Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2023 ▲▼ | Q1 2024 ▲▼ | Change ▲▼ | Q4 2023 ▲▼ | Q1 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Revolution Medicines, Inc.(RVMD) | 5,148,657 | 7,549,249 | +2,400,592 | 147,663 | 243,312 | 3.05% | +95,649 |
| Bicycle Therapeutics plc | 1,790,390 | 4,942,823 | +3,152,433 | 32,370 | 123,076 | 1.54% | +90,706 |
| Kymera Therapeutics, Inc.(KYMR) | 5,995,928 | 5,995,928 | 0 | 152,656 | 241,036 | 3.02% | +88,380 |
| Edgewise Therapeutics, Inc.(EWTX) | 3,112,786 | 5,840,059 | +2,727,273 | 34,054 | 106,523 | 1.34% | +72,469 |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 1,969,798 | 1,969,798 | 0 | 455,772 | 526,015 | 6.60% | +70,243 |
| Kodiak Sciences Inc.(KOD) | 17,310,490 | 17,310,490 | 0 | 52,624 | 91,053 | 1.14% | +38,429 |
| Stoke Therapeutics, Inc.(STOK) | 2,030,134 | 3,368,443 | +1,338,309 | 10,679 | 45,474 | 0.57% | +34,795 |
| Celcuity Inc.(CELC) | 535,478 | 1,552,478 | +1,017,000 | 7,802 | 33,534 | 0.42% | +25,732 |
| Denali Therapeutics Inc.(DNLI) | 2,607,196 | 3,731,695 | +1,124,499 | 55,950 | 76,574 | 0.96% | +20,624 |
| Nurix Therapeutics, Inc.(NRIX) | 3,882,125 | 3,882,125 | 0 | 40,064 | 57,067 | 0.72% | +17,004 |
| Sera Prognostics, Inc. | 5,434,399 | 5,434,399 | 0 | 32,498 | 49,453 | 0.62% | +16,955 |
| Sana Biotechnology, Inc.(SANA) | 2,000,000 | 2,380,949 | +380,949 | 8,160 | 23,809 | 0.30% | +15,649 |
| Neurogene Inc. | 453,516 | 456,015 | +2,499 | 8,789 | 23,211 | 0.29% | +14,422 |
| 2seventy bio, Inc. | 0 | 2,497,526 | +2,497,526 | 0 | 13,362 | 0.17% | +13,362 |
| Fate Therapeutics, Inc. | 0 | 1,818,181 | +1,818,181 | 0 | 13,345 | 0.17% | +13,345 |
| Akero Therapeutics, Inc. | 0 | 2,713,205 | +2,713,205 | 0 | 68,536 | 0.86% | +68,536 |
| Aerovate Therapeutics, Inc. | 1,680,517 | 1,680,517 | 0 | 38,030 | 49,693 | 0.62% | +11,663 |
| Krystal Biotech, Inc.(KRYS) | 169,934 | 169,934 | 0 | 21,082 | 30,236 | 0.38% | +9,154 |
| IDEAYA Biosciences, Inc.(IDYA) | 1,062,123 | 1,062,123 | 0 | 37,790 | 46,606 | 0.58% | +8,816 |
| IGM Biosciences, Inc. | 3,691,011 | 4,088,322 | +397,311 | 30,672 | 39,452 | 0.49% | +8,780 |
| Neumora Therapeutics, Inc. | 0 | 633,851 | +633,851 | 0 | 8,715 | 0.11% | +8,715 |
| Adaptimmune Therapeutics plc | 10,969,282 | 10,787,022 | -182,260 | 8,699 | 17,043 | 0.21% | +8,345 |
| Dyne Therapeutics, Inc.(DYN) | 0 | 285,000 | +285,000 | 0 | 8,091 | 0.10% | +8,091 |
| Praxis Precision Medicines, Inc.(PRAX) | 0 | 131,533 | +131,533 | 0 | 8,026 | 0.10% | +8,026 |
| Sage Therapeutics, Inc. | 0 | 407,217 | +407,217 | 0 | 7,631 | 0.10% | +7,631 |
| Monte Rosa Therapeutics, Inc.(GLUE) | 4,916,095 | 4,916,095 | 0 | 27,776 | 34,658 | 0.43% | +6,883 |
| Xencor, Inc.(XNCR) | 245,431 | 545,431 | +300,000 | 5,211 | 12,070 | 0.15% | +6,860 |
| Immatics N.V.(IMTX) | 5,838,853 | 6,443,398 | +604,545 | 61,483 | 67,720 | 0.85% | +6,237 |
| Kiniksa Pharmaceuticals, Ltd. | 2,809,577 | 2,809,577 | 0 | 49,280 | 55,433 | 0.70% | +6,153 |
| TScan Therapeutics, Inc. | 2,784,792 | 2,784,792 | 0 | 16,235 | 22,111 | 0.28% | +5,876 |
| Prelude Therapeutics Inc. | 10,123,824 | 10,123,824 | 0 | 43,229 | 47,987 | 0.60% | +4,758 |
| Taysha Gene Therapies, Inc.(TSHA) | 4,004,756 | 4,004,756 | 0 | 7,088 | 11,494 | 0.14% | +4,405 |
| Alpine Immune Sciences, Inc. | 0 | 81,578 | +81,578 | 0 | 3,234 | 0.04% | +3,234 |
| 4D Molecular Therapeutics, Inc. | 0 | 100,000 | +100,000 | 0 | 3,186 | 0.04% | +3,186 |
| Design Therapeutics, Inc.(DSGN) | 1,500,000 | 1,662,120 | +162,120 | 3,975 | 6,698 | 0.08% | +2,723 |
| Mersana Therapeutics, Inc. | 1,086,115 | 1,086,115 | 0 | 2,520 | 4,866 | 0.06% | +2,346 |
| NewAmsterdam Pharma Company N.V. ORDINARY SHARES | 0 | 96,827 | +96,827 | 0 | 2,290 | 0.03% | +2,290 |
| vTv Therapeutics, Inc. | 0 | 97,314 | +97,314 | 0 | 2,290 | 0.03% | +2,290 |
| Enliven Therapeutics, Inc. | 0 | 114,833 | +114,833 | 0 | 2,020 | 0.03% | +2,020 |
| argenx SE(ARGX) | 151,215 | 151,215 | 0 | 57,527 | 59,536 | 0.75% | +2,010 |
| Generation Bio Co. | 0 | 371,219 | +371,219 | 0 | 1,511 | 0.02% | +1,511 |
| Opthea Limited | 2,588,645 | 2,177,826 | -410,819 | 7,637 | 8,951 | 0.11% | +1,314 |
| Mural Oncology plc | 0 | 222,503 | +222,503 | 0 | 1,088 | 0.01% | +1,088 |
| Athira Pharma, Inc. | 3,153,807 | 3,153,807 | 0 | 7,664 | 8,641 | 0.11% | +978 |
| Biomea Fusion, Inc. | 2,108,949 | 2,108,949 | 0 | 30,622 | 31,529 | 0.40% | +907 |
| Century Therapeutics, Inc. | 797,460 | 797,460 | 0 | 2,648 | 3,333 | 0.04% | +686 |
| Talis Biomedical Corporation | 508,323 | 508,323 | 0 | 3,787 | 4,448 | 0.06% | +661 |
| Aligos Therapeutics, Inc. | 2,076,400 | 2,076,400 | 0 | 1,379 | 2,035 | 0.03% | +656 |
| Compass Therapeutics, Inc. | 1,557,630 | 1,557,630 | 0 | 2,430 | 3,084 | 0.04% | +654 |
| Celldex Therapeutics, Inc.(CLDX) | 247,644 | 247,644 | 0 | 9,822 | 10,394 | 0.13% | +572 |
| Protara Therapeutics, Inc. | 199,671 | 199,671 | 0 | 374 | 801 | 0.01% | +426 |
| Acrivon Therapeutics, Inc. | 0 | 52,885 | +52,885 | 0 | 378 | 0.00% | +378 |
| Vaxcyte, Inc.(PCVX) | 48,885 | 48,885 | 0 | 3,070 | 3,339 | 0.04% | +269 |
| KALA BIO, Inc. | 266,613 | 266,613 | 0 | 1,866 | 2,125 | 0.03% | +259 |
| Tyra Biosciences, Inc.(TYRA) | 10,607 | 10,607 | 0 | 147 | 174 | 0.00% | +27 |
| Foghorn Therapeutics Inc. | 45,027 | 45,027 | 0 | 290 | 302 | 0.00% | +12 |
| Surrozen, Inc. | 833,333 | 833,333 | 0 | 16 | 25 | 0.00% | +9 |
| Pfizer Inc.(PFE) | 35,000 | 35,000 | 0 | 1,008 | 971 | 0.01% | -36 |
| Cabaletta Bio, Inc. | 0 | 13,331 | +13,331 | 0 | 227 | 0.00% | +227 |
| Cerevel Therapeutics Holdings, Inc. | 1,600,000 | 1,600,000 | 0 | 67,840 | 67,632 | 0.85% | -208 |
| Atreca, Inc. | 2,177,499 | 0 | -2,177,499 | 287 | 0 | — | -287 |
| Achilles Therapeutics plc | 2,102,792 | 1,208,775 | -894,017 | 1,869 | 1,511 | 0.02% | -358 |
| Sagimet Biosciences Inc. | 1,456,518 | 1,381,898 | -74,620 | 7,894 | 7,490 | 0.09% | -404 |
| PMV Pharmaceuticals, Inc. | 322,024 | 322,024 | 0 | 998 | 547 | 0.01% | -451 |
| Aadi Bioscience, Inc. | 251,727 | 0 | -251,727 | 508 | 0 | — | -508 |
| HOOKIPA Pharma Inc. | 8,128,151 | 8,128,151 | 0 | 6,584 | 5,787 | 0.07% | -797 |
| Mirum Pharmaceuticals, Inc.(MIRM) | 190,476 | 190,476 | 0 | 5,623 | 4,785 | 0.06% | -838 |
| Invitae Corporation | 1,764,546 | 0 | -1,764,546 | 1,106 | 0 | — | -1,106 |
| Verve Therapeutics, Inc. | 1,691,530 | 1,691,530 | 0 | 23,580 | 22,464 | 0.28% | -1,116 |
| Insmed Incorporated(INSM) | 343,000 | 343,000 | 0 | 10,630 | 9,306 | 0.12% | -1,324 |
| Tango Therapeutics, Inc.(TNGX) | 750,000 | 750,000 | 0 | 7,425 | 5,955 | 0.07% | -1,470 |
| Ultragenyx Pharmaceutical Inc.(RARE) | 1,466,547 | 1,466,547 | 0 | 70,130 | 68,473 | 0.86% | -1,657 |
| Leap Therapeutics, Inc. | 1,172,175 | 1,172,175 | 0 | 4,859 | 3,118 | 0.04% | -1,741 |
| Prime Medicine, Inc. | 1,028,466 | 1,028,466 | 0 | 9,112 | 7,199 | 0.09% | -1,913 |
| Replimune Group, Inc.(REPL) | 9,545,336 | 9,545,336 | 0 | 80,467 | 77,985 | 0.98% | -2,482 |
| Perspective Therapeutics, Inc. | 7,639,703 | 149,787 | -7,489,916 | 3,071 | 178 | 0.00% | -2,893 |
| Praxis Precision Medicines, Inc. | 131,533 | 0 | -131,533 | 2,931 | 0 | — | -2,931 |
| DBV Technologies S.A. | 14,614,264 | 14,614,264 | 0 | 13,924 | 10,948 | 0.14% | -2,977 |
| Xenon Pharmaceuticals Inc.(XENE) | 993,679 | 993,679 | 0 | 45,769 | 42,778 | 0.54% | -2,991 |
| Relay Therapeutics, Inc.(RLAY) | 1,160,117 | 1,160,117 | 0 | 12,773 | 9,629 | 0.12% | -3,144 |
| Immunovant, Inc.(IMVT) | 425,009 | 425,009 | 0 | 17,906 | 13,732 | 0.17% | -4,174 |
| Entrada Therapeutics, Inc. | 4,865,819 | 4,865,819 | 0 | 73,425 | 68,949 | 0.86% | -4,477 |
| Cerus Corporation | 19,477,339 | 19,477,339 | 0 | 42,071 | 36,812 | 0.46% | -5,259 |
| AbCellera Biologics Inc.(ABCL) | 22,909,753 | 27,525,640 | +4,615,887 | 130,815 | 124,691 | 1.56% | -6,124 |
| Invitae Corporation | 0 | 0 | 0 | 6,273 | 0 | — | -6,273 |
| Roivant Sciences Ltd.(ROIV) | 0 | 7,413,834 | +7,413,834 | 0 | 78,142 | 0.98% | +78,142 |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 0 | 10,126,176 | +10,126,176 | 0 | 51,441 | 0.65% | +51,441 |
| 2seventy bio, Inc. | 2,497,526 | 0 | -2,497,526 | 10,664 | 0 | — | -10,664 |
| ARS Pharmaceuticals, Inc. | 2,006,451 | 0 | -2,006,451 | 10,995 | 0 | — | -10,995 |
| Day One Biopharmaceuticals, Inc. COM | 1,000,000 | 0 | -1,000,000 | 14,600 | 0 | — | -14,600 |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 6,398,365 | 6,398,365 | 0 | 294,133 | 277,241 | 3.48% | -16,892 |
| Gracell Biotechnologies Inc. | 2,080,000 | 0 | -2,080,000 | 20,883 | 0 | — | -20,883 |
| Immunocore Holdings plc(IMCR) | 2,520,731 | 1,515,318 | -1,005,413 | 172,216 | 98,496 | 1.24% | -73,721 |
| Invitae Corporation | 0 | 0 | 0 | 131,153 | 0 | — | -131,152 |
| Incyte Corporation(INCY) | 36,179,122 | 36,179,665 | +543 | 2,271,687 | 2,061,156 | 25.86% | -210,532 |
| Mirati Therapeutics, Inc. | 4,121,440 | 0 | -4,121,440 | 242,135 | 0 | — | -242,135 |
| BeiGene, Ltd.(ONC) | 0 | 10,568,897 | +10,568,897 | 0 | 1,652,870 | 20.73% | +1,652,870 |
| ACADIA Pharmaceuticals Inc. | 42,864,612 | 42,864,612 | 0 | 1,342,091 | 792,567 | 9.94% | -549,524 |