Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q1 2025 ▲▼ | Q2 2025 ▲▼ | Change ▲▼ | Q1 2025 ▲▼ | Q2 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ASCENDIS PHARMA A/S(ASND) | 0 | 963,886 | +963,886 | 0 | 166,367 | 6.24% | +166,367 |
| VERONA PHARMA PLC | 6,563,340 | 5,507,591 | -1,055,749 | 416,706 | 520,908 | 19.55% | +104,202 |
| OMADA HEALTH INC(OMDA) | 0 | 2,426,330 | +2,426,330 | 0 | 44,402 | 1.67% | +44,402 |
| ROIVANT SCIENCES LTD(ROIV) | 0 | 3,331,465 | +3,331,465 | 0 | 37,546 | 1.41% | +37,546 |
| CARIS LIFE SCIENCES INC(CAI) | 0 | 1,098,163 | +1,098,163 | 0 | 29,343 | 1.10% | +29,343 |
| INSMED INC(INSM) | 509,300 | 650,252 | +140,952 | 38,854 | 65,441 | 2.46% | +26,587 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 7,874,348 | 7,902,365 | +28,017 | 27,875 | 50,654 | 1.90% | +22,779 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 100,050 | 255,050 | +155,000 | 11,066 | 32,057 | 1.20% | +20,992 |
| ARTIVION INC(AORT) | 2,793,703 | 2,793,703 | 0 | 68,669 | 86,884 | 3.26% | +18,215 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 2,548,445 | 2,418,299 | -130,146 | 134,991 | 152,812 | 5.73% | +17,821 |
| BOSTON SCIENTIFIC CORP(BSX) | 130,000 | 280,000 | +150,000 | 13,114 | 30,075 | 1.13% | +16,960 |
| AKERO THERAPEUTICS INC | 792,960 | 915,887 | +122,927 | 32,099 | 48,872 | 1.83% | +16,773 |
| CYTOMX THERAPEUTICS INC(CTMX) | 0 | 6,993,646 | +6,993,646 | 0 | 15,876 | 0.60% | +15,876 |
| CHARLES RIV LABS INTL INC(CRL) | 0 | 100,000 | +100,000 | 0 | 15,173 | 0.57% | +15,173 |
| SOLID BIOSCIENCES INC | 11,906,646 | 11,906,646 | 0 | 44,055 | 57,985 | 2.18% | +13,931 |
| TRAVERE THERAPEUTICS INC(TVTX) | 0 | 834,252 | +834,252 | 0 | 12,347 | 0.46% | +12,347 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 0 | 270,000 | +270,000 | 0 | 9,817 | 0.37% | +9,817 |
| APOGEE THERAPEUTICS INC(APGE) | 1,122,767 | 1,182,148 | +59,381 | 41,947 | 51,341 | 1.93% | +9,394 |
| KYMERA THERAPEUTICS INC(KYMR) | 0 | 210,106 | +210,106 | 0 | 9,169 | 0.34% | +9,169 |
| NURIX THERAPEUTICS INC(NRIX) | 297,553 | 1,096,985 | +799,432 | 3,535 | 12,495 | 0.47% | +8,960 |
| PENUMBRA INC(PEN) | 0 | 32,797 | +32,797 | 0 | 8,417 | 0.32% | +8,417 |
| MERUS N V | 690,485 | 708,176 | +17,691 | 29,063 | 37,250 | 1.40% | +8,188 |
| IMMATICS N.V(IMTX) | 9,383,456 | 9,383,456 | 0 | 42,319 | 50,483 | 1.89% | +8,164 |
| SIONNA THERAPEUTICS INC(SION) | 1,251,101 | 1,216,045 | -35,056 | 13,087 | 21,098 | 0.79% | +8,012 |
| CRESCENT BIOPHARMA INC.(CBIO) | 0 | 453,686 | +453,686 | 0 | 7,322 | 0.27% | +7,322 |
| OUTSET MED INC(OM) | 833,333 | 833,333 | 0 | 9,217 | 16,008 | 0.60% | +6,792 |
| PROTAGONIST THERAPEUTICS INC | 1,091,271 | 1,074,448 | -16,823 | 52,774 | 59,385 | 2.23% | +6,611 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 0 | 1,438,595 | +1,438,595 | 0 | 5,754 | 0.22% | +5,754 |
| SEPTERNA INC(SEPN) | 0 | 541,450 | +541,450 | 0 | 5,723 | 0.21% | +5,723 |
| GLOBUS MED INC(GMED) | 0 | 88,500 | +88,500 | 0 | 5,223 | 0.20% | +5,223 |
| ENVVENO MEDICAL CORPORATION(NVNO) | 0 | 1,284,966 | +1,284,966 | 0 | 5,127 | 0.19% | +5,127 |
| ADAGIO MED HLDGS INC(ADGM) | 9,812,419 | 9,876,576 | +64,157 | 7,899 | 12,840 | 0.48% | +4,941 |
| INTUITIVE SURGICAL INC | 40,619 | 45,119 | +4,500 | 20,117 | 24,518 | 0.92% | +4,401 |
| REPLIGEN CORP(RGEN) | 129,801 | 166,000 | +36,199 | 16,516 | 20,647 | 0.77% | +4,131 |
| BETA BIONICS INC(BBNX) | 1,593,608 | 1,593,608 | 0 | 19,506 | 23,203 | 0.87% | +3,697 |
| LYRA THERAPEUTICS INC | 0 | 255,150 | +255,150 | 0 | 2,286 | 0.09% | +2,286 |
| RAPT THERAPEUTICS INC | 0 | 183,890 | +183,890 | 0 | 1,471 | 0.06% | +1,471 |
| TRINITY BIOTECH PLC(TRIB) | 0 | 1,790,000 | +1,790,000 | 0 | 1,164 | 0.04% | +1,164 |
| FORTE BIOSCIENCES INC(FBRX) | 0 | 68,192 | +68,192 | 0 | 882 | 0.03% | +882 |
| SCPHARMACEUTICALS INC | 500,000 | 500,000 | 0 | 1,315 | 1,905 | 0.07% | +590 |
| INSULET CORP(PODD) | 71,597 | 60,387 | -11,210 | 18,802 | 18,972 | 0.71% | +170 |
| APYX MEDICAL CORPORATION(APYX) | 150,000 | 150,000 | 0 | 206 | 338 | 0.01% | +132 |
| ASTRIA THERAPEUTICS INC | 6,485,420 | 6,485,420 | 0 | 34,632 | 34,762 | 1.30% | +130 |
| ATHIRA PHARMA INC | 5,402,964 | 5,402,964 | 0 | 1,539 | 1,632 | 0.06% | +92 |
| LEXEO THERAPEUTICS INC(LXEO) | 139,835 | 139,835 | 0 | 485 | 562 | 0.02% | +77 |
| REVOLUTION MEDICINES INC(RVMD) | 250,000 | 250,000 | 0 | 10 | 66 | 0.00% | +56 |
| SURROZEN INC(SRZN) | 166,666 | 166,666 | 0 | 5 | 3 | 0.00% | -2 |
| ENSYSCE BIOSCIENCES INC(ENSC) | 86,666 | 86,666 | 0 | 222 | 193 | 0.01% | -29 |
| OPUS GENETICS INC(IRD) | 4,325,000 | 4,325,000 | 0 | 4,246 | 4,075 | 0.15% | -172 |
| HELIX ACQUISITION CORP II | 398,000 | 398,000 | 0 | 4,497 | 4,227 | 0.16% | -271 |
| NANOBIOTIX(NBTX) | 105,053 | 0 | -105,053 | 376 | 0 | — | -376 |
| APPLIED THERAPEUTICS INC | 860,000 | 0 | -860,000 | 420 | 0 | — | -420 |
| CULLINAN THERAPEUTICS INC(CGEM) | 80,100 | 0 | -80,100 | 606 | 0 | — | -606 |
| BIODESIX INC(BDSX) | 2,173,880 | 2,173,880 | 0 | 1,359 | 613 | 0.02% | -746 |
| INHIBRX BIOSCIENCES INC(INBX) | 1,064,026 | 977,892 | -86,134 | 14,886 | 13,955 | 0.52% | -931 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 140,726 | 0 | -140,726 | 939 | 0 | — | -939 |
| TRAWS PHARMA INC(TRAW) | 421,781 | 0 | -421,781 | 970 | 0 | — | -970 |
| ANTERIS TECHNOLOGIES GLOBAL(AVR) | 2,140,000 | 1,705,130 | -434,870 | 7,790 | 6,462 | 0.24% | -1,327 |
| KALA BIO INC(KALA) | 277,610 | 55,227 | -222,383 | 1,591 | 263 | 0.01% | -1,328 |
| LYRA THERAPEUTICS INC | 12,757,562 | 0 | -12,757,562 | 1,607 | 0 | — | -1,607 |
| NAUTILUS BIOTECHNOLOGY INC(NAUT) | 12,594,211 | 12,594,211 | 0 | 10,844 | 9,131 | 0.34% | -1,713 |
| MEREO BIOPHARMA GROUP PLC(MREO) | 876,961 | 0 | -876,961 | 1,973 | 0 | — | -1,973 |
| CELCUITY INC(CELC) | 2,362,279 | 1,633,208 | -729,071 | 23,883 | 21,803 | 0.82% | -2,079 |
| VIKING THERAPEUTICS INC(VKTX) | 509,005 | 380,700 | -128,305 | 12,292 | 10,089 | 0.38% | -2,204 |
| INHIBIKASE THERAPEUTICS INC(IKT) | 5,925,000 | 5,432,293 | -492,707 | 12,976 | 10,593 | 0.40% | -2,383 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 659,662 | 447,507 | -212,155 | 8,892 | 6,256 | 0.23% | -2,636 |
| DYNE THERAPEUTICS INC(DYN) | 2,313,403 | 2,247,390 | -66,013 | 24,198 | 21,395 | 0.80% | -2,803 |
| MEIRAGTX HLDGS PLC(MGTX) | 12,581,103 | 12,626,103 | +45,000 | 85,255 | 82,231 | 3.09% | -3,024 |
| AVALO THERAPEUTICS INC(AVTX) | 520,000 | 139,667 | -380,333 | 4,165 | 697 | 0.03% | -3,468 |
| ADMA BIOLOGICS INC | 1,373,233 | 1,303,468 | -69,765 | 27,245 | 23,736 | 0.89% | -3,509 |
| AQUESTIVE THERAPEUTICS INC | 3,727,208 | 2,190,420 | -1,536,788 | 10,809 | 7,250 | 0.27% | -3,559 |
| ONKURE THERAPEUTICS INC(OKUR) | 1,004,439 | 0 | -1,004,439 | 4,319 | 0 | — | -4,319 |
| XENON PHARMACEUTICALS INC(XENE) | 325,324 | 200,791 | -124,533 | 10,915 | 6,285 | 0.24% | -4,630 |
| KESTRA MED TECHNOLOGIES LTD SHS | 200,000 | 0 | -200,000 | 4,984 | 0 | — | -4,984 |
| BRIGHT MINDS BIOSCIENCES INC(DRUG) | 444,649 | 420,690 | -23,959 | 16,038 | 10,984 | 0.41% | -5,054 |
| RAPT THERAPEUTICS INC | 4,418,947 | 0 | -4,418,947 | 5,391 | 0 | — | -5,391 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 980,894 | 752,921 | -227,973 | 37,146 | 31,660 | 1.19% | -5,486 |
| DELCATH SYS INC(DCTH) | 462,422 | 0 | -462,422 | 5,887 | 0 | — | -5,887 |
| ZYMEWORKS INC(ZYME) | 1,864,672 | 1,275,274 | -589,398 | 22,208 | 16,005 | 0.60% | -6,204 |
| OCULAR THERAPEUTIX INC(OCUL) | 915,775 | 0 | -915,775 | 6,713 | 0 | — | -6,713 |
| ADAPTIVE BIOTECHNOLOGIES COR(ADPT) | 930,972 | 0 | -930,972 | 6,917 | 0 | — | -6,917 |
| CONTINEUM THERAPEUTICS INC(CTNM) | 1,441,249 | 699,486 | -741,763 | 10,060 | 2,777 | 0.10% | -7,283 |
| ORCHESTRA BIOMED HLDGS INC(OBIO) | 4,592,556 | 4,592,556 | 0 | 19,656 | 12,308 | 0.46% | -7,348 |
| DISC MEDICINE INC(IRON) | 150,000 | 0 | -150,000 | 7,446 | 0 | — | -7,446 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 1,537,274 | 0 | -1,537,274 | 8,332 | 0 | — | -8,332 |
| CARGO THERAPEUTICS INC | 2,431,085 | 0 | -2,431,085 | 9,895 | 0 | — | -9,895 |
| ACRIVON THERAPEUTICS INC | 5,360,858 | 0 | -5,360,858 | 10,883 | 0 | — | -10,883 |
| NUVALENT INC | 1,633,968 | 1,375,180 | -258,788 | 115,881 | 104,926 | 3.94% | -10,955 |
| DEXCOM INC(DXCM) | 178,000 | 0 | -178,000 | 12,156 | 0 | — | -12,156 |
| IMMUNOVANT INC(IMVT) | 2,844,072 | 2,137,890 | -706,182 | 48,605 | 34,206 | 1.28% | -14,399 |
| SPYRE THERAPEUTICS INC(SYRE) | 2,313,272 | 1,529,445 | -783,827 | 37,325 | 22,896 | 0.86% | -14,429 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 46,500 | 0 | -46,500 | 15,402 | 0 | — | -15,402 |
| JANUX THERAPEUTICS INC(JANX) | 970,412 | 292,686 | -677,726 | 26,201 | 6,761 | 0.25% | -19,440 |
| AXSOME THERAPEUTICS INC(AXSM) | 355,107 | 198,534 | -156,573 | 41,416 | 20,725 | 0.78% | -20,691 |
| VAXCYTE INC(PCVX) | 706,567 | 0 | -706,567 | 26,680 | 0 | — | -26,680 |
| EVOLUS INC(EOLS) | 4,129,142 | 2,474,843 | -1,654,299 | 49,674 | 22,793 | 0.86% | -26,880 |
| CENTESSA PHARMACEUTICALS PLC | 3,040,395 | 1,146,935 | -1,893,460 | 43,721 | 15,071 | 0.57% | -28,650 |
| ARCELLX INC COMMON STOCK | 2,926,478 | 2,478,000 | -448,478 | 191,977 | 163,176 | 6.12% | -28,801 |
| ARGENX SE(ARGX) | 59,510 | 0 | -59,510 | 35,222 | 0 | — | -35,222 |
| ALDEYRA THERAPEUTICS INC(ALDX) | 9,275,851 | 4,051,631 | -5,224,220 | 53,336 | 15,518 | 0.58% | -37,818 |