Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2023 ▲▼ | Q4 2023 ▲▼ | Change ▲▼ | Q3 2023 ▲▼ | Q4 2023 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| CEREVEL THERAPEUTICS HLDNG I | 10,088,385 | 10,965,193 | +876,808 | 220,229 | 464,924 | 10.39% | +244,695 |
| LIANBIO(LIANY) | 57,558,451 | 57,558,451 | 0 | 85,762 | 257,256 | 5.75% | +171,494 |
| ARCELLX INC COMMON STOCK | 3,965,978 | 4,544,809 | +578,831 | 142,299 | 252,237 | 5.64% | +109,938 |
| NUVALENT INC | 2,463,451 | 2,917,991 | +454,540 | 113,245 | 214,735 | 4.80% | +101,490 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 380,828 | 2,154,110 | +1,773,282 | 8,730 | 99,024 | 2.21% | +90,294 |
| INHIBRX INC | 4,256,104 | 4,256,104 | 0 | 78,100 | 161,732 | 3.62% | +83,632 |
| CARGO THERAPEUTICS INC | 0 | 3,436,600 | +3,436,600 | 0 | 79,557 | 1.78% | +79,557 |
| AMICUS THERAPEUTICS INC COM | 27,692,917 | 28,057,456 | +364,539 | 336,746 | 398,135 | 8.90% | +61,389 |
| SPYRE THERAPEUTICS INC(SYRE) | 81,116 | 2,606,679 | +2,525,563 | 994 | 56,096 | 1.25% | +55,102 |
| BIOHAVEN LTD(BHVN) | 751,820 | 1,725,047 | +973,227 | 19,555 | 73,832 | 1.65% | +54,277 |
| AXSOME THERAPEUTICS INC(AXSM) | 481,649 | 1,038,019 | +556,370 | 33,662 | 82,616 | 1.85% | +48,953 |
| NATERA INC(NTRA) | 218,178 | 850,225 | +632,047 | 9,654 | 53,258 | 1.19% | +43,604 |
| IOVANCE BIOTHERAPEUTICS INC(IOVA) | 11,962,938 | 11,979,415 | +16,477 | 54,431 | 97,393 | 2.18% | +42,961 |
| ABBVIE INC(ABBV) | 0 | 238,000 | +238,000 | 0 | 36,883 | 0.82% | +36,883 |
| SPRINGWORKS THERAPEUTICS INC | 1,520,416 | 1,957,246 | +436,830 | 35,152 | 71,439 | 1.60% | +36,287 |
| CYMABAY THERAPEUTICS INC | 4,043,191 | 4,024,400 | -18,791 | 60,284 | 95,056 | 2.12% | +34,772 |
| MEDTRONIC PLC(MDT) | 587,000 | 976,652 | +389,652 | 45,997 | 80,457 | 1.80% | +34,459 |
| SOLENO THERAPEUTICS INC | 3,074,542 | 3,074,542 | 0 | 90,730 | 123,750 | 2.77% | +33,021 |
| VERRICA PHARMACEUTICALS INC(VRCA) | 5,038,983 | 7,099,182 | +2,060,199 | 19,576 | 51,966 | 1.16% | +32,390 |
| XENON PHARMACEUTICALS INC(XENE) | 617,500 | 1,100,748 | +483,248 | 21,094 | 50,700 | 1.13% | +29,607 |
| RAYZEBIO INC | 776,805 | 744,056 | -32,749 | 17,245 | 46,258 | 1.03% | +29,013 |
| CABALETTA BIO INC(CABA) | 1,132,491 | 2,003,058 | +870,567 | 17,237 | 45,469 | 1.02% | +28,233 |
| EVOLUS INC(EOLS) | 1,485,801 | 3,963,424 | +2,477,623 | 13,580 | 41,735 | 0.93% | +28,155 |
| BRIDGEBIO PHARMA INC(BBIO) | 1,748,933 | 1,748,933 | 0 | 46,119 | 70,604 | 1.58% | +24,485 |
| MEIRAGTX HLDGS PLC(MGTX) | 11,331,103 | 11,331,103 | 0 | 55,636 | 79,544 | 1.78% | +23,909 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 1,011,205 | 1,730,212 | +719,007 | 15,512 | 37,684 | 0.84% | +22,172 |
| CELCUITY INC(CELC) | 0 | 1,481,300 | +1,481,300 | 0 | 21,583 | 0.48% | +21,583 |
| SAREPTA THERAPEUTICS INC(SRPT) | 182,720 | 451,873 | +269,153 | 22,149 | 43,574 | 0.97% | +21,425 |
| RAPT THERAPEUTICS INC | 1,920,658 | 2,139,950 | +219,292 | 31,921 | 53,178 | 1.19% | +21,256 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 1,517,467 | 1,707,398 | +189,931 | 31,093 | 51,171 | 1.14% | +20,078 |
| FUSION PHARMACEUTICALS INC | 2,751,395 | 2,751,395 | 0 | 7,154 | 26,441 | 0.59% | +19,287 |
| INTUITIVE SURGICAL INC | 0 | 55,000 | +55,000 | 0 | 18,555 | 0.41% | +18,555 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 159,242 | 270,794 | +111,552 | 17,915 | 35,680 | 0.80% | +17,765 |
| DISC MEDICINE INC(IRON) | 895,641 | 1,023,045 | +127,404 | 42,077 | 59,091 | 1.32% | +17,014 |
| LYRA THERAPEUTICS INC | 12,757,562 | 12,757,562 | 0 | 49,882 | 66,850 | 1.49% | +16,968 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 124,637 | 151,151 | +26,514 | 18,202 | 34,973 | 0.78% | +16,771 |
| ASCENDIS PHARMAA/S(ASND) | 0 | 132,176 | +132,176 | 0 | 16,648 | 0.37% | +16,648 |
| ARVINAS INC(ARVN) | 0 | 354,082 | +354,082 | 0 | 14,574 | 0.33% | +14,574 |
| ASTRIA THERAPEUTICS INC | 2,189,462 | 4,004,070 | +1,814,608 | 16,333 | 30,751 | 0.69% | +14,418 |
| APPLIED THERAPEUTICS INC | 0 | 4,080,249 | +4,080,249 | 0 | 13,669 | 0.31% | +13,669 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 0 | 589,646 | +589,646 | 0 | 13,627 | 0.30% | +13,627 |
| SOLID BIOSCIENCES INC | 3,495,933 | 3,495,933 | 0 | 8,810 | 21,465 | 0.48% | +12,655 |
| APOGEE THERAPEUTICS INC(APGE) | 1,827,901 | 1,827,901 | 0 | 38,934 | 51,072 | 1.14% | +12,137 |
| AUTOLUS THERAPEUTICS PLC(AUTL) | 0 | 1,831,167 | +1,831,167 | 0 | 11,793 | 0.26% | +11,793 |
| VERONA PHARMA PLC | 4,007,197 | 3,866,214 | -140,983 | 65,317 | 76,860 | 1.72% | +11,543 |
| NAUTILUS BIOTECHNOLOGY INC(NAUT) | 9,111,151 | 12,594,211 | +3,483,060 | 28,791 | 37,657 | 0.84% | +8,865 |
| INTRA-CELLULAR THERAPIES INC | 0 | 108,000 | +108,000 | 0 | 7,735 | 0.17% | +7,735 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 0 | 539,831 | +539,831 | 0 | 7,574 | 0.17% | +7,574 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 1,263,732 | 1,255,512 | -8,220 | 37,583 | 44,671 | 1.00% | +7,088 |
| REGENXBIO INC(RGNX) | 0 | 342,408 | +342,408 | 0 | 6,146 | 0.14% | +6,146 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 0 | 555,555 | +555,555 | 0 | 6,078 | 0.14% | +6,078 |
| MACROGENICS INC(MGNX) | 0 | 611,932 | +611,932 | 0 | 5,887 | 0.13% | +5,887 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 0 | 82,398 | +82,398 | 0 | 4,976 | 0.11% | +4,976 |
| ADMA BIOLOGICS INC | 6,984,319 | 6,433,369 | -550,950 | 25,004 | 29,079 | 0.65% | +4,075 |
| ATHIRA PHARMA INC | 4,797,278 | 5,402,964 | +605,686 | 9,691 | 13,129 | 0.29% | +3,439 |
| VERU INC(VERU) | 1,089,878 | 5,584,699 | +4,494,821 | 784 | 4,021 | 0.09% | +3,237 |
| TARSUS PHARMACEUTICALS(TARS) | 1,296,416 | 1,296,416 | 0 | 23,037 | 26,252 | 0.59% | +3,215 |
| ACADIA PHARMACEUTICALS INC | 0 | 101,000 | +101,000 | 0 | 3,162 | 0.07% | +3,162 |
| ARTIVION INC(AORT) | 931,352 | 931,352 | 0 | 14,119 | 16,653 | 0.37% | +2,533 |
| CYTOKINETICS INC(CYTK) | 0 | 30,317 | +30,317 | 0 | 2,531 | 0.06% | +2,531 |
| ZYMEWORKS INC(ZYME) | 1,446,123 | 1,074,807 | -371,316 | 9,168 | 11,167 | 0.25% | +1,999 |
| MORPHIC HLDGS INC | 0 | 56,980 | +56,980 | 0 | 1,646 | 0.04% | +1,646 |
| TERNS PHARMACEUTICALS INC | 1,075,000 | 1,075,000 | 0 | 5,407 | 6,977 | 0.16% | +1,570 |
| AXOGEN INC(AXGN) | 875,898 | 808,380 | -67,518 | 4,379 | 5,521 | 0.12% | +1,142 |
| AMBRX BIOPHARMA INC | 0 | 78,811 | +78,811 | 0 | 1,122 | 0.03% | +1,122 |
| ORCHESTRA BIOMED HLDGS INC(OBIO) | 2,432,089 | 2,432,089 | 0 | 21,208 | 22,205 | 0.50% | +997 |
| FORTE BIOSCIENCES INC | 3,265,359 | 3,265,359 | 0 | 2,162 | 2,683 | 0.06% | +521 |
| BIOATLA INC(BCAB) | 0 | 73,000 | +73,000 | 0 | 180 | 0.00% | +180 |
| TACTILE SYS TECHNOLOGY INC(TCMD) | 707,159 | 707,159 | 0 | 9,936 | 10,112 | 0.23% | +177 |
| LEAP THERAPEUTICS INC(CYPH) | 44,971 | 44,971 | 0 | 62 | 186 | 0.00% | +124 |
| REVOLUTION MEDICINES INC(RVMD) | 0 | 250,000 | +250,000 | 0 | 83 | 0.00% | +83 |
| SINGULAR GENOMICS SYSTEMS IN | 2,363,214 | 2,126,893 | -236,321 | 900 | 979 | 0.02% | +78 |
| TYRA BIOSCIENCES INC(TYRA) | 360,000 | 360,000 | 0 | 4,957 | 4,986 | 0.11% | +29 |
| TRAVERE THERAPEUTICS INC(TVTX) | 400,000 | 400,000 | 0 | 3,576 | 3,596 | 0.08% | +20 |
| SURROZEN INC(SRZN) | 166,666 | 166,666 | 0 | 7 | 3 | 0.00% | -3 |
| EQRX INC | 250,000 | 0 | -250,000 | 10 | 0 | — | -10 |
| CAREMAX INC | 60,000 | 60,000 | 0 | 11 | 0 | 0.00% | -11 |
| MOTUS GI HLDGS INC | 90,027 | 0 | -90,027 | 41 | 0 | — | -41 |
| KRONOS BIO INC | 1,752,745 | 1,752,745 | 0 | 2,279 | 2,191 | 0.05% | -88 |
| VAXCYTE INC(PCVX) | 1,342,751 | 1,088,486 | -254,265 | 68,453 | 68,357 | 1.53% | -97 |
| VBI VACCINES INC CDA | 1,381,355 | 1,381,355 | 0 | 926 | 815 | 0.02% | -111 |
| LANDOS BIOPHARMA INC | 1,486,991 | 1,486,991 | 0 | 5,770 | 5,442 | 0.12% | -327 |
| NANOBIOTIX(NBTX) | 555,066 | 555,066 | 0 | 4,857 | 4,041 | 0.09% | -816 |
| X4 PHARMACEUTICALS INC(XFOR) | 3,545,454 | 3,545,454 | 0 | 3,865 | 2,973 | 0.07% | -892 |
| ENVVENO MEDICAL CORPORATION(NVNO) | 781,615 | 623,315 | -158,300 | 4,213 | 3,204 | 0.07% | -1,009 |
| ACELYRIN INC | 200,000 | 0 | -200,000 | 2,034 | 0 | — | -2,034 |
| SOMALOGIC INC | 1,500,000 | 0 | -1,500,000 | 3,585 | 0 | — | -3,585 |
| IMMATICS N.V(IMTX) | 3,491,500 | 3,491,500 | 0 | 40,432 | 36,765 | 0.82% | -3,666 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 672,042 | 534,942 | -137,100 | 21,237 | 15,791 | 0.35% | -5,445 |
| CAREMAX INC | 3,823,557 | 3,679,284 | -144,273 | 8,106 | 1,832 | 0.04% | -6,274 |
| OUTSET MED INC(OM) | 661,977 | 0 | -661,977 | 7,202 | 0 | — | -7,202 |
| PROTHENA CORP PLC SHS | 165,615 | 0 | -165,615 | 7,991 | 0 | — | -7,991 |
| TREACE MED CONCEPTS INC(TMCI) | 1,834,060 | 1,250,405 | -583,655 | 24,045 | 15,943 | 0.36% | -8,102 |
| PROTAGONIST THERAPEUTICS INC | 1,054,273 | 383,260 | -671,013 | 17,585 | 8,788 | 0.20% | -8,797 |
| BIOMEA FUSION(BMEA) | 716,441 | 0 | -716,441 | 9,858 | 0 | — | -9,858 |
| ESTABLISHMENT LABS HLDGS INC(ESTA) | 277,683 | 82,299 | -195,384 | 13,626 | 2,131 | 0.05% | -11,495 |
| REVOLUTION MEDICINES INC(RVMD) | 1,321,795 | 818,882 | -502,913 | 36,587 | 23,486 | 0.53% | -13,102 |
| ACRIVON THERAPEUTICS INC | 3,007,858 | 3,007,858 | 0 | 28,755 | 14,799 | 0.33% | -13,956 |
| COGENT BIOSCIENCES INC(COGT) | 2,309,470 | 1,122,958 | -1,186,512 | 22,517 | 6,603 | 0.15% | -15,914 |
| TANGO THERAPEUTICS INC(TNGX) | 2,418,968 | 1,111,870 | -1,307,098 | 27,238 | 11,008 | 0.25% | -16,230 |