Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2024 ▲▼ | Q4 2024 ▲▼ | Change ▲▼ | Q3 2024 ▲▼ | Q4 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| VERONA PHARMA PLC | 6,315,933 | 6,392,106 | +76,173 | 181,709 | 296,849 | 8.27% | +115,140 |
| JANUX THERAPEUTICS INC(JANX) | 0 | 817,895 | +817,895 | 0 | 43,790 | 1.22% | +43,790 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 1,164,035 | 1,329,735 | +165,700 | 66,979 | 102,336 | 2.85% | +35,358 |
| INSULET CORP(PODD) | 142,269 | 232,269 | +90,000 | 33,113 | 60,638 | 1.69% | +27,525 |
| MEIRAGTX HLDGS PLC(MGTX) | 12,581,103 | 12,581,103 | 0 | 52,430 | 76,584 | 2.13% | +24,153 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 3,560,214 | 3,680,473 | +120,259 | 186,520 | 206,033 | 5.74% | +19,513 |
| INHIBIKASE THERAPEUTICS INC(IKT) | 0 | 5,925,000 | +5,925,000 | 0 | 19,256 | 0.54% | +19,256 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 2,125,649 | 6,774,348 | +4,648,699 | 6,887 | 25,607 | 0.71% | +18,720 |
| PENUMBRA INC(PEN) | 0 | 73,338 | +73,338 | 0 | 17,416 | 0.49% | +17,416 |
| SEPTERNA INC(SEPN) | 0 | 750,000 | +750,000 | 0 | 17,175 | 0.48% | +17,175 |
| BRIGHT MINDS BIOSCIENCES INC(DRUG) | 0 | 403,649 | +403,649 | 0 | 14,539 | 0.41% | +14,539 |
| ANTERIS TECHNOLOGIES GLOBAL(AVR) | 0 | 2,140,000 | +2,140,000 | 0 | 11,941 | 0.33% | +11,941 |
| EDWARDS LIFESCIENCES CORP | 0 | 145,000 | +145,000 | 0 | 10,734 | 0.30% | +10,734 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 2,330,294 | 2,685,537 | +355,243 | 62,196 | 71,704 | 2.00% | +9,508 |
| RAPT THERAPEUTICS INC | 0 | 5,880,000 | +5,880,000 | 0 | 9,290 | 0.26% | +9,290 |
| INARI MED INC | 0 | 178,797 | +178,797 | 0 | 9,128 | 0.25% | +9,128 |
| ONKURE THERAPEUTICS INC(OKUR) | 0 | 1,004,439 | +1,004,439 | 0 | 8,638 | 0.24% | +8,638 |
| NURIX THERAPEUTICS INC(NRIX) | 0 | 330,614 | +330,614 | 0 | 6,229 | 0.17% | +6,229 |
| CENTESSA PHARMACEUTICALS PLC | 6,282,290 | 6,349,220 | +66,930 | 100,454 | 106,349 | 2.96% | +5,896 |
| ARTIVION INC(AORT) | 2,793,703 | 2,793,703 | 0 | 74,368 | 79,872 | 2.23% | +5,504 |
| CERIBELL INC(CBLL) | 0 | 180,546 | +180,546 | 0 | 4,673 | 0.13% | +4,673 |
| INTUITIVE SURGICAL INC | 58,119 | 63,119 | +5,000 | 28,552 | 32,946 | 0.92% | +4,393 |
| IRHYTHM TECHNOLOGIES INC(IRTC) | 22,591 | 65,153 | +42,562 | 1,677 | 5,875 | 0.16% | +4,198 |
| ZYMEWORKS INC(ZYME) | 2,180,020 | 2,130,020 | -50,000 | 27,359 | 31,183 | 0.87% | +3,824 |
| PERSPECTIVE THERAPEUTICS INC(CATX) | 0 | 1,190,263 | +1,190,263 | 0 | 3,797 | 0.11% | +3,797 |
| LINEAGE CELL THERAPEUTICS IN(LCTX) | 0 | 7,236,843 | +7,236,843 | 0 | 3,637 | 0.10% | +3,637 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 1,037,274 | 1,537,274 | +500,000 | 8,288 | 11,453 | 0.32% | +3,165 |
| IMMUNITYBIO INC(IBRX) | 0 | 1,221,734 | +1,221,734 | 0 | 3,128 | 0.09% | +3,128 |
| SCPHARMACEUTICALS INC | 0 | 500,000 | +500,000 | 0 | 1,770 | 0.05% | +1,770 |
| FORTE BIOSCIENCES INC(FBRX) | 95,742 | 95,742 | 0 | 535 | 2,174 | 0.06% | +1,639 |
| TRAWS PHARMA INC(TRAW) | 0 | 164,157 | +164,157 | 0 | 1,458 | 0.04% | +1,458 |
| FULCRUM THERAPEUTICS INC(FULC) | 0 | 238,000 | +238,000 | 0 | 1,119 | 0.03% | +1,119 |
| ATHIRA PHARMA INC | 5,402,964 | 5,402,964 | 0 | 2,410 | 3,170 | 0.09% | +760 |
| ENSYSCE BIOSCIENCES INC(ENSC) | 0 | 86,666 | +86,666 | 0 | 705 | 0.02% | +705 |
| DELCATH SYS INC(DCTH) | 0 | 50,000 | +50,000 | 0 | 602 | 0.02% | +602 |
| MEREO BIOPHARMA GROUP PLC(MREO) | 815,722 | 1,085,512 | +269,790 | 3,353 | 3,799 | 0.11% | +447 |
| APYX MEDICAL CORPORATION(APYX) | 0 | 150,000 | +150,000 | 0 | 237 | 0.01% | +237 |
| HELIX ACQUISITION CORP II | 500,000 | 500,000 | 0 | 5,225 | 5,250 | 0.15% | +25 |
| REVOLUTION MEDICINES INC(RVMD) | 250,000 | 250,000 | 0 | 35 | 45 | 0.00% | +10 |
| SURROZEN INC(SRZN) | 166,666 | 166,666 | 0 | 2 | 4 | 0.00% | +2 |
| CAREMAX INC | 60,000 | 0 | -60,000 | 1 | 0 | — | -1 |
| CAREMAX INC | 100,000 | 0 | -100,000 | 170 | 0 | — | -170 |
| SYROS PHARMACEUTICALS INC | 116,754 | 0 | -116,754 | 251 | 0 | — | -251 |
| INHIBRX BIOSCIENCES INC(INBX) | 1,064,026 | 1,064,026 | 0 | 16,663 | 16,386 | 0.46% | -277 |
| LEXEO THERAPEUTICS INC(LXEO) | 139,835 | 139,835 | 0 | 1,264 | 920 | 0.03% | -344 |
| TRINITY BIOTECH PLC(TRIB) | 1,800,000 | 1,790,000 | -10,000 | 1,980 | 1,575 | 0.04% | -405 |
| BIODESIX INC(BDSX) | 2,173,880 | 2,173,880 | 0 | 3,870 | 3,326 | 0.09% | -543 |
| LYRA THERAPEUTICS INC | 12,757,562 | 12,757,562 | 0 | 3,279 | 2,628 | 0.07% | -651 |
| KYVERNA THERAPEUTICS INC(KYTX) | 150,000 | 0 | -150,000 | 734 | 0 | — | -733 |
| SINGULAR GENOMICS SYSTEMS IN | 50,896 | 0 | -50,896 | 798 | 0 | — | -798 |
| FATE THERAPEUTICS INC(FATE) | 345,575 | 0 | -345,575 | 1,210 | 0 | — | -1,210 |
| VERU INC(VERU) | 7,283,157 | 6,483,157 | -800,000 | 5,601 | 4,217 | 0.12% | -1,383 |
| STRUCTURE THERAPEUTICS INC | 34,852 | 0 | -34,852 | 1,530 | 0 | — | -1,530 |
| PYXIS ONCOLOGY INC(PYXS) | 508,462 | 188,462 | -320,000 | 1,866 | 294 | 0.01% | -1,572 |
| PROCEPT BIOROBOTICS CORP(PRCT) | 315,659 | 290,659 | -25,000 | 25,291 | 23,404 | 0.65% | -1,887 |
| KYMERA THERAPEUTICS INC(KYMR) | 46,213 | 0 | -46,213 | 2,187 | 0 | — | -2,187 |
| ENVVENO MEDICAL CORPORATION(NVNO) | 694,315 | 0 | -694,315 | 2,333 | 0 | — | -2,333 |
| X4 PHARMACEUTICALS INC(XFOR) | 3,545,454 | 0 | -3,545,454 | 2,373 | 0 | — | -2,373 |
| MERUS N V | 300,000 | 300,000 | 0 | 14,988 | 12,615 | 0.35% | -2,373 |
| NANOBIOTIX(NBTX) | 555,066 | 266,093 | -288,973 | 3,192 | 764 | 0.02% | -2,428 |
| ABSCI CORPORATION | 700,000 | 0 | -700,000 | 2,674 | 0 | — | -2,674 |
| BICYCLE THERAPEUTICS PLC | 255,994 | 197,108 | -58,886 | 5,793 | 2,760 | 0.08% | -3,034 |
| INSMED INC(INSM) | 180,000 | 144,000 | -36,000 | 13,140 | 9,942 | 0.28% | -3,198 |
| ALDEYRA THERAPEUTICS INC(ALDX) | 9,275,851 | 9,275,851 | 0 | 49,997 | 46,286 | 1.29% | -3,710 |
| PRECISION BIOSCIENCES INC(DTIL) | 426,293 | 0 | -426,293 | 3,820 | 0 | — | -3,820 |
| CELCUITY INC(CELC) | 2,362,279 | 2,362,279 | 0 | 35,222 | 30,922 | 0.86% | -4,299 |
| ORCHESTRA BIOMED HLDGS INC(OBIO) | 4,592,556 | 4,592,556 | 0 | 23,606 | 18,370 | 0.51% | -5,236 |
| ACRIVON THERAPEUTICS INC | 5,360,858 | 5,360,858 | 0 | 37,526 | 32,272 | 0.90% | -5,254 |
| ADMA BIOLOGICS INC | 1,060,200 | 890,280 | -169,920 | 21,193 | 15,268 | 0.43% | -5,925 |
| ALLOGENE THERAPEUTICS INC | 2,725,000 | 0 | -2,725,000 | 7,630 | 0 | — | -7,630 |
| XENON PHARMACEUTICALS INC(XENE) | 524,930 | 325,324 | -199,606 | 20,666 | 12,753 | 0.36% | -7,914 |
| CONTINEUM THERAPEUTICS INC(CTNM) | 1,516,668 | 1,441,249 | -75,419 | 29,029 | 21,114 | 0.59% | -7,915 |
| VERRICA PHARMACEUTICALS INC(VRCA) | 7,099,182 | 3,249,669 | -3,849,513 | 10,294 | 2,275 | 0.06% | -8,019 |
| NATERA INC(NTRA) | 220,000 | 125,000 | -95,000 | 27,929 | 19,788 | 0.55% | -8,141 |
| EXACT SCIENCES CORP(EXK) | 125,000 | 0 | -125,000 | 8,515 | 0 | — | -8,515 |
| PEPGEN INC(PEPG) | 1,410,438 | 829,536 | -580,902 | 12,059 | 3,144 | 0.09% | -8,915 |
| ARRIVENT BIOPHARMA INC(AVBP) | 415,000 | 0 | -415,000 | 9,753 | 0 | — | -9,752 |
| ROIVANT SCIENCES LTD(ROIV) | 847,745 | 0 | -847,745 | 9,783 | 0 | — | -9,783 |
| RAPPORT THERAPEUTICS INC(RAPP) | 748,183 | 311,551 | -436,632 | 15,323 | 5,527 | 0.15% | -9,796 |
| XENCOR INC(XNCR) | 527,671 | 0 | -527,671 | 10,611 | 0 | — | -10,611 |
| NEUROCRINE BIOSCIENCES(NBIX) | 212,228 | 100,050 | -112,178 | 24,453 | 13,657 | 0.38% | -10,796 |
| INTRA-CELLULAR THERAPIES INC | 1,622,215 | 1,288,328 | -333,887 | 118,697 | 107,601 | 3.00% | -11,096 |
| ARVINAS INC(ARVN) | 1,027,749 | 740,749 | -287,000 | 25,313 | 14,200 | 0.40% | -11,113 |
| TYRA BIOSCIENCES INC(TYRA) | 511,226 | 0 | -511,226 | 12,019 | 0 | — | -12,019 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 931,851 | 378,584 | -553,267 | 17,211 | 4,759 | 0.13% | -12,452 |
| ARCUTIS BIOTHERAPEUTICS INC(ARQT) | 1,358,500 | 0 | -1,358,500 | 12,634 | 0 | — | -12,634 |
| ICON PLC(ICLR) | 44,353 | 0 | -44,353 | 12,743 | 0 | — | -12,743 |
| PROTAGONIST THERAPEUTICS INC | 1,374,563 | 1,271,662 | -102,901 | 61,855 | 49,086 | 1.37% | -12,769 |
| DYNE THERAPEUTICS INC(DYN) | 718,144 | 543,277 | -174,867 | 25,796 | 12,800 | 0.36% | -12,996 |
| ZENAS BIOPHARMA INC(ZBIO) | 1,144,035 | 744,035 | -400,000 | 19,357 | 6,094 | 0.17% | -13,263 |
| ASTRIA THERAPEUTICS INC | 6,485,420 | 6,485,420 | 0 | 71,404 | 57,980 | 1.62% | -13,425 |
| ORUKA THERAPEUTICS INC(ORKA) | 1,235,187 | 845,567 | -389,620 | 30,274 | 16,396 | 0.46% | -13,879 |
| AXSOME THERAPEUTICS INC(AXSM) | 782,844 | 664,074 | -118,770 | 70,354 | 56,187 | 1.57% | -14,167 |
| NAUTILUS BIOTECHNOLOGY INC(NAUT) | 12,594,211 | 12,594,211 | 0 | 35,894 | 21,158 | 0.59% | -14,735 |
| IMMUNOVANT INC(IMVT) | 2,378,762 | 2,139,199 | -239,563 | 67,819 | 52,988 | 1.48% | -14,831 |
| CARGO THERAPEUTICS INC | 3,683,004 | 3,683,004 | 0 | 67,951 | 53,109 | 1.48% | -14,843 |
| ADAGIO MED HLDGS INC(ADGM) | 9,812,419 | 9,812,419 | 0 | 25,316 | 10,303 | 0.29% | -15,013 |
| CG ONCOLOGY INC(CGON) | 733,695 | 419,450 | -314,245 | 27,682 | 12,030 | 0.34% | -15,652 |
| AKERO THERAPEUTICS INC | 1,714,806 | 1,185,592 | -529,214 | 49,198 | 32,983 | 0.92% | -16,215 |
| DISC MEDICINE INC(IRON) | 387,017 | 0 | -387,017 | 19,018 | 0 | — | -19,018 |