Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| PRAXIS PRECISION MEDICINES I(PRAX) | 1,564,554 | 1,995,986 | +431,432 | 82,921 | 588,297 | 10.78% | +505,376 |
| CELCUITY INC(CELC) | 2,956,319 | 3,160,200 | +203,881 | 146,042 | 315,198 | 5.77% | +169,156 |
| APOGEE THERAPEUTICS INC(APGE) | 1,351,989 | 2,330,651 | +978,662 | 53,715 | 175,918 | 3.22% | +122,203 |
| EXACT SCIENCES CORP(EXK) | 465,487 | 1,200,487 | +735,000 | 25,467 | 121,921 | 2.23% | +96,455 |
| SPYRE THERAPEUTICS INC(SYRE) | 1,229,445 | 3,069,225 | +1,839,780 | 20,605 | 100,548 | 1.84% | +79,942 |
| TRAVERE THERAPEUTICS INC(TVTX) | 3,794,615 | 4,278,180 | +483,565 | 90,691 | 163,469 | 2.99% | +72,778 |
| INHIBRX BIOSCIENCES INC(INBX) | 1,327,707 | 1,452,707 | +125,000 | 44,717 | 114,764 | 2.10% | +70,047 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 1,462,400 | 3,042,703 | +1,580,303 | 31,559 | 94,689 | 1.73% | +63,130 |
| BOSTON SCIENTIFIC CORP(BSX) | 310,000 | 979,000 | +669,000 | 30,265 | 93,348 | 1.71% | +63,082 |
| BELITE BIO INC(BLTE) | 49,788 | 414,239 | +364,451 | 3,684 | 66,262 | 1.21% | +62,577 |
| ROIVANT SCIENCES LTD(ROIV) | 7,368,461 | 7,985,461 | +617,000 | 111,485 | 173,285 | 3.17% | +61,800 |
| DYNE THERAPEUTICS INC(DYN) | 540,444 | 3,478,944 | +2,938,500 | 6,837 | 68,048 | 1.25% | +61,212 |
| NURIX THERAPEUTICS INC(NRIX) | 1,416,149 | 3,555,877 | +2,139,728 | 13,085 | 67,455 | 1.24% | +54,370 |
| INVIVYD INC(IVVD) | 0 | 21,785,166 | +21,785,166 | 0 | 53,809 | 0.99% | +53,809 |
| ZYMEWORKS INC(ZYME) | 2,090,663 | 3,261,850 | +1,171,187 | 35,709 | 85,885 | 1.57% | +50,176 |
| PROTAGONIST THERAPEUTICS INC | 1,030,134 | 1,350,425 | +320,291 | 68,432 | 117,946 | 2.16% | +49,514 |
| EDGEWISE THERAPEUTICS(EWTX) | 3,795,894 | 4,457,974 | +662,080 | 61,569 | 110,625 | 2.03% | +49,055 |
| DANAHER CORPORATION(DHR) | 0 | 200,000 | +200,000 | 0 | 45,784 | 0.84% | +45,784 |
| AMICUS THERAPEUTICS INC COM | 6,370,851 | 6,370,851 | 0 | 50,202 | 90,721 | 1.66% | +40,519 |
| ENGENE HOLDINGS INC COM | 2,097,236 | 5,869,076 | +3,771,840 | 14,324 | 52,998 | 0.97% | +38,674 |
| ASTRIA THERAPEUTICS INC | 6,485,420 | 6,485,420 | 0 | 47,214 | 84,894 | 1.56% | +37,680 |
| CIDARA THERAPEUTICS INC | 0 | 165,131 | +165,131 | 0 | 36,476 | 0.67% | +36,476 |
| DISC MEDICINE INC(IRON) | 0 | 450,743 | +450,743 | 0 | 35,794 | 0.66% | +35,794 |
| NUVALENT INC | 1,562,336 | 1,665,105 | +102,769 | 135,111 | 167,493 | 3.07% | +32,382 |
| ALTO NEUROSCIENCE INC(ANRO) | 155,366 | 1,784,393 | +1,629,027 | 625 | 31,762 | 0.58% | +31,138 |
| IMMATICS N.V(IMTX) | 9,383,456 | 10,383,456 | +1,000,000 | 79,947 | 109,026 | 2.00% | +29,079 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 0 | 170,000 | +170,000 | 0 | 28,900 | 0.53% | +28,900 |
| ABIVAX SA(ABVX) | 388,608 | 458,343 | +69,735 | 32,993 | 61,810 | 1.13% | +28,817 |
| PALISADE BIO INC(PALI) | 0 | 12,050,000 | +12,050,000 | 0 | 28,318 | 0.52% | +28,318 |
| INTUITIVE SURGICAL INC | 52,119 | 87,919 | +35,800 | 23,309 | 49,794 | 0.91% | +26,485 |
| AXOGEN INC(AXGN) | 0 | 784,140 | +784,140 | 0 | 25,665 | 0.47% | +25,665 |
| X4 PHARMACEUTICALS INC(XFOR) | 0 | 6,314,452 | +6,314,452 | 0 | 25,258 | 0.46% | +25,258 |
| IMMUNOVANT INC(IMVT) | 1,587,890 | 1,994,890 | +407,000 | 25,597 | 50,710 | 0.93% | +25,113 |
| BIOCRYST PHARMACEUTICALS INC(BCRX) | 0 | 3,162,529 | +3,162,529 | 0 | 24,668 | 0.45% | +24,668 |
| RAPT THERAPEUTICS INC | 183,890 | 825,890 | +642,000 | 4,743 | 27,973 | 0.51% | +23,230 |
| BIOGEN INC(BIIB) | 0 | 124,000 | +124,000 | 0 | 21,823 | 0.40% | +21,823 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 0 | 259,545 | +259,545 | 0 | 20,501 | 0.38% | +20,501 |
| ORUKA THERAPEUTICS INC(ORKA) | 1,268,021 | 1,476,501 | +208,480 | 24,384 | 44,753 | 0.82% | +20,369 |
| GRAIL INC(GRAL) | 0 | 237,342 | +237,342 | 0 | 20,314 | 0.37% | +20,314 |
| CVS HEALTH CORP(CVS) | 0 | 220,000 | +220,000 | 0 | 17,459 | 0.32% | +17,459 |
| GUARDANT HEALTH INC(GH) | 0 | 160,000 | +160,000 | 0 | 16,342 | 0.30% | +16,342 |
| RELAY THERAPEUTICS INC(RLAY) | 0 | 1,903,245 | +1,903,245 | 0 | 16,101 | 0.29% | +16,101 |
| GLAUKOS CORP(GKOS) | 0 | 140,000 | +140,000 | 0 | 15,807 | 0.29% | +15,807 |
| REPLIGEN CORP(RGEN) | 270,428 | 315,541 | +45,113 | 36,148 | 51,705 | 0.95% | +15,556 |
| DEXCOM INC(DXCM) | 0 | 225,758 | +225,758 | 0 | 14,984 | 0.27% | +14,984 |
| SAVARA INC(SVRA) | 0 | 2,400,000 | +2,400,000 | 0 | 14,472 | 0.27% | +14,472 |
| ASCENDIS PHARMA A/S(ASND) | 1,088,501 | 1,081,421 | -7,080 | 216,405 | 230,602 | 4.22% | +14,197 |
| NAUTILUS BIOTECHNOLOGY INC(NAUT) | 12,594,211 | 12,594,211 | 0 | 10,642 | 24,559 | 0.45% | +13,917 |
| SIONNA THERAPEUTICS INC(SION) | 1,179,098 | 1,179,098 | 0 | 34,677 | 48,508 | 0.89% | +13,831 |
| KODIAK SCIENCES INC(KOD) | 634,577 | 848,900 | +214,323 | 10,388 | 23,735 | 0.43% | +13,347 |
| BETA BIONICS INC(BBNX) | 277,944 | 602,944 | +325,000 | 5,523 | 18,372 | 0.34% | +12,849 |
| ATHIRA PHARMA INC(LONA) | 540,296 | 1,859,322 | +1,319,026 | 2,237 | 14,075 | 0.26% | +11,838 |
| CYTOMX THERAPEUTICS INC(CTMX) | 9,680,185 | 9,680,185 | 0 | 30,880 | 41,238 | 0.76% | +10,358 |
| OCULIS HOLDING AG(OCS) | 0 | 493,827 | +493,827 | 0 | 9,862 | 0.18% | +9,862 |
| MAPLIGHT THERAPEUTICS INC(MPLT) | 0 | 550,000 | +550,000 | 0 | 9,661 | 0.18% | +9,661 |
| AXSOME THERAPEUTICS INC(AXSM) | 148,900 | 148,900 | 0 | 18,084 | 27,195 | 0.50% | +9,111 |
| RAPPORT THERAPEUTICS INC(RAPP) | 403,923 | 673,923 | +270,000 | 11,997 | 20,447 | 0.37% | +8,450 |
| CONTINEUM THERAPEUTICS INC(CTNM) | 714,592 | 1,464,592 | +750,000 | 8,396 | 16,740 | 0.31% | +8,344 |
| ORCHESTRA BIOMED HLDGS INC(OBIO) | 5,292,556 | 5,127,256 | -165,300 | 13,126 | 21,278 | 0.39% | +8,153 |
| BRIGHT MINDS BIOSCIENCES INC(DRUG) | 449,290 | 449,290 | 0 | 27,254 | 35,063 | 0.64% | +7,809 |
| KESTRA MED TECHNOLOGIES LTD SHS | 0 | 285,000 | +285,000 | 0 | 7,558 | 0.14% | +7,558 |
| BILLIONTOONE INC | 0 | 72,812 | +72,812 | 0 | 5,959 | 0.11% | +5,959 |
| CELCUITY INC(CELC) | 0 | 0 | 0 | 8,724 | 14,098 | 0.26% | +5,375 |
| TENAX THERAPEUTICS INC(TENX) | 0 | 439,142 | +439,142 | 0 | 5,353 | 0.10% | +5,353 |
| TANGO THERAPEUTICS INC(TNGX) | 0 | 513,035 | +513,035 | 0 | 4,545 | 0.08% | +4,545 |
| COGENT BIOSCIENCES INC(COGT) | 0 | 121,082 | +121,082 | 0 | 4,301 | 0.08% | +4,301 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 0 | 165,713 | +165,713 | 0 | 4,143 | 0.08% | +4,143 |
| SCHRODINGER INC(SDGR) | 0 | 202,400 | +202,400 | 0 | 3,619 | 0.07% | +3,619 |
| PALVELLA THERAPEUTICS INC NE(PVLA) | 395,093 | 266,287 | -128,806 | 24,768 | 27,872 | 0.51% | +3,104 |
| SAB BIOTHERAPEUTICS INC(SABS) | 0 | 803,210 | +803,210 | 0 | 3,004 | 0.06% | +3,004 |
| INHIBIKASE THERAPEUTICS INC(IKT) | 5,421,568 | 5,421,568 | 0 | 8,783 | 11,114 | 0.20% | +2,331 |
| CONNECT BIOPHARMA HLDGS LTD(CNTB) | 0 | 792,696 | +792,696 | 0 | 2,235 | 0.04% | +2,235 |
| SEPTERNA INC(SEPN) | 541,450 | 433,160 | -108,290 | 10,185 | 12,077 | 0.22% | +1,892 |
| IMMIX BIOPHARMA INC(IMMX) | 0 | 338,941 | +338,941 | 0 | 1,773 | 0.03% | +1,773 |
| PEPGEN INC(PEPG) | 829,870 | 829,870 | 0 | 3,834 | 5,402 | 0.10% | +1,568 |
| OPUS GENETICS INC(IRD) | 4,325,000 | 4,325,000 | 0 | 7,136 | 8,693 | 0.16% | +1,557 |
| CUMBERLAND PHARMACEUTICALS I(CPIX) | 0 | 341,087 | +341,087 | 0 | 1,358 | 0.02% | +1,358 |
| MEDLINE INC(MDLN) | 0 | 28,000 | +28,000 | 0 | 1,176 | 0.02% | +1,176 |
| PALATIN TECHNOLOGIES INC(PTN) | 0 | 70,000 | +70,000 | 0 | 1,077 | 0.02% | +1,077 |
| XENON PHARMACEUTICALS INC(XENE) | 200,791 | 200,791 | 0 | 8,062 | 8,999 | 0.16% | +938 |
| LENZ THERAPEUTICS INC(LENZ) | 0 | 50,000 | +50,000 | 0 | 800 | 0.01% | +800 |
| AVALO THERAPEUTICS INC(AVTX) | 139,667 | 139,667 | 0 | 1,775 | 2,536 | 0.05% | +761 |
| ANTERIS TECHNOLOGIES GLOBAL(AVR) | 1,705,130 | 1,675,476 | -29,654 | 7,673 | 8,361 | 0.15% | +688 |
| LEXEO THERAPEUTICS INC(LXEO) | 139,835 | 139,835 | 0 | 929 | 1,389 | 0.03% | +460 |
| IOVANCE BIOTHERAPEUTICS INC(IOVA) | 0 | 152,714 | +152,714 | 0 | 417 | 0.01% | +417 |
| REVOLUTION MEDICINES INC(RVMD) | 250,000 | 250,000 | 0 | 75 | 235 | 0.00% | +160 |
| SURROZEN INC(SRZN) | 166,666 | 166,666 | 0 | 3 | 3 | 0.00% | 0 |
| CRESCENT BIOPHARMA INC.(CBIO) | 453,686 | 453,686 | 0 | 5,394 | 5,381 | 0.10% | -14 |
| BIODESIX(BDSX) | 108,694 | 108,694 | 0 | 821 | 739 | 0.01% | -82 |
| ENSYSCE BIOSCIENCES INC(ENSC) | 86,666 | 86,666 | 0 | 205 | 80 | 0.00% | -126 |
| GOSSAMER BIO INC(GOSS) | 3,812,797 | 3,139,669 | -673,128 | 10,028 | 9,733 | 0.18% | -295 |
| APYX MEDICAL CORPORATION(APYX) | 150,000 | 0 | -150,000 | 321 | 0 | — | -321 |
| ADMA BIOLOGICS INC | 1,153,468 | 883,468 | -270,000 | 16,910 | 16,114 | 0.30% | -795 |
| ENVVENO MEDICAL CORPORATION(NVNO) | 1,759,035 | 1,759,035 | 0 | 1,594 | 564 | 0.01% | -1,029 |
| UNIQURE NV(QURE) | 20,000 | 0 | -20,000 | 1,167 | 0 | — | -1,167 |
| LYRA THERAPEUTICS INC | 229,382 | 0 | -229,382 | 1,498 | 0 | — | -1,498 |
| TRINITY BIOTECH PLC(TRIB) | 1,790,000 | 0 | -1,790,000 | 1,862 | 0 | — | -1,862 |
| KRYSTAL BIOTECH INC(KRYS) | 35,000 | 17,500 | -17,500 | 6,179 | 4,314 | 0.08% | -1,864 |
| IRHYTHM TECHNOLOGIES INC(IRTC) | 123,000 | 108,000 | -15,000 | 21,155 | 19,164 | 0.35% | -1,991 |
| CENTESSA PHARMACEUTICALS PLC | 3,100,902 | 2,917,634 | -183,268 | 75,197 | 72,970 | 1.34% | -2,227 |