Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2024 ▲▼ | Q1 2025 ▲▼ | Change ▲▼ | Q4 2024 ▲▼ | Q1 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| BeiGene, Ltd.(ONC) | 0 | 8,799,053 | +8,799,053 | 0 | 2,394,838 | 26.50% | +2,394,838 |
| Insmed Incorporated(INSM) | 5,006,863 | 5,380,626 | +373,763 | 345,674 | 410,488 | 4.54% | +64,814 |
| Immunovant, Inc.(IMVT) | 1,707,881 | 5,457,881 | +3,750,000 | 42,304 | 93,275 | 1.03% | +50,971 |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 1,974,590 | 1,974,590 | 0 | 609,299 | 654,043 | 7.24% | +44,744 |
| Summit Therapeutics Inc.(SMMT) | 0 | 24,424,865 | +24,424,865 | 0 | 471,156 | 5.21% | +471,156 |
| Alkermes plc(ALKS) | 4,181,751 | 4,483,285 | +301,534 | 120,267 | 148,038 | 1.64% | +27,771 |
| Immunocore Holdings plc(IMCR) | 1,515,318 | 2,322,656 | +807,338 | 44,702 | 68,913 | 0.76% | +24,211 |
| Vaxcyte, Inc.(PCVX) | 48,885 | 640,885 | +592,000 | 4,002 | 24,200 | 0.27% | +20,198 |
| Verona Pharma plc | 0 | 223,843 | +223,843 | 0 | 14,212 | 0.16% | +14,212 |
| GRAIL, Inc.(GRAL) | 1,630,125 | 1,630,125 | 0 | 29,098 | 41,633 | 0.46% | +12,536 |
| Insmed Incorporated(INSM) | 0 | 0 | 0 | 92,929 | 101,588 | 1.12% | +8,660 |
| Celcuity Inc.(CELC) | 2,678,553 | 4,257,735 | +1,579,182 | 35,062 | 43,046 | 0.48% | +7,983 |
| Kiniksa Pharmaceuticals International, plc(KNSA) | 2,818,323 | 2,818,323 | 0 | 55,746 | 62,595 | 0.69% | +6,849 |
| Rocket Pharmaceuticals, Inc. | 97,079 | 1,097,079 | +1,000,000 | 1,220 | 7,318 | 0.08% | +6,097 |
| DBV Technologies S.A.(DBVT) | 1,461,425 | 1,461,425 | 0 | 4,516 | 9,967 | 0.11% | +5,451 |
| 2seventy bio, Inc. | 2,497,526 | 2,497,526 | 0 | 7,343 | 12,338 | 0.14% | +4,995 |
| Regulus Therapeutics Inc. | 0 | 2,694,044 | +2,694,044 | 0 | 4,715 | 0.05% | +4,715 |
| Sionna Therapeutics, Inc. | 0 | 400,000 | +400,000 | 0 | 4,184 | 0.05% | +4,184 |
| Neurogene Inc. | 674,450 | 1,486,200 | +811,750 | 15,418 | 17,403 | 0.19% | +1,985 |
| Tectonic Therapeutic, Inc. | 0 | 100,000 | +100,000 | 0 | 1,771 | 0.02% | +1,771 |
| vTv Therapeutics, Inc. | 97,314 | 97,314 | 0 | 1,344 | 1,685 | 0.02% | +342 |
| Surrozen, Inc. | 833,333 | 833,333 | 0 | 18 | 25 | 0.00% | +7 |
| Tyra Biosciences, Inc.(TYRA) | 10,607 | 10,607 | 0 | 147 | 99 | 0.00% | -49 |
| Foghorn Therapeutics Inc. | 45,027 | 0 | -45,027 | 213 | 0 | — | -213 |
| Acrivon Therapeutics, Inc. | 52,885 | 22,809 | -30,076 | 318 | 46 | 0.00% | -272 |
| Enliven Therapeutics, Inc. | 114,833 | 114,833 | 0 | 2,584 | 2,260 | 0.03% | -324 |
| Sana Biotechnology, Inc.(SANA) | 2,380,949 | 2,030,949 | -350,000 | 3,881 | 3,412 | 0.04% | -469 |
| PMV Pharmaceuticals, Inc. | 322,024 | 0 | -322,024 | 486 | 0 | — | -486 |
| Protara Therapeutics, Inc. | 536,832 | 536,832 | 0 | 2,834 | 2,287 | 0.03% | -548 |
| Century Therapeutics, Inc. | 797,460 | 241,684 | -555,776 | 805 | 115 | 0.00% | -690 |
| HOOKIPA Pharma Inc. | 812,814 | 812,814 | 0 | 1,634 | 878 | 0.01% | -756 |
| PTC Therapeutics, Inc.(PTCT) | 20,400 | 0 | -20,400 | 921 | 0 | — | -921 |
| Prime Medicine, Inc. | 1,028,466 | 1,028,466 | 0 | 3,003 | 2,047 | 0.02% | -956 |
| BioNTech SE(BNTX) | 45,031 | 45,031 | 0 | 5,131 | 4,101 | 0.05% | -1,031 |
| Disc Medicine, Inc.(IRON) | 77,050 | 77,050 | 0 | 4,885 | 3,825 | 0.04% | -1,060 |
| Sagimet Biosciences Inc. | 952,996 | 952,996 | 0 | 4,288 | 3,107 | 0.03% | -1,182 |
| Compass Therapeutics, Inc. | 1,557,630 | 547,498 | -1,010,132 | 2,259 | 1,040 | 0.01% | -1,218 |
| Generation Bio Co. | 1,944,945 | 1,944,945 | 0 | 2,062 | 788 | 0.01% | -1,274 |
| Taysha Gene Therapies, Inc.(TSHA) | 4,004,756 | 4,004,756 | 0 | 6,928 | 5,567 | 0.06% | -1,362 |
| KALA BIO, Inc. | 1,201,894 | 1,201,894 | 0 | 8,341 | 6,887 | 0.08% | -1,454 |
| Wave Life Sciences Ltd.(WVE) | 344,063 | 344,063 | 0 | 4,256 | 2,780 | 0.03% | -1,476 |
| Mersana Therapeutics, Inc. | 1,086,115 | 0 | -1,086,115 | 1,553 | 0 | — | -1,553 |
| Ionis Pharmaceuticals, Inc.(IONS) | 357,915 | 357,915 | 0 | 12,513 | 10,798 | 0.12% | -1,714 |
| Relay Therapeutics, Inc.(RLAY) | 1,160,117 | 1,160,117 | 0 | 4,780 | 3,040 | 0.03% | -1,740 |
| Celldex Therapeutics, Inc.(CLDX) | 247,644 | 247,644 | 0 | 6,258 | 4,495 | 0.05% | -1,763 |
| Skye Bioscience, Inc. | 1,450,638 | 1,450,638 | 0 | 4,105 | 2,307 | 0.03% | -1,799 |
| Verve Therapeutics, Inc. | 1,691,530 | 1,691,530 | 0 | 9,540 | 7,730 | 0.09% | -1,810 |
| Contineum Therapeutics, Inc. | 312,500 | 312,500 | 0 | 4,578 | 2,181 | 0.02% | -2,397 |
| Arcturus Therapeutics Holdings Inc. | 151,329 | 0 | -151,329 | 2,568 | 0 | — | -2,568 |
| Aligos Therapeutics, Inc. | 83,055 | 83,055 | 0 | 3,309 | 685 | 0.01% | -2,624 |
| Alumis Inc. | 1,562,500 | 1,562,500 | 0 | 12,281 | 9,594 | 0.11% | -2,687 |
| Fate Therapeutics, Inc. | 3,258,402 | 3,258,402 | 0 | 5,376 | 2,574 | 0.03% | -2,802 |
| Centessa Pharmaceuticals plc | 1,227,178 | 1,227,178 | 0 | 20,555 | 17,647 | 0.20% | -2,908 |
| Intellia Therapeutics, Inc.(NTLA) | 644,116 | 644,116 | 0 | 7,510 | 4,580 | 0.05% | -2,931 |
| Cerus Corporation | 19,477,339 | 19,351,087 | -126,252 | 29,995 | 26,898 | 0.30% | -3,097 |
| Leap Therapeutics, Inc. | 1,172,175 | 404,744 | -767,431 | 3,370 | 123 | 0.00% | -3,247 |
| Structure Therapeutics Inc. | 361,565 | 361,565 | 0 | 9,806 | 6,259 | 0.07% | -3,547 |
| Bicara Therapeutics Inc. | 833,333 | 833,333 | 0 | 14,517 | 10,858 | 0.12% | -3,658 |
| Design Therapeutics, Inc.(DSGN) | 1,743,725 | 1,743,725 | 0 | 10,759 | 6,731 | 0.07% | -4,028 |
| Vir Biotechnology, Inc.(VIR) | 1,084,539 | 542,539 | -542,000 | 7,961 | 3,516 | 0.04% | -4,445 |
| TScan Therapeutics, Inc. | 2,784,792 | 2,784,792 | 0 | 8,466 | 3,843 | 0.04% | -4,623 |
| Prelude Therapeutics Inc. | 10,123,824 | 10,123,824 | 0 | 12,908 | 7,775 | 0.09% | -5,133 |
| Biomea Fusion, Inc. | 1,451,990 | 0 | -1,451,990 | 5,634 | 0 | — | -5,634 |
| Roivant Sciences Ltd.(ROIV) | 3,767,773 | 3,767,773 | 0 | 44,573 | 38,017 | 0.42% | -6,556 |
| Arvinas, Inc. | 405,576 | 0 | -405,576 | 7,775 | 0 | — | -7,775 |
| Mirum Pharmaceuticals, Inc.(MIRM) | 190,476 | 0 | -190,476 | 7,876 | 0 | — | -7,876 |
| Xencor, Inc.(XNCR) | 670,431 | 670,431 | 0 | 15,407 | 7,133 | 0.08% | -8,273 |
| Akero Therapeutics, Inc. | 1,097,082 | 548,713 | -548,369 | 30,521 | 22,212 | 0.25% | -8,309 |
| Opthea Limited | 2,173,622 | 2,087,320 | -86,302 | 8,537 | 0 | — | -8,537 |
| Dyne Therapeutics, Inc.(DYN) | 672,096 | 672,096 | 0 | 15,835 | 7,030 | 0.08% | -8,804 |
| Ultragenyx Pharmaceutical Inc.(RARE) | 1,576,114 | 1,576,114 | 0 | 66,307 | 57,071 | 0.63% | -9,236 |
| Merus N.V. | 450,000 | 223,500 | -226,500 | 18,923 | 9,407 | 0.10% | -9,515 |
| IDEAYA Biosciences, Inc.(IDYA) | 1,062,123 | 1,062,123 | 0 | 27,297 | 17,398 | 0.19% | -9,899 |
| Neumora Therapeutics, Inc. | 1,034,600 | 1,034,600 | 0 | 10,967 | 1,035 | 0.01% | -9,932 |
| Monte Rosa Therapeutics, Inc.(GLUE) | 4,916,095 | 4,916,095 | 0 | 34,118 | 22,811 | 0.25% | -11,307 |
| Candel Therapeutics, Inc. | 2,981,983 | 2,437,189 | -544,794 | 25,884 | 13,770 | 0.15% | -12,113 |
| Praxis Precision Medicines, Inc.(PRAX) | 331,533 | 331,533 | 0 | 25,515 | 12,555 | 0.14% | -12,960 |
| Immatics N.V.(IMTX) | 7,275,830 | 7,275,830 | 0 | 51,731 | 32,814 | 0.36% | -18,917 |
| AbCellera Biologics Inc.(ABCL) | 27,525,640 | 27,525,640 | 0 | 80,650 | 61,382 | 0.68% | -19,268 |
| Stoke Therapeutics, Inc.(STOK) | 4,633,838 | 4,633,838 | 0 | 51,111 | 30,815 | 0.34% | -20,296 |
| IGM Biosciences, Inc. | 4,094,304 | 4,095,257 | +953 | 25,016 | 4,710 | 0.05% | -20,307 |
| argenx SE(ARGX) | 111,904 | 77,760 | -34,144 | 68,821 | 46,023 | 0.51% | -22,798 |
| Sera Prognostics, Inc. | 5,434,399 | 5,498,170 | +63,771 | 44,236 | 20,233 | 0.22% | -24,003 |
| Denali Therapeutics Inc.(DNLI) | 3,731,695 | 3,731,695 | 0 | 76,052 | 50,732 | 0.56% | -25,320 |
| Replimune Group, Inc.(REPL) | 11,045,336 | 11,045,336 | 0 | 133,759 | 107,692 | 1.19% | -26,067 |
| Krystal Biotech, Inc.(KRYS) | 169,934 | 0 | -169,934 | 26,622 | 0 | — | -26,622 |
| Nurix Therapeutics, Inc.(NRIX) | 3,882,125 | 3,882,125 | 0 | 73,139 | 46,120 | 0.51% | -27,020 |
| Xenon Pharmaceuticals Inc.(XENE) | 993,679 | 347,408 | -646,271 | 38,952 | 11,656 | 0.13% | -27,297 |
| Edgewise Therapeutics, Inc.(EWTX) | 6,155,940 | 6,155,940 | 0 | 164,364 | 135,431 | 1.50% | -28,933 |
| CRISPR Therapeutics AG(CRSP) | 1,308,011 | 654,099 | -653,912 | 51,483 | 22,259 | 0.25% | -29,224 |
| Ionis Pharmaceuticals, Inc.(IONS) | 0 | 0 | 0 | 29,544 | 0 | — | -29,544 |
| Entrada Therapeutics, Inc. | 4,865,819 | 4,865,819 | 0 | 84,130 | 43,987 | 0.49% | -40,143 |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 6,084,249 | 5,604,483 | -479,766 | 340,596 | 296,869 | 3.29% | -43,727 |
| Bicycle Therapeutics plc | 0 | 10,885,357 | +10,885,357 | 0 | 92,417 | 1.02% | +92,417 |
| Revolution Medicines, Inc.(RVMD) | 7,936,972 | 7,936,972 | 0 | 347,163 | 280,651 | 3.11% | -66,512 |
| ACADIA Pharmaceuticals Inc. | 42,877,916 | 42,877,916 | 0 | 786,810 | 712,202 | 7.88% | -74,608 |
| Kymera Therapeutics, Inc.(KYMR) | 5,995,929 | 5,995,929 | 0 | 241,216 | 164,109 | 1.82% | -77,108 |
| Kodiak Sciences Inc.(KOD) | 17,310,490 | 17,310,490 | 0 | 172,239 | 48,556 | 0.54% | -123,683 |
| Incyte Corporation(INCY) | 30,739,466 | 30,739,953 | +487 | 2,123,175 | 1,861,304 | 20.60% | -261,871 |