Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Praxis Precision Medicines, Inc.(PRAX) | 1,995,986 | 2,035,986 | +40,000 | $588.30M | $655.97M | 12.96% | +$67.68M |
| Celcuity Inc.(CELC) | 3,160,200 | 3,127,200 | -33,000 | $315.20M | $356.94M | 7.05% | +$41.74M |
| Ascendis Pharma A/SADR(ASND) | 1,081,421 | 1,531,421 | +450,000 | $230.60M | $350.28M | 6.92% | +$119.68M |
| Roivant Sciences Ltd.SHS(ROIV) | 7,985,461 | 8,285,461 | +300,000 | $173.28M | $229.51M | 4.53% | +$56.22M |
| Centessa Pharmaceuticals PlcADS | 2,917,634 | 5,258,903 | +2,341,269 | $72.97M | $208.88M | 4.13% | +$135.91M |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 2,546,391 | 2,373,795 | -172,596 | $272.57M | $206.45M | 4.08% | -$66.12M |
| Spyre Therapeutics, Inc.(SYRE) | 3,069,225 | 3,783,225 | +714,000 | $100.55M | $190.83M | 3.77% | +$90.28M |
| Nuvalent Inc | 1,665,105 | 1,580,505 | -84,600 | $167.49M | $161.92M | 3.20% | -$5.57M |
| Edgewise Therapeutics, Inc.(EWTX) | 4,457,974 | 4,423,974 | -34,000 | $110.62M | $139.36M | 2.75% | +$28.73M |
| Protagonist Therapeutics Inc | 1,350,425 | 1,230,879 | -119,546 | $117.95M | $129.73M | 2.56% | +$11.79M |
| Apogee Therapeutics Inc | 2,330,651 | 1,540,384 | -790,267 | $175.92M | $129.65M | 2.56% | -$46.26M |
| Travere Therapeutics, Inc.(TVTX) | 4,278,180 | 4,142,551 | -135,629 | $163.47M | $123.08M | 2.43% | -$40.39M |
| Amylyx Pharmaceuticals, Inc.(AMLX) | 8,284,882 | 8,284,882 | 0 | $100.08M | $115.16M | 2.27% | +$15.08M |
| Immatics N.V.SHS(IMTX) | 10,383,456 | 10,383,456 | 0 | $109.03M | $102.17M | 2.02% | -$6.85M |
| Relay Therapeutics, Inc.(RLAY) | 1,903,245 | 9,751,141 | +7,847,896 | $16.10M | $97.02M | 1.92% | +$80.92M |
| Inhibrx Biosciences, Inc.(INBX) | 1,452,707 | 1,442,707 | -10,000 | $114.76M | $96.99M | 1.92% | -$17.77M |
| MeiraGTx Holdings plc(MGTX) | 10,326,103 | 10,326,103 | 0 | $82.09M | $89.31M | 1.76% | +$7.22M |
| Zymeworks Inc.(ZYME) | 3,261,850 | 3,510,078 | +248,228 | $85.88M | $87.89M | 1.74% | +$2.01M |
| Solid Biosciences Inc | 11,833,539 | 11,906,646 | +73,107 | $66.74M | $85.73M | 1.69% | +$18.99M |
| Dyne Therapeutics, Inc.(DYN) | 3,478,944 | 4,668,839 | +1,189,895 | $68.05M | $84.65M | 1.67% | +$16.60M |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 3,162,529 | 7,434,033 | +4,271,504 | $24.67M | $70.77M | 1.40% | +$46.10M |
| Oruka Therapeutics, Inc.(ORKA) | 1,476,501 | 1,395,501 | -81,000 | $44.75M | $68.45M | 1.35% | +$23.70M |
| Artivion, Inc.(AORT) | 1,722,290 | 1,637,290 | -85,000 | $78.55M | $59.96M | 1.18% | -$18.60M |
| Nurix Therapeutics, Inc.(NRIX) | 3,555,877 | 3,710,877 | +155,000 | $67.45M | $57.52M | 1.14% | -$9.94M |
| Nautilus Biotechnology, Inc.(NAUT) | 12,594,211 | 12,594,211 | 0 | $24.56M | $48.87M | 0.97% | +$24.31M |
| CytomX Therapeutics, Inc.(CTMX) | 9,680,185 | 10,098,824 | +418,639 | $41.24M | $47.46M | 0.94% | +$6.23M |
| Alto Neuroscience, Inc.(ANRO) | 1,784,393 | 2,009,893 | +225,500 | $31.76M | $45.18M | 0.89% | +$13.42M |
| Engene Holdings Inc COM | 5,869,076 | 5,827,506 | -41,570 | $53.00M | $39.69M | 0.78% | -$13.31M |
| Immunovant, Inc.(IMVT) | 1,994,890 | 1,597,383 | -397,507 | $50.71M | $39.68M | 0.78% | -$11.03M |
| Intuitive Surgical, Inc.(ISRG) | 87,919 | 85,419 | -2,500 | $49.79M | $39.38M | 0.78% | -$10.42M |
| Ionis Pharmaceuticals, Inc.(IONS) | 0 | 504,000 | +504,000 | $0 | $37.85M | 0.75% | +$37.85M |
| Day One Biopharmaceuticals I COM | 0 | 1,755,799 | +1,755,799 | $0 | $37.64M | 0.74% | +$37.64M |
| ABIVAX Société AnonymeADS(ABVX) | 458,343 | 328,884 | -129,459 | $61.81M | $36.62M | 0.72% | -$25.19M |
| Corvus Pharmaceuticals, Inc.(CRVS) | 692,441 | 2,292,441 | +1,600,000 | $5.33M | $33.54M | 0.66% | +$28.21M |
| Repligen Corporation(RGEN) | 315,541 | 280,541 | -35,000 | $51.70M | $33.05M | 0.65% | -$18.65M |
| Jazz Pharmaceuticals plcSHS USD(JAZZ) | 170,000 | 170,000 | 0 | $28.90M | $32.14M | 0.63% | +$3.24M |
| Damora Therapeutics, Inc.(DMRA) | 0 | 1,223,000 | +1,223,000 | $0 | $31.68M | 0.63% | +$31.68M |
| X4 Pharmaceuticals, Inc.(XFOR) | 6,314,452 | 6,737,648 | +423,196 | $25.26M | $27.83M | 0.55% | +$2.57M |
| Guardant Health, Inc.(GH) | 160,000 | 300,000 | +140,000 | $16.34M | $27.71M | 0.55% | +$11.37M |
| Bright Minds Biosciences Inc.(DRUG) | 449,290 | 377,544 | -71,746 | $35.06M | $27.55M | 0.54% | -$7.51M |
| Invivyd, Inc.(IVVD) | 21,785,166 | 20,859,303 | -925,863 | $53.81M | $27.12M | 0.54% | -$26.69M |
| Sionna Therapeutics, Inc.(SION) | 1,179,098 | 658,439 | -520,659 | $48.51M | $26.40M | 0.52% | -$22.11M |
| Axsome Therapeutics, Inc.(AXSM) | 148,900 | 149,950 | +1,050 | $27.20M | $25.34M | 0.50% | -$1.85M |
| Revolution Medicines, Inc.(RVMD) | 0 | 258,600 | +258,600 | $0 | $25.15M | 0.50% | +$25.15M |
| SAB Biotherapeutics, Inc.(SABS) | 803,210 | 6,431,743 | +5,628,533 | $3.00M | $24.63M | 0.49% | +$21.63M |
| Belite Bio, IncADS(BLTE) | 414,239 | 151,979 | -262,260 | $66.26M | $24.23M | 0.48% | -$42.03M |
| Tenax Therapeutics, Inc.(TENX) | 439,142 | 1,447,782 | +1,008,640 | $5.35M | $23.15M | 0.46% | +$17.80M |
| Axogen, Inc.(AXGN) | 784,140 | 697,312 | -86,828 | $25.66M | $23.10M | 0.46% | -$2.56M |
| Viridian Therapeutics, Inc.(VRDN) | 3,042,703 | 1,170,829 | -1,871,874 | $94.69M | $22.90M | 0.45% | -$71.79M |
| Orchestra BioMed Holdings, Inc.(OBIO) | 5,127,256 | 5,037,906 | -89,350 | $21.28M | $21.41M | 0.42% | +$133.0K |
| Rapport Therapeutics, Inc.(RAPP) | 673,923 | 673,923 | 0 | $20.45M | $21.09M | 0.42% | +$640.2K |
| DBV Technologies S.A.ADS(DBVT) | 0 | 964,391 | +964,391 | $0 | $20.15M | 0.40% | +$20.15M |
| LeonaBio, Inc.(LONA) | 1,859,322 | 1,859,322 | 0 | $14.08M | $19.11M | 0.38% | +$5.04M |
| Anteris Technologies Global Corp.(AVR) | 1,675,476 | 3,425,476 | +1,750,000 | $8.36M | $19.01M | 0.38% | +$10.65M |
| Sutro Biopharma, Inc.(STRO) | 0 | 715,307 | +715,307 | $0 | $17.82M | 0.35% | +$17.82M |
| Tango Therapeutics, Inc.(TNGX) | 513,035 | 808,153 | +295,118 | $4.55M | $16.91M | 0.33% | +$12.36M |
| Contineum Therapeutics, Inc.CL A(CTNM) | 1,464,592 | 1,255,592 | -209,000 | $16.74M | $16.40M | 0.32% | -$342.3K |
| Celcuity Inc.NOTE 2 750 8 0(CELC) | 0 | 0 | 0 | $14.10M | $15.88M | 0.31% | +$1.78M |
| Palisade Bio, Inc.(PALI) | 12,050,000 | 8,928,149 | -3,121,851 | $28.32M | $15.62M | 0.31% | -$12.69M |
| Oculis Holding AG(OCS) | 493,827 | 493,827 | 0 | $9.86M | $13.13M | 0.26% | +$3.27M |
| iRhythm Holdings, Inc.(IRTC) | 108,000 | 105,026 | -2,974 | $19.16M | $12.40M | 0.24% | -$6.77M |
| Adagio Medical Holdings, Inc.(ADGM) | 9,876,576 | 9,876,576 | 0 | $10.27M | $11.01M | 0.22% | +$740.7K |
| Evommune, Inc.(EVMN) | 0 | 448,350 | +448,350 | $0 | $10.31M | 0.20% | +$10.31M |
| Phathom Pharmaceuticals, Inc.(PHAT) | 0 | 925,000 | +925,000 | $0 | $10.28M | 0.20% | +$10.28M |
| Neumora Therapeutics, Inc.(NMRA) | 0 | 5,104,097 | +5,104,097 | $0 | $9.95M | 0.20% | +$9.95M |
| Omada Health, Inc.(OMDA) | 2,396,330 | 786,330 | -1,610,000 | $37.81M | $9.88M | 0.20% | -$27.93M |
| Neurocrine Biosciences, Inc.(NBIX) | 331,050 | 65,050 | -266,000 | $46.95M | $8.57M | 0.17% | -$38.38M |
| Beta Bionics, Inc.(BBNX) | 602,944 | 842,944 | +240,000 | $18.37M | $8.45M | 0.17% | -$9.93M |
| Opus Genetics, Inc.(IRD) | 4,325,000 | 1,835,842 | -2,489,158 | $8.69M | $8.35M | 0.16% | -$340.2K |
| Billiontoone IncCL A | 72,812 | 91,812 | +19,000 | $5.96M | $7.25M | 0.14% | +$1.29M |
| Twist Bioscience Corporation(TWST) | 0 | 150,000 | +150,000 | $0 | $7.13M | 0.14% | +$7.13M |
| Surrozen, Inc.(SRZN) | 0 | 229,393 | +229,393 | $0 | $6.68M | 0.13% | +$6.68M |
| AgomAb Therapeutics NVADS(AGMB) | 0 | 600,000 | +600,000 | $0 | $6.29M | 0.12% | +$6.29M |
| Evolus, Inc.(EOLS) | 0 | 1,286,862 | +1,286,862 | $0 | $5.29M | 0.10% | +$5.29M |
| Cogent Biosciences, Inc.(COGT) | 121,082 | 121,082 | 0 | $4.30M | $4.66M | 0.09% | +$359.6K |
| Adma Biologics Inc | 883,468 | 467,233 | -416,235 | $16.11M | $4.21M | 0.08% | -$11.90M |
| Inhibikase Therapeutics, Inc.(IKT) | 5,421,568 | 2,315,000 | -3,106,568 | $11.11M | $3.89M | 0.08% | -$7.23M |
| Crescent Biopharma, Inc.(CBIO) | 453,686 | 206,942 | -246,744 | $5.38M | $3.80M | 0.08% | -$1.58M |
| Apellis Pharmaceuticals Inc COM | 0 | 80,956 | +80,956 | $0 | $3.26M | 0.06% | +$3.26M |
| Outset Medical, Inc.(OM) | 833,333 | 833,333 | 0 | $3.09M | $3.20M | 0.06% | +$108.3K |
| Edesa Biotech, Inc.(EDSA) | 0 | 563,239 | +563,239 | $0 | $2.95M | 0.06% | +$2.95M |
| Adaptive Biotechnologies Corporation(ADPT) | 0 | 152,500 | +152,500 | $0 | $2.12M | 0.04% | +$2.12M |
| Avalo Therapeutics, Inc.(AVTX) | 139,667 | 139,667 | 0 | $2.54M | $2.09M | 0.04% | -$451.1K |
| Connect Biopharma Holdings LimitedSHS(CNTB) | 792,696 | 792,696 | 0 | $2.24M | $2.08M | 0.04% | -$158.5K |
| Corcept Therapeutics Incorporated(CORT) | 0 | 50,000 | +50,000 | $0 | $2.02M | 0.04% | +$2.02M |
| Medline Inc.CL A(MDLN) | 28,000 | 28,000 | 0 | $1.18M | $1.25M | 0.02% | +$70.0K |
| Palatin Technologies, Inc.(PTN) | 70,000 | 61,945 | -8,055 | $1.08M | $1.08M | 0.02% | +$2.5K |
| Cumberland Pharmaceuticals Inc.(CPIX) | 341,087 | 196,978 | -144,109 | $1.36M | $640.2K | 0.01% | -$717.3K |
| Revolution Medicines, Inc.W EXP 12 17 202(RVMD) | 250,000 | 250,000 | 0 | $235.0K | $447.5K | 0.01% | +$212.5K |
| Exagen Inc.(XGN) | 0 | 114,893 | +114,893 | $0 | $344.7K | 0.01% | +$344.7K |
| Ensysce Biosciences, Inc.(ENSC) | 86,666 | 86,666 | 0 | $79.7K | $46.7K | 0.00% | -$33.1K |
| Surrozen, Inc.W EXP 08 01 203(SRZN) | 166,666 | 166,666 | 0 | $3.3K | $2.7K | 0.00% | -$666 |
| Aldeyra Therapeutics, Inc.(ALDX) | 4,185,632 | 0 | -4,185,632 | $21.68M | $0 | — | -$21.68M |
| Amicus Therapeutics Inc COM | 6,370,851 | 0 | -6,370,851 | $90.72M | $0 | — | -$90.72M |
| Aquestive Therapeutics Inc | 747,193 | 0 | -747,193 | $4.83M | $0 | — | -$4.83M |
| Arcellx Inc COMMON STOCK | 1,466,071 | 0 | -1,466,071 | $95.59M | $0 | — | -$95.59M |
| Astria Therapeutics Inc | 6,485,420 | 0 | -6,485,420 | $84.89M | $0 | — | -$84.89M |
| Biodesix, Inc.(BDSX) | 108,694 | 0 | -108,694 | $739.1K | $0 | — | -$739.1K |
| Biogen Inc.(BIIB) | 124,000 | 0 | -124,000 | $21.82M | $0 | — | -$21.82M |
| Boston Scientific Corporation(BSX) | 979,000 | 0 | -979,000 | $93.35M | $0 | — | -$93.35M |