Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q1 2025 ▲▼ | Q2 2025 ▲▼ | Change ▲▼ | Q1 2025 ▲▼ | Q2 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| BeOne Medicines AGADS(ONC) | 8,799,053 | 8,799,053 | 0 | $2.39B | $2.13B | 20.66% | -$264.85M |
| Incyte Corporation(INCY) | 30,739,953 | 30,743,275 | +3,322 | $1.86B | $2.09B | 20.31% | +$232.31M |
| ACADIA Pharmaceuticals Inc. | 42,877,916 | 42,896,690 | +18,774 | $712.20M | $925.28M | 8.98% | +$213.08M |
| Insmed Incorporated(INSM) | 5,380,626 | 7,712,900 | +2,332,274 | $410.49M | $776.23M | 7.53% | +$365.74M |
| Summit Therapeutics Inc.(SMMT) | 24,424,865 | 33,722,974 | +9,298,109 | $471.16M | $717.62M | 6.96% | +$246.47M |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 1,974,590 | 1,976,018 | +1,428 | $654.04M | $598.02M | 5.80% | -$56.02M |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 5,604,483 | 5,604,483 | 0 | $296.87M | $354.15M | 3.44% | +$57.28M |
| Revolution Medicines, Inc.(RVMD) | 7,936,972 | 9,364,972 | +1,428,000 | $280.65M | $344.54M | 3.34% | +$63.89M |
| Kymera Therapeutics, Inc.(KYMR) | 5,995,929 | 6,651,429 | +655,500 | $164.11M | $290.27M | 2.82% | +$126.16M |
| Alkermes plcSHS(ALKS) | 4,483,285 | 6,410,603 | +1,927,318 | $148.04M | $183.41M | 1.78% | +$35.37M |
| Replimune Group, Inc.(REPL) | 11,045,336 | 11,045,336 | 0 | $107.69M | $102.61M | 1.00% | -$5.08M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 1,576,114 | 2,772,692 | +1,196,578 | $57.07M | $100.82M | 0.98% | +$43.74M |
| Edgewise Therapeutics, Inc.(EWTX) | 6,155,940 | 7,305,940 | +1,150,000 | $135.43M | $95.78M | 0.93% | -$39.65M |
| AbCellera Biologics Inc.(ABCL) | 27,525,640 | 27,525,640 | 0 | $61.38M | $94.41M | 0.92% | +$33.03M |
| Immunovant, Inc.(IMVT) | 5,457,881 | 5,457,881 | 0 | $93.28M | $87.33M | 0.85% | -$5.95M |
| GRAIL, Inc.(GRAL) | 1,630,125 | 1,630,125 | 0 | $41.63M | $83.82M | 0.81% | +$42.19M |
| Kiniksa Pharmaceuticals International, plcCL A(KNSA) | 2,818,323 | 2,824,669 | +6,346 | $62.59M | $78.16M | 0.76% | +$15.56M |
| Bicycle Therapeutics plcADS | 10,885,357 | 10,885,357 | 0 | $92.42M | $75.65M | 0.73% | -$16.76M |
| Immunocore Holdings plcADS(IMCR) | 2,322,656 | 2,322,656 | 0 | $68.91M | $72.88M | 0.71% | +$3.97M |
| Celcuity Inc.(CELC) | 4,257,735 | 5,450,445 | +1,192,710 | $43.05M | $72.76M | 0.71% | +$29.72M |
| Kodiak Sciences Inc.(KOD) | 17,310,490 | 17,310,490 | 0 | $48.56M | $64.57M | 0.63% | +$16.01M |
| Immatics N.V.SHS(IMTX) | 7,275,830 | 10,168,901 | +2,893,071 | $32.81M | $54.71M | 0.53% | +$21.89M |
| Stoke Therapeutics, Inc.(STOK) | 4,633,838 | 4,633,838 | 0 | $30.82M | $52.59M | 0.51% | +$21.78M |
| Denali Therapeutics Inc.(DNLI) | 3,731,695 | 3,731,695 | 0 | $50.73M | $52.21M | 0.51% | +$1.47M |
| Structure Therapeutics Inc.ADS | 361,565 | 2,508,767 | +2,147,202 | $6.26M | $52.03M | 0.50% | +$45.77M |
| IDEAYA Biosciences, Inc.(IDYA) | 1,062,123 | 2,118,728 | +1,056,605 | $17.40M | $44.54M | 0.43% | +$27.14M |
| Nurix Therapeutics, Inc.(NRIX) | 3,882,125 | 3,882,125 | 0 | $46.12M | $44.22M | 0.43% | -$1.90M |
| Roivant Sciences Ltd.SHS(ROIV) | 3,767,773 | 3,767,773 | 0 | $38.02M | $42.46M | 0.41% | +$4.45M |
| BioNTech SEADS(BNTX) | 45,031 | 368,923 | +323,892 | $4.10M | $39.28M | 0.38% | +$35.18M |
| Entrada Therapeutics, Inc.(TRDA) | 4,865,819 | 4,865,819 | 0 | $43.99M | $32.70M | 0.32% | -$11.29M |
| Merus N.V. | 223,500 | 574,377 | +350,877 | $9.41M | $30.21M | 0.29% | +$20.81M |
| Praxis Precision Medicines, Inc.(PRAX) | 331,533 | 689,488 | +357,955 | $12.56M | $28.99M | 0.28% | +$16.44M |
| Intellia Therapeutics, Inc.(NTLA) | 644,116 | 2,675,674 | +2,031,558 | $4.58M | $25.10M | 0.24% | +$20.52M |
| Viridian Therapeutics, Inc.(VRDN) | 0 | 1,744,406 | +1,744,406 | $0 | $24.39M | 0.24% | +$24.39M |
| Monte Rosa Therapeutics, Inc.(GLUE) | 4,916,095 | 4,916,095 | 0 | $22.81M | $22.17M | 0.22% | -$639.1K |
| Verona Pharma plcADS | 223,843 | 223,843 | 0 | $14.21M | $21.17M | 0.21% | +$6.96M |
| Vaxcyte, Inc.(PCVX) | 640,885 | 640,885 | 0 | $24.20M | $20.84M | 0.20% | -$3.36M |
| argenx SEADR(ARGX) | 77,760 | 37,760 | -40,000 | $46.02M | $20.81M | 0.20% | -$25.21M |
| Verve Therapeutics, Inc. | 1,691,530 | 1,691,530 | 0 | $7.73M | $19.00M | 0.18% | +$11.27M |
| Cerus Corporation(CERS) | 19,351,087 | 12,883,844 | -6,467,243 | $26.90M | $18.17M | 0.18% | -$8.73M |
| Disc Medicine, Inc.(IRON) | 77,050 | 337,050 | +260,000 | $3.82M | $17.85M | 0.17% | +$14.03M |
| Akero Therapeutics, Inc. | 548,713 | 324,630 | -224,083 | $22.21M | $17.32M | 0.17% | -$4.89M |
| Blueprint Medicines Corporation | 0 | 125,538 | +125,538 | $0 | $16.09M | 0.16% | +$16.09M |
| Sera Prognostics, Inc.CL A(SERA) | 5,498,170 | 5,498,170 | 0 | $20.23M | $15.23M | 0.15% | -$5.00M |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | 0 | 939,174 | +939,174 | $0 | $14.84M | 0.14% | +$14.84M |
| Neurogene Inc.(NGNE) | 1,486,200 | 991,691 | -494,509 | $17.40M | $14.83M | 0.14% | -$2.58M |
| Dianthus Therapeutics, Inc.(DNTH) | 0 | 789,759 | +789,759 | $0 | $14.71M | 0.14% | +$14.71M |
| Celldex Therapeutics, Inc.(CLDX) | 247,644 | 665,370 | +417,726 | $4.49M | $13.54M | 0.13% | +$9.05M |
| DBV Technologies S.A.ADS(DBVT) | 1,461,425 | 1,461,425 | 0 | $9.97M | $13.39M | 0.13% | +$3.42M |
| Xenon Pharmaceuticals Inc.(XENE) | 347,408 | 370,208 | +22,800 | $11.66M | $11.59M | 0.11% | -$68.0K |
| Cidara Therapeutics, Inc. | 0 | 227,272 | +227,272 | $0 | $11.07M | 0.11% | +$11.07M |
| Arcellx, Inc. COMMON STOCK | 0 | 166,825 | +166,825 | $0 | $10.99M | 0.11% | +$10.99M |
| Nuvalent, Inc. | 0 | 143,937 | +143,937 | $0 | $10.98M | 0.11% | +$10.98M |
| Spyre Therapeutics, Inc.(SYRE) | 0 | 626,703 | +626,703 | $0 | $9.38M | 0.09% | +$9.38M |
| Taysha Gene Therapies, Inc.(TSHA) | 4,004,756 | 4,004,756 | 0 | $5.57M | $9.25M | 0.09% | +$3.68M |
| Prelude Therapeutics Incorporated(PRLD) | 10,123,824 | 10,123,824 | 0 | $7.78M | $8.19M | 0.08% | +$419.1K |
| Crinetics Pharmaceuticals, Inc. | 0 | 280,000 | +280,000 | $0 | $8.05M | 0.08% | +$8.05M |
| CytomX Therapeutics, Inc.(CTMX) | 0 | 3,484,226 | +3,484,226 | $0 | $7.91M | 0.08% | +$7.91M |
| Sagimet Biosciences Inc.COM SER A(SGMT) | 952,996 | 952,996 | 0 | $3.11M | $7.26M | 0.07% | +$4.16M |
| Sionna Therapeutics, Inc.(SION) | 400,000 | 400,000 | 0 | $4.18M | $6.94M | 0.07% | +$2.76M |
| Agios Pharmaceuticals, Inc.(AGIO) | 0 | 189,866 | +189,866 | $0 | $6.31M | 0.06% | +$6.31M |
| Rapport Therapeutics, Inc.(RAPP) | 0 | 550,090 | +550,090 | $0 | $6.25M | 0.06% | +$6.25M |
| Skye Bioscience, Inc.(SKYE) | 1,450,638 | 1,450,638 | 0 | $2.31M | $6.06M | 0.06% | +$3.76M |
| Design Therapeutics, Inc.(DSGN) | 1,743,725 | 1,712,882 | -30,843 | $6.73M | $5.77M | 0.06% | -$958.4K |
| KALA BIO, Inc.(KALA) | 1,201,894 | 1,201,894 | 0 | $6.89M | $5.72M | 0.06% | -$1.17M |
| Sana Biotechnology, Inc.(SANA) | 2,030,949 | 2,030,949 | 0 | $3.41M | $5.54M | 0.05% | +$2.13M |
| Xencor, Inc.(XNCR) | 670,431 | 670,431 | 0 | $7.13M | $5.27M | 0.05% | -$1.86M |
| Alumis Inc. | 1,562,500 | 1,562,500 | 0 | $9.59M | $4.69M | 0.05% | -$4.91M |
| IGM Biosciences, Inc. | 4,095,257 | 4,096,210 | +953 | $4.71M | $4.59M | 0.04% | -$121.8K |
| TScan Therapeutics, Inc.(TCRX) | 2,784,792 | 2,784,792 | 0 | $3.84M | $4.04M | 0.04% | +$194.9K |
| Relay Therapeutics, Inc.(RLAY) | 1,160,117 | 1,160,117 | 0 | $3.04M | $4.01M | 0.04% | +$974.5K |
| Fate Therapeutics, Inc.(FATE) | 3,258,402 | 2,485,018 | -773,384 | $2.57M | $2.78M | 0.03% | +$208.8K |
| Vir Biotechnology, Inc.(VIR) | 542,539 | 542,539 | 0 | $3.52M | $2.73M | 0.03% | -$781.3K |
| Enliven Therapeutics, Inc. | 114,833 | 114,833 | 0 | $2.26M | $2.30M | 0.02% | +$43.6K |
| Wave Life Sciences, Inc.SHS(WVE) | 344,063 | 344,063 | 0 | $2.78M | $2.24M | 0.02% | -$543.6K |
| Tectonic Therapeutic, Inc.(TECX) | 100,000 | 100,000 | 0 | $1.77M | $1.99M | 0.02% | +$216.0K |
| Candel Therapeutics, Inc.(CADL) | 2,437,189 | 355,112 | -2,082,077 | $13.77M | $1.80M | 0.02% | -$11.97M |
| Protara Therapeutics, Inc.(TARA) | 536,832 | 536,832 | 0 | $2.29M | $1.63M | 0.02% | -$660.3K |
| vTv Therapeutics Inc.CL A(VTVT) | 97,314 | 97,314 | 0 | $1.69M | $1.46M | 0.01% | -$225.8K |
| Rocket Pharmaceuticals, Inc.(RCKT) | 1,097,079 | 552,079 | -545,000 | $7.32M | $1.35M | 0.01% | -$5.96M |
| Contineum Therapeutics, Inc.CL A(CTNM) | 312,500 | 312,500 | 0 | $2.18M | $1.24M | 0.01% | -$940.6K |
| HOOKIPA Pharma Inc. | 812,814 | 812,814 | 0 | $877.8K | $1.02M | 0.01% | +$142.2K |
| Neumora Therapeutics, Inc.(NMRA) | 1,034,600 | 1,034,600 | 0 | $1.03M | $758.7K | 0.01% | -$275.9K |
| Generation Bio Co. | 1,944,945 | 1,944,945 | 0 | $787.7K | $622.6K | 0.01% | -$165.1K |
| Aligos Therapeutics, Inc.(ALGS) | 83,055 | 83,055 | 0 | $685.2K | $598.8K | 0.01% | -$86.4K |
| Tyra Biosciences, Inc.(TYRA) | 10,607 | 10,607 | 0 | $98.6K | $101.5K | 0.00% | +$2.9K |
| Acrivon Therapeutics, Inc. | 22,809 | 22,809 | 0 | $46.3K | $27.1K | 0.00% | -$19.2K |
| Surrozen, Inc.W EXP 8 11 2026(SRZN) | 833,333 | 833,333 | 0 | $25.0K | $15.1K | 0.00% | -$9.9K |
| Ceryvyn Therapeutics LimitedADS(CKDXF) | 2,087,320 | 2,087,320 | 0 | $0 | $0 | — | $0 |
| 2seventy bio, Inc. | 2,497,526 | 0 | -2,497,526 | $12.34M | $0 | — | -$12.34M |
| Bicara Therapeutics Inc. | 833,333 | 0 | -833,333 | $10.86M | $0 | — | -$10.86M |
| Centessa Pharmaceuticals plcADS | 1,227,178 | 0 | -1,227,178 | $17.65M | $0 | — | -$17.65M |
| Century Therapeutics, Inc.(IPSC) | 241,684 | 0 | -241,684 | $115.0K | $0 | — | -$115.0K |
| Compass Therapeutics, Inc.(CMPX) | 547,498 | 0 | -547,498 | $1.04M | $0 | — | -$1.04M |
| CRISPR Therapeutics AGNAMEN AKT(CRSP) | 654,099 | 0 | -654,099 | $22.26M | $0 | — | -$22.26M |
| Dyne Therapeutics, Inc.(DYN) | 672,096 | 0 | -672,096 | $7.03M | $0 | — | -$7.03M |
| Ionis Pharmaceuticals, Inc.(IONS) | 357,915 | 0 | -357,915 | $10.80M | $0 | — | -$10.80M |
| Cypherpunk Technologies Inc.(CYPH) | 404,744 | 0 | -404,744 | $123.5K | $0 | — | -$123.5K |
| Prime Medicine, Inc.(PRME) | 1,028,466 | 0 | -1,028,466 | $2.05M | $0 | — | -$2.05M |
| Regulus Therapeutics Inc. | 2,694,044 | 0 | -2,694,044 | $4.71M | $0 | — | -$4.71M |