Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Praxis Precision Medicines, Inc.(PRAX) | 1,564,554 | 1,995,986 | +431,432 | $82.92M | $588.30M | 10.78% | +$505.38M |
| Celcuity Inc.(CELC) | 2,956,319 | 3,160,200 | +203,881 | $146.04M | $315.20M | 5.77% | +$169.16M |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 2,438,969 | 2,546,391 | +107,422 | $288.39M | $272.57M | 4.99% | -$15.82M |
| Ascendis Pharma A/SADR(ASND) | 1,088,501 | 1,081,421 | -7,080 | $216.40M | $230.60M | 4.22% | +$14.20M |
| Apogee Therapeutics Inc | 1,351,989 | 2,330,651 | +978,662 | $53.71M | $175.92M | 3.22% | +$122.20M |
| Roivant Sciences Ltd.SHS(ROIV) | 7,368,461 | 7,985,461 | +617,000 | $111.48M | $173.28M | 3.17% | +$61.80M |
| Nuvalent Inc | 1,562,336 | 1,665,105 | +102,769 | $135.11M | $167.49M | 3.07% | +$32.38M |
| Travere Therapeutics, Inc.(TVTX) | 3,794,615 | 4,278,180 | +483,565 | $90.69M | $163.47M | 2.99% | +$72.78M |
| Endeavour Silver Corp.(EXK) | 465,487 | 1,200,487 | +735,000 | $25.47M | $121.92M | 2.23% | +$96.45M |
| Protagonist Therapeutics Inc | 1,030,134 | 1,350,425 | +320,291 | $68.43M | $117.95M | 2.16% | +$49.51M |
| Inhibrx Biosciences, Inc.(INBX) | 1,327,707 | 1,452,707 | +125,000 | $44.72M | $114.76M | 2.10% | +$70.05M |
| Edgewise Therapeutics, Inc.(EWTX) | 3,795,894 | 4,457,974 | +662,080 | $61.57M | $110.62M | 2.03% | +$49.06M |
| Immatics N.V.SHS(IMTX) | 9,383,456 | 10,383,456 | +1,000,000 | $79.95M | $109.03M | 2.00% | +$29.08M |
| Spyre Therapeutics, Inc.(SYRE) | 1,229,445 | 3,069,225 | +1,839,780 | $20.61M | $100.55M | 1.84% | +$79.94M |
| Amylyx Pharmaceuticals, Inc.(AMLX) | 8,952,365 | 8,284,882 | -667,483 | $121.66M | $100.08M | 1.83% | -$21.58M |
| Arcellx Inc COMMON STOCK | 2,468,353 | 1,466,071 | -1,002,282 | $202.65M | $95.59M | 1.75% | -$107.06M |
| Viridian Therapeutics, Inc.(VRDN) | 1,462,400 | 3,042,703 | +1,580,303 | $31.56M | $94.69M | 1.73% | +$63.13M |
| Boston Scientific Corporation(BSX) | 310,000 | 979,000 | +669,000 | $30.27M | $93.35M | 1.71% | +$63.08M |
| Amicus Therapeutics Inc COM | 6,370,851 | 6,370,851 | 0 | $50.20M | $90.72M | 1.66% | +$40.52M |
| Zymeworks Inc.(ZYME) | 2,090,663 | 3,261,850 | +1,171,187 | $35.71M | $85.88M | 1.57% | +$50.18M |
| Astria Therapeutics Inc | 6,485,420 | 6,485,420 | 0 | $47.21M | $84.89M | 1.56% | +$37.68M |
| MeiraGTx Holdings plc(MGTX) | 12,626,103 | 10,326,103 | -2,300,000 | $103.79M | $82.09M | 1.50% | -$21.70M |
| Artivion, Inc.(AORT) | 2,020,000 | 1,722,290 | -297,710 | $85.53M | $78.55M | 1.44% | -$6.97M |
| Centessa Pharmaceuticals PlcADS | 3,100,902 | 2,917,634 | -183,268 | $75.20M | $72.97M | 1.34% | -$2.23M |
| Dyne Therapeutics, Inc.(DYN) | 540,444 | 3,478,944 | +2,938,500 | $6.84M | $68.05M | 1.25% | +$61.21M |
| Nurix Therapeutics, Inc.(NRIX) | 1,416,149 | 3,555,877 | +2,139,728 | $13.09M | $67.45M | 1.24% | +$54.37M |
| Solid Biosciences Inc | 11,833,539 | 11,833,539 | 0 | $73.01M | $66.74M | 1.22% | -$6.27M |
| Belite Bio, IncADS(BLTE) | 49,788 | 414,239 | +364,451 | $3.68M | $66.26M | 1.21% | +$62.58M |
| ABIVAX Société AnonymeADS(ABVX) | 388,608 | 458,343 | +69,735 | $32.99M | $61.81M | 1.13% | +$28.82M |
| Invivyd, Inc.(IVVD) | 0 | 21,785,166 | +21,785,166 | $0 | $53.81M | 0.99% | +$53.81M |
| Engene Holdings Inc COM | 2,097,236 | 5,869,076 | +3,771,840 | $14.32M | $53.00M | 0.97% | +$38.67M |
| Repligen Corporation(RGEN) | 270,428 | 315,541 | +45,113 | $36.15M | $51.70M | 0.95% | +$15.56M |
| Immunovant, Inc.(IMVT) | 1,587,890 | 1,994,890 | +407,000 | $25.60M | $50.71M | 0.93% | +$25.11M |
| Intuitive Surgical, Inc.(ISRG) | 52,119 | 87,919 | +35,800 | $23.31M | $49.79M | 0.91% | +$26.48M |
| Sionna Therapeutics, Inc.(SION) | 1,179,098 | 1,179,098 | 0 | $34.68M | $48.51M | 0.89% | +$13.83M |
| Neurocrine Biosciences, Inc.(NBIX) | 450,050 | 331,050 | -119,000 | $63.18M | $46.95M | 0.86% | -$16.23M |
| Danaher Corporation(DHR) | 0 | 200,000 | +200,000 | $0 | $45.78M | 0.84% | +$45.78M |
| Oruka Therapeutics, Inc.(ORKA) | 1,268,021 | 1,476,501 | +208,480 | $24.38M | $44.75M | 0.82% | +$20.37M |
| CytomX Therapeutics, Inc.(CTMX) | 9,680,185 | 9,680,185 | 0 | $30.88M | $41.24M | 0.76% | +$10.36M |
| Omada Health, Inc.(OMDA) | 2,396,330 | 2,396,330 | 0 | $52.98M | $37.81M | 0.69% | -$15.17M |
| Cidara Therapeutics Inc | 0 | 165,131 | +165,131 | $0 | $36.48M | 0.67% | +$36.48M |
| Disc Medicine, Inc.(IRON) | 0 | 450,743 | +450,743 | $0 | $35.79M | 0.66% | +$35.79M |
| Bright Minds Biosciences Inc.(DRUG) | 449,290 | 449,290 | 0 | $27.25M | $35.06M | 0.64% | +$7.81M |
| Penumbra, Inc.(PEN) | 220,547 | 110,529 | -110,018 | $55.87M | $34.36M | 0.63% | -$21.50M |
| Alto Neuroscience, Inc.(ANRO) | 155,366 | 1,784,393 | +1,629,027 | $624.6K | $31.76M | 0.58% | +$31.14M |
| Caris Life Sciences, Inc.(CAI) | 1,098,163 | 1,136,206 | +38,043 | $33.22M | $30.65M | 0.56% | -$2.56M |
| Jazz Pharmaceuticals plcSHS USD(JAZZ) | 0 | 170,000 | +170,000 | $0 | $28.90M | 0.53% | +$28.90M |
| Palisade Bio, Inc.(PALI) | 0 | 12,050,000 | +12,050,000 | $0 | $28.32M | 0.52% | +$28.32M |
| Rapt Therapeutics Inc | 183,890 | 825,890 | +642,000 | $4.74M | $27.97M | 0.51% | +$23.23M |
| Palvella Therapeutics, Inc.(PVLA) | 395,093 | 266,287 | -128,806 | $24.77M | $27.87M | 0.51% | +$3.10M |
| Axsome Therapeutics, Inc.(AXSM) | 148,900 | 148,900 | 0 | $18.08M | $27.20M | 0.50% | +$9.11M |
| Axogen, Inc.(AXGN) | 0 | 784,140 | +784,140 | $0 | $25.66M | 0.47% | +$25.66M |
| X4 Pharmaceuticals, Inc.(XFOR) | 0 | 6,314,452 | +6,314,452 | $0 | $25.26M | 0.46% | +$25.26M |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 0 | 3,162,529 | +3,162,529 | $0 | $24.67M | 0.45% | +$24.67M |
| Nautilus Biotechnology, Inc.(NAUT) | 12,594,211 | 12,594,211 | 0 | $10.64M | $24.56M | 0.45% | +$13.92M |
| Kodiak Sciences Inc.(KOD) | 634,577 | 848,900 | +214,323 | $10.39M | $23.74M | 0.43% | +$13.35M |
| Biogen Inc.(BIIB) | 0 | 124,000 | +124,000 | $0 | $21.82M | 0.40% | +$21.82M |
| Aldeyra Therapeutics, Inc.(ALDX) | 5,222,311 | 4,185,632 | -1,036,679 | $27.26M | $21.68M | 0.40% | -$5.58M |
| Orchestra BioMed Holdings, Inc.(OBIO) | 5,292,556 | 5,127,256 | -165,300 | $13.13M | $21.28M | 0.39% | +$8.15M |
| Mirum Pharmaceuticals, Inc.(MIRM) | 0 | 259,545 | +259,545 | $0 | $20.50M | 0.38% | +$20.50M |
| Rapport Therapeutics, Inc.(RAPP) | 403,923 | 673,923 | +270,000 | $12.00M | $20.45M | 0.37% | +$8.45M |
| GRAIL, Inc.(GRAL) | 0 | 237,342 | +237,342 | $0 | $20.31M | 0.37% | +$20.31M |
| iRhythm Holdings, Inc.(IRTC) | 123,000 | 108,000 | -15,000 | $21.15M | $19.16M | 0.35% | -$1.99M |
| Beta Bionics, Inc.(BBNX) | 277,944 | 602,944 | +325,000 | $5.52M | $18.37M | 0.34% | +$12.85M |
| CVS Health Corporation(CVS) | 0 | 220,000 | +220,000 | $0 | $17.46M | 0.32% | +$17.46M |
| Contineum Therapeutics, Inc.CL A(CTNM) | 714,592 | 1,464,592 | +750,000 | $8.40M | $16.74M | 0.31% | +$8.34M |
| Guardant Health, Inc.(GH) | 0 | 160,000 | +160,000 | $0 | $16.34M | 0.30% | +$16.34M |
| Adma Biologics Inc | 1,153,468 | 883,468 | -270,000 | $16.91M | $16.11M | 0.30% | -$795.4K |
| Relay Therapeutics, Inc.(RLAY) | 0 | 1,903,245 | +1,903,245 | $0 | $16.10M | 0.29% | +$16.10M |
| Glaukos Corporation(GKOS) | 0 | 140,000 | +140,000 | $0 | $15.81M | 0.29% | +$15.81M |
| DexCom, Inc.(DXCM) | 0 | 225,758 | +225,758 | $0 | $14.98M | 0.27% | +$14.98M |
| Savara Inc.(SVRA) | 0 | 2,400,000 | +2,400,000 | $0 | $14.47M | 0.27% | +$14.47M |
| Celcuity Inc.NOTE 2 750 8 0(CELC) | 0 | 0 | 0 | $8.72M | $14.10M | 0.26% | +$5.37M |
| LeonaBio, Inc.(LONA) | 540,296 | 1,859,322 | +1,319,026 | $2.24M | $14.08M | 0.26% | +$11.84M |
| Septerna, Inc.(SEPN) | 541,450 | 433,160 | -108,290 | $10.18M | $12.08M | 0.22% | +$1.89M |
| Inhibikase Therapeutics, Inc.(IKT) | 5,421,568 | 5,421,568 | 0 | $8.78M | $11.11M | 0.20% | +$2.33M |
| Adagio Medical Holdings, Inc.(ADGM) | 9,876,576 | 9,876,576 | 0 | $19.16M | $10.27M | 0.19% | -$8.89M |
| Oculis Holding AG(OCS) | 0 | 493,827 | +493,827 | $0 | $9.86M | 0.18% | +$9.86M |
| Gossamer Bio, Inc.(GOSS) | 3,812,797 | 3,139,669 | -673,128 | $10.03M | $9.73M | 0.18% | -$294.7K |
| MapLight Therapeutics, Inc.(MPLT) | 0 | 550,000 | +550,000 | $0 | $9.66M | 0.18% | +$9.66M |
| Xenon Pharmaceuticals Inc.(XENE) | 200,791 | 200,791 | 0 | $8.06M | $9.00M | 0.16% | +$937.7K |
| Opus Genetics, Inc.(IRD) | 4,325,000 | 4,325,000 | 0 | $7.14M | $8.69M | 0.16% | +$1.56M |
| Anteris Technologies Global Corp.(AVR) | 1,705,130 | 1,675,476 | -29,654 | $7.67M | $8.36M | 0.15% | +$687.5K |
| Kestra Med Technologies LtdSHS SHS | 0 | 285,000 | +285,000 | $0 | $7.56M | 0.14% | +$7.56M |
| Billiontoone IncCL A | 0 | 72,812 | +72,812 | $0 | $5.96M | 0.11% | +$5.96M |
| Kymera Therapeutics, Inc.(KYMR) | 169,796 | 69,935 | -99,861 | $9.61M | $5.44M | 0.10% | -$4.17M |
| PepGen Inc.(PEPG) | 829,870 | 829,870 | 0 | $3.83M | $5.40M | 0.10% | +$1.57M |
| Crescent Biopharma, Inc.(CBIO) | 453,686 | 453,686 | 0 | $5.39M | $5.38M | 0.10% | -$13.6K |
| Tenax Therapeutics, Inc.(TENX) | 0 | 439,142 | +439,142 | $0 | $5.35M | 0.10% | +$5.35M |
| Corvus Pharmaceuticals, Inc.(CRVS) | 1,438,595 | 692,441 | -746,154 | $10.60M | $5.33M | 0.10% | -$5.27M |
| Aquestive Therapeutics Inc | 3,760,099 | 747,193 | -3,012,906 | $21.02M | $4.83M | 0.09% | -$16.19M |
| Tango Therapeutics, Inc.(TNGX) | 0 | 513,035 | +513,035 | $0 | $4.55M | 0.08% | +$4.55M |
| Krystal Biotech, Inc.(KRYS) | 35,000 | 17,500 | -17,500 | $6.18M | $4.31M | 0.08% | -$1.86M |
| Cogent Biosciences, Inc.(COGT) | 0 | 121,082 | +121,082 | $0 | $4.30M | 0.08% | +$4.30M |
| Olema Pharmaceuticals, Inc.(OLMA) | 0 | 165,713 | +165,713 | $0 | $4.14M | 0.08% | +$4.14M |
| Schrödinger, Inc.(SDGR) | 0 | 202,400 | +202,400 | $0 | $3.62M | 0.07% | +$3.62M |
| Outset Medical, Inc.(OM) | 833,333 | 833,333 | 0 | $11.77M | $3.09M | 0.06% | -$8.67M |
| SAB Biotherapeutics, Inc.(SABS) | 0 | 803,210 | +803,210 | $0 | $3.00M | 0.06% | +$3.00M |
| Avalo Therapeutics, Inc.(AVTX) | 139,667 | 139,667 | 0 | $1.78M | $2.54M | 0.05% | +$761.2K |
| Connect Biopharma Holdings LimitedSHS(CNTB) | 0 | 792,696 | +792,696 | $0 | $2.24M | 0.04% | +$2.24M |