Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 2,418,299 | 2,438,969 | +20,670 | 152,812 | 288,391 | 8.33% | +135,578 |
| CELCUITY INC(CELC) | 1,633,208 | 2,956,319 | +1,323,111 | 21,803 | 146,042 | 4.22% | +124,239 |
| MERUS N V | 708,176 | 1,353,093 | +644,917 | 37,250 | 127,394 | 3.68% | +90,144 |
| TRAVERE THERAPEUTICS INC(TVTX) | 834,252 | 3,794,615 | +2,960,363 | 12,347 | 90,691 | 2.62% | +78,344 |
| ROIVANT SCIENCES LTD(ROIV) | 3,331,465 | 7,368,461 | +4,036,996 | 37,546 | 111,485 | 3.22% | +73,939 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 7,902,365 | 8,952,365 | +1,050,000 | 50,654 | 121,663 | 3.52% | +71,008 |
| CENTESSA PHARMACEUTICALS PLC | 1,146,935 | 3,100,902 | +1,953,967 | 15,071 | 75,197 | 2.17% | +60,126 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 752,921 | 1,564,554 | +811,633 | 31,660 | 82,921 | 2.40% | +51,261 |
| ASCENDIS PHARMA A/S(ASND) | 963,886 | 1,088,501 | +124,615 | 166,367 | 216,405 | 6.25% | +50,038 |
| PENUMBRA INC(PEN) | 32,797 | 220,547 | +187,750 | 8,417 | 55,869 | 1.61% | +47,452 |
| ARCELLX INC COMMON STOCK | 2,478,000 | 2,468,353 | -9,647 | 163,176 | 202,652 | 5.86% | +39,475 |
| INSMED INC(INSM) | 650,252 | 702,130 | +51,878 | 65,441 | 101,114 | 2.92% | +35,672 |
| ABIVAX SA(ABVX) | 0 | 388,608 | +388,608 | 0 | 32,993 | 0.95% | +32,993 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 255,050 | 450,050 | +195,000 | 32,057 | 63,178 | 1.83% | +31,121 |
| INHIBRX BIOSCIENCES INC(INBX) | 977,892 | 1,327,707 | +349,815 | 13,955 | 44,717 | 1.29% | +30,763 |
| NUVALENT INC | 1,375,180 | 1,562,336 | +187,156 | 104,926 | 135,111 | 3.90% | +30,185 |
| IMMATICS N.V(IMTX) | 9,383,456 | 9,383,456 | 0 | 50,483 | 79,947 | 2.31% | +29,464 |
| EXACT SCIENCES CORP(EXK) | 0 | 465,487 | +465,487 | 0 | 25,467 | 0.74% | +25,467 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 447,507 | 1,462,400 | +1,014,893 | 6,256 | 31,559 | 0.91% | +25,302 |
| PALVELLA THERAPEUTICS INC NE(PVLA) | 0 | 395,093 | +395,093 | 0 | 24,768 | 0.72% | +24,768 |
| ORUKA THERAPEUTICS INC(ORKA) | 0 | 1,268,021 | +1,268,021 | 0 | 24,384 | 0.70% | +24,384 |
| MEIRAGTX HLDGS PLC(MGTX) | 12,626,103 | 12,626,103 | 0 | 82,231 | 103,793 | 3.00% | +21,562 |
| IRHYTHM TECHNOLOGIES INC(IRTC) | 0 | 123,000 | +123,000 | 0 | 21,155 | 0.61% | +21,155 |
| ZYMEWORKS INC(ZYME) | 1,275,274 | 2,090,663 | +815,389 | 16,005 | 35,709 | 1.03% | +19,704 |
| BRIGHT MINDS BIOSCIENCES INC(DRUG) | 420,690 | 449,290 | +28,600 | 10,984 | 27,254 | 0.79% | +16,270 |
| REPLIGEN CORP(RGEN) | 166,000 | 270,428 | +104,428 | 20,647 | 36,148 | 1.04% | +15,501 |
| SOLID BIOSCIENCES INC | 11,906,646 | 11,833,539 | -73,107 | 57,985 | 73,013 | 2.11% | +15,028 |
| CYTOMX THERAPEUTICS INC(CTMX) | 6,993,646 | 9,680,185 | +2,686,539 | 15,876 | 30,880 | 0.89% | +15,004 |
| ENGENE HOLDINGS INC COM | 0 | 2,097,236 | +2,097,236 | 0 | 14,324 | 0.41% | +14,324 |
| AQUESTIVE THERAPEUTICS INC | 2,190,420 | 3,760,099 | +1,569,679 | 7,250 | 21,019 | 0.61% | +13,769 |
| SIONNA THERAPEUTICS INC(SION) | 1,216,045 | 1,179,098 | -36,947 | 21,098 | 34,677 | 1.00% | +13,579 |
| ASTRIA THERAPEUTICS INC | 6,485,420 | 6,485,420 | 0 | 34,762 | 47,214 | 1.36% | +12,452 |
| RAPPORT THERAPEUTICS INC(RAPP) | 0 | 403,923 | +403,923 | 0 | 11,997 | 0.35% | +11,997 |
| ALDEYRA THERAPEUTICS INC(ALDX) | 4,051,631 | 5,222,311 | +1,170,680 | 15,518 | 27,260 | 0.79% | +11,743 |
| KODIAK SCIENCES INC(KOD) | 0 | 634,577 | +634,577 | 0 | 10,388 | 0.30% | +10,388 |
| GOSSAMER BIO INC(GOSS) | 0 | 3,812,797 | +3,812,797 | 0 | 10,028 | 0.29% | +10,028 |
| PROTAGONIST THERAPEUTICS INC | 1,074,448 | 1,030,134 | -44,314 | 59,385 | 68,432 | 1.98% | +9,047 |
| CELCUITY INC(CELC) | 0 | 0 | 0 | 0 | 8,724 | 0.25% | +8,724 |
| OMADA HEALTH INC(OMDA) | 2,426,330 | 2,396,330 | -30,000 | 44,402 | 52,983 | 1.53% | +8,581 |
| AMICUS THERAPEUTICS INC COM | 7,412,830 | 6,370,851 | -1,041,979 | 42,476 | 50,202 | 1.45% | +7,727 |
| TEMPUS AI INC(TEM) | 0 | 85,000 | +85,000 | 0 | 6,860 | 0.20% | +6,860 |
| ADAGIO MED HLDGS INC(ADGM) | 9,876,576 | 9,876,576 | 0 | 12,840 | 19,161 | 0.55% | +6,321 |
| KRYSTAL BIOTECH INC(KRYS) | 0 | 35,000 | +35,000 | 0 | 6,179 | 0.18% | +6,179 |
| CONTINEUM THERAPEUTICS INC(CTNM) | 699,486 | 714,592 | +15,106 | 2,777 | 8,396 | 0.24% | +5,619 |
| AKERO THERAPEUTICS INC | 915,887 | 1,135,766 | +219,879 | 48,872 | 53,926 | 1.56% | +5,054 |
| HEARTFLOW INC(HTFL) | 0 | 150,000 | +150,000 | 0 | 5,049 | 0.15% | +5,049 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 1,438,595 | 1,438,595 | 0 | 5,754 | 10,602 | 0.31% | +4,848 |
| SEPTERNA INC(SEPN) | 541,450 | 541,450 | 0 | 5,723 | 10,185 | 0.29% | +4,462 |
| CARIS LIFE SCIENCES INC(CAI) | 1,098,163 | 1,098,163 | 0 | 29,343 | 33,219 | 0.96% | +3,877 |
| PEPGEN INC(PEPG) | 0 | 829,870 | +829,870 | 0 | 3,834 | 0.11% | +3,834 |
| BELITE BIO INC(BLTE) | 0 | 49,788 | +49,788 | 0 | 3,684 | 0.11% | +3,684 |
| RAPT THERAPEUTICS INC | 183,890 | 183,890 | 0 | 1,471 | 4,743 | 0.14% | +3,271 |
| OPUS GENETICS INC(IRD) | 4,325,000 | 4,325,000 | 0 | 4,075 | 7,136 | 0.21% | +3,062 |
| PYXIS ONCOLOGY INC(PYXS) | 0 | 1,178,307 | +1,178,307 | 0 | 2,616 | 0.08% | +2,616 |
| APOGEE THERAPEUTICS INC(APGE) | 1,182,148 | 1,351,989 | +169,841 | 51,341 | 53,715 | 1.55% | +2,374 |
| ATHIRA PHARMA INC(LONA) | 0 | 540,296 | +540,296 | 0 | 2,237 | 0.06% | +2,237 |
| XENON PHARMACEUTICALS INC(XENE) | 200,791 | 200,791 | 0 | 6,285 | 8,062 | 0.23% | +1,777 |
| NAUTILUS BIOTECHNOLOGY INC(NAUT) | 12,594,211 | 12,594,211 | 0 | 9,131 | 10,642 | 0.31% | +1,511 |
| SCPHARMACEUTICALS INC | 500,000 | 583,142 | +83,142 | 1,905 | 3,306 | 0.10% | +1,401 |
| ANTERIS TECHNOLOGIES GLOBAL(AVR) | 1,705,130 | 1,705,130 | 0 | 6,462 | 7,673 | 0.22% | +1,211 |
| UNIQURE NV(QURE) | 0 | 20,000 | +20,000 | 0 | 1,167 | 0.03% | +1,167 |
| AVALO THERAPEUTICS INC(AVTX) | 139,667 | 139,667 | 0 | 697 | 1,775 | 0.05% | +1,078 |
| BIODESIX(BDSX) | 0 | 108,694 | +108,694 | 0 | 821 | 0.02% | +821 |
| ORCHESTRA BIOMED HLDGS INC(OBIO) | 4,592,556 | 5,292,556 | +700,000 | 12,308 | 13,126 | 0.38% | +817 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 4,639,949 | 3,795,894 | -844,055 | 60,830 | 61,569 | 1.78% | +740 |
| TRINITY BIOTECH PLC(TRIB) | 1,790,000 | 1,790,000 | 0 | 1,164 | 1,862 | 0.05% | +698 |
| ALTO NEUROSCIENCE INC(ANRO) | 0 | 155,366 | +155,366 | 0 | 625 | 0.02% | +625 |
| NURIX THERAPEUTICS INC(NRIX) | 1,096,985 | 1,416,149 | +319,164 | 12,495 | 13,085 | 0.38% | +591 |
| KYMERA THERAPEUTICS INC(KYMR) | 210,106 | 169,796 | -40,310 | 9,169 | 9,610 | 0.28% | +441 |
| JANUX THERAPEUTICS INC(JANX) | 292,686 | 292,686 | 0 | 6,761 | 7,153 | 0.21% | +392 |
| LEXEO THERAPEUTICS INC(LXEO) | 139,835 | 139,835 | 0 | 562 | 929 | 0.03% | +366 |
| BOSTON SCIENTIFIC CORP(BSX) | 280,000 | 310,000 | +30,000 | 30,075 | 30,265 | 0.87% | +191 |
| ENSYSCE BIOSCIENCES INC(ENSC) | 86,666 | 86,666 | 0 | 193 | 205 | 0.01% | +12 |
| REVOLUTION MEDICINES INC(RVMD) | 250,000 | 250,000 | 0 | 66 | 75 | 0.00% | +9 |
| SURROZEN INC(SRZN) | 166,666 | 166,666 | 0 | 3 | 3 | 0.00% | -0 |
| APYX MEDICAL CORPORATION(APYX) | 150,000 | 150,000 | 0 | 338 | 321 | 0.01% | -16 |
| KALA BIO INC(KALA) | 55,227 | 0 | -55,227 | 263 | 0 | — | -263 |
| BIODESIX INC(BDSX) | 2,173,880 | 0 | -2,173,880 | 613 | 0 | — | -613 |
| LYRA THERAPEUTICS INC | 255,150 | 229,382 | -25,768 | 2,286 | 1,498 | 0.04% | -788 |
| FORTE BIOSCIENCES INC(FBRX) | 68,192 | 0 | -68,192 | 882 | 0 | — | -882 |
| INTUITIVE SURGICAL INC | 45,119 | 52,119 | +7,000 | 24,518 | 23,309 | 0.67% | -1,209 |
| ARTIVION INC(AORT) | 2,793,703 | 2,020,000 | -773,703 | 86,884 | 85,527 | 2.47% | -1,357 |
| ATHIRA PHARMA INC | 5,402,964 | 0 | -5,402,964 | 1,632 | 0 | — | -1,632 |
| INHIBIKASE THERAPEUTICS INC(IKT) | 5,432,293 | 5,421,568 | -10,725 | 10,593 | 8,783 | 0.25% | -1,810 |
| CRESCENT BIOPHARMA INC.(CBIO) | 453,686 | 453,686 | 0 | 7,322 | 5,394 | 0.16% | -1,928 |
| SPYRE THERAPEUTICS INC(SYRE) | 1,529,445 | 1,229,445 | -300,000 | 22,896 | 20,605 | 0.60% | -2,290 |
| AXSOME THERAPEUTICS INC(AXSM) | 198,534 | 148,900 | -49,634 | 20,725 | 18,084 | 0.52% | -2,641 |
| ENVVENO MEDICAL CORPORATION(NVNO) | 1,284,966 | 1,759,035 | +474,069 | 5,127 | 1,594 | 0.05% | -3,533 |
| HELIX ACQUISITION CORP II | 398,000 | 0 | -398,000 | 4,227 | 0 | — | -4,227 |
| OUTSET MED INC(OM) | 833,333 | 833,333 | 0 | 16,008 | 11,767 | 0.34% | -4,242 |
| GLOBUS MED INC(GMED) | 88,500 | 0 | -88,500 | 5,223 | 0 | — | -5,223 |
| ADMA BIOLOGICS INC | 1,303,468 | 1,153,468 | -150,000 | 23,736 | 16,910 | 0.49% | -6,826 |
| VIKING THERAPEUTICS INC(VKTX) | 380,700 | 105,597 | -275,103 | 10,089 | 2,775 | 0.08% | -7,313 |
| IMMUNOVANT INC(IMVT) | 2,137,890 | 1,587,890 | -550,000 | 34,206 | 25,597 | 0.74% | -8,609 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 270,000 | 0 | -270,000 | 9,817 | 0 | — | -9,817 |
| DYNE THERAPEUTICS INC(DYN) | 2,247,390 | 540,444 | -1,706,946 | 21,395 | 6,837 | 0.20% | -14,559 |
| CHARLES RIV LABS INTL INC(CRL) | 100,000 | 0 | -100,000 | 15,173 | 0 | — | -15,173 |
| BETA BIONICS INC(BBNX) | 1,593,608 | 277,944 | -1,315,664 | 23,203 | 5,523 | 0.16% | -17,680 |
| INSULET CORP(PODD) | 60,387 | 0 | -60,387 | 18,972 | 0 | — | -18,972 |
| EVOLUS INC(EOLS) | 2,474,843 | 0 | -2,474,843 | 22,793 | 0 | — | -22,793 |