PERCEPTIVE ADVISORS LLC
Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| CENTESSA PHARMACEUTICALS PLC | 2,917,634 | 5,258,903 | +2,341,269 | 72,970,026 | 208,883,627 | 4.13% | +135,913,601 |
| ASCENDIS PHARMA A/S(ASND) | 1,081,421 | 1,531,421 | +450,000 | 230,602,214 | 350,281,925 | 6.92% | +119,679,711 |
| SPYRE THERAPEUTICS INC(SYRE) | 3,069,225 | 3,783,225 | +714,000 | 100,547,811 | 190,825,869 | 3.77% | +90,278,058 |
| RELAY THERAPEUTICS INC(RLAY) | 1,903,245 | 9,751,141 | +7,847,896 | 16,101,453 | 97,023,853 | 1.92% | +80,922,400 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 1,995,986 | 2,035,986 | +40,000 | 588,296,914 | 655,974,329 | 12.96% | +67,677,415 |
| ROIVANT SCIENCES LTD(ROIV) | 7,985,461 | 8,285,461 | +300,000 | 173,284,504 | 229,507,270 | 4.53% | +56,222,766 |
| MODERNA INC(MRNA)(Put) | 0 | 1,000,000 | +1,000,000 | 0 | 50,800,000 | — | +50,800,000 |
| BIOCRYST PHARMACEUTICALS INC(BCRX) | 3,162,529 | 7,434,033 | +4,271,504 | 24,667,726 | 70,771,994 | 1.40% | +46,104,268 |
| CELCUITY INC(CELC) | 3,160,200 | 3,127,200 | -33,000 | 315,198,348 | 356,938,608 | 7.05% | +41,740,260 |
| IONIS PHARMACEUTICALS INC(IONS) | 0 | 504,000 | +504,000 | 0 | 37,845,360 | 0.75% | +37,845,360 |
| DAY ONE BIOPHARMACEUTICALS I COM | 0 | 1,755,799 | +1,755,799 | 0 | 37,644,331 | 0.74% | +37,644,331 |
| DAMORA THERAPEUTICS INC(DMRA) | 0 | 1,223,000 | +1,223,000 | 0 | 31,675,700 | 0.63% | +31,675,700 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 4,457,974 | 4,423,974 | -34,000 | 110,624,625 | 139,355,181 | 2.75% | +28,730,556 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 692,441 | 2,292,441 | +1,600,000 | 5,331,796 | 33,538,412 | 0.66% | +28,206,616 |
| REVOLUTION MEDICINES INC(RVMD) | 0 | 258,600 | +258,600 | 0 | 25,148,850 | 0.50% | +25,148,850 |
| NAUTILUS BIOTECHNOLOGY INC | 12,594,211 | 12,594,211 | 0 | 24,558,711 | 48,865,538 | 0.97% | +24,306,827 |
| ORUKA THERAPEUTICS INC(ORKA) | 1,476,501 | 1,395,501 | -81,000 | 44,752,745 | 68,449,324 | 1.35% | +23,696,579 |
| SAB BIOTHERAPEUTICS INC | 803,210 | 6,431,743 | +5,628,533 | 3,004,005 | 24,633,576 | 0.49% | +21,629,571 |
| DBV TECHNOLOGIES S A | 0 | 964,391 | +964,391 | 0 | 20,146,128 | 0.40% | +20,146,128 |
| SOLID BIOSCIENCES INC | 11,833,539 | 11,906,646 | +73,107 | 66,741,160 | 85,727,851 | 1.69% | +18,986,691 |
| SUTRO BIOPHARMA INC | 0 | 715,307 | +715,307 | 0 | 17,818,297 | 0.35% | +17,818,297 |
| TENAX THERAPEUTICS INC | 439,142 | 1,447,782 | +1,008,640 | 5,353,141 | 23,150,034 | 0.46% | +17,796,893 |
| DYNE THERAPEUTICS INC(DYN) | 3,478,944 | 4,668,839 | +1,189,895 | 68,048,145 | 84,646,051 | 1.67% | +16,597,906 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 8,284,882 | 8,284,882 | 0 | 100,081,375 | 115,159,860 | 2.27% | +15,078,485 |
| ALTO NEUROSCIENCE INC(ANRO) | 1,784,393 | 2,009,893 | +225,500 | 31,762,195 | 45,182,395 | 0.89% | +13,420,200 |
| TANGO THERAPEUTICS INC(TNGX) | 513,035 | 808,153 | +295,118 | 4,545,490 | 16,906,561 | 0.33% | +12,361,071 |
| PROTAGONIST THERAPEUTICS INC | 1,350,425 | 1,230,879 | -119,546 | 117,946,120 | 129,734,647 | 2.56% | +11,788,527 |
| GUARDANT HEALTH INC(GH) | 160,000 | 300,000 | +140,000 | 16,342,400 | 27,711,000 | 0.55% | +11,368,600 |
| ANTERIS TECHNOLOGIES GLOBAL | 1,675,476 | 3,425,476 | +1,750,000 | 8,360,625 | 19,011,392 | 0.38% | +10,650,767 |
| EVOMMUNE INC | 0 | 448,350 | +448,350 | 0 | 10,307,567 | 0.20% | +10,307,567 |
| PHATHOM PHARMACEUTICALS INC(PHAT) | 0 | 925,000 | +925,000 | 0 | 10,276,750 | 0.20% | +10,276,750 |
| NEUMORA THERAPEUTICS INC. | 0 | 5,104,097 | +5,104,097 | 0 | 9,952,989 | 0.20% | +9,952,989 |
| MEIRAGTX HLDGS PLC(MGTX) | 10,326,103 | 10,326,103 | 0 | 82,092,519 | 89,312,864 | 1.76% | +7,220,345 |
| TWIST BIOSCIENCE CORP(TWST) | 0 | 150,000 | +150,000 | 0 | 7,128,000 | 0.14% | +7,128,000 |
| SURROZEN INC | 0 | 229,393 | +229,393 | 0 | 6,682,218 | 0.13% | +6,682,218 |
| AGOMAB THERAPEUTICS NV | 0 | 600,000 | +600,000 | 0 | 6,294,000 | 0.12% | +6,294,000 |
| CYTOMX THERAPEUTICS INC. | 9,680,185 | 10,098,824 | +418,639 | 41,237,588 | 47,464,473 | 0.94% | +6,226,885 |
| EVOLUS INC | 0 | 1,286,862 | +1,286,862 | 0 | 5,289,003 | 0.10% | +5,289,003 |
| LEONABIO INC | 1,859,322 | 1,859,322 | 0 | 14,075,067 | 19,113,830 | 0.38% | +5,038,763 |
| OCULAR THERAPEUTIX INC(OCUL)(Call) | 0 | 500,000 | +500,000 | 0 | 4,235,000 | — | +4,235,000 |
| OCULIS HOLDING AG | 493,827 | 493,827 | 0 | 9,861,725 | 13,130,860 | 0.26% | +3,269,135 |
| APELLIS PHARMACEUTICALS INC COM | 0 | 80,956 | +80,956 | 0 | 3,256,860 | 0.06% | +3,256,860 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 170,000 | 170,000 | 0 | 28,900,000 | 32,138,500 | 0.63% | +3,238,500 |
| EDESA BIOTECH INC | 0 | 563,239 | +563,239 | 0 | 2,945,740 | 0.06% | +2,945,740 |
| X4 PHARMACEUTICALS INC | 6,314,452 | 6,737,648 | +423,196 | 25,257,808 | 27,826,486 | 0.55% | +2,568,678 |
| ADAPTIVE BIOTECHNOLOGIES COR(ADPT) | 0 | 152,500 | +152,500 | 0 | 2,116,700 | 0.04% | +2,116,700 |
| CORCEPT THERAPEUTICS INC(CORT) | 0 | 50,000 | +50,000 | 0 | 2,015,500 | 0.04% | +2,015,500 |
| ZYMEWORKS INC(ZYME) | 3,261,850 | 3,510,078 | +248,228 | 85,884,511 | 87,892,353 | 1.74% | +2,007,842 |
| CELCUITY INC(CELC) | 0 | 0 | 0 | 14,098,435 | 15,875,774 | 0.31% | +1,777,339 |
| BILLIONTOONE INC | 72,812 | 91,812 | +19,000 | 5,958,934 | 7,247,639 | 0.14% | +1,288,705 |
| ADAGIO MED HLDGS INC | 9,876,576 | 9,876,576 | 0 | 10,271,639 | 11,012,382 | 0.22% | +740,743 |
| RAPPORT THERAPEUTICS INC(RAPP) | 673,923 | 673,923 | 0 | 20,446,824 | 21,087,051 | 0.42% | +640,227 |
| COGENT BIOSCIENCES INC(COGT) | 121,082 | 121,082 | 0 | 4,300,833 | 4,660,446 | 0.09% | +359,613 |
| EXAGEN INC | 0 | 114,893 | +114,893 | 0 | 344,679 | 0.01% | +344,679 |
| REVOLUTION MEDICINES INC(RVMD) | 250,000 | 250,000 | 0 | 234,975 | 447,500 | 0.01% | +212,525 |
| ORCHESTRA BIOMED HLDGS INC | 5,127,256 | 5,037,906 | -89,350 | 21,278,112 | 21,411,101 | 0.42% | +132,989 |
| OUTSET MED INC | 833,333 | 833,333 | 0 | 3,091,665 | 3,199,998 | 0.06% | +108,333 |
| MEDLINE INC(MDLN) | 28,000 | 28,000 | 0 | 1,176,000 | 1,246,000 | 0.02% | +70,000 |
| PALATIN TECHNOLOGIES INC | 70,000 | 61,945 | -8,055 | 1,076,600 | 1,079,082 | 0.02% | +2,482 |
| SURROZEN INC | 166,666 | 166,666 | 0 | 3,333 | 2,667 | 0.00% | -666 |
| ENSYSCE BIOSCIENCES INC | 86,666 | 86,666 | 0 | 79,733 | 46,670 | 0.00% | -33,063 |
| CONNECT BIOPHARMA HLDGS LTD | 792,696 | 792,696 | 0 | 2,235,403 | 2,076,864 | 0.04% | -158,539 |
| OPUS GENETICS INC | 4,325,000 | 1,835,842 | -2,489,158 | 8,693,250 | 8,353,081 | 0.16% | -340,169 |
| CONTINEUM THERAPEUTICS INC | 1,464,592 | 1,255,592 | -209,000 | 16,740,287 | 16,398,032 | 0.32% | -342,255 |
| IOVANCE BIOTHERAPEUTICS INC(IOVA) | 152,714 | 0 | -152,714 | 416,909 | 0 | — | -416,909 |
| AVALO THERAPEUTICS INC(AVTX) | 139,667 | 139,667 | 0 | 2,536,353 | 2,085,228 | 0.04% | -451,125 |
| ENVVENO MEDICAL CORPORATION | 1,759,035 | 0 | -1,759,035 | 564,298 | 0 | — | -564,298 |
| CUMBERLAND PHARMACEUTICALS I | 341,087 | 196,978 | -144,109 | 1,357,526 | 640,179 | 0.01% | -717,347 |
| BIODESIX | 108,694 | 0 | -108,694 | 739,119 | 0 | — | -739,119 |
| LENZ THERAPEUTICS INC | 50,000 | 0 | -50,000 | 800,000 | 0 | — | -800,000 |
| LEXEO THERAPEUTICS INC | 139,835 | 0 | -139,835 | 1,388,562 | 0 | — | -1,388,562 |
| CRESCENT BIOPHARMA INC. | 453,686 | 206,942 | -246,744 | 5,380,716 | 3,801,525 | 0.08% | -1,579,191 |
| IMMIX BIOPHARMA INC | 338,941 | 0 | -338,941 | 1,772,661 | 0 | — | -1,772,661 |
| AXSOME THERAPEUTICS INC.(AXSM) | 148,900 | 149,950 | +1,050 | 27,195,096 | 25,344,549 | 0.50% | -1,850,547 |
| AXOGEN INC(AXGN) | 784,140 | 697,312 | -86,828 | 25,664,902 | 23,101,947 | 0.46% | -2,562,955 |
| SCHRODINGER INC(SDGR) | 202,400 | 0 | -202,400 | 3,618,912 | 0 | — | -3,618,912 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 165,713 | 0 | -165,713 | 4,142,825 | 0 | — | -4,142,825 |
| KRYSTAL BIOTECH INC(KRYS) | 17,500 | 0 | -17,500 | 4,314,450 | 0 | — | -4,314,450 |
| AQUESTIVE THERAPEUTICS INC | 747,193 | 0 | -747,193 | 4,826,867 | 0 | — | -4,826,867 |
| TECTONIC THERAPEUTIC INC(Call) | 250,000 | 0 | -250,000 | 5,215,000 | 0 | — | -5,215,000 |
| PEPGEN INC | 829,870 | 0 | -829,870 | 5,402,454 | 0 | — | -5,402,454 |
| KYMERA THERAPEUTICS INC(KYMR) | 69,935 | 0 | -69,935 | 5,441,642 | 0 | — | -5,441,642 |
| NUVALENT INC(NUVL) | 1,665,105 | 1,580,505 | -84,600 | 167,492,912 | 161,922,737 | 3.20% | -5,570,175 |
| BIOHAVEN LTD(BHVN)(Call) | 500,000 | 0 | -500,000 | 5,645,000 | 0 | — | -5,645,000 |
| IRHYTHM HOLDINGS INC(IRTC) | 108,000 | 105,026 | -2,974 | 19,163,520 | 12,395,169 | 0.24% | -6,768,351 |
| IMMATICS N.V(IMTX) | 10,383,456 | 10,383,456 | 0 | 109,026,288 | 102,173,207 | 2.02% | -6,853,081 |
| CAPRICOR THERAPEUTICS INC(CAPR)(Call) | 242,100 | 0 | -242,100 | 6,987,006 | 0 | — | -6,987,006 |
| INHIBIKASE THERAPEUTICS INC | 5,421,568 | 2,315,000 | -3,106,568 | 11,114,214 | 3,889,200 | 0.08% | -7,225,014 |
| BRIGHT MINDS BIOSCIENCES INC | 449,290 | 377,544 | -71,746 | 35,062,592 | 27,549,386 | 0.54% | -7,513,206 |
| KESTRA MED TECHNOLOGIES LTD SHS | 285,000 | 0 | -285,000 | 7,558,200 | 0 | — | -7,558,200 |
| XENON PHARMACEUTICALS INC(XENE) | 200,791 | 0 | -200,791 | 8,999,453 | 0 | — | -8,999,453 |
| MAPLIGHT THERAPEUTICS INC(MPLT) | 550,000 | 0 | -550,000 | 9,660,750 | 0 | — | -9,660,750 |
| GOSSAMER BIO INC | 3,139,669 | 0 | -3,139,669 | 9,732,974 | 0 | — | -9,732,974 |
| BETA BIONICS INC | 602,944 | 842,944 | +240,000 | 18,371,704 | 8,446,299 | 0.17% | -9,925,405 |
| NURIX THERAPEUTICS INC(NRIX) | 3,555,877 | 3,710,877 | +155,000 | 67,454,987 | 57,518,594 | 1.14% | -9,936,393 |
| INTUITIVE SURGICAL INC | 87,919 | 85,419 | -2,500 | 49,793,805 | 39,377,305 | 0.78% | -10,416,500 |
| IMMUNOVANT INC(IMVT) | 1,994,890 | 1,597,383 | -397,507 | 50,710,104 | 39,678,994 | 0.78% | -11,031,110 |
| ADMA BIOLOGICS INC | 883,468 | 467,233 | -416,235 | 16,114,456 | 4,209,769 | 0.08% | -11,904,687 |
| SEPTERNA INC(SEPN) | 433,160 | 0 | -433,160 | 12,076,501 | 0 | — | -12,076,501 |
| PALISADE BIO INC | 12,050,000 | 8,928,149 | -3,121,851 | 28,317,500 | 15,624,261 | 0.31% | -12,693,239 |