Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Praxis Precision Medicines, Inc.(PRAX) | 1,126,488 | 1,753,198 | +626,710 | 332,021 | 564,863 | 3.24% | +232,842 |
| Kodiak Sciences Inc.(KOD) | 19,919,186 | 19,919,186 | 0 | 556,940 | 759,319 | 4.36% | +202,379 |
| Revolution Medicines, Inc.(RVMD) | 9,455,357 | 9,555,357 | +100,000 | 753,119 | 929,258 | 5.34% | +176,139 |
| Celcuity Inc.(CELC) | 7,915,792 | 7,915,792 | 0 | 789,521 | 903,508 | 5.19% | +113,987 |
| Alkermes plc(ALKS) | 10,012,267 | 10,012,267 | 0 | 280,143 | 354,034 | 2.03% | +73,891 |
| Insmed Incorporated(INSM) | 6,592,746 | 7,421,111 | +828,365 | 1,147,402 | 1,213,500 | 6.97% | +66,099 |
| Summit Therapeutics Inc.(SMMT) | 36,391,063 | 36,391,063 | 0 | 636,480 | 689,975 | 3.96% | +53,495 |
| Kymera Therapeutics, Inc.(KYMR) | 8,657,242 | 8,657,242 | 0 | 673,620 | 721,062 | 4.14% | +47,442 |
| Edgewise Therapeutics, Inc.(EWTX) | 6,575,940 | 6,575,940 | 0 | 163,182 | 207,142 | 1.19% | +43,960 |
| Mirum Pharmaceuticals, Inc.(MIRM) | 0 | 445,975 | +445,975 | 0 | 41,199 | 0.24% | +41,199 |
| Dianthus Therapeutics, Inc.(DNTH) | 789,759 | 852,164 | +62,405 | 32,546 | 71,514 | 0.41% | +38,968 |
| Enliven Therapeutics, Inc. | 271,406 | 905,191 | +633,785 | 4,180 | 35,483 | 0.20% | +31,304 |
| GRAIL, Inc.(GRAL) | 2,085,333 | 4,028,614 | +1,943,281 | 178,484 | 208,199 | 1.20% | +29,715 |
| Alumis Inc. | 1,562,500 | 2,012,500 | +450,000 | 15,250 | 44,335 | 0.25% | +29,085 |
| Kiniksa Pharmaceuticals International, plc(KNSA) | 2,826,246 | 2,826,246 | 0 | 116,583 | 136,084 | 0.78% | +19,501 |
| Evommune, Inc.(EVMN) | 0 | 847,390 | +847,390 | 0 | 19,481 | 0.11% | +19,481 |
| Aktis Oncology, Inc.(AKTS) | 0 | 996,351 | +996,351 | 0 | 17,825 | 0.10% | +17,825 |
| Generate Biomedicines, Inc.(GENB) | 0 | 1,423,602 | +1,423,602 | 0 | 17,795 | 0.10% | +17,795 |
| Spyre Therapeutics, Inc.(SYRE) | 1,000,000 | 1,000,000 | 0 | 32,760 | 50,440 | 0.29% | +17,680 |
| Roivant Sciences Ltd.(ROIV) | 5,555,017 | 4,867,723 | -687,294 | 120,544 | 134,836 | 0.77% | +14,292 |
| COMPASS Pathways plc(CMPS) | 0 | 2,344,720 | +2,344,720 | 0 | 12,966 | 0.07% | +12,966 |
| Ionis Pharmaceuticals, Inc.(IONS) | 1,791,841 | 2,047,727 | +255,886 | 141,753 | 153,764 | 0.88% | +12,011 |
| Entrada Therapeutics, Inc.(TRDA) | 5,072,730 | 5,072,730 | 0 | 52,148 | 64,018 | 0.37% | +11,870 |
| AbCellera Biologics Inc.(ABCL) | 27,525,640 | 30,275,938 | +2,750,298 | 94,138 | 105,663 | 0.61% | +11,525 |
| Denali Therapeutics Inc.(DNLI) | 3,731,695 | 3,731,695 | 0 | 61,610 | 71,649 | 0.41% | +10,038 |
| Centessa Pharmaceuticals plc | 670,751 | 670,751 | 0 | 16,775 | 26,642 | 0.15% | +9,867 |
| Crinetics Pharmaceuticals, Inc.(CRNX) | 1,648,869 | 2,351,465 | +702,596 | 76,755 | 85,405 | 0.49% | +8,650 |
| Celcuity Inc.(CELC) | 0 | 30,750,000 | +30,750,000 | 66,580 | 74,869 | 0.43% | +8,289 |
| Design Therapeutics, Inc.(DSGN) | 2,233,099 | 2,585,978 | +352,879 | 20,946 | 27,515 | 0.16% | +6,568 |
| IDEAYA Biosciences, Inc.(IDYA) | 3,618,826 | 3,946,515 | +327,689 | 125,103 | 131,498 | 0.76% | +6,395 |
| Eikon Therapeutics, Inc.(EIKN) | 0 | 555,555 | +555,555 | 0 | 5,878 | 0.03% | +5,878 |
| CytomX Therapeutics, Inc.(CTMX) | 4,250,826 | 4,975,826 | +725,000 | 18,109 | 23,386 | 0.13% | +5,278 |
| Prelude Therapeutics Inc.(PRLD) | 10,123,824 | 10,123,824 | 0 | 29,359 | 34,623 | 0.20% | +5,264 |
| Xenon Pharmaceuticals Inc.(XENE) | 370,208 | 370,208 | 0 | 16,593 | 21,528 | 0.12% | +4,935 |
| Monte Rosa Therapeutics, Inc.(GLUE) | 4,345,736 | 4,345,736 | 0 | 68,141 | 71,487 | 0.41% | +3,346 |
| Verastem, Inc.(VSTM) | 0 | 584,757 | +584,757 | 0 | 3,099 | 0.02% | +3,099 |
| Celldex Therapeutics, Inc.(CLDX) | 665,370 | 665,370 | 0 | 18,071 | 21,106 | 0.12% | +3,034 |
| Stoke Therapeutics, Inc.(STOK) | 3,336,697 | 3,336,697 | 0 | 105,907 | 108,643 | 0.62% | +2,736 |
| Arcus Biosciences, Inc.(RCUS) | 270,000 | 415,621 | +145,621 | 6,434 | 8,977 | 0.05% | +2,543 |
| DBV Technologies S.A.(DBVT) | 1,461,425 | 1,461,425 | 0 | 28,016 | 30,529 | 0.18% | +2,514 |
| Contineum Therapeutics, Inc.(CTNM) | 1,420,838 | 1,420,838 | 0 | 16,240 | 18,556 | 0.11% | +2,316 |
| Relay Therapeutics, Inc.(RLAY) | 1,160,117 | 1,160,117 | 0 | 9,815 | 11,543 | 0.07% | +1,729 |
| Rapport Therapeutics, Inc.(RAPP) | 1,547,090 | 1,547,090 | 0 | 46,939 | 48,408 | 0.28% | +1,470 |
| MapLight Therapeutics, Inc.(MPLT) | 364,705 | 364,705 | 0 | 6,406 | 7,414 | 0.04% | +1,008 |
| LB Pharmaceuticals Inc.(LBRX) | 200,000 | 200,000 | 0 | 4,452 | 4,932 | 0.03% | +480 |
| Pharvaris N.V. COM | 375,000 | 375,000 | 0 | 10,406 | 10,594 | 0.06% | +188 |
| Tyra Biosciences, Inc.(TYRA) | 10,607 | 10,607 | 0 | 279 | 406 | 0.00% | +127 |
| Wave Life Sciences Ltd.(WVE) | 344,063 | 822,638 | +478,575 | 5,849 | 5,964 | 0.03% | +115 |
| TScan Therapeutics, Inc.(TCRX) | 2,784,792 | 2,784,792 | 0 | 2,785 | 2,813 | 0.02% | +28 |
| Surrozen, Inc.(SRZN) | 833,333 | 833,333 | 0 | 17 | 13 | 0.00% | -3 |
| vTv Therapeutics, Inc.(VTVT) | 148,314 | 148,314 | 0 | 5,931 | 5,882 | 0.03% | -49 |
| Acrivon Therapeutics, Inc. | 22,809 | 0 | -22,809 | 55 | 0 | — | -55 |
| Tectonic Therapeutic, Inc.(TECX) | 903,400 | 607,788 | -295,612 | 18,845 | 18,787 | 0.11% | -58 |
| Protara Therapeutics, Inc.(TARA) | 971,614 | 971,614 | 0 | 5,179 | 5,062 | 0.03% | -117 |
| Skye Bioscience, Inc.(SKYE) | 1,450,638 | 1,575,243 | +124,605 | 1,088 | 968 | 0.01% | -119 |
| Aligos Therapeutics, Inc.(ALGS) | 83,055 | 83,055 | 0 | 774 | 617 | 0.00% | -157 |
| Sana Biotechnology, Inc.(SANA) | 310,483 | 310,483 | 0 | 1,264 | 894 | 0.01% | -369 |
| Sionna Therapeutics, Inc.(SION) | 400,000 | 400,000 | 0 | 16,456 | 16,036 | 0.09% | -420 |
| Neurogene Inc.(NGNE) | 991,691 | 991,691 | 0 | 20,429 | 19,992 | 0.11% | -436 |
| Sagimet Biosciences Inc.(SGMT) | 952,996 | 952,996 | 0 | 5,642 | 4,979 | 0.03% | -662 |
| KALA BIO, Inc.(KALA) | 1,804,055 | 0 | -1,804,055 | 1,003 | 0 | — | -1,003 |
| Absci Corporation | 2,134,803 | 2,134,803 | 0 | 7,450 | 6,404 | 0.04% | -1,046 |
| Dyne Therapeutics, Inc.(DYN) | 813,449 | 813,449 | 0 | 15,911 | 14,748 | 0.08% | -1,163 |
| Jade Biosciences, Inc. | 1,641,137 | 1,641,137 | 0 | 25,323 | 23,058 | 0.13% | -2,265 |
| Cerus Corporation(CERS) | 10,008,345 | 10,008,345 | 0 | 20,617 | 18,215 | 0.10% | -2,402 |
| argenx SE(ARGX) | 25,174 | 25,174 | 0 | 21,170 | 18,383 | 0.11% | -2,787 |
| Immunovant, Inc.(IMVT) | 5,457,881 | 5,457,881 | 0 | 138,739 | 135,574 | 0.78% | -3,166 |
| Vir Biotechnology, Inc.(VIR) | 542,539 | 0 | -542,539 | 3,272 | 0 | — | -3,272 |
| 4D Molecular Therapeutics, Inc. | 475,737 | 0 | -475,737 | 3,568 | 0 | — | -3,568 |
| Xencor, Inc.(XNCR) | 1,102,106 | 1,102,106 | 0 | 16,873 | 13,291 | 0.08% | -3,582 |
| Taysha Gene Therapies, Inc.(TSHA) | 4,004,756 | 4,004,756 | 0 | 22,026 | 17,901 | 0.10% | -4,125 |
| Disc Medicine, Inc.(IRON) | 337,050 | 349,657 | +12,607 | 26,765 | 22,357 | 0.13% | -4,408 |
| Sera Prognostics, Inc.(SERA) | 5,498,170 | 5,498,170 | 0 | 16,220 | 11,161 | 0.06% | -5,058 |
| Nuvalent, Inc. | 143,937 | 0 | -143,937 | 14,479 | 0 | — | -14,479 |
| Nurix Therapeutics, Inc.(NRIX) | 4,658,556 | 4,658,556 | 0 | 88,373 | 72,208 | 0.41% | -16,165 |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | 2,175,645 | 1,992,783 | -182,862 | 144,441 | 124,947 | 0.72% | -19,494 |
| Immatics N.V.(IMTX) | 12,094,094 | 10,916,693 | -1,177,401 | 126,988 | 107,420 | 0.62% | -19,568 |
| Abivax S.A.(ABVX) | 875,796 | 875,796 | 0 | 118,105 | 97,520 | 0.56% | -20,586 |
| Ventyx Biosciences, Inc. | 2,349,280 | 0 | -2,349,280 | 21,214 | 0 | — | -21,214 |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 2,822,727 | 0 | -2,822,727 | 22,017 | 0 | — | -22,017 |
| Viridian Therapeutics, Inc.(VRDN) | 1,971,678 | 1,971,678 | 0 | 61,359 | 38,566 | 0.22% | -22,793 |
| Replimune Group, Inc.(REPL) | 11,045,336 | 11,045,336 | 0 | 107,361 | 84,497 | 0.49% | -22,864 |
| BioNTech SE(BNTX) | 368,923 | 119,743 | -249,180 | 35,121 | 10,643 | 0.06% | -24,479 |
| Bicycle Therapeutics plc | 10,885,357 | 10,885,357 | 0 | 77,068 | 50,508 | 0.29% | -26,560 |
| Structure Therapeutics Inc. | 1,432,529 | 1,432,529 | 0 | 99,632 | 69,048 | 0.40% | -30,584 |
| Terns Pharmaceuticals, Inc. | 950,000 | 0 | -950,000 | 38,380 | 0 | — | -38,380 |
| Immunocore Holdings plc(IMCR) | 2,322,656 | 734,397 | -1,588,259 | 80,619 | 22,142 | 0.13% | -58,477 |
| BeOne Medicines Ltd.(ONC) | 8,799,053 | 8,799,053 | 0 | 2,673,240 | 2,613,055 | 15.00% | -60,186 |
| Ultragenyx Pharmaceutical Inc.(RARE) | 2,772,692 | 0 | -2,772,692 | 63,772 | 0 | — | -63,772 |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 5,604,483 | 5,604,483 | 0 | 599,904 | 487,422 | 2.80% | -112,482 |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 2,141,701 | 2,141,701 | 0 | 1,247,198 | 1,121,116 | 6.44% | -126,082 |
| Incyte Corporation(INCY) | 30,743,991 | 30,744,412 | +421 | 3,036,584 | 2,893,664 | 16.62% | -142,920 |
| ACADIA Pharmaceuticals Inc. | 42,896,690 | 42,896,690 | 0 | 1,145,771 | 954,880 | 5.48% | -190,890 |