Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Aurinia Pharmaceuticals Inc.(AUPH) | 11,329,500 | 11,329,500 | 0 | $125.19M | $180.71M | 8.93% | +$55.51M |
| Lakefront Biotherapeutics NVADR(LKFT) | 4,151,194 | 3,921,219 | -229,975 | $143.80M | $128.22M | 6.33% | -$15.57M |
| PTC Therapeutics, Inc.(PTCT) | 1,500,000 | 1,500,000 | 0 | $92.06M | $113.94M | 5.63% | +$21.89M |
| Celcuity Inc.(CELC) | 1,150,000 | 1,050,000 | -100,000 | $56.81M | $104.73M | 5.17% | +$47.92M |
| Mirum Pharmaceuticals, Inc.(MIRM) | 1,236,027 | 1,236,027 | 0 | $90.61M | $97.63M | 4.82% | +$7.02M |
| Tarsus Pharmaceuticals, Inc.(TARS) | 2,454,797 | 1,188,624 | -1,266,173 | $145.89M | $97.32M | 4.81% | -$48.56M |
| Kiniksa Pharmaceuticals International, plcCL A(KNSA) | 2,328,609 | 2,259,889 | -68,720 | $90.42M | $93.22M | 4.60% | +$2.80M |
| Immunocore Holdings plcADS(IMCR) | 2,305,608 | 2,628,538 | +322,930 | $83.76M | $91.24M | 4.51% | +$7.47M |
| Compass Therapeutics, Inc.(CMPX) | 16,811,963 | 16,790,809 | -21,154 | $58.84M | $90.17M | 4.45% | +$31.32M |
| Kalvista Pharmaceuticals Inc | 5,041,798 | 4,573,530 | -468,268 | $61.41M | $73.86M | 3.65% | +$12.45M |
| Avidity Biosciences Inc | 0 | 900,000 | +900,000 | $0 | $64.92M | 3.21% | +$64.92M |
| Anaptysbio Inc | 1,333,639 | 1,332,087 | -1,552 | $40.84M | $64.58M | 3.19% | +$23.74M |
| Spyre Therapeutics, Inc.(SYRE) | 3,200,000 | 1,892,200 | -1,307,800 | $53.63M | $61.99M | 3.06% | +$8.36M |
| Viridian Therapeutics, Inc.(VRDN) | 2,842,925 | 1,792,626 | -1,050,299 | $61.35M | $55.79M | 2.76% | -$5.56M |
| Capricor Therapeutics, Inc.(CAPR) | 0 | 1,700,000 | +1,700,000 | $0 | $49.06M | 2.42% | +$49.06M |
| BioNTech SEADS(BNTX) | 270,000 | 470,000 | +200,000 | $26.63M | $44.74M | 2.21% | +$18.12M |
| ANI Pharmaceuticals, Inc.(ANIP) | 317,500 | 481,437 | +163,937 | $29.08M | $38.00M | 1.88% | +$8.92M |
| Vertex Pharmaceuticals Incorporated(VRTX) | 80,000 | 80,000 | 0 | $31.33M | $36.27M | 1.79% | +$4.94M |
| Nuvation Bio Inc.CL A(NUVB) | 4,200,000 | 3,857,457 | -342,543 | $15.54M | $34.56M | 1.71% | +$19.02M |
| Travere Therapeutics, Inc.(TVTX) | 700,000 | 700,000 | 0 | $16.73M | $26.75M | 1.32% | +$10.02M |
| Ventyx Biosciences Inc | 3,100,000 | 2,814,000 | -286,000 | $9.64M | $25.41M | 1.26% | +$15.77M |
| NVIDIA Corporation(NVDA) | 130,509 | 127,788 | -2,721 | $24.35M | $23.83M | 1.18% | -$518.0K |
| Precigen, Inc.(PGEN) | 12,400,000 | 5,617,500 | -6,782,500 | $40.80M | $23.48M | 1.16% | -$17.31M |
| State Street SPDR S&P 500 ETF TrustTR UNIT(SPY) | 0 | 30,000 | +30,000 | $0 | $20.46M | 1.01% | +$20.46M |
| Moderna, Inc.(MRNA) | 305,300 | 692,820 | +387,520 | $7.89M | $20.43M | 1.01% | +$12.55M |
| Viking Therapeutics, Inc.(VKTX) | 870,000 | 500,000 | -370,000 | $22.86M | $17.59M | 0.87% | -$5.27M |
| Atea Pharmaceuticals, Inc.(AVIR) | 4,826,200 | 4,814,700 | -11,500 | $14.00M | $17.19M | 0.85% | +$3.19M |
| Stoke Therapeutics, Inc.(STOK) | 500,000 | 500,000 | 0 | $11.75M | $15.87M | 0.78% | +$4.12M |
| IDEAYA Biosciences, Inc.(IDYA) | 400,000 | 450,000 | +50,000 | $10.88M | $15.56M | 0.77% | +$4.67M |
| Meta Platforms, Inc.CL A(META) | 26,008 | 23,331 | -2,677 | $19.10M | $15.40M | 0.76% | -$3.70M |
| GSK plcADR(GSK) | 400,000 | 300,000 | -100,000 | $17.26M | $14.71M | 0.73% | -$2.55M |
| Journey Medical Corporation(DERM) | 1,854,596 | 1,854,596 | 0 | $13.20M | $14.30M | 0.71% | +$1.09M |
| LENZ Therapeutics, Inc.(LENZ) | 897,616 | 865,169 | -32,447 | $41.81M | $13.84M | 0.68% | -$27.97M |
| Vaxcyte, Inc.(PCVX) | 300,000 | 275,000 | -25,000 | $10.81M | $12.69M | 0.63% | +$1.88M |
| Dianthus Therapeutics, Inc.(DNTH) | 264,692 | 264,692 | 0 | $10.42M | $10.91M | 0.54% | +$492.3K |
| Harmony Biosciences Holdings, Inc.(HRMY) | 281,200 | 290,292 | +9,092 | $7.75M | $10.86M | 0.54% | +$3.11M |
| Bristol-Myers Squibb Company(BMY) | 0 | 200,000 | +200,000 | $0 | $10.79M | 0.53% | +$10.79M |
| Insmed Incorporated(INSM) | 200,000 | 60,000 | -140,000 | $28.80M | $10.44M | 0.52% | -$18.36M |
| Crescent Biopharma, Inc.(CBIO) | 679,824 | 872,398 | +192,574 | $8.08M | $10.35M | 0.51% | +$2.26M |
| Wave Life Sciences, Inc.SHS(WVE) | 0 | 600,000 | +600,000 | $0 | $10.20M | 0.50% | +$10.20M |
| Teladoc Health, Inc.(TDOC) | 1,400,000 | 1,400,000 | 0 | $10.82M | $9.80M | 0.48% | -$1.02M |
| Dynavax Technologies Corp | 1,949,500 | 556,359 | -1,393,141 | $19.36M | $8.56M | 0.42% | -$10.80M |
| Evolus, Inc.(EOLS) | 5,488,299 | 1,245,692 | -4,242,607 | $33.70M | $8.28M | 0.41% | -$25.41M |
| Verastem, Inc.(VSTM) | 789,810 | 1,069,810 | +280,000 | $6.97M | $8.26M | 0.41% | +$1.28M |
| UroGen Pharma Ltd.(URGN) | 1,000,000 | 350,000 | -650,000 | $19.95M | $8.20M | 0.40% | -$11.75M |
| Heron Therapeutics, Inc.(HRTX) | 3,450,000 | 6,250,000 | +2,800,000 | $4.35M | $8.13M | 0.40% | +$3.78M |
| Acadia Pharmaceuticals Inc | 1,500,000 | 300,000 | -1,200,000 | $32.01M | $8.01M | 0.40% | -$24.00M |
| Altimmune, Inc.(ALT) | 2,131,307 | 2,131,307 | 0 | $8.04M | $7.69M | 0.38% | -$341.0K |
| Sarepta Therapeutics, Inc.(SRPT) | 600,000 | 349,220 | -250,780 | $11.56M | $7.52M | 0.37% | -$4.05M |
| Pliant Therapeutics, Inc.(PLRX) | 6,003,446 | 6,143,132 | +139,686 | $8.89M | $7.49M | 0.37% | -$1.39M |
| Arvinas, Inc.(ARVN) | 1,393,800 | 569,698 | -824,102 | $11.88M | $6.76M | 0.33% | -$5.12M |
| Theravance Biopharma Inc | 264,308 | 351,252 | +86,944 | $3.86M | $6.57M | 0.32% | +$2.71M |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 800,000 | 800,000 | 0 | $6.07M | $6.24M | 0.31% | +$168.0K |
| PMV Pharmaceuticals, Inc.(PMVP) | 4,785,201 | 4,940,000 | +154,799 | $6.70M | $6.17M | 0.31% | -$524.3K |
| Regeneron Pharmaceuticals, Inc.(REGN) | 10,000 | 8,000 | -2,000 | $5.62M | $6.17M | 0.31% | +$552.3K |
| Biogen Inc.(BIIB) | 35,000 | 35,000 | 0 | $4.90M | $6.16M | 0.30% | +$1.26M |
| Corcept Therapeutics Incorporated(CORT) | 0 | 156,764 | +156,764 | $0 | $5.46M | 0.27% | +$5.46M |
| Abeona Therapeutics Inc.(ABEO) | 0 | 1,000,000 | +1,000,000 | $0 | $5.27M | 0.26% | +$5.27M |
| ImmunityBio, Inc.(IBRX) | 2,333,333 | 2,333,333 | 0 | $5.74M | $4.62M | 0.23% | -$1.12M |
| Kezar Life Sciences Inc COM NEW | 720,000 | 664,314 | -55,686 | $2.81M | $4.18M | 0.21% | +$1.37M |
| Coherus Oncology, Inc.(CHRS) | 5,097,362 | 2,724,509 | -2,372,853 | $8.36M | $3.87M | 0.19% | -$4.49M |
| Erasca, Inc.(ERAS) | 1,502,915 | 900,000 | -602,915 | $3.28M | $3.35M | 0.17% | +$71.6K |
| Nkarta, Inc.(NKTX) | 7,055,576 | 1,480,823 | -5,574,753 | $14.61M | $2.74M | 0.14% | -$11.87M |
| Nuvalent Inc | 50,000 | 21,880 | -28,120 | $4.32M | $2.20M | 0.11% | -$2.12M |
| Alexandria Real Estate Eq In | 40,000 | 40,000 | 0 | $3.33M | $1.96M | 0.10% | -$1.38M |
| Neumora Therapeutics, Inc.(NMRA) | 1,400,000 | 967,235 | -432,765 | $2.55M | $1.73M | 0.09% | -$816.6K |
| Sutro Biopharma, Inc.(STRO) | 0 | 139,617 | +139,617 | $0 | $1.62M | 0.08% | +$1.62M |
| Biohaven Ltd.(BHVN) | 140,000 | 140,000 | 0 | $2.10M | $1.58M | 0.08% | -$520.8K |
| Revolution Medicines, Inc.(RVMD) | 100,000 | 15,640 | -84,360 | $4.67M | $1.25M | 0.06% | -$3.42M |
| Fate Therapeutics, Inc.(FATE) | 1,867,773 | 1,167,773 | -700,000 | $2.35M | $1.15M | 0.06% | -$1.21M |
| Zymeworks Inc.(ZYME) | 1,100,000 | 34,631 | -1,065,369 | $18.79M | $911.8K | 0.05% | -$17.88M |
| Rocket Pharmaceuticals, Inc.(RCKT) | 850,000 | 100,000 | -750,000 | $2.77M | $351.0K | 0.02% | -$2.42M |
| Adicet Bio Inc | 0 | 6,158 | +6,158 | $0 | $51.9K | 0.00% | +$51.9K |
| TScan Therapeutics, Inc.(TCRX) | 600,000 | 46,131 | -553,869 | $1.09M | $46.1K | 0.00% | -$1.05M |
| Filana Therapeutics, Inc.(FLNA) | 7,073 | 7,073 | 0 | $20.6K | $14.0K | 0.00% | -$6.6K |
| AbCellera Biologics Inc.(ABCL) | 2,600,000 | 0 | -2,600,000 | $13.08M | $0 | — | -$13.08M |
| Adicet Bio Inc | 8,223,612 | 0 | -8,223,612 | $6.66M | $0 | — | -$6.66M |
| Adma Biologics Inc | 1,050,000 | 0 | -1,050,000 | $15.39M | $0 | — | -$15.39M |
| Alibaba Group Holding LimitedADS(BABA) | 70,000 | 0 | -70,000 | $12.51M | $0 | — | -$12.51M |
| The Allstate Corporation(ALL) | 2,700 | 0 | -2,700 | $579.6K | $0 | — | -$579.6K |
| Alumis Inc | 1,167,009 | 0 | -1,167,009 | $4.66M | $0 | — | -$4.66M |
| Amazon.com, Inc.(AMZN) | 2,583 | 0 | -2,583 | $567.1K | $0 | — | -$567.1K |
| American Assets Tr Inc | 50,000 | 0 | -50,000 | $1.02M | $0 | — | -$1.02M |
| American Express Company(AXP) | 1,931 | 0 | -1,931 | $641.3K | $0 | — | -$641.3K |
| Amylyx Pharmaceuticals, Inc.(AMLX) | 100,000 | 0 | -100,000 | $1.36M | $0 | — | -$1.36M |
| Apogee Therapeutics Inc | 200,000 | 0 | -200,000 | $7.95M | $0 | — | -$7.95M |
| AstraZeneca PLCADR(AZN) | 150,000 | 0 | -150,000 | $11.51M | $0 | — | -$11.51M |
| Astria Therapeutics Inc | 100,000 | 0 | -100,000 | $728.0K | $0 | — | -$728.0K |
| LeonaBio, Inc.(LONA) | 59,998 | 0 | -59,998 | $248.4K | $0 | — | -$248.4K |
| Atyr Pharma Inc | 671,134 | 0 | -671,134 | $484.2K | $0 | — | -$484.2K |
| Avadel Pharmaceuticals Plc | 2,097,500 | 0 | -2,097,500 | $32.03M | $0 | — | -$32.03M |
| Bausch Health Cos Inc | 1,300,000 | 0 | -1,300,000 | $8.38M | $0 | — | -$8.38M |
| Bausch Plus Lomb Corp | 444,467 | 0 | -444,467 | $6.70M | $0 | — | -$6.70M |
| Beam Therapeutics Inc.(BEAM) | 255,000 | 0 | -255,000 | $6.19M | $0 | — | -$6.19M |
| Berkshire Hathaway Inc DelCL B | 3,250 | 0 | -3,250 | $1.63M | $0 | — | -$1.63M |
| BioAge Labs, Inc.(BIOA) | 1,600,000 | 0 | -1,600,000 | $9.41M | $0 | — | -$9.41M |
| BioAtla, Inc.(BCAB) | 1,374,076 | 0 | -1,374,076 | $945.2K | $0 | — | -$945.2K |
| Black Diamond Therapeutics I | 2,070,209 | 0 | -2,070,209 | $7.85M | $0 | — | -$7.85M |
| The Boeing Company(BA) | 3,225 | 0 | -3,225 | $696.1K | $0 | — | -$696.1K |
| Bolt Biotherapeutics Inc | 66,879 | 0 | -66,879 | $355.8K | $0 | — | -$355.8K |