,040 | 1,506,602 | +5,562 | 67,472 | 107,647 | 3.82% | +40,175 |
| INSMED INC(INSM) | 144,000 | 509,300 | +365,300 | 9,942 | 38,854 | 1.38% | +28,913 |
| BETA BIONICS INC(BBNX) | 0 | 1,593,608 | +1,593,608 | 0 | 19,506 | 0.69% | +19,506 |
| REPLIGEN CORP(RGEN) | 0 | 129,801 | +129,801 | 0 | 16,516 | 0.59% | +16,516 |
| MERUS N V | 300,000 | 690,485 | +390,485 | 12,615 | 29,063 | 1.03% | +16,448 |
| SOLID BIOSCIENCES INC | 6,906,646 | 11,906,646 | +5,000,000 | 27,627 | 44,055 | 1.56% | +16,428 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 0 | 46,500 | +46,500 | 0 | 15,402 | 0.55% | +15,402 |
| BOSTON SCIENTIFIC CORP(BSX) | 0 | 130,000 | +130,000 | 0 | 13,114 | 0.47% | +13,114 |
| SIONNA THERAPEUTICS INC(SION) | 0 | 1,251,101 | +1,251,101 | 0 | 13,087 | 0.46% | +13,087 |
| DEXCOM INC(DXCM) | 0 | 178,000 | +178,000 | 0 | 12,156 | 0.43% | +12,156 |
| ADMA BIOLOGICS INC | 890,280 | 1,373,233 | +482,953 | 15,268 | 27,245 | 0.97% | +11,977 |
| DYNE THERAPEUTICS INC(DYN) | 543,277 | 2,313,403 | +1,770,126 | 12,800 | 24,198 | 0.86% | +11,399 |
| AQUESTIVE THERAPEUTICS INC | 0 | 3,727,208 | +3,727,208 | 0 | 10,809 | 0.38% | +10,809 |
| OUTSET MED INC(OM) | 0 | 833,333 | +833,333 | 0 | 9,217 | 0.33% | +9,217 |
| MEIRAGTX HLDGS PLC(MGTX) | 12,581,103 | 12,581,103 | 0 | 76,584 | 85,255 | 3.02% | +8,671 |
| DISC MEDICINE INC(IRON) | 0 | 150,000 | +150,000 | 0 | 7,446 | 0.26% | +7,446 |
| ALDEYRA THERAPEUTICS INC(ALDX) | 9,275,851 | 9,275,851 | 0 | 46,286 | 53,336 | 1.89% | +7,050 |
| ADAPTIVE BIOTECHNOLOGIES COR(ADPT) | 0 | 930,972 | +930,972 | 0 | 6,917 | 0.25% | +6,917 |
| DELCATH SYS INC(DCTH) | 50,000 | 462,422 | +412,422 | 602 | 5,887 | 0.21% | +5,285 |
| KESTRA MED TECHNOLOGIES LTD SHS | 0 | 200,000 | +200,000 | 0 | 4,984 | 0.18% | +4,984 |
| OPUS GENETICS INC(IRD) | 0 | 4,325,000 | +4,325,000 | 0 | 4,246 | 0.15% | +4,246 |
| AVALO THERAPEUTICS INC(AVTX) | 0 | 520,000 | +520,000 | 0 | 4,165 | 0.15% | +4,165 |
| PROTAGONIST THERAPEUTICS INC | 1,271,662 | 1,091,271 | -180,391 | 49,086 | 52,774 | 1.87% | +3,688 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 6,774,348 | 7,874,348 | +1,100,000 | 25,607 | 27,875 | 0.99% | +2,268 |
| KALA BIO INC(KALA) | 0 | 277,610 | +277,610 | 0 | 1,591 | 0.06% | +1,591 |
| BRIGHT MINDS BIOSCIENCES INC(DRUG) | 403,649 | 444,649 | +41,000 | 14,539 | 16,038 | 0.57% | +1,499 |
| ORCHESTRA BIOMED HLDGS INC(OBIO) | 4,592,556 | 4,592,556 | 0 | 18,370 | 19,656 | 0.70% | +1,286 |
| CULLINAN THERAPEUTICS INC(CGEM) | 0 | 80,100 | +80,100 | 0 | 606 | 0.02% | +606 |
| SURROZEN INC(SRZN) | 166,666 | 166,666 | 0 | 4 | 5 | 0.00% | +1 |
| APYX MEDICAL CORPORATION(APYX) | 150,000 | 150,000 | 0 | 237 | 206 | 0.01% | -31 |
| REVOLUTION MEDICINES INC(RVMD) | 250,000 | 250,000 | 0 | 45 | 10 | 0.00% | -35 |
| PYXIS ONCOLOGY INC(PYXS) | 188,462 | 0 | -188,462 | 294 | 0 | — | -294 |
| APPLIED THERAPEUTICS INC | 860,000 | 860,000 | 0 | 736 | 420 | 0.01% | -316 |
| NANOBIOTIX(NBTX) | 266,093 | 105,053 | -161,040 | 764 | 376 | 0.01% | -388 |
| LEXEO THERAPEUTICS INC(LXEO) | 139,835 | 139,835 | 0 | 920 | 485 | 0.02% | -435 |
| SCPHARMACEUTICALS INC | 500,000 | 500,000 | 0 | 1,770 | 1,315 | 0.05% | -455 |
| ENSYSCE BIOSCIENCES INC(ENSC) | 86,666 | 86,666 | 0 | 705 | 222 | 0.01% | -484 |
| TRAWS PHARMA INC(TRAW) | 164,157 | 421,781 | +257,624 | 1,458 | 970 | 0.03% | -488 |
| HELIX ACQUISITION CORP II | 500,000 | 398,000 | -102,000 | 5,250 | 4,497 | 0.16% | -753 |
| AKERO THERAPEUTICS INC | 1,185,592 | 792,960 | -392,632 | 32,983 | 32,099 | 1.14% | -884 |
| LYRA THERAPEUTICS INC | 12,757,562 | 12,757,562 | 0 | 2,628 | 1,607 | 0.06% | -1,021 |
| FULCRUM THERAPEUTICS INC(FULC) | 238,000 | 0 | -238,000 | 1,119 | 0 | — | -1,119 |
| INHIBRX BIOSCIENCES INC(INBX) | 1,064,026 | 1,064,026 | 0 | 16,386 | 14,886 | 0.53% | -1,500 |
| TRINITY BIOTECH PLC(TRIB) | 1,790,000 | 0 | -1,790,000 | 1,575 | 0 | — | -1,575 |
| ATHIRA PHARMA INC | 5,402,964 | 5,402,964 | 0 | 3,170 | 1,539 | 0.05% | -1,631 |
| MEREO BIOPHARMA GROUP PLC(MREO) | 1,085,512 | 876,961 | -208,551 | 3,799 | 1,973 | 0.07% | -1,826 |
| XENON PHARMACEUTICALS INC(XENE) | 325,324 | 325,324 | 0 | 12,753 | 10,915 | 0.39% | -1,838 |
| BIODESIX INC(BDSX) | 2,173,880 | 2,173,880 | 0 | 3,326 | 1,359 | 0.05% | -1,967 |
| FORTE BIOSCIENCES INC(FBRX) | 95,742 | 0 | -95,742 | 2,174 | 0 | — | -2,174 |
| VERRICA PHARMACEUTICALS INC(VRCA) | 3,249,669 | 0 | -3,249,669 | 2,275 | 0 | — | -2,275 |
| ADAGIO MED HLDGS INC(ADGM) | 9,812,419 | 9,812,419 | 0 | 10,303 | 7,899 | 0.28% | -2,404 |
| OCULAR THERAPEUTIX INC(OCUL) | 1,078,495 | 915,775 | -162,720 | 9,210 | 6,713 | 0.24% | -2,498 |
| NEUROCRINE BIOSCIENCES(NBIX) | 100,050 | 100,050 | 0 | 13,657 | 11,066 | 0.39% | -2,591 |
| NURIX THERAPEUTICS INC(NRIX) | 330,614 | 297,553 | -33,061 | 6,229 | 3,535 | 0.13% | -2,694 |
| BICYCLE THERAPEUTICS PLC | 197,108 | 0 | -197,108 | 2,760 | 0 | — | -2,760 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 1,537,274 | 1,537,274 | 0 | 11,453 | 8,332 | 0.30% | -3,121 |
| IMMUNITYBIO INC(IBRX) | 1,221,734 | 0 | -1,221,734 | 3,128 | 0 | — | -3,128 |
| PEPGEN INC(PEPG) | 829,536 | 0 | -829,536 | 3,144 | 0 | — | -3,144 |
| LINEAGE CELL THERAPEUTICS IN(LCTX) | 7,236,843 | 0 | -7,236,843 | 3,637 | 0 | — | -3,637 |
| PERSPECTIVE THERAPEUTICS INC(CATX) | 1,190,263 | 0 | -1,190,263 | 3,797 | 0 | — | -3,797 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 378,584 | 140,726 | -237,858 | 4,759 | 939 | 0.03% | -3,820 |
| INTRA-CELLULAR THERAPIES INC | 1,288,328 | 786,358 | -501,970 | 107,601 | 103,736 | 3.68% | -3,865 |
| RAPT THERAPEUTICS INC | 5,880,000 | 4,418,947 | -1,461,053 | 9,290 | 5,391 | 0.19% | -3,899 |
| ANTERIS TECHNOLOGIES GLOBAL(AVR) | 2,140,000 | 2,140,000 | 0 | 11,941 | 7,790 | 0.28% | -4,152 |
| VERU INC(VERU) | 6,483,157 | 0 | -6,483,157 | 4,217 | 0 | — | -4,217 |
| ONKURE THERAPEUTICS INC(OKUR) | 1,004,439 | 1,004,439 | 0 | 8,638 | 4,319 | 0.15% | -4,319 |
| IMMUNOVANT INC(IMVT) | 2,139,199 | 2,844,072 | +704,873 | 52,988 | 48,605 | 1.72% | -4,383 |
| CERIBELL INC(CBLL) | 180,546 | 0 | -180,546 | 4,673 | 0 | — | -4,673 |
| APOGEE THERAPEUTICS INC(APGE) | 1,047,232 | 1,122,767 | +75,535 | 47,440 | 41,947 | 1.49% | -5,493 |
| RAPPORT THERAPEUTICS INC(RAPP) | 311,551 | 0 | -311,551 | 5,527 | 0 | — | -5,527 |
| IRHYTHM TECHNOLOGIES INC(IRTC) | 65,153 | 0 | -65,153 | 5,875 | 0 | — | -5,875 |
| ZENAS BIOPHARMA INC(ZBIO) | 744,035 | 0 | -744,035 | 6,094 | 0 | — | -6,094 |
| ARGENX SE(ARGX) | 67,471 | 59,510 | -7,961 | 41,495 | 35,222 | 1.25% | -6,273 |
| INHIBIKASE THERAPEUTICS INC(IKT) | 5,925,000 | 5,925,000 | 0 | 19,256 | 12,976 | 0.46% | -6,280 |
| CELCUITY INC(CELC) | 2,362,279 | 2,362,279 | 0 | 30,922 | 23,883 | 0.85% | -7,040 |
| EVOLUS INC(EOLS) | 5,145,846 | 4,129,142 | -1,016,704 | 56,810 | 49,674 | 1.76% | -7,137 |
| ZYMEWORKS INC(ZYME) | 2,130,020 | 1,864,672 | -265,348 | 31,183 | 22,208 | 0.79% | -8,975 |
| INARI MED INC | 178,797 | 0 | -178,797 | 9,128 | 0 | — | -9,128 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 184,525 | 0 | -184,525 | 9,435 | 0 | — | -9,435 |
| NAUTILUS BIOTECHNOLOGY INC(NAUT) | 12,594,211 | 12,594,211 | 0 | 21,158 | 10,844 | 0.38% | -10,315 |
| TARSUS PHARMACEUTICALS INC(TARS) | 186,662 | 0 | -186,662 | 10,335 | 0 | — | -10,335 |
| EDWARDS LIFESCIENCES CORP | 145,000 | 0 | -145,000 | 10,734 | 0 | — | -10,734 |
| CONTINEUM THERAPEUTICS INC(CTNM) | 1,441,249 | 1,441,249 | 0 | 21,114 | 10,060 | 0.36% | -11,054 |
| ARTIVION INC(AORT) | 2,793,703 | 2,793,703 | 0 | 79,872 | 68,669 | 2.44% | -11,203 |
| CG ONCOLOGY INC(CGON) | 419,450 | 0 | -419,450 | 12,030 | 0 | — | -12,030 |
| INTUITIVE SURGICAL INC | 63,119 | 40,619 | -22,500 | 32,946 | 20,117 | 0.71% | -12,828 |
| ARVINAS INC(ARVN) | 740,749 | 0 | -740,749 | 14,200 | 0 | — | -14,200 |
| AXSOME THERAPEUTICS INC(AXSM) | 664,074 | 355,107 | -308,967 | 56,187 | 41,416 | 1.47% | -14,771 |
| ORUKA THERAPEUTICS INC(ORKA) | 845,567 | 0 | -845,567 | 16,396 | 0 | — | -16,396 |
| SEPTERNA INC(SEPN) | 750,000 | 0 | -750,000 | 17,175 | 0 | — | -17,175 |
| PENUMBRA INC(PEN) | 73,338 | 0 | -73,338 | 17,416 | 0 | — | -17,416 |
| JANUX THERAPEUTICS INC(JANX) | 817,895 | 970,412 | +152,517 | 43,790 | 26,201 | 0.93% | -17,589 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 1,486,508 | 659,662 | -826,846 | 28,496 | 8,892 | 0.32% | -19,604 |
| NATERA INC(NTRA) | 125,000 | 0 | -125,000 | 19,788 | 0 | — | -19,787 |
| ACRIVON THERAPEUTICS INC | 5,360,858 | 5,360,858 | 0 | 32,272 | 10,883 | 0.39% | -21,390 |
| SPYRE THERAPEUTICS INC(SYRE) | 2,574,723 | 2,313,272 | -261,451 | 59,940 | 37,325 | 1.32% | -22,615 |
| ASTRIA THERAPEUTICS INC | 6,485,420 | 6,485,420 | 0 | 57,980 | 34,632 | 1.23% | -23,348 |
| PROCEPT BIOROBOTICS CORP(PRCT) | 290,659 | 0 | -290,659 | 23,404 | 0 | — | -23,404 |