Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q1 2025 ▲▼ | Q2 2025 ▲▼ | Change ▲▼ | Q1 2025 ▲▼ | Q2 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| BeOne Medicines Ltd.(ONC) | 0 | 8,799,053 | +8,799,053 | 0 | 2,129,987 | 20.66% | +2,129,987 |
| Insmed Incorporated(INSM) | 5,380,626 | 7,712,900 | +2,332,274 | 410,488 | 776,226 | 7.53% | +365,738 |
| Summit Therapeutics Inc.(SMMT) | 24,424,865 | 33,722,974 | +9,298,109 | 471,156 | 717,625 | 6.96% | +246,469 |
| Incyte Corporation(INCY) | 30,739,953 | 30,743,275 | +3,322 | 1,861,304 | 2,093,617 | 20.31% | +232,313 |
| ACADIA Pharmaceuticals Inc. | 42,877,916 | 42,896,690 | +18,774 | 712,202 | 925,282 | 8.98% | +213,079 |
| Kymera Therapeutics, Inc.(KYMR) | 5,995,929 | 6,651,429 | +655,500 | 164,109 | 290,268 | 2.82% | +126,160 |
| Revolution Medicines, Inc.(RVMD) | 7,936,972 | 9,364,972 | +1,428,000 | 280,651 | 344,537 | 3.34% | +63,886 |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 5,604,483 | 5,604,483 | 0 | 296,869 | 354,147 | 3.44% | +57,278 |
| Structure Therapeutics Inc. | 361,565 | 2,508,767 | +2,147,202 | 6,259 | 52,032 | 0.50% | +45,773 |
| Ultragenyx Pharmaceutical Inc.(RARE) | 1,576,114 | 2,772,692 | +1,196,578 | 57,071 | 100,815 | 0.98% | +43,744 |
| GRAIL, Inc.(GRAL) | 1,630,125 | 1,630,125 | 0 | 41,633 | 83,821 | 0.81% | +42,188 |
| Alkermes plc(ALKS) | 4,483,285 | 6,410,603 | +1,927,318 | 148,038 | 183,407 | 1.78% | +35,369 |
| BioNTech SE(BNTX) | 45,031 | 368,923 | +323,892 | 4,101 | 39,279 | 0.38% | +35,179 |
| AbCellera Biologics Inc.(ABCL) | 27,525,640 | 27,525,640 | 0 | 61,382 | 94,413 | 0.92% | +33,031 |
| Celcuity Inc.(CELC) | 4,257,735 | 5,450,445 | +1,192,710 | 43,046 | 72,763 | 0.71% | +29,718 |
| IDEAYA Biosciences, Inc.(IDYA) | 1,062,123 | 2,118,728 | +1,056,605 | 17,398 | 44,536 | 0.43% | +27,138 |
| Viridian Therapeutics, Inc.(VRDN) | 0 | 1,744,406 | +1,744,406 | 0 | 24,387 | 0.24% | +24,387 |
| Immatics N.V.(IMTX) | 7,275,830 | 10,168,901 | +2,893,071 | 32,814 | 54,709 | 0.53% | +21,895 |
| Stoke Therapeutics, Inc.(STOK) | 4,633,838 | 4,633,838 | 0 | 30,815 | 52,594 | 0.51% | +21,779 |
| Merus N.V. | 223,500 | 574,377 | +350,877 | 9,407 | 30,212 | 0.29% | +20,805 |
| Intellia Therapeutics, Inc.(NTLA) | 644,116 | 2,675,674 | +2,031,558 | 4,580 | 25,098 | 0.24% | +20,518 |
| Praxis Precision Medicines, Inc.(PRAX) | 331,533 | 689,488 | +357,955 | 12,555 | 28,993 | 0.28% | +16,438 |
| Blueprint Medicines Corporation | 0 | 125,538 | +125,538 | 0 | 16,091 | 0.16% | +16,091 |
| Kodiak Sciences Inc.(KOD) | 17,310,490 | 17,310,490 | 0 | 48,556 | 64,568 | 0.63% | +16,012 |
| Kiniksa Pharmaceuticals International, plc(KNSA) | 2,818,323 | 2,824,669 | +6,346 | 62,595 | 78,159 | 0.76% | +15,564 |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | 0 | 939,174 | +939,174 | 0 | 14,839 | 0.14% | +14,839 |
| Dianthus Therapeutics, Inc.(DNTH) | 0 | 789,759 | +789,759 | 0 | 14,713 | 0.14% | +14,713 |
| Disc Medicine, Inc.(IRON) | 77,050 | 337,050 | +260,000 | 3,825 | 17,850 | 0.17% | +14,025 |
| Verve Therapeutics, Inc. | 1,691,530 | 1,691,530 | 0 | 7,730 | 18,996 | 0.18% | +11,266 |
| Cidara Therapeutics, Inc. | 0 | 227,272 | +227,272 | 0 | 11,070 | 0.11% | +11,070 |
| Arcellx, Inc. COMMON STOCK | 0 | 166,825 | +166,825 | 0 | 10,985 | 0.11% | +10,985 |
| Nuvalent, Inc. | 0 | 143,937 | +143,937 | 0 | 10,982 | 0.11% | +10,982 |
| Spyre Therapeutics, Inc.(SYRE) | 0 | 626,703 | +626,703 | 0 | 9,382 | 0.09% | +9,382 |
| Celldex Therapeutics, Inc.(CLDX) | 247,644 | 665,370 | +417,726 | 4,495 | 13,540 | 0.13% | +9,046 |
| Crinetics Pharmaceuticals, Inc.(CRNX) | 0 | 280,000 | +280,000 | 0 | 8,053 | 0.08% | +8,053 |
| CytomX Therapeutics, Inc. | 0 | 3,484,226 | +3,484,226 | 0 | 7,909 | 0.08% | +7,909 |
| Verona Pharma plc | 223,843 | 223,843 | 0 | 14,212 | 21,171 | 0.21% | +6,959 |
| Agios Pharmaceuticals, Inc.(AGIO) | 0 | 189,866 | +189,866 | 0 | 6,315 | 0.06% | +6,315 |
| Rapport Therapeutics, Inc.(RAPP) | 0 | 550,090 | +550,090 | 0 | 6,255 | 0.06% | +6,255 |
| Roivant Sciences Ltd.(ROIV) | 3,767,773 | 3,767,773 | 0 | 38,017 | 42,463 | 0.41% | +4,446 |
| Sagimet Biosciences Inc. | 952,996 | 952,996 | 0 | 3,107 | 7,262 | 0.07% | +4,155 |
| Immunocore Holdings plc(IMCR) | 2,322,656 | 2,322,656 | 0 | 68,913 | 72,885 | 0.71% | +3,972 |
| Skye Bioscience, Inc. | 1,450,638 | 1,450,638 | 0 | 2,307 | 6,064 | 0.06% | +3,757 |
| Taysha Gene Therapies, Inc.(TSHA) | 4,004,756 | 4,004,756 | 0 | 5,567 | 9,251 | 0.09% | +3,684 |
| DBV Technologies S.A.(DBVT) | 1,461,425 | 1,461,425 | 0 | 9,967 | 13,387 | 0.13% | +3,420 |
| Sionna Therapeutics, Inc. | 400,000 | 400,000 | 0 | 4,184 | 6,940 | 0.07% | +2,756 |
| Sana Biotechnology, Inc.(SANA) | 2,030,949 | 2,030,949 | 0 | 3,412 | 5,544 | 0.05% | +2,132 |
| Denali Therapeutics Inc.(DNLI) | 3,731,695 | 3,731,695 | 0 | 50,732 | 52,206 | 0.51% | +1,474 |
| Relay Therapeutics, Inc.(RLAY) | 1,160,117 | 1,160,117 | 0 | 3,040 | 4,014 | 0.04% | +974 |
| Prelude Therapeutics Inc. | 10,123,824 | 10,123,824 | 0 | 7,775 | 8,194 | 0.08% | +419 |
| Tectonic Therapeutic, Inc. | 100,000 | 100,000 | 0 | 1,771 | 1,987 | 0.02% | +216 |
| Fate Therapeutics, Inc. | 3,258,402 | 2,485,018 | -773,384 | 2,574 | 2,783 | 0.03% | +209 |
| TScan Therapeutics, Inc. | 2,784,792 | 2,784,792 | 0 | 3,843 | 4,038 | 0.04% | +195 |
| HOOKIPA Pharma Inc. | 812,814 | 812,814 | 0 | 878 | 1,020 | 0.01% | +142 |
| Enliven Therapeutics, Inc. | 114,833 | 114,833 | 0 | 2,260 | 2,304 | 0.02% | +44 |
| Tyra Biosciences, Inc.(TYRA) | 10,607 | 10,607 | 0 | 99 | 102 | 0.00% | +3 |
| Opthea Limited | 2,087,320 | 2,087,320 | 0 | 0 | 0 | — | 0 |
| Surrozen, Inc. | 833,333 | 833,333 | 0 | 25 | 15 | 0.00% | -10 |
| Acrivon Therapeutics, Inc. | 22,809 | 22,809 | 0 | 46 | 27 | 0.00% | -19 |
| Xenon Pharmaceuticals Inc.(XENE) | 347,408 | 370,208 | +22,800 | 11,656 | 11,588 | 0.11% | -68 |
| Aligos Therapeutics, Inc. | 83,055 | 83,055 | 0 | 685 | 599 | 0.01% | -86 |
| Century Therapeutics, Inc. | 241,684 | 0 | -241,684 | 115 | 0 | — | -115 |
| IGM Biosciences, Inc. | 4,095,257 | 4,096,210 | +953 | 4,710 | 4,588 | 0.04% | -122 |
| Leap Therapeutics, Inc. | 404,744 | 0 | -404,744 | 123 | 0 | — | -123 |
| Generation Bio Co. | 1,944,945 | 1,944,945 | 0 | 788 | 623 | 0.01% | -165 |
| vTv Therapeutics, Inc. | 97,314 | 97,314 | 0 | 1,685 | 1,460 | 0.01% | -226 |
| Neumora Therapeutics, Inc. | 1,034,600 | 1,034,600 | 0 | 1,035 | 759 | 0.01% | -276 |
| Wave Life Sciences Ltd.(WVE) | 344,063 | 344,063 | 0 | 2,780 | 2,236 | 0.02% | -544 |
| Monte Rosa Therapeutics, Inc.(GLUE) | 4,916,095 | 4,916,095 | 0 | 22,811 | 22,172 | 0.22% | -639 |
| Protara Therapeutics, Inc. | 536,832 | 536,832 | 0 | 2,287 | 1,627 | 0.02% | -660 |
| Vir Biotechnology, Inc.(VIR) | 542,539 | 542,539 | 0 | 3,516 | 2,734 | 0.03% | -781 |
| Contineum Therapeutics, Inc. | 312,500 | 312,500 | 0 | 2,181 | 1,241 | 0.01% | -941 |
| Design Therapeutics, Inc.(DSGN) | 1,743,725 | 1,712,882 | -30,843 | 6,731 | 5,772 | 0.06% | -958 |
| Compass Therapeutics, Inc. | 547,498 | 0 | -547,498 | 1,040 | 0 | — | -1,040 |
| KALA BIO, Inc. | 1,201,894 | 1,201,894 | 0 | 6,887 | 5,721 | 0.06% | -1,166 |
| Xencor, Inc.(XNCR) | 670,431 | 670,431 | 0 | 7,133 | 5,270 | 0.05% | -1,864 |
| Nurix Therapeutics, Inc.(NRIX) | 3,882,125 | 3,882,125 | 0 | 46,120 | 44,217 | 0.43% | -1,902 |
| Prime Medicine, Inc. | 1,028,466 | 0 | -1,028,466 | 2,047 | 0 | — | -2,047 |
| Neurogene Inc. | 1,486,200 | 991,691 | -494,509 | 17,403 | 14,826 | 0.14% | -2,578 |
| Vaxcyte, Inc.(PCVX) | 640,885 | 640,885 | 0 | 24,200 | 20,835 | 0.20% | -3,365 |
| Regulus Therapeutics Inc. | 2,694,044 | 0 | -2,694,044 | 4,715 | 0 | — | -4,715 |
| Akero Therapeutics, Inc. | 548,713 | 324,630 | -224,083 | 22,212 | 17,322 | 0.17% | -4,890 |
| Alumis Inc. | 1,562,500 | 1,562,500 | 0 | 9,594 | 4,688 | 0.05% | -4,906 |
| Sera Prognostics, Inc. | 5,498,170 | 5,498,170 | 0 | 20,233 | 15,230 | 0.15% | -5,003 |
| Replimune Group, Inc.(REPL) | 11,045,336 | 11,045,336 | 0 | 107,692 | 102,611 | 1.00% | -5,081 |
| Immunovant, Inc.(IMVT) | 5,457,881 | 5,457,881 | 0 | 93,275 | 87,326 | 0.85% | -5,949 |
| Rocket Pharmaceuticals, Inc. | 1,097,079 | 552,079 | -545,000 | 7,318 | 1,353 | 0.01% | -5,965 |
| Dyne Therapeutics, Inc.(DYN) | 672,096 | 0 | -672,096 | 7,030 | 0 | — | -7,030 |
| Cerus Corporation | 19,351,087 | 12,883,844 | -6,467,243 | 26,898 | 18,166 | 0.18% | -8,732 |
| Ionis Pharmaceuticals, Inc.(IONS) | 357,915 | 0 | -357,915 | 10,798 | 0 | — | -10,798 |
| Bicara Therapeutics Inc. | 833,333 | 0 | -833,333 | 10,858 | 0 | — | -10,858 |
| Entrada Therapeutics, Inc. | 4,865,819 | 4,865,819 | 0 | 43,987 | 32,698 | 0.32% | -11,289 |
| Candel Therapeutics, Inc. | 2,437,189 | 355,112 | -2,082,077 | 13,770 | 1,797 | 0.02% | -11,973 |
| 2seventy bio, Inc. | 2,497,526 | 0 | -2,497,526 | 12,338 | 0 | — | -12,338 |
| Bicycle Therapeutics plc | 10,885,357 | 10,885,357 | 0 | 92,417 | 75,653 | 0.73% | -16,763 |
| Centessa Pharmaceuticals plc | 1,227,178 | 0 | -1,227,178 | 17,647 | 0 | — | -17,647 |
| CRISPR Therapeutics AG(CRSP) | 654,099 | 0 | -654,099 | 22,259 | 0 | — | -22,259 |
| argenx SE(ARGX) | 77,760 | 37,760 | -40,000 | 46,023 | 20,814 | 0.20% | -25,209 |
| Edgewise Therapeutics, Inc.(EWTX) | 6,155,940 | 7,305,940 | +1,150,000 | 135,431 | 95,781 | 0.93% | -39,650 |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 1,974,590 | 1,976,018 | +1,428 | 654,043 | 598,022 | 5.80% | -56,021 |