Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q2 2024 ▲▼ | Q3 2024 ▲▼ | Change ▲▼ | Q2 2024 ▲▼ | Q3 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| VERONA PHARMA PLC | 2,433,725 | 6,315,933 | +3,882,208 | 35,192 | 181,709 | 3.90% | +146,518 |
| NUVALENT INC | 2,549,077 | 2,979,235 | +430,158 | 193,373 | 304,776 | 6.54% | +111,403 |
| ARCELLX INC COMMON STOCK | 3,889,739 | 3,888,669 | -1,070 | 214,675 | 324,743 | 6.97% | +110,068 |
| VAXCYTE INC(PCVX) | 1,862,608 | 2,027,608 | +165,000 | 140,646 | 231,695 | 4.97% | +91,049 |
| VIKING THERAPEUTICS INC(VKTX) | 721,377 | 1,699,987 | +978,610 | 38,240 | 107,626 | 2.31% | +69,386 |
| CENTESSA PHARMACEUTICALS PLC | 3,933,307 | 6,282,290 | +2,348,983 | 35,518 | 100,454 | 2.16% | +64,936 |
| ARGENX SE(ARGX) | 15,600 | 118,839 | +103,239 | 6,709 | 64,420 | 1.38% | +57,712 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 3,446,579 | 3,560,214 | +113,635 | 141,517 | 186,520 | 4.00% | +45,003 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 1,631,828 | 2,812,665 | +1,180,837 | 21,230 | 63,988 | 1.37% | +42,758 |
| IOVANCE BIOTHERAPEUTICS INC(IOVA) | 25,933,142 | 26,617,709 | +684,567 | 207,984 | 249,940 | 5.36% | +41,956 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 750,230 | 1,164,035 | +413,805 | 31,030 | 66,979 | 1.44% | +35,949 |
| APOGEE THERAPEUTICS INC(APGE) | 2,105,636 | 2,015,007 | -90,629 | 82,857 | 118,362 | 2.54% | +35,505 |
| AXSOME THERAPEUTICS INC(AXSM) | 459,111 | 782,844 | +323,733 | 36,958 | 70,354 | 1.51% | +33,396 |
| INSULET CORP(PODD) | 0 | 142,269 | +142,269 | 0 | 33,113 | 0.71% | +33,113 |
| SOLENO THERAPEUTICS INC | 3,204,976 | 3,204,976 | 0 | 130,763 | 161,819 | 3.47% | +31,056 |
| APPLIED THERAPEUTICS INC | 8,005,000 | 8,005,000 | 0 | 37,383 | 68,043 | 1.46% | +30,659 |
| ORUKA THERAPEUTICS INC(ORKA) | 0 | 1,235,187 | +1,235,187 | 0 | 30,274 | 0.65% | +30,274 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 1,856,417 | 2,330,294 | +473,877 | 33,434 | 62,196 | 1.33% | +28,761 |
| DYNE THERAPEUTICS INC(DYN) | 0 | 718,144 | +718,144 | 0 | 25,796 | 0.55% | +25,796 |
| ADAGIO MED HLDGS INC(ADGM) | 0 | 9,812,419 | +9,812,419 | 0 | 25,316 | 0.54% | +25,316 |
| EVOLUS INC(EOLS) | 5,753,798 | 5,356,622 | -397,176 | 62,429 | 86,777 | 1.86% | +24,349 |
| INSTIL BIO INC(TIL) | 0 | 345,545 | +345,545 | 0 | 23,262 | 0.50% | +23,262 |
| BIOHAVEN LTD(BHVN) | 1,485,232 | 1,485,232 | 0 | 51,552 | 74,217 | 1.59% | +22,665 |
| AMICUS THERAPEUTICS INC COM | 28,057,456 | 28,057,456 | 0 | 278,330 | 299,654 | 6.43% | +21,324 |
| ZENAS BIOPHARMA INC(ZBIO) | 0 | 1,144,035 | +1,144,035 | 0 | 19,357 | 0.42% | +19,357 |
| ALDEYRA THERAPEUTICS INC(ALDX) | 9,275,851 | 9,275,851 | 0 | 30,703 | 49,997 | 1.07% | +19,294 |
| PROTAGONIST THERAPEUTICS INC | 1,268,735 | 1,374,563 | +105,828 | 43,962 | 61,855 | 1.33% | +17,894 |
| IMMUNOVANT INC(IMVT) | 1,923,786 | 2,378,762 | +454,976 | 50,788 | 67,819 | 1.46% | +17,031 |
| AKERO THERAPEUTICS INC | 1,499,897 | 1,714,806 | +214,909 | 35,188 | 49,198 | 1.06% | +14,010 |
| SPYRE THERAPEUTICS INC(SYRE) | 3,031,018 | 2,872,547 | -158,471 | 71,259 | 84,482 | 1.81% | +13,222 |
| ZYMEWORKS INC(ZYME) | 1,667,711 | 2,180,020 | +512,309 | 14,192 | 27,359 | 0.59% | +13,167 |
| PROCEPT BIOROBOTICS CORP(PRCT) | 210,659 | 315,659 | +105,000 | 12,869 | 25,291 | 0.54% | +12,421 |
| ASTRIA THERAPEUTICS INC | 6,485,420 | 6,485,420 | 0 | 59,017 | 71,404 | 1.53% | +12,387 |
| XENCOR INC(XNCR) | 0 | 527,671 | +527,671 | 0 | 10,611 | 0.23% | +10,611 |
| ROIVANT SCIENCES LTD(ROIV) | 0 | 847,745 | +847,745 | 0 | 9,783 | 0.21% | +9,783 |
| SOLID BIOSCIENCES INC | 6,906,646 | 6,906,646 | 0 | 39,161 | 48,139 | 1.03% | +8,979 |
| EXACT SCIENCES CORP(EXK) | 0 | 125,000 | +125,000 | 0 | 8,515 | 0.18% | +8,515 |
| CARGO THERAPEUTICS INC | 3,683,004 | 3,683,004 | 0 | 60,475 | 67,951 | 1.46% | +7,476 |
| TARSUS PHARMACEUTICALS INC(TARS) | 1,296,416 | 1,296,416 | 0 | 35,237 | 42,639 | 0.91% | +7,403 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 0 | 2,125,649 | +2,125,649 | 0 | 6,887 | 0.15% | +6,887 |
| ACRIVON THERAPEUTICS INC | 5,360,858 | 5,360,858 | 0 | 31,093 | 37,526 | 0.81% | +6,433 |
| NAUTILUS BIOTECHNOLOGY INC(NAUT) | 12,594,211 | 12,594,211 | 0 | 29,470 | 35,894 | 0.77% | +6,423 |
| OCULAR THERAPEUTIX INC(OCUL) | 3,324,468 | 3,324,468 | 0 | 22,739 | 28,923 | 0.62% | +6,184 |
| MEIRAGTX HLDGS PLC(MGTX) | 11,331,103 | 12,581,103 | +1,250,000 | 47,668 | 52,430 | 1.12% | +4,762 |
| CG ONCOLOGY INC(CGON) | 733,695 | 733,695 | 0 | 23,163 | 27,682 | 0.59% | +4,520 |
| ICON PLC(ICLR) | 31,250 | 44,353 | +13,103 | 9,796 | 12,743 | 0.27% | +2,947 |
| ORCHESTRA BIOMED HLDGS INC(OBIO) | 2,545,881 | 4,592,556 | +2,046,675 | 20,749 | 23,606 | 0.51% | +2,857 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 640,274 | 1,037,274 | +397,000 | 5,570 | 8,288 | 0.18% | +2,717 |
| ARTIVION INC(AORT) | 2,793,703 | 2,793,703 | 0 | 71,658 | 74,368 | 1.60% | +2,710 |
| KYMERA THERAPEUTICS INC(KYMR) | 0 | 46,213 | +46,213 | 0 | 2,187 | 0.05% | +2,187 |
| ARRIVENT BIOPHARMA INC(AVBP) | 415,000 | 415,000 | 0 | 7,698 | 9,753 | 0.21% | +2,054 |
| PYXIS ONCOLOGY INC(PYXS) | 0 | 508,462 | +508,462 | 0 | 1,866 | 0.04% | +1,866 |
| INHIBRX BIOSCIENCES INC(INBX) | 1,064,026 | 1,064,026 | 0 | 15,077 | 16,663 | 0.36% | +1,585 |
| CONTINEUM THERAPEUTICS INC(CTNM) | 1,566,668 | 1,516,668 | -50,000 | 27,589 | 29,029 | 0.62% | +1,440 |
| ALLOGENE THERAPEUTICS INC | 2,725,000 | 2,725,000 | 0 | 6,349 | 7,630 | 0.16% | +1,281 |
| LEXEO THERAPEUTICS INC(LXEO) | 0 | 139,835 | +139,835 | 0 | 1,264 | 0.03% | +1,264 |
| INTRA-CELLULAR THERAPIES INC | 1,716,407 | 1,622,215 | -94,192 | 117,557 | 118,697 | 2.55% | +1,141 |
| INSMED INC(INSM) | 180,000 | 180,000 | 0 | 12,060 | 13,140 | 0.28% | +1,080 |
| INTUITIVE SURGICAL INC | 61,800 | 58,119 | -3,681 | 27,492 | 28,552 | 0.61% | +1,060 |
| BIODESIX INC(BDSX) | 2,173,880 | 2,173,880 | 0 | 3,326 | 3,870 | 0.08% | +543 |
| FORTE BIOSCIENCES INC(FBRX) | 0 | 95,742 | +95,742 | 0 | 535 | 0.01% | +535 |
| ABSCI CORPORATION | 700,000 | 700,000 | 0 | 2,156 | 2,674 | 0.06% | +518 |
| NANOBIOTIX(NBTX) | 555,066 | 555,066 | 0 | 2,775 | 3,192 | 0.07% | +416 |
| X4 PHARMACEUTICALS INC(XFOR) | 3,545,454 | 3,545,454 | 0 | 2,056 | 2,373 | 0.05% | +317 |
| SINGULAR GENOMICS SYSTEMS IN | 70,896 | 50,896 | -20,000 | 599 | 798 | 0.02% | +198 |
| STRUCTURE THERAPEUTICS INC | 34,852 | 34,852 | 0 | 1,369 | 1,530 | 0.03% | +161 |
| HELIX ACQUISITION CORP II | 500,000 | 500,000 | 0 | 5,110 | 5,225 | 0.11% | +115 |
| FATE THERAPEUTICS INC(FATE) | 345,575 | 345,575 | 0 | 1,133 | 1,210 | 0.03% | +76 |
| REVOLUTION MEDICINES INC(RVMD) | 250,000 | 250,000 | 0 | 26 | 35 | 0.00% | +9 |
| CAREMAX INC | 60,000 | 60,000 | 0 | 1 | 1 | 0.00% | -0 |
| SURROZEN INC(SRZN) | 166,666 | 166,666 | 0 | 3 | 2 | 0.00% | -1 |
| CAREMAX INC | 122,643 | 100,000 | -22,643 | 342 | 170 | 0.00% | -172 |
| AXOGEN INC(AXGN) | 30,421 | 0 | -30,421 | 220 | 0 | — | -220 |
| LYRA THERAPEUTICS INC | 12,757,562 | 12,757,562 | 0 | 3,534 | 3,279 | 0.07% | -255 |
| PRECISION BIOSCIENCES INC(DTIL) | 426,293 | 426,293 | 0 | 4,148 | 3,820 | 0.08% | -328 |
| VERU INC(VERU) | 7,063,277 | 7,283,157 | +219,880 | 5,942 | 5,601 | 0.12% | -342 |
| SYROS PHARMACEUTICALS INC | 116,754 | 116,754 | 0 | 602 | 251 | 0.01% | -351 |
| KYVERNA THERAPEUTICS INC(KYTX) | 150,000 | 150,000 | 0 | 1,125 | 734 | 0.02% | -391 |
| TACTILE SYS TECHNOLOGY INC(TCMD) | 62,639 | 0 | -62,639 | 748 | 0 | — | -748 |
| VBI VACCINES INC CDA | 1,261,710 | 0 | -1,261,710 | 833 | 0 | — | -833 |
| ENVVENO MEDICAL CORPORATION(NVNO) | 623,315 | 694,315 | +71,000 | 3,272 | 2,333 | 0.05% | -940 |
| EAGLE PHARMACEUTICALS INC | 173,365 | 0 | -173,365 | 971 | 0 | — | -971 |
| MEREO BIOPHARMA GROUP PLC(MREO) | 1,253,250 | 815,722 | -437,528 | 4,512 | 3,353 | 0.07% | -1,159 |
| REVANCE THERAPEUTICS INC | 600,000 | 0 | -600,000 | 1,542 | 0 | — | -1,542 |
| IMMATICS N.V(IMTX) | 8,086,159 | 8,086,159 | 0 | 93,961 | 92,263 | 1.98% | -1,698 |
| FORTE BIOSCIENCES INC | 3,265,359 | 0 | -3,265,359 | 1,753 | 0 | — | -1,753 |
| LIVANOVA PLC(LIVN) | 444,000 | 429,000 | -15,000 | 24,340 | 22,540 | 0.48% | -1,800 |
| TRINITY BIOTECH PLC(TRIB) | 1,800,000 | 1,800,000 | 0 | 3,834 | 1,980 | 0.04% | -1,854 |
| ARCUTIS BIOTHERAPEUTICS INC(ARQT) | 1,558,500 | 1,358,500 | -200,000 | 14,494 | 12,634 | 0.27% | -1,860 |
| ARVINAS INC(ARVN) | 1,027,749 | 1,027,749 | 0 | 27,359 | 25,313 | 0.54% | -2,045 |
| XENON PHARMACEUTICALS INC(XENE) | 583,256 | 524,930 | -58,326 | 22,741 | 20,666 | 0.44% | -2,075 |
| RAPPORT THERAPEUTICS INC(RAPP) | 748,183 | 748,183 | 0 | 17,403 | 15,323 | 0.33% | -2,080 |
| SPDR SER TR ST STR SP BIOT | 22,665 | 0 | -22,665 | 2,101 | 0 | — | -2,101 |
| IRHYTHM TECHNOLOGIES INC(IRTC) | 35,205 | 22,591 | -12,614 | 3,789 | 1,677 | 0.04% | -2,112 |
| MERUS N V | 300,000 | 300,000 | 0 | 17,751 | 14,988 | 0.32% | -2,763 |
| FOGHORN THERAPEUTICS INC(FHTX) | 544,000 | 0 | -544,000 | 3,128 | 0 | — | -3,128 |
| CELCUITY INC(CELC) | 2,362,279 | 2,362,279 | 0 | 38,694 | 35,222 | 0.76% | -3,473 |
| SKYE BIOSCIENCE INC(SKYE) | 500,000 | 0 | -500,000 | 4,005 | 0 | — | -4,005 |
| TYRA BIOSCIENCES INC(TYRA) | 1,007,367 | 511,226 | -496,141 | 16,108 | 12,019 | 0.26% | -4,089 |
| CABALETTA BIO INC(CABA) | 585,045 | 0 | -585,045 | 4,376 | 0 | — | -4,376 |