Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q4 2023 ▲▼ | Q1 2024 ▲▼ | Change ▲▼ | Q4 2023 ▲▼ | Q1 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Incyte Corporation(INCY) | 36,179,122 | 36,179,665 | +543 | $2.27B | $2.06B | 25.86% | -$210.53M |
| BeOne Medicines AGADR(ONC) | 10,568,897 | 10,568,897 | 0 | $1.91B | $1.65B | 20.73% | -$253.34M |
| ACADIA Pharmaceuticals Inc. | 42,864,612 | 42,864,612 | 0 | $1.34B | $792.57M | 9.94% | -$549.52M |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 1,969,798 | 1,969,798 | 0 | $455.77M | $526.01M | 6.60% | +$70.24M |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 6,398,365 | 6,398,365 | 0 | $294.13M | $277.24M | 3.48% | -$16.89M |
| Revolution Medicines, Inc.(RVMD) | 5,148,657 | 7,549,249 | +2,400,592 | $147.66M | $243.31M | 3.05% | +$95.65M |
| Kymera Therapeutics, Inc.(KYMR) | 5,995,928 | 5,995,928 | 0 | $152.66M | $241.04M | 3.02% | +$88.38M |
| AbCellera Biologics Inc.(ABCL) | 22,909,753 | 27,525,640 | +4,615,887 | $130.81M | $124.69M | 1.56% | -$6.12M |
| Bicycle Therapeutics plcADS | 1,790,390 | 4,942,823 | +3,152,433 | $32.37M | $123.08M | 1.54% | +$90.71M |
| Edgewise Therapeutics, Inc.(EWTX) | 3,112,786 | 5,840,059 | +2,727,273 | $34.05M | $106.52M | 1.34% | +$72.47M |
| Immunocore Holdings plcADS(IMCR) | 2,520,731 | 1,515,318 | -1,005,413 | $172.22M | $98.50M | 1.24% | -$73.72M |
| Kodiak Sciences Inc.(KOD) | 17,310,490 | 17,310,490 | 0 | $52.62M | $91.05M | 1.14% | +$38.43M |
| Roivant Sciences Ltd.SHS(ROIV) | 7,593,024 | 7,413,834 | -179,190 | $85.27M | $78.14M | 0.98% | -$7.13M |
| Replimune Group, Inc.(REPL) | 9,545,336 | 9,545,336 | 0 | $80.47M | $77.99M | 0.98% | -$2.48M |
| Denali Therapeutics Inc.(DNLI) | 2,607,196 | 3,731,695 | +1,124,499 | $55.95M | $76.57M | 0.96% | +$20.62M |
| Entrada Therapeutics, Inc.(TRDA) | 4,865,819 | 4,865,819 | 0 | $73.43M | $68.95M | 0.86% | -$4.48M |
| Akero Therapeutics, Inc. | 2,368,378 | 2,713,205 | +344,827 | $55.30M | $68.54M | 0.86% | +$13.23M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 1,466,547 | 1,466,547 | 0 | $70.13M | $68.47M | 0.86% | -$1.66M |
| Immatics N.V.SHS(IMTX) | 5,838,853 | 6,443,398 | +604,545 | $61.48M | $67.72M | 0.85% | +$6.24M |
| Cerevel Therapeutics Holdings, Inc. | 1,600,000 | 1,600,000 | 0 | $67.84M | $67.63M | 0.85% | -$208.0K |
| argenx SEADR(ARGX) | 151,215 | 151,215 | 0 | $57.53M | $59.54M | 0.75% | +$2.01M |
| Nurix Therapeutics, Inc.(NRIX) | 3,882,125 | 3,882,125 | 0 | $40.06M | $57.07M | 0.72% | +$17.00M |
| Kiniksa Pharmaceuticals, Ltd.CL A | 2,809,577 | 2,809,577 | 0 | $49.28M | $55.43M | 0.70% | +$6.15M |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 10,126,176 | 10,126,176 | 0 | $60.66M | $51.44M | 0.65% | -$9.21M |
| Aerovate Therapeutics, Inc. | 1,680,517 | 1,680,517 | 0 | $38.03M | $49.69M | 0.62% | +$11.66M |
| Sera Prognostics, Inc.CL A(SERA) | 5,434,399 | 5,434,399 | 0 | $32.50M | $49.45M | 0.62% | +$16.96M |
| Prelude Therapeutics Incorporated(PRLD) | 10,123,824 | 10,123,824 | 0 | $43.23M | $47.99M | 0.60% | +$4.76M |
| IDEAYA Biosciences, Inc.(IDYA) | 1,062,123 | 1,062,123 | 0 | $37.79M | $46.61M | 0.58% | +$8.82M |
| Stoke Therapeutics, Inc.(STOK) | 2,030,134 | 3,368,443 | +1,338,309 | $10.68M | $45.47M | 0.57% | +$34.80M |
| Xenon Pharmaceuticals Inc.(XENE) | 993,679 | 993,679 | 0 | $45.77M | $42.78M | 0.54% | -$2.99M |
| IGM Biosciences, Inc. | 3,691,011 | 4,088,322 | +397,311 | $30.67M | $39.45M | 0.49% | +$8.78M |
| Cerus Corporation(CERS) | 19,477,339 | 19,477,339 | 0 | $42.07M | $36.81M | 0.46% | -$5.26M |
| Monte Rosa Therapeutics, Inc.(GLUE) | 4,916,095 | 4,916,095 | 0 | $27.78M | $34.66M | 0.43% | +$6.88M |
| Celcuity Inc.(CELC) | 535,478 | 1,552,478 | +1,017,000 | $7.80M | $33.53M | 0.42% | +$25.73M |
| Biomea Fusion, Inc.(BMEA) | 2,108,949 | 2,108,949 | 0 | $30.62M | $31.53M | 0.40% | +$906.8K |
| Krystal Biotech, Inc.(KRYS) | 169,934 | 169,934 | 0 | $21.08M | $30.24M | 0.38% | +$9.15M |
| Sana Biotechnology, Inc.(SANA) | 2,000,000 | 2,380,949 | +380,949 | $8.16M | $23.81M | 0.30% | +$15.65M |
| Neurogene Inc.(NGNE) | 453,516 | 456,015 | +2,499 | $8.79M | $23.21M | 0.29% | +$14.42M |
| Verve Therapeutics, Inc. | 1,691,530 | 1,691,530 | 0 | $23.58M | $22.46M | 0.28% | -$1.12M |
| TScan Therapeutics, Inc.(TCRX) | 2,784,792 | 2,784,792 | 0 | $16.24M | $22.11M | 0.28% | +$5.88M |
| Adaptimmune Therapeutics plcADR(ADAPY) | 10,969,282 | 10,787,022 | -182,260 | $8.70M | $17.04M | 0.21% | +$8.34M |
| Immunovant, Inc.(IMVT) | 425,009 | 425,009 | 0 | $17.91M | $13.73M | 0.17% | -$4.17M |
| 2seventy bio, Inc. | 2,497,526 | 2,497,526 | 0 | $10.66M | $13.36M | 0.17% | +$2.70M |
| Fate Therapeutics, Inc.(FATE) | 0 | 1,818,181 | +1,818,181 | $0 | $13.35M | 0.17% | +$13.35M |
| Xencor, Inc.(XNCR) | 245,431 | 545,431 | +300,000 | $5.21M | $12.07M | 0.15% | +$6.86M |
| Taysha Gene Therapies, Inc.(TSHA) | 4,004,756 | 4,004,756 | 0 | $7.09M | $11.49M | 0.14% | +$4.41M |
| DBV Technologies S.A.ADR | 14,614,264 | 14,614,264 | 0 | $13.92M | $10.95M | 0.14% | -$2.98M |
| Celldex Therapeutics, Inc.(CLDX) | 247,644 | 247,644 | 0 | $9.82M | $10.39M | 0.13% | +$572.1K |
| Relay Therapeutics, Inc.(RLAY) | 1,160,117 | 1,160,117 | 0 | $12.77M | $9.63M | 0.12% | -$3.14M |
| Insmed Incorporated(INSM) | 343,000 | 343,000 | 0 | $10.63M | $9.31M | 0.12% | -$1.32M |
| Ceryvyn Therapeutics LimitedADS(CKDXF) | 2,588,645 | 2,177,826 | -410,819 | $7.64M | $8.95M | 0.11% | +$1.31M |
| Neumora Therapeutics, Inc.(NMRA) | 0 | 633,851 | +633,851 | $0 | $8.72M | 0.11% | +$8.72M |
| Athira Pharma, Inc. | 3,153,807 | 3,153,807 | 0 | $7.66M | $8.64M | 0.11% | +$977.7K |
| Dyne Therapeutics, Inc.(DYN) | 0 | 285,000 | +285,000 | $0 | $8.09M | 0.10% | +$8.09M |
| Praxis Precision Medicines, Inc.(PRAX) | 0 | 131,533 | +131,533 | $0 | $8.03M | 0.10% | +$8.03M |
| Sage Therapeutics, Inc. | 0 | 407,217 | +407,217 | $0 | $7.63M | 0.10% | +$7.63M |
| Sagimet Biosciences Inc.COM SER A(SGMT) | 1,456,518 | 1,381,898 | -74,620 | $7.89M | $7.49M | 0.09% | -$404.4K |
| Prime Medicine, Inc.(PRME) | 1,028,466 | 1,028,466 | 0 | $9.11M | $7.20M | 0.09% | -$1.91M |
| Design Therapeutics, Inc.(DSGN) | 1,500,000 | 1,662,120 | +162,120 | $3.98M | $6.70M | 0.08% | +$2.72M |
| Tango Therapeutics, Inc.(TNGX) | 750,000 | 750,000 | 0 | $7.42M | $5.96M | 0.07% | -$1.47M |
| HOOKIPA Pharma Inc. | 8,128,151 | 8,128,151 | 0 | $6.58M | $5.79M | 0.07% | -$796.6K |
| Mersana Therapeutics, Inc. | 1,086,115 | 1,086,115 | 0 | $2.52M | $4.87M | 0.06% | +$2.35M |
| Mirum Pharmaceuticals, Inc.(MIRM) | 190,476 | 190,476 | 0 | $5.62M | $4.78M | 0.06% | -$838.1K |
| Talis Biomedical Corporation | 508,323 | 508,323 | 0 | $3.79M | $4.45M | 0.06% | +$660.8K |
| Vaxcyte, Inc.(PCVX) | 48,885 | 48,885 | 0 | $3.07M | $3.34M | 0.04% | +$269.4K |
| Century Therapeutics, Inc.(IPSC) | 797,460 | 797,460 | 0 | $2.65M | $3.33M | 0.04% | +$685.8K |
| Alpine Immune Sciences, Inc. | 0 | 81,578 | +81,578 | $0 | $3.23M | 0.04% | +$3.23M |
| 4D Molecular Therapeutics, Inc. | 0 | 100,000 | +100,000 | $0 | $3.19M | 0.04% | +$3.19M |
| Cypherpunk Technologies Inc.(CYPH) | 1,172,175 | 1,172,175 | 0 | $4.86M | $3.12M | 0.04% | -$1.74M |
| Compass Therapeutics, Inc.(CMPX) | 1,557,630 | 1,557,630 | 0 | $2.43M | $3.08M | 0.04% | +$654.2K |
| NewAmsterdam Pharma Company N.V. ORDINARY SHARES | 0 | 96,827 | +96,827 | $0 | $2.29M | 0.03% | +$2.29M |
| vTv Therapeutics Inc.CL A(VTVT) | 0 | 97,314 | +97,314 | $0 | $2.29M | 0.03% | +$2.29M |
| KALA BIO, Inc.(KALA) | 266,613 | 266,613 | 0 | $1.87M | $2.12M | 0.03% | +$258.6K |
| Aligos Therapeutics, Inc. | 2,076,400 | 2,076,400 | 0 | $1.38M | $2.03M | 0.03% | +$656.1K |
| Enliven Therapeutics, Inc. | 0 | 114,833 | +114,833 | $0 | $2.02M | 0.03% | +$2.02M |
| Achilles Therapeutics plcADS | 2,102,792 | 1,208,775 | -894,017 | $1.87M | $1.51M | 0.02% | -$358.4K |
| Generation Bio Co. | 0 | 371,219 | +371,219 | $0 | $1.51M | 0.02% | +$1.51M |
| Mural Oncology plc | 0 | 222,503 | +222,503 | $0 | $1.09M | 0.01% | +$1.09M |
| Pfizer Inc.(PFE) | 35,000 | 35,000 | 0 | $1.01M | $971.3K | 0.01% | -$36.4K |
| Protara Therapeutics, Inc.(TARA) | 199,671 | 199,671 | 0 | $374.4K | $800.7K | 0.01% | +$426.3K |
| PMV Pharmaceuticals, Inc.(PMVP) | 322,024 | 322,024 | 0 | $998.3K | $547.4K | 0.01% | -$450.8K |
| Acrivon Therapeutics, Inc. | 0 | 52,885 | +52,885 | $0 | $378.1K | 0.00% | +$378.1K |
| Foghorn Therapeutics Inc.(FHTX) | 45,027 | 45,027 | 0 | $290.4K | $302.1K | 0.00% | +$11.7K |
| Cabaletta Bio, Inc.(CABA) | 13,331 | 13,331 | 0 | $302.6K | $227.4K | 0.00% | -$75.2K |
| Perspective Therapeutics, Inc.(CATX) | 7,639,703 | 149,787 | -7,489,916 | $3.07M | $178.2K | 0.00% | -$2.89M |
| Tyra Biosciences, Inc.(TYRA) | 10,607 | 10,607 | 0 | $146.9K | $174.0K | 0.00% | +$27.0K |
| Surrozen, Inc.W EXP 8 11 2026(SRZN) | 833,333 | 833,333 | 0 | $16.2K | $25.2K | 0.00% | +$9.0K |
| Whitehawk Therapeutics, Inc.(WHWK) | 251,727 | 0 | -251,727 | $508.5K | $0 | — | -$508.5K |
| ARS Pharmaceuticals, Inc.(SPRY) | 2,006,451 | 0 | -2,006,451 | $11.00M | $0 | — | -$11.00M |
| Atreca, Inc.CL A | 2,177,499 | 0 | -2,177,499 | $287.4K | $0 | — | -$287.4K |
| Day One Biopharmaceuticals, Inc. COM | 1,000,000 | 0 | -1,000,000 | $14.60M | $0 | — | -$14.60M |
| Gracell Biotechnologies Inc.ADS | 2,080,000 | 0 | -2,080,000 | $20.88M | $0 | — | -$20.88M |
| Invitae Corporation | 1,764,546 | 0 | -1,764,546 | $1.11M | $0 | — | -$1.11M |
| Mirati Therapeutics, Inc. | 4,121,440 | 0 | -4,121,440 | $242.13M | $0 | — | -$242.13M |
| Praxis Precision Medicines, Inc. | 131,533 | 0 | -131,533 | $2.93M | $0 | — | -$2.93M |
| Invitae CorporationNOTES 1 5 4 1 2028 | 0 | 0 | 0 | $131.15M | $0 | — | -$131.15M |
| Invitae CorporationSERIES A NOTES 4 5 3 15 2028 | 0 | 0 | 0 | $6.27M | $0 | — | -$6.27M |