Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| CENTESSA PHARMACEUTICALS PLC | 2,917,634 | 5,258,903 | +2,341,269 | 72,970 | 208,884 | 4.13% | +135,914 |
| ASCENDIS PHARMA A/S(ASND) | 1,081,421 | 1,531,421 | +450,000 | 230,602 | 350,282 | 6.92% | +119,680 |
| SPYRE THERAPEUTICS INC(SYRE) | 3,069,225 | 3,783,225 | +714,000 | 100,548 | 190,826 | 3.77% | +90,278 |
| RELAY THERAPEUTICS INC(RLAY) | 1,903,245 | 9,751,141 | +7,847,896 | 16,101 | 97,024 | 1.92% | +80,922 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 1,995,986 | 2,035,986 | +40,000 | 588,297 | 655,974 | 12.96% | +67,677 |
| ROIVANT SCIENCES LTD(ROIV) | 7,985,461 | 8,285,461 | +300,000 | 173,285 | 229,507 | 4.53% | +56,223 |
| BIOCRYST PHARMACEUTICALS INC(BCRX) | 3,162,529 | 7,434,033 | +4,271,504 | 24,668 | 70,772 | 1.40% | +46,104 |
| CELCUITY INC(CELC) | 3,160,200 | 3,127,200 | -33,000 | 315,198 | 356,939 | 7.05% | +41,740 |
| IONIS PHARMACEUTICALS INC(IONS) | 0 | 504,000 | +504,000 | 0 | 37,845 | 0.75% | +37,845 |
| DAY ONE BIOPHARMACEUTICALS I COM | 0 | 1,755,799 | +1,755,799 | 0 | 37,644 | 0.74% | +37,644 |
| DAMORA THERAPEUTICS INC(DMRA) | 0 | 1,223,000 | +1,223,000 | 0 | 31,676 | 0.63% | +31,676 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 4,457,974 | 4,423,974 | -34,000 | 110,625 | 139,355 | 2.75% | +28,731 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 692,441 | 2,292,441 | +1,600,000 | 5,332 | 33,538 | 0.66% | +28,207 |
| REVOLUTION MEDICINES INC(RVMD) | 0 | 258,600 | +258,600 | 0 | 25,149 | 0.50% | +25,149 |
| NAUTILUS BIOTECHNOLOGY INC(NAUT) | 12,594,211 | 12,594,211 | 0 | 24,559 | 48,866 | 0.97% | +24,307 |
| ORUKA THERAPEUTICS INC(ORKA) | 1,476,501 | 1,395,501 | -81,000 | 44,753 | 68,449 | 1.35% | +23,697 |
| SAB BIOTHERAPEUTICS INC(SABS) | 803,210 | 6,431,743 | +5,628,533 | 3,004 | 24,634 | 0.49% | +21,630 |
| DBV TECHNOLOGIES S A(DBVT) | 0 | 964,391 | +964,391 | 0 | 20,146 | 0.40% | +20,146 |
| SOLID BIOSCIENCES INC | 11,833,539 | 11,906,646 | +73,107 | 66,741 | 85,728 | 1.69% | +18,987 |
| SUTRO BIOPHARMA INC(STRO) | 0 | 715,307 | +715,307 | 0 | 17,818 | 0.35% | +17,818 |
| TENAX THERAPEUTICS INC(TENX) | 439,142 | 1,447,782 | +1,008,640 | 5,353 | 23,150 | 0.46% | +17,797 |
| DYNE THERAPEUTICS INC(DYN) | 3,478,944 | 4,668,839 | +1,189,895 | 68,048 | 84,646 | 1.67% | +16,598 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 8,284,882 | 8,284,882 | 0 | 100,081 | 115,160 | 2.27% | +15,078 |
| ALTO NEUROSCIENCE INC(ANRO) | 1,784,393 | 2,009,893 | +225,500 | 31,762 | 45,182 | 0.89% | +13,420 |
| TANGO THERAPEUTICS INC(TNGX) | 513,035 | 808,153 | +295,118 | 4,545 | 16,907 | 0.33% | +12,361 |
| PROTAGONIST THERAPEUTICS INC | 1,350,425 | 1,230,879 | -119,546 | 117,946 | 129,735 | 2.56% | +11,789 |
| GUARDANT HEALTH INC(GH) | 160,000 | 300,000 | +140,000 | 16,342 | 27,711 | 0.55% | +11,369 |
| ANTERIS TECHNOLOGIES GLOBAL(AVR) | 1,675,476 | 3,425,476 | +1,750,000 | 8,361 | 19,011 | 0.38% | +10,651 |
| EVOMMUNE INC(EVMN) | 0 | 448,350 | +448,350 | 0 | 10,308 | 0.20% | +10,308 |
| PHATHOM PHARMACEUTICALS INC(PHAT) | 0 | 925,000 | +925,000 | 0 | 10,277 | 0.20% | +10,277 |
| NEUMORA THERAPEUTICS INC.(NMRA) | 0 | 5,104,097 | +5,104,097 | 0 | 9,953 | 0.20% | +9,953 |
| MEIRAGTX HLDGS PLC(MGTX) | 10,326,103 | 10,326,103 | 0 | 82,093 | 89,313 | 1.76% | +7,220 |
| TWIST BIOSCIENCE CORP(TWST) | 0 | 150,000 | +150,000 | 0 | 7,128 | 0.14% | +7,128 |
| SURROZEN INC(SRZN) | 0 | 229,393 | +229,393 | 0 | 6,682 | 0.13% | +6,682 |
| AGOMAB THERAPEUTICS NV(AGMB) | 0 | 600,000 | +600,000 | 0 | 6,294 | 0.12% | +6,294 |
| CYTOMX THERAPEUTICS INC.(CTMX) | 9,680,185 | 10,098,824 | +418,639 | 41,238 | 47,464 | 0.94% | +6,227 |
| EVOLUS INC(EOLS) | 0 | 1,286,862 | +1,286,862 | 0 | 5,289 | 0.10% | +5,289 |
| LEONABIO INC(LONA) | 1,859,322 | 1,859,322 | 0 | 14,075 | 19,114 | 0.38% | +5,039 |
| OCULIS HOLDING AG(OCS) | 493,827 | 493,827 | 0 | 9,862 | 13,131 | 0.26% | +3,269 |
| APELLIS PHARMACEUTICALS INC COM | 0 | 80,956 | +80,956 | 0 | 3,257 | 0.06% | +3,257 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 170,000 | 170,000 | 0 | 28,900 | 32,139 | 0.63% | +3,239 |
| EDESA BIOTECH INC(EDSA) | 0 | 563,239 | +563,239 | 0 | 2,946 | 0.06% | +2,946 |
| X4 PHARMACEUTICALS INC(XFOR) | 6,314,452 | 6,737,648 | +423,196 | 25,258 | 27,826 | 0.55% | +2,569 |
| ADAPTIVE BIOTECHNOLOGIES COR(ADPT) | 0 | 152,500 | +152,500 | 0 | 2,117 | 0.04% | +2,117 |
| CORCEPT THERAPEUTICS INC(CORT) | 0 | 50,000 | +50,000 | 0 | 2,016 | 0.04% | +2,016 |
| ZYMEWORKS INC(ZYME) | 3,261,850 | 3,510,078 | +248,228 | 85,885 | 87,892 | 1.74% | +2,008 |
| CELCUITY INC(CELC) | 0 | 0 | 0 | 14,098 | 15,876 | 0.31% | +1,777 |
| BILLIONTOONE INC | 72,812 | 91,812 | +19,000 | 5,959 | 7,248 | 0.14% | +1,289 |
| ADAGIO MED HLDGS INC(ADGM) | 9,876,576 | 9,876,576 | 0 | 10,272 | 11,012 | 0.22% | +741 |
| RAPPORT THERAPEUTICS INC(RAPP) | 673,923 | 673,923 | 0 | 20,447 | 21,087 | 0.42% | +640 |
| COGENT BIOSCIENCES INC(COGT) | 121,082 | 121,082 | 0 | 4,301 | 4,660 | 0.09% | +360 |
| EXAGEN INC(XGN) | 0 | 114,893 | +114,893 | 0 | 345 | 0.01% | +345 |
| REVOLUTION MEDICINES INC(RVMD) | 250,000 | 250,000 | 0 | 235 | 448 | 0.01% | +213 |
| ORCHESTRA BIOMED HLDGS INC(OBIO) | 5,127,256 | 5,037,906 | -89,350 | 21,278 | 21,411 | 0.42% | +133 |
| OUTSET MED INC(OM) | 833,333 | 833,333 | 0 | 3,092 | 3,200 | 0.06% | +108 |
| MEDLINE INC(MDLN) | 28,000 | 28,000 | 0 | 1,176 | 1,246 | 0.02% | +70 |
| PALATIN TECHNOLOGIES INC(PTN) | 70,000 | 61,945 | -8,055 | 1,077 | 1,079 | 0.02% | +2 |
| SURROZEN INC(SRZN) | 166,666 | 166,666 | 0 | 3 | 3 | 0.00% | -1 |
| ENSYSCE BIOSCIENCES INC(ENSC) | 86,666 | 86,666 | 0 | 80 | 47 | 0.00% | -33 |
| CONNECT BIOPHARMA HLDGS LTD(CNTB) | 792,696 | 792,696 | 0 | 2,235 | 2,077 | 0.04% | -159 |
| OPUS GENETICS INC(IRD) | 4,325,000 | 1,835,842 | -2,489,158 | 8,693 | 8,353 | 0.16% | -340 |
| CONTINEUM THERAPEUTICS INC(CTNM) | 1,464,592 | 1,255,592 | -209,000 | 16,740 | 16,398 | 0.32% | -342 |
| IOVANCE BIOTHERAPEUTICS INC(IOVA) | 152,714 | 0 | -152,714 | 417 | 0 | — | -417 |
| AVALO THERAPEUTICS INC(AVTX) | 139,667 | 139,667 | 0 | 2,536 | 2,085 | 0.04% | -451 |
| ENVVENO MEDICAL CORPORATION(NVNO) | 1,759,035 | 0 | -1,759,035 | 564 | 0 | — | -564 |
| CUMBERLAND PHARMACEUTICALS I(CPIX) | 341,087 | 196,978 | -144,109 | 1,358 | 640 | 0.01% | -717 |
| BIODESIX(BDSX) | 108,694 | 0 | -108,694 | 739 | 0 | — | -739 |
| LENZ THERAPEUTICS INC(LENZ) | 50,000 | 0 | -50,000 | 800 | 0 | — | -800 |
| LEXEO THERAPEUTICS INC(LXEO) | 139,835 | 0 | -139,835 | 1,389 | 0 | — | -1,389 |
| CRESCENT BIOPHARMA INC.(CBIO) | 453,686 | 206,942 | -246,744 | 5,381 | 3,802 | 0.08% | -1,579 |
| IMMIX BIOPHARMA INC(IMMX) | 338,941 | 0 | -338,941 | 1,773 | 0 | — | -1,773 |
| AXSOME THERAPEUTICS INC.(AXSM) | 148,900 | 149,950 | +1,050 | 27,195 | 25,345 | 0.50% | -1,851 |
| AXOGEN INC(AXGN) | 784,140 | 697,312 | -86,828 | 25,665 | 23,102 | 0.46% | -2,563 |
| SCHRODINGER INC(SDGR) | 202,400 | 0 | -202,400 | 3,619 | 0 | — | -3,619 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 165,713 | 0 | -165,713 | 4,143 | 0 | — | -4,143 |
| KRYSTAL BIOTECH INC(KRYS) | 17,500 | 0 | -17,500 | 4,314 | 0 | — | -4,314 |
| AQUESTIVE THERAPEUTICS INC | 747,193 | 0 | -747,193 | 4,827 | 0 | — | -4,827 |
| PEPGEN INC(PEPG) | 829,870 | 0 | -829,870 | 5,402 | 0 | — | -5,402 |
| KYMERA THERAPEUTICS INC(KYMR) | 69,935 | 0 | -69,935 | 5,442 | 0 | — | -5,442 |
| NUVALENT INC | 1,665,105 | 1,580,505 | -84,600 | 167,493 | 161,923 | 3.20% | -5,570 |
| IRHYTHM HOLDINGS INC(IRTC) | 108,000 | 105,026 | -2,974 | 19,164 | 12,395 | 0.24% | -6,768 |
| IMMATICS N.V(IMTX) | 10,383,456 | 10,383,456 | 0 | 109,026 | 102,173 | 2.02% | -6,853 |
| INHIBIKASE THERAPEUTICS INC(IKT) | 5,421,568 | 2,315,000 | -3,106,568 | 11,114 | 3,889 | 0.08% | -7,225 |
| BRIGHT MINDS BIOSCIENCES INC(DRUG) | 449,290 | 377,544 | -71,746 | 35,063 | 27,549 | 0.54% | -7,513 |
| KESTRA MED TECHNOLOGIES LTD SHS | 285,000 | 0 | -285,000 | 7,558 | 0 | — | -7,558 |
| XENON PHARMACEUTICALS INC(XENE) | 200,791 | 0 | -200,791 | 8,999 | 0 | — | -8,999 |
| MAPLIGHT THERAPEUTICS INC(MPLT) | 550,000 | 0 | -550,000 | 9,661 | 0 | — | -9,661 |
| GOSSAMER BIO INC(GOSS) | 3,139,669 | 0 | -3,139,669 | 9,733 | 0 | — | -9,733 |
| BETA BIONICS INC(BBNX) | 602,944 | 842,944 | +240,000 | 18,372 | 8,446 | 0.17% | -9,925 |
| NURIX THERAPEUTICS INC(NRIX) | 3,555,877 | 3,710,877 | +155,000 | 67,455 | 57,519 | 1.14% | -9,936 |
| INTUITIVE SURGICAL INC | 87,919 | 85,419 | -2,500 | 49,794 | 39,377 | 0.78% | -10,416 |
| IMMUNOVANT INC(IMVT) | 1,994,890 | 1,597,383 | -397,507 | 50,710 | 39,679 | 0.78% | -11,031 |
| ADMA BIOLOGICS INC | 883,468 | 467,233 | -416,235 | 16,114 | 4,210 | 0.08% | -11,905 |
| SEPTERNA INC(SEPN) | 433,160 | 0 | -433,160 | 12,077 | 0 | — | -12,077 |
| PALISADE BIO INC(PALI) | 12,050,000 | 8,928,149 | -3,121,851 | 28,318 | 15,624 | 0.31% | -12,693 |
| ENGENE HOLDINGS INC COM | 5,869,076 | 5,827,506 | -41,570 | 52,998 | 39,685 | 0.78% | -13,312 |
| SAVARA INC(SVRA) | 2,400,000 | 0 | -2,400,000 | 14,472 | 0 | — | -14,472 |
| DEXCOM INC(DXCM) | 225,758 | 0 | -225,758 | 14,984 | 0 | — | -14,984 |
| GLAUKOS CORP(GKOS) | 140,000 | 0 | -140,000 | 15,807 | 0 | — | -15,807 |
| CVS HEALTH CORP(CVS) | 220,000 | 0 | -220,000 | 17,459 | 0 | — | -17,459 |