Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2024 ▲▼ | Q1 2025 ▲▼ | Change ▲▼ | Q4 2024 ▲▼ | Q1 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| DYNAVAX TECHNOLOGIES CORP | 1,850,000 | 5,750,000 | +3,900,000 | 23,625 | 74,578 | 4.13% | +50,953 |
| GALAPAGOS NV(LKFT) | 2,161,200 | 3,961,797 | +1,800,597 | 59,433 | 99,520 | 5.51% | +40,087 |
| KINIKSA PHARMACEUTICALS INTL(KNSA) | 628,609 | 2,118,579 | +1,489,970 | 12,434 | 47,054 | 2.60% | +34,620 |
| SPYRE THERAPEUTICS INC(SYRE) | 0 | 2,050,000 | +2,050,000 | 0 | 33,077 | 1.83% | +33,077 |
| ACELYRIN INC | 0 | 9,818,115 | +9,818,115 | 0 | 24,251 | 1.34% | +24,251 |
| PTC THERAPEUTICS INC(PTCT) | 700,000 | 1,000,000 | +300,000 | 31,598 | 50,960 | 2.82% | +19,362 |
| KALVISTA PHARMACEUTICALS INC | 4,893,847 | 4,941,798 | +47,951 | 41,451 | 57,028 | 3.15% | +15,577 |
| ITEOS THERAPEUTICS INC | 221,716 | 2,689,200 | +2,467,484 | 1,703 | 16,055 | 0.89% | +14,352 |
| LEGEND BIOTECH CORP(LEGN) | 450,000 | 830,000 | +380,000 | 14,643 | 28,162 | 1.56% | +13,519 |
| COMPASS THERAPEUTICS INC(CMPX) | 5,900,000 | 11,052,632 | +5,152,632 | 8,555 | 21,000 | 1.16% | +12,445 |
| ADMA BIOLOGICS INC | 550,000 | 1,050,000 | +500,000 | 9,433 | 20,832 | 1.15% | +11,400 |
| KEROS THERAPEUTICS INC(KROS) | 0 | 1,100,000 | +1,100,000 | 0 | 11,209 | 0.62% | +11,209 |
| ANAPTYSBIO INC | 1,330,879 | 1,545,153 | +214,274 | 17,621 | 28,724 | 1.59% | +11,104 |
| IMMUNOCORE HLDGS PLC(IMCR) | 1,555,600 | 1,915,708 | +360,108 | 45,890 | 56,839 | 3.14% | +10,949 |
| ARVINAS INC(ARVN) | 0 | 1,393,800 | +1,393,800 | 0 | 9,784 | 0.54% | +9,784 |
| ALIBABA GROUP HOLDING LTD ADR(BABA) | 0 | 70,000 | +70,000 | 0 | 9,256 | 0.51% | +9,256 |
| ASTRAZENECA PLC(AZN) | 150,000 | 250,000 | +100,000 | 9,828 | 18,375 | 1.02% | +8,547 |
| PLIANT THERAPEUTICS INC ORD(PLRX) | 0 | 6,000,000 | +6,000,000 | 0 | 8,100 | 0.45% | +8,100 |
| NKARTA INC(NKTX) | 2,293,719 | 7,055,576 | +4,761,857 | 5,711 | 12,982 | 0.72% | +7,271 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 140,000 | 190,000 | +50,000 | 17,241 | 23,589 | 1.30% | +6,348 |
| EVOLUS INC(EOLS) | 4,997,399 | 4,997,399 | 0 | 55,171 | 60,119 | 3.33% | +4,947 |
| AURINIA PHARMACEUTICALS INC(AUPH) | 8,429,500 | 10,029,500 | +1,600,000 | 75,697 | 80,637 | 4.46% | +4,940 |
| REGENERON PHARMACEUTICALS(REGN) | 2,000 | 10,000 | +8,000 | 1,425 | 6,342 | 0.35% | +4,918 |
| LIQUIDIA CORPORATION(LQDA) | 1,100,000 | 1,200,000 | +100,000 | 12,936 | 17,700 | 0.98% | +4,764 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 1,237,107 | 1,237,107 | 0 | 51,154 | 55,732 | 3.08% | +4,577 |
| JOURNEY MED CORP(DERM) | 1,725,569 | 1,854,596 | +129,027 | 6,747 | 10,942 | 0.61% | +4,195 |
| INTRA-CELLULAR THERAPIES INC | 300,000 | 220,000 | -80,000 | 25,056 | 29,022 | 1.61% | +3,966 |
| ANI PHARMACEUTICALS INC(ANIP) | 317,500 | 317,500 | 0 | 17,551 | 21,257 | 1.18% | +3,705 |
| VERA THERAPEUTICS INC CL A(VERA) | 0 | 150,000 | +150,000 | 0 | 3,603 | 0.20% | +3,603 |
| PHATHOM PHARMACEUTICALS INC(PHAT) | 500,000 | 1,200,000 | +700,000 | 4,060 | 7,524 | 0.42% | +3,464 |
| VIR BIOTECHNOLOGY INC(VIR) | 0 | 500,000 | +500,000 | 0 | 3,240 | 0.18% | +3,240 |
| BEIGENE LTD(ONC) | 37,000 | 37,000 | 0 | 6,834 | 10,070 | 0.56% | +3,236 |
| CARGO THERAPEUTICS INC | 640,000 | 3,059,630 | +2,419,630 | 9,229 | 12,453 | 0.69% | +3,224 |
| MINERALYS THERAPEUTICS INC(MLYS) | 0 | 200,000 | +200,000 | 0 | 3,176 | 0.18% | +3,176 |
| APOGEE THERAPEUTICS INC(APGE) | 100,000 | 200,000 | +100,000 | 4,530 | 7,472 | 0.41% | +2,942 |
| KALARIS THERAPEUTICS, INC(KLRS) | 0 | 309,221 | +309,221 | 0 | 2,483 | 0.14% | +2,483 |
| ZENTALIS PHARMACEUTICALS INC(ZNTL) | 0 | 1,500,000 | +1,500,000 | 0 | 2,385 | 0.13% | +2,385 |
| IOVANCE BIOTHERAPEUTICS INC(IOVA) | 500,000 | 1,800,000 | +1,300,000 | 3,700 | 5,994 | 0.33% | +2,294 |
| GSK PLC(GSK) | 400,000 | 400,000 | 0 | 13,528 | 15,496 | 0.86% | +1,968 |
| SANOFI(SNY) | 270,000 | 270,000 | 0 | 13,022 | 14,974 | 0.83% | +1,952 |
| BLUEBIRD BIO INC | 0 | 400,000 | +400,000 | 0 | 1,952 | 0.11% | +1,952 |
| GENMAB A/S(GMAB) | 100,000 | 200,000 | +100,000 | 2,087 | 3,916 | 0.22% | +1,829 |
| THIRD HARMONIC BIO INC | 150,000 | 929,727 | +779,727 | 1,544 | 3,226 | 0.18% | +1,683 |
| HERON THERAPEUTICS INC(HRTX) | 2,140,271 | 2,235,459 | +95,188 | 3,275 | 4,918 | 0.27% | +1,643 |
| ALLAKOS INC | 378,552 | 8,693,687 | +8,315,135 | 458 | 1,979 | 0.11% | +1,521 |
| NEUMORA THERAPEUTICS INC(NMRA) | 0 | 1,400,000 | +1,400,000 | 0 | 1,400 | 0.08% | +1,400 |
| JANUX THERAPEUTICS INC(JANX) | 50,000 | 150,000 | +100,000 | 2,677 | 4,050 | 0.22% | +1,373 |
| SOLENO THERAPEUTICS INC | 50,000 | 50,000 | 0 | 2,248 | 3,573 | 0.20% | +1,325 |
| TARSUS PHARMACEUTICALS INC(TARS) | 2,254,797 | 2,454,797 | +200,000 | 124,848 | 126,103 | 6.98% | +1,255 |
| CLIMB BIO INC(CLYM) | 0 | 1,000,000 | +1,000,000 | 0 | 1,220 | 0.07% | +1,220 |
| ALIGOS THERAPEUTICS INC(ALGS) | 0 | 141,131 | +141,131 | 0 | 1,164 | 0.06% | +1,164 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 100,000 | 200,000 | +100,000 | 1,322 | 2,457 | 0.14% | +1,135 |
| PYXIS ONCOLOGY INC COM(PYXS) | 0 | 1,100,000 | +1,100,000 | 0 | 1,078 | 0.06% | +1,078 |
| AMERICAN ASSETS TRUST INC COM | 0 | 50,000 | +50,000 | 0 | 1,007 | 0.06% | +1,007 |
| MIND MEDICINE MINDMED INC | 200,000 | 400,200 | +200,200 | 1,392 | 2,341 | 0.13% | +949 |
| BERKSHIRE HATHAWAY INC DEL | 3,099 | 4,401 | +1,302 | 1,405 | 2,344 | 0.13% | +939 |
| TG THERAPEUTICS INC(TGTX) | 100,000 | 100,000 | 0 | 3,010 | 3,943 | 0.22% | +933 |
| COCA COLA CO(KO) | 19,714 | 29,762 | +10,048 | 1,227 | 2,132 | 0.12% | +904 |
| VERIZON COMMUNICATIONS INC(VZ) | 30,877 | 47,153 | +16,276 | 1,235 | 2,139 | 0.12% | +904 |
| JOHNSON & JOHNSON(JNJ) | 7,959 | 12,243 | +4,284 | 1,151 | 2,030 | 0.11% | +879 |
| VISA INC(V) | 4,718 | 6,570 | +1,852 | 1,491 | 2,302 | 0.13% | +811 |
| INTEL CORP(INTC) | 55,997 | 84,945 | +28,948 | 1,123 | 1,929 | 0.11% | +806 |
| EXXON MOBIL CORP | 11,053 | 16,597 | +5,544 | 1,189 | 1,974 | 0.11% | +785 |
| CAPRICOR THERAPEUTICS INC(CAPR) | 0 | 79,100 | +79,100 | 0 | 751 | 0.04% | +751 |
| INSMED INC(INSM) | 100,000 | 100,000 | 0 | 6,904 | 7,629 | 0.42% | +725 |
| CENTESSA PHARMACEUTICALS PLC | 0 | 50,000 | +50,000 | 0 | 719 | 0.04% | +719 |
| UNITEDHEALTH GROUP INC(UNH) | 2,308 | 3,541 | +1,233 | 1,168 | 1,855 | 0.10% | +687 |
| AVADEL PHARMACEUTICALS PLC | 1,497,500 | 2,097,500 | +600,000 | 15,739 | 16,423 | 0.91% | +685 |
| PROCTER AND GAMBLE CO(PG) | 7,962 | 11,813 | +3,851 | 1,335 | 2,013 | 0.11% | +678 |
| PRECISION BIOSCIENCES INC(DTIL) | 673,332 | 673,332 | 0 | 2,565 | 3,212 | 0.18% | +646 |
| SPRINGWORKS THERAPEUTICS INC | 74,265 | 74,265 | 0 | 2,683 | 3,277 | 0.18% | +594 |
| JPMORGAN CHASE & CO.(JPM) | 6,601 | 8,854 | +2,253 | 1,582 | 2,172 | 0.12% | +589 |
| PFIZER INC(PFE) | 42,908 | 66,800 | +23,892 | 1,138 | 1,693 | 0.09% | +554 |
| TEXAS INSTRS INC(TXN) | 6,568 | 9,775 | +3,207 | 1,232 | 1,757 | 0.10% | +525 |
| WALMART INC(WMT) | 17,423 | 23,802 | +6,379 | 1,574 | 2,090 | 0.12% | +515 |
| HOME DEPOT INC(HD) | 3,353 | 4,850 | +1,497 | 1,304 | 1,778 | 0.10% | +473 |
| TSCAN THERAPEUTICS INC(TCRX) | 117,847 | 600,000 | +482,153 | 358 | 828 | 0.05% | +470 |
| LANTHEUS HLDGS INC(LNTH) | 50,000 | 50,000 | 0 | 4,473 | 4,880 | 0.27% | +407 |
| DISNEY WALT CO(DIS) | 13,095 | 18,626 | +5,531 | 1,458 | 1,838 | 0.10% | +380 |
| NIKE INC(NKE) | 15,789 | 24,764 | +8,975 | 1,195 | 1,572 | 0.09% | +377 |
| MICROSOFT CORP(MSFT) | 3,413 | 4,825 | +1,412 | 1,438 | 1,811 | 0.10% | +373 |
| META PLATFORMS INC(META) | 26,600 | 27,575 | +975 | 15,574 | 15,893 | 0.88% | +319 |
| CASSAVA SCIENCES INC COMMON STOCK(FLNA) | 0 | 200,000 | +200,000 | 0 | 300 | 0.02% | +300 |
| KODIAK SCIENCES INC(KOD) | 0 | 100,000 | +100,000 | 0 | 281 | 0.02% | +281 |
| QUINCE THERAPEUTICS INC COMMON STOCK(QNCX) | 0 | 184,383 | +184,383 | 0 | 245 | 0.01% | +245 |
| VERASTEM INC(VSTM) | 270,000 | 270,000 | 0 | 1,396 | 1,628 | 0.09% | +232 |
| COMPASS PATHWAYS PLC(CMPS) | 1,000,000 | 1,400,000 | +400,000 | 3,780 | 4,004 | 0.22% | +224 |
| METAGENOMI INC(MGX) | 0 | 134,978 | +134,978 | 0 | 184 | 0.01% | +184 |
| REVIVA PHARMACEUTCLS HLDGS I | 170,000 | 510,329 | +340,329 | 308 | 487 | 0.03% | +179 |
| AEROVATE THERAPEUTICS INC COMMON STOCK | 0 | 69,754 | +69,754 | 0 | 175 | 0.01% | +175 |
| T-MOBILE US INC(TMUS) | 4,509 | 4,328 | -181 | 995 | 1,154 | 0.06% | +159 |
| KRONOS BIO INC | 1,003,382 | 1,345,413 | +342,031 | 953 | 1,110 | 0.06% | +157 |
| GE AEROSPACE(GE) | 5,911 | 5,675 | -236 | 986 | 1,136 | 0.06% | +150 |
| OUTLOOK THERAPEUTICS INC(OTLK) | 182,502 | 400,000 | +217,498 | 345 | 488 | 0.03% | +143 |
| SERES THERAPEUTICS INC(MCRB) | 0 | 203,904 | +203,904 | 0 | 143 | 0.01% | +143 |
| SUTRO BIOPHARMA INC(STRO) | 0 | 200,000 | +200,000 | 0 | 130 | 0.01% | +130 |
| ERASCA INC(ERAS) | 602,915 | 1,190,012 | +587,097 | 1,513 | 1,630 | 0.09% | +117 |
| PAYPAL HLDGS INC(PYPL) | 15,714 | 22,108 | +6,394 | 1,341 | 1,443 | 0.08% | +101 |
| INVIVYD INC(IVVD) | 330,172 | 400,000 | +69,828 | 146 | 242 | 0.01% | +96 |
| CHEVRON CORP NEW(CVX) | 5,978 | 5,697 | -281 | 866 | 953 | 0.05% | +87 |