Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 2,418,299 | 2,438,969 | +20,670 | $152.81M | $288.39M | 8.33% | +$135.58M |
| Ascendis Pharma A/SADR(ASND) | 963,886 | 1,088,501 | +124,615 | $166.37M | $216.40M | 6.25% | +$50.04M |
| Arcellx Inc COMMON STOCK | 2,478,000 | 2,468,353 | -9,647 | $163.18M | $202.65M | 5.86% | +$39.48M |
| Celcuity Inc.(CELC) | 1,633,208 | 2,956,319 | +1,323,111 | $21.80M | $146.04M | 4.22% | +$124.24M |
| Nuvalent Inc | 1,375,180 | 1,562,336 | +187,156 | $104.93M | $135.11M | 3.90% | +$30.18M |
| Merus N V | 708,176 | 1,353,093 | +644,917 | $37.25M | $127.39M | 3.68% | +$90.14M |
| Amylyx Pharmaceuticals, Inc.(AMLX) | 7,902,365 | 8,952,365 | +1,050,000 | $50.65M | $121.66M | 3.52% | +$71.01M |
| Roivant Sciences Ltd.SHS(ROIV) | 3,331,465 | 7,368,461 | +4,036,996 | $37.55M | $111.48M | 3.22% | +$73.94M |
| MeiraGTx Holdings plc(MGTX) | 12,626,103 | 12,626,103 | 0 | $82.23M | $103.79M | 3.00% | +$21.56M |
| Insmed Incorporated(INSM) | 650,252 | 702,130 | +51,878 | $65.44M | $101.11M | 2.92% | +$35.67M |
| Travere Therapeutics, Inc.(TVTX) | 834,252 | 3,794,615 | +2,960,363 | $12.35M | $90.69M | 2.62% | +$78.34M |
| Artivion, Inc.(AORT) | 2,793,703 | 2,020,000 | -773,703 | $86.88M | $85.53M | 2.47% | -$1.36M |
| Praxis Precision Medicines, Inc.(PRAX) | 752,921 | 1,564,554 | +811,633 | $31.66M | $82.92M | 2.40% | +$51.26M |
| Immatics N.V.SHS(IMTX) | 9,383,456 | 9,383,456 | 0 | $50.48M | $79.95M | 2.31% | +$29.46M |
| Centessa Pharmaceuticals PlcADS | 1,146,935 | 3,100,902 | +1,953,967 | $15.07M | $75.20M | 2.17% | +$60.13M |
| Solid Biosciences Inc | 11,906,646 | 11,833,539 | -73,107 | $57.99M | $73.01M | 2.11% | +$15.03M |
| Protagonist Therapeutics Inc | 1,074,448 | 1,030,134 | -44,314 | $59.38M | $68.43M | 1.98% | +$9.05M |
| Neurocrine Biosciences, Inc.(NBIX) | 255,050 | 450,050 | +195,000 | $32.06M | $63.18M | 1.83% | +$31.12M |
| Edgewise Therapeutics, Inc.(EWTX) | 4,639,949 | 3,795,894 | -844,055 | $60.83M | $61.57M | 1.78% | +$739.7K |
| Verona Pharma PlcADS | 5,507,591 | 524,088 | -4,983,503 | $520.91M | $55.93M | 1.62% | -$464.98M |
| Penumbra, Inc.(PEN) | 32,797 | 220,547 | +187,750 | $8.42M | $55.87M | 1.61% | +$47.45M |
| Akero Therapeutics Inc | 915,887 | 1,135,766 | +219,879 | $48.87M | $53.93M | 1.56% | +$5.05M |
| Apogee Therapeutics Inc | 1,182,148 | 1,351,989 | +169,841 | $51.34M | $53.71M | 1.55% | +$2.37M |
| Omada Health, Inc.(OMDA) | 2,426,330 | 2,396,330 | -30,000 | $44.40M | $52.98M | 1.53% | +$8.58M |
| Amicus Therapeutics Inc COM | 7,412,830 | 6,370,851 | -1,041,979 | $42.48M | $50.20M | 1.45% | +$7.73M |
| Astria Therapeutics Inc | 6,485,420 | 6,485,420 | 0 | $34.76M | $47.21M | 1.36% | +$12.45M |
| Inhibrx Biosciences, Inc.(INBX) | 977,892 | 1,327,707 | +349,815 | $13.95M | $44.72M | 1.29% | +$30.76M |
| Repligen Corporation(RGEN) | 166,000 | 270,428 | +104,428 | $20.65M | $36.15M | 1.04% | +$15.50M |
| Zymeworks Inc.(ZYME) | 1,275,274 | 2,090,663 | +815,389 | $16.00M | $35.71M | 1.03% | +$19.70M |
| Sionna Therapeutics, Inc.(SION) | 1,216,045 | 1,179,098 | -36,947 | $21.10M | $34.68M | 1.00% | +$13.58M |
| Caris Life Sciences, Inc.(CAI) | 1,098,163 | 1,098,163 | 0 | $29.34M | $33.22M | 0.96% | +$3.88M |
| ABIVAX Société AnonymeADS(ABVX) | 0 | 388,608 | +388,608 | $0 | $32.99M | 0.95% | +$32.99M |
| Viridian Therapeutics, Inc.(VRDN) | 447,507 | 1,462,400 | +1,014,893 | $6.26M | $31.56M | 0.91% | +$25.30M |
| CytomX Therapeutics, Inc.(CTMX) | 6,993,646 | 9,680,185 | +2,686,539 | $15.88M | $30.88M | 0.89% | +$15.00M |
| Boston Scientific Corporation(BSX) | 280,000 | 310,000 | +30,000 | $30.07M | $30.27M | 0.87% | +$190.5K |
| Aldeyra Therapeutics, Inc.(ALDX) | 4,051,631 | 5,222,311 | +1,170,680 | $15.52M | $27.26M | 0.79% | +$11.74M |
| Bright Minds Biosciences Inc.(DRUG) | 420,690 | 449,290 | +28,600 | $10.98M | $27.25M | 0.79% | +$16.27M |
| Immunovant, Inc.(IMVT) | 2,137,890 | 1,587,890 | -550,000 | $34.21M | $25.60M | 0.74% | -$8.61M |
| Endeavour Silver Corp.(EXK) | 0 | 465,487 | +465,487 | $0 | $25.47M | 0.74% | +$25.47M |
| Palvella Therapeutics, Inc.(PVLA) | 0 | 395,093 | +395,093 | $0 | $24.77M | 0.72% | +$24.77M |
| Oruka Therapeutics, Inc.(ORKA) | 0 | 1,268,021 | +1,268,021 | $0 | $24.38M | 0.70% | +$24.38M |
| Intuitive Surgical, Inc.(ISRG) | 45,119 | 52,119 | +7,000 | $24.52M | $23.31M | 0.67% | -$1.21M |
| iRhythm Holdings, Inc.(IRTC) | 0 | 123,000 | +123,000 | $0 | $21.15M | 0.61% | +$21.15M |
| Aquestive Therapeutics Inc | 2,190,420 | 3,760,099 | +1,569,679 | $7.25M | $21.02M | 0.61% | +$13.77M |
| Spyre Therapeutics, Inc.(SYRE) | 1,529,445 | 1,229,445 | -300,000 | $22.90M | $20.61M | 0.60% | -$2.29M |
| Adagio Medical Holdings, Inc.(ADGM) | 9,876,576 | 9,876,576 | 0 | $12.84M | $19.16M | 0.55% | +$6.32M |
| Axsome Therapeutics, Inc.(AXSM) | 198,534 | 148,900 | -49,634 | $20.72M | $18.08M | 0.52% | -$2.64M |
| Adma Biologics Inc | 1,303,468 | 1,153,468 | -150,000 | $23.74M | $16.91M | 0.49% | -$6.83M |
| Engene Holdings Inc COM | 0 | 2,097,236 | +2,097,236 | $0 | $14.32M | 0.41% | +$14.32M |
| Orchestra BioMed Holdings, Inc.(OBIO) | 4,592,556 | 5,292,556 | +700,000 | $12.31M | $13.13M | 0.38% | +$817.5K |
| Nurix Therapeutics, Inc.(NRIX) | 1,096,985 | 1,416,149 | +319,164 | $12.49M | $13.09M | 0.38% | +$590.6K |
| Rapport Therapeutics, Inc.(RAPP) | 0 | 403,923 | +403,923 | $0 | $12.00M | 0.35% | +$12.00M |
| Outset Medical, Inc.(OM) | 833,333 | 833,333 | 0 | $16.01M | $11.77M | 0.34% | -$4.24M |
| Nautilus Biotechnology, Inc.(NAUT) | 12,594,211 | 12,594,211 | 0 | $9.13M | $10.64M | 0.31% | +$1.51M |
| Corvus Pharmaceuticals, Inc.(CRVS) | 1,438,595 | 1,438,595 | 0 | $5.75M | $10.60M | 0.31% | +$4.85M |
| Kodiak Sciences Inc.(KOD) | 0 | 634,577 | +634,577 | $0 | $10.39M | 0.30% | +$10.39M |
| Septerna, Inc.(SEPN) | 541,450 | 541,450 | 0 | $5.72M | $10.18M | 0.29% | +$4.46M |
| Gossamer Bio, Inc.(GOSS) | 0 | 3,812,797 | +3,812,797 | $0 | $10.03M | 0.29% | +$10.03M |
| Kymera Therapeutics, Inc.(KYMR) | 210,106 | 169,796 | -40,310 | $9.17M | $9.61M | 0.28% | +$441.4K |
| Inhibikase Therapeutics, Inc.(IKT) | 5,432,293 | 5,421,568 | -10,725 | $10.59M | $8.78M | 0.25% | -$1.81M |
| Celcuity Inc.NOTE 2 750 8 0(CELC) | 0 | 0 | 0 | $0 | $8.72M | 0.25% | +$8.72M |
| Contineum Therapeutics, Inc.CL A(CTNM) | 699,486 | 714,592 | +15,106 | $2.78M | $8.40M | 0.24% | +$5.62M |
| Xenon Pharmaceuticals Inc.(XENE) | 200,791 | 200,791 | 0 | $6.28M | $8.06M | 0.23% | +$1.78M |
| Anteris Technologies Global Corp.(AVR) | 1,705,130 | 1,705,130 | 0 | $6.46M | $7.67M | 0.22% | +$1.21M |
| Janux Therapeutics, Inc.(JANX) | 292,686 | 292,686 | 0 | $6.76M | $7.15M | 0.21% | +$392.2K |
| Opus Genetics, Inc.(IRD) | 4,325,000 | 4,325,000 | 0 | $4.07M | $7.14M | 0.21% | +$3.06M |
| Tempus AI, Inc.CL A(TEM) | 0 | 85,000 | +85,000 | $0 | $6.86M | 0.20% | +$6.86M |
| Dyne Therapeutics, Inc.(DYN) | 2,247,390 | 540,444 | -1,706,946 | $21.40M | $6.84M | 0.20% | -$14.56M |
| Krystal Biotech, Inc.(KRYS) | 0 | 35,000 | +35,000 | $0 | $6.18M | 0.18% | +$6.18M |
| Beta Bionics, Inc.(BBNX) | 1,593,608 | 277,944 | -1,315,664 | $23.20M | $5.52M | 0.16% | -$17.68M |
| Crescent Biopharma, Inc.(CBIO) | 453,686 | 453,686 | 0 | $7.32M | $5.39M | 0.16% | -$1.93M |
| Heartflow, Inc.(HTFL) | 0 | 150,000 | +150,000 | $0 | $5.05M | 0.15% | +$5.05M |
| Rapt Therapeutics Inc | 183,890 | 183,890 | 0 | $1.47M | $4.74M | 0.14% | +$3.27M |
| PepGen Inc.(PEPG) | 0 | 829,870 | +829,870 | $0 | $3.83M | 0.11% | +$3.83M |
| Belite Bio, IncADS(BLTE) | 0 | 49,788 | +49,788 | $0 | $3.68M | 0.11% | +$3.68M |
| Scpharmaceuticals Inc | 500,000 | 583,142 | +83,142 | $1.91M | $3.31M | 0.10% | +$1.40M |
| Viking Therapeutics, Inc.(VKTX) | 380,700 | 105,597 | -275,103 | $10.09M | $2.78M | 0.08% | -$7.31M |
| Pyxis Oncology, Inc.(PYXS) | 0 | 1,178,307 | +1,178,307 | $0 | $2.62M | 0.08% | +$2.62M |
| LeonaBio, Inc.(LONA) | 0 | 540,296 | +540,296 | $0 | $2.24M | 0.06% | +$2.24M |
| Trinity Biotech plcADR(TRIB) | 1,790,000 | 1,790,000 | 0 | $1.16M | $1.86M | 0.05% | +$698.1K |
| Avalo Therapeutics, Inc.(AVTX) | 139,667 | 139,667 | 0 | $696.9K | $1.78M | 0.05% | +$1.08M |
| enVVeno Medical Corporation(NVNO) | 1,284,966 | 1,759,035 | +474,069 | $5.13M | $1.59M | 0.05% | -$3.53M |
| Lyra Therapeutics Inc | 255,150 | 229,382 | -25,768 | $2.29M | $1.50M | 0.04% | -$788.3K |
| uniQure N.V.SHS(QURE) | 0 | 20,000 | +20,000 | $0 | $1.17M | 0.03% | +$1.17M |
| Lexeo Therapeutics, Inc.(LXEO) | 139,835 | 139,835 | 0 | $562.1K | $928.5K | 0.03% | +$366.4K |
| Biodesix, Inc.(BDSX) | 0 | 108,694 | +108,694 | $0 | $820.6K | 0.02% | +$820.6K |
| Alto Neuroscience, Inc.(ANRO) | 0 | 155,366 | +155,366 | $0 | $624.6K | 0.02% | +$624.6K |
| Apyx Medical Corporation(APYX) | 150,000 | 150,000 | 0 | $337.5K | $321.0K | 0.01% | -$16.5K |
| Ensysce Biosciences, Inc.(ENSC) | 86,666 | 86,666 | 0 | $193.3K | $205.4K | 0.01% | +$12.1K |
| Revolution Medicines, Inc.W EXP 12 17 202(RVMD) | 250,000 | 250,000 | 0 | $65.7K | $75.0K | 0.00% | +$9.3K |
| Surrozen, Inc.W EXP 08 01 203(SRZN) | 166,666 | 166,666 | 0 | $3.0K | $3.0K | 0.00% | -$50 |
| Athira Pharma Inc | 5,402,964 | 0 | -5,402,964 | $1.63M | $0 | — | -$1.63M |
| Biodesix, Inc.(BDSX) | 2,173,880 | 0 | -2,173,880 | $613.0K | $0 | — | -$613.0K |
| Charles River Laboratories International, Inc.(CRL) | 100,000 | 0 | -100,000 | $15.17M | $0 | — | -$15.17M |
| Evolus, Inc.(EOLS) | 2,474,843 | 0 | -2,474,843 | $22.79M | $0 | — | -$22.79M |
| Forte Biosciences Inc | 68,192 | 0 | -68,192 | $881.7K | $0 | — | -$881.7K |
| Globus Medical, Inc.CL A(GMED) | 88,500 | 0 | -88,500 | $5.22M | $0 | — | -$5.22M |
| Helix Acquisition Corp IiCL A | 398,000 | 0 | -398,000 | $4.23M | $0 | — | -$4.23M |
| Insulet Corporation(PODD) | 60,387 | 0 | -60,387 | $18.97M | $0 | — | -$18.97M |
| KALA BIO, Inc.(KALA) | 55,227 | 0 | -55,227 | $262.9K | $0 | — | -$262.9K |