Fund HoldingsBAKER BROS. ADVISORS LP

Total Portfolio Value
$19.96B
Total Bought
$2.84B
Total Sold
$653.75M
Net Transaction
+$2.19B
Filing Period:
Securities
SharesValue ($K)
Q1 2026
Q2 2026
Change
Q1 2026
Q2 2026
Weight (%)
Change
Revolution Medicines, Inc.(RVMD)9,555,35711,443,357+1,888,000929,2582,143,11210.74%+1,213,853
Incyte Corporation(INCY)30,744,41230,762,330+17,9182,893,6643,487,21817.48%+593,554
Kymera Therapeutics, Inc.(KYMR)8,657,2428,657,2420721,062992,7264.97%+271,664
Alkermes plc(ALKS)10,012,26710,012,2670354,034524,5932.63%+170,559
AbCellera Biologics Inc.(ABCL)30,275,93833,012,138+2,736,200105,663259,1451.30%+153,482
Rhythm Pharmaceuticals, Inc.(RYTM)5,604,4835,604,4830487,422622,2663.12%+134,844
ACADIA Pharmaceuticals Inc.42,896,69042,912,904+16,214954,8801,085,6965.44%+130,816
Immunovant, Inc.(IMVT)5,457,8815,435,220-22,661135,574209,4191.05%+73,845
GRAIL, Inc.(GRAL)4,028,6144,028,6140208,199275,0331.38%+66,835
IDEAYA Biosciences, Inc.(IDYA)3,946,5155,010,030+1,063,515131,498186,7240.94%+55,226
Kiniksa Pharmaceuticals International, plc(KNSA)2,826,2462,834,643+8,397136,084181,2750.91%+45,192
Relay Therapeutics, Inc.(RLAY)1,160,1172,826,783+1,666,66611,54352,8890.27%+41,346
Nurix Therapeutics, Inc.(NRIX)4,658,5564,658,556072,208113,0170.57%+40,809
Replimune Group, Inc.(REPL)11,045,33611,045,336084,497122,2720.61%+37,775
Arrowhead Pharmaceuticals, Inc.(ARWR)1,992,7831,992,7830124,947162,4320.81%+37,484
Monte Rosa Therapeutics, Inc.(GLUE)4,345,7364,345,736071,487105,1670.53%+33,679
Faeth Therapeutics, Inc.01,286,411+1,286,411032,1600.16%+32,160
Roivant Sciences Ltd.(ROIV)4,867,7234,716,831-150,892134,836166,9290.84%+32,093
Madrigal Pharmaceuticals, Inc.(MDGL)2,141,7012,143,131+1,4301,121,1161,150,7545.77%+29,638
Denali Therapeutics Inc.(DNLI)3,731,6953,734,336+2,64171,64996,0470.48%+24,399
Celldex Therapeutics, Inc.(CLDX)665,3701,182,611+517,24121,10644,0050.22%+22,899
Praxis Precision Medicines, Inc.(PRAX)1,753,1981,753,1980564,863586,9532.94%+22,090
Prelude Therapeutics Inc.10,123,82410,123,824034,62353,9600.27%+19,337
Absci Corporation2,134,8032,134,80306,40424,7420.12%+18,338
Cytokinetics, Incorporated(CYTK)0211,267+211,267017,9980.09%+17,998
Arcus Biosciences, Inc.(RCUS)415,621844,816+429,1958,97726,0460.13%+17,068
Kodiak Sciences Inc.(KOD)19,919,18619,919,1860759,319776,0513.89%+16,732
Rapport Therapeutics, Inc.(RAPP)1,547,0901,547,090048,40864,4670.32%+16,059
Intellia Therapeutics, Inc.(NTLA)0930,232+930,232015,7400.08%+15,740
Aktis Oncology, Inc.(AKTS)996,351996,351017,82532,1120.16%+14,288
Parabilis Medicines, Inc.0500,000+500,000013,6850.07%+13,685
Alumis Inc.2,012,5002,012,500044,33556,6320.28%+12,296
Dianthus Therapeutics, Inc.(DNTH)852,164852,164071,51483,0690.42%+11,555
Avalyn Pharma Inc.0350,000+350,000011,5220.06%+11,522
Design Therapeutics, Inc.(DSGN)2,585,9782,678,430+92,45227,51538,7570.19%+11,242
Neurogene Inc.991,691991,691019,99231,1890.16%+11,196
Mirum Pharmaceuticals, Inc.(MIRM)445,975445,975041,19952,2100.26%+11,011
Enliven Therapeutics, Inc.905,191905,191035,48345,9380.23%+10,455
Tango Therapeutics, Inc.(TNGX)0333,333+333,333010,4200.05%+10,420
Avalo Therapeutics, Inc.(AVTX)0550,000+550,000010,1640.05%+10,164
Taysha Gene Therapies, Inc.(TSHA)4,004,7564,004,756017,90127,2720.14%+9,371
Ionis Pharmaceuticals, Inc.(IONS)2,047,7272,047,7270153,764162,3640.81%+8,600
Structure Therapeutics Inc.1,432,5291,432,529069,04876,8840.39%+7,836
Verastem, Inc.584,7572,499,338+1,914,5813,0999,5470.05%+6,448
Generate Biomedicines, Inc.(GENB)1,423,6021,423,602017,79524,0160.12%+6,221
MapLight Therapeutics, Inc.364,705364,70507,41413,0710.07%+5,657
Viridian Therapeutics, Inc.(VRDN)1,971,6782,383,025+411,34738,56643,7760.22%+5,210
Xencor, Inc.(XNCR)1,102,1061,102,106013,29117,7440.09%+4,453
Jade Biosciences, Inc.1,641,1371,230,426-410,71123,05827,3400.14%+4,282
Dyne Therapeutics, Inc.(DYN)813,449813,449014,74818,0670.09%+3,319
Disc Medicine, Inc.(IRON)349,657349,657022,35725,5740.13%+3,217
Crinetics Pharmaceuticals, Inc.(CRNX)2,351,4652,351,465085,40587,9920.44%+2,587
Sagimet Biosciences Inc.952,996952,99604,9797,3670.04%+2,387
Tectonic Therapeutic, Inc.607,788607,788018,78720,8930.10%+2,106
Sionna Therapeutics, Inc.400,000400,000016,03617,5960.09%+1,560
LB Pharmaceuticals Inc.(LBRX)200,000200,00004,9326,4910.03%+1,559
Eikon Therapeutics, Inc.555,555555,55505,8787,2500.04%+1,372
Immunome, Inc.(IMNM)055,306+55,30601,1720.01%+1,172
Xenon Pharmaceuticals Inc.(XENE)370,208370,208021,52822,3460.11%+818
Stoke Therapeutics, Inc.(STOK)3,336,6973,336,6970108,643109,1770.55%+534
BioNTech SE(BNTX)119,743119,743010,64311,1420.06%+499
Cerus Corporation10,008,3456,395,431-3,612,91418,21518,6750.09%+459
Sana Biotechnology, Inc.(SANA)310,483310,48308941,0840.01%+189
Skye Bioscience, Inc.1,575,2431,575,24309681,0920.01%+124
Surrozen, Inc. Warrants @ $172.50 8/11/2026 (15 FOR 1)833,333833,333013140.00%0
Tyra Biosciences, Inc.(TYRA)10,60710,60704063390.00%-67
TScan Therapeutics, Inc.2,784,7922,784,79202,8132,7290.01%-83
Aligos Therapeutics, Inc.83,05583,05506174790.00%-138
vTv Therapeutics, Inc.148,314148,31405,8825,5840.03%-298
Sera Prognostics, Inc.5,498,1705,498,170011,16110,0070.05%-1,155
Wave Life Sciences Ltd.(WVE)822,638822,63805,9644,7800.02%-1,185
Protara Therapeutics, Inc.971,614971,61405,0623,7120.02%-1,351
Bicycle Therapeutics plc10,885,35710,885,357050,50846,1540.23%-4,354
CytomX Therapeutics, Inc.4,975,8264,975,826023,38618,6590.09%-4,727
Celcuity Inc.(CELC)30,750,0000-30,750,00074,86969,1590.35%-5,710
DBV Technologies S.A.(DBVT)1,461,4251,461,425030,52923,9670.12%-6,562
Evommune, Inc.847,390847,390019,48111,2620.06%-8,220
Pharvaris N.V.
COM
375,0000-375,00010,5940-10,594
Immatics N.V.(IMTX)10,916,6939,508,565-1,408,128107,42096,3220.48%-11,098
COMPASS Pathways plc(CMPS)2,344,7200-2,344,72012,9660-12,966
argenx SE(ARGX)25,1740-25,17418,3830-18,383
Contineum Therapeutics, Inc.1,420,8380-1,420,83818,5560-18,556
Immunocore Holdings plc(IMCR)734,3970-734,39722,1420-22,142
Centessa Pharmaceuticals plc670,7510-670,75126,6420-26,642
Entrada Therapeutics, Inc.5,072,7305,072,730064,01837,3350.19%-26,683
Spyre Therapeutics, Inc.(SYRE)1,000,0000-1,000,00050,4400-50,440
Edgewise Therapeutics, Inc.(EWTX)6,575,9403,701,719-2,874,221207,142150,4010.75%-56,741
Celcuity Inc.(CELC)7,915,7927,915,7920903,508828,1504.15%-75,358
Abivax S.A.(ABVX)875,7960-875,79697,5200-97,520
BeOne Medicines Ltd.(ONC)8,799,0538,801,567+2,5142,613,0552,508,18312.57%-104,872
Summit Therapeutics Inc.(SMMT)36,391,06332,786,348-3,604,715689,975477,6972.39%-212,277
Insmed Incorporated(INSM)7,421,1118,796,111+1,375,0001,213,500937,8414.70%-275,659
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