Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| BeOne Medicines Ltd.(ONC) | 8,799,053 | 8,799,053 | 0 | 2,129,987 | 2,997,837 | 21.66% | +867,851 |
| Incyte Corporation(INCY) | 30,743,275 | 30,743,663 | +388 | 2,093,617 | 2,607,370 | 18.84% | +513,753 |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 1,976,018 | 2,141,701 | +165,683 | 598,022 | 982,313 | 7.10% | +384,290 |
| Celcuity Inc.(CELC) | 5,450,445 | 7,915,792 | +2,465,347 | 72,763 | 391,040 | 2.83% | +318,277 |
| Kodiak Sciences Inc.(KOD) | 17,310,490 | 17,310,490 | 0 | 64,568 | 283,373 | 2.05% | +218,805 |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 5,604,483 | 5,604,483 | 0 | 354,147 | 565,997 | 4.09% | +211,849 |
| Insmed Incorporated(INSM) | 7,712,900 | 6,703,484 | -1,009,416 | 776,226 | 965,369 | 6.98% | +189,142 |
| Revolution Medicines, Inc.(RVMD) | 9,364,972 | 9,455,357 | +90,385 | 344,537 | 441,565 | 3.19% | +97,028 |
| Kymera Therapeutics, Inc.(KYMR) | 6,651,429 | 6,651,429 | 0 | 290,268 | 376,471 | 2.72% | +86,203 |
| Abivax S.A.(ABVX) | 0 | 875,796 | +875,796 | 0 | 74,355 | 0.54% | +74,355 |
| Alkermes plc(ALKS) | 6,410,603 | 8,091,351 | +1,680,748 | 183,407 | 242,741 | 1.75% | +59,333 |
| Stoke Therapeutics, Inc.(STOK) | 4,633,838 | 4,633,838 | 0 | 52,594 | 108,895 | 0.79% | +56,301 |
| Immatics N.V.(IMTX) | 10,168,901 | 12,094,094 | +1,925,193 | 54,709 | 103,042 | 0.74% | +48,333 |
| IDEAYA Biosciences, Inc.(IDYA) | 2,118,728 | 3,275,444 | +1,156,716 | 44,536 | 89,125 | 0.64% | +44,589 |
| AbCellera Biologics Inc.(ABCL) | 27,525,640 | 27,525,640 | 0 | 94,413 | 138,454 | 1.00% | +44,041 |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | 939,174 | 1,670,762 | +731,588 | 14,839 | 57,625 | 0.42% | +42,786 |
| Celcuity Inc.(CELC) | 0 | 0 | 0 | 0 | 40,905 | 0.30% | +40,905 |
| Rapport Therapeutics, Inc.(RAPP) | 550,090 | 1,547,090 | +997,000 | 6,255 | 45,949 | 0.33% | +39,694 |
| Ionis Pharmaceuticals, Inc.(IONS) | 0 | 566,798 | +566,798 | 0 | 37,080 | 0.27% | +37,080 |
| Kiniksa Pharmaceuticals International, plc(KNSA) | 2,824,669 | 2,824,669 | 0 | 78,159 | 109,682 | 0.79% | +31,523 |
| Avidity Biosciences, Inc. | 0 | 625,000 | +625,000 | 0 | 27,231 | 0.20% | +27,231 |
| Merus N.V. | 574,377 | 574,377 | 0 | 30,212 | 54,078 | 0.39% | +23,865 |
| Edgewise Therapeutics, Inc.(EWTX) | 7,305,940 | 7,305,940 | 0 | 95,781 | 118,502 | 0.86% | +22,721 |
| Intellia Therapeutics, Inc.(NTLA) | 2,675,674 | 2,746,674 | +71,000 | 25,098 | 47,435 | 0.34% | +22,337 |
| Dianthus Therapeutics, Inc.(DNTH) | 789,759 | 789,759 | 0 | 14,713 | 31,077 | 0.22% | +16,364 |
| Roivant Sciences Ltd.(ROIV) | 3,767,773 | 3,767,773 | 0 | 42,463 | 57,006 | 0.41% | +14,544 |
| Monte Rosa Therapeutics, Inc.(GLUE) | 4,916,095 | 4,916,095 | 0 | 22,172 | 36,428 | 0.26% | +14,257 |
| Viridian Therapeutics, Inc.(VRDN) | 1,744,406 | 1,744,406 | 0 | 24,387 | 37,644 | 0.27% | +13,257 |
| GRAIL, Inc.(GRAL) | 1,630,125 | 1,630,125 | 0 | 83,821 | 96,389 | 0.70% | +12,568 |
| Immunocore Holdings plc(IMCR) | 2,322,656 | 2,322,656 | 0 | 72,885 | 84,382 | 0.61% | +11,497 |
| Cidara Therapeutics, Inc. | 227,272 | 227,272 | 0 | 11,070 | 21,764 | 0.16% | +10,693 |
| Viking Therapeutics, Inc.(VKTX) | 0 | 366,083 | +366,083 | 0 | 9,621 | 0.07% | +9,621 |
| Pharvaris N.V. COM | 0 | 375,000 | +375,000 | 0 | 9,356 | 0.07% | +9,356 |
| Bicycle Therapeutics plc | 10,885,357 | 10,885,357 | 0 | 75,653 | 84,253 | 0.61% | +8,599 |
| Xencor, Inc.(XNCR) | 670,431 | 1,102,106 | +431,675 | 5,270 | 12,928 | 0.09% | +7,658 |
| Praxis Precision Medicines, Inc.(PRAX) | 689,488 | 689,488 | 0 | 28,993 | 36,543 | 0.26% | +7,550 |
| Spyre Therapeutics, Inc.(SYRE) | 626,703 | 1,000,000 | +373,297 | 9,382 | 16,760 | 0.12% | +7,378 |
| Design Therapeutics, Inc.(DSGN) | 1,712,882 | 1,712,882 | 0 | 5,772 | 12,898 | 0.09% | +7,126 |
| argenx SE(ARGX) | 37,760 | 37,760 | 0 | 20,814 | 27,850 | 0.20% | +7,036 |
| Prelude Therapeutics Inc.(PRLD) | 10,123,824 | 10,123,824 | 0 | 8,194 | 14,578 | 0.11% | +6,384 |
| CytomX Therapeutics, Inc.(CTMX) | 3,484,226 | 4,250,826 | +766,600 | 7,909 | 13,560 | 0.10% | +5,651 |
| Heron Therapeutics, Inc.(HRTX) | 0 | 4,251,951 | +4,251,951 | 0 | 5,357 | 0.04% | +5,357 |
| MBX Biosciences, Inc.(MBX) | 0 | 277,777 | +277,777 | 0 | 4,861 | 0.04% | +4,861 |
| Sionna Therapeutics, Inc.(SION) | 400,000 | 400,000 | 0 | 6,940 | 11,764 | 0.09% | +4,824 |
| Disc Medicine, Inc.(IRON) | 337,050 | 337,050 | 0 | 17,850 | 22,272 | 0.16% | +4,422 |
| Taysha Gene Therapies, Inc.(TSHA) | 4,004,756 | 4,004,756 | 0 | 9,251 | 13,096 | 0.09% | +3,845 |
| Celldex Therapeutics, Inc.(CLDX) | 665,370 | 665,370 | 0 | 13,540 | 17,213 | 0.12% | +3,673 |
| Crinetics Pharmaceuticals, Inc.(CRNX) | 280,000 | 280,000 | 0 | 8,053 | 11,662 | 0.08% | +3,609 |
| Xenon Pharmaceuticals Inc.(XENE) | 370,208 | 370,208 | 0 | 11,588 | 14,864 | 0.11% | +3,276 |
| Ventyx Biosciences, Inc. | 0 | 1,023,130 | +1,023,130 | 0 | 3,182 | 0.02% | +3,182 |
| LB Pharmaceuticals Inc.(LBRX) | 0 | 200,000 | +200,000 | 0 | 3,158 | 0.02% | +3,158 |
| Arcellx, Inc. COMMON STOCK | 166,825 | 166,825 | 0 | 10,985 | 13,696 | 0.10% | +2,711 |
| Neurogene Inc.(NGNE) | 991,691 | 991,691 | 0 | 14,826 | 17,186 | 0.12% | +2,360 |
| Vaxcyte, Inc.(PCVX) | 640,885 | 640,885 | 0 | 20,835 | 23,085 | 0.17% | +2,250 |
| Relay Therapeutics, Inc.(RLAY) | 1,160,117 | 1,160,117 | 0 | 4,014 | 6,056 | 0.04% | +2,042 |
| vTv Therapeutics, Inc.(VTVT) | 97,314 | 148,314 | +51,000 | 1,460 | 3,463 | 0.03% | +2,003 |
| Denali Therapeutics Inc.(DNLI) | 3,731,695 | 3,731,695 | 0 | 52,206 | 54,184 | 0.39% | +1,978 |
| Sana Biotechnology, Inc.(SANA) | 2,030,949 | 2,030,949 | 0 | 5,544 | 7,210 | 0.05% | +1,665 |
| Sera Prognostics, Inc.(SERA) | 5,498,170 | 5,498,170 | 0 | 15,230 | 16,824 | 0.12% | +1,594 |
| Alumis Inc. | 1,562,500 | 1,562,500 | 0 | 4,688 | 6,234 | 0.05% | +1,547 |
| Nuvalent, Inc. | 143,937 | 143,937 | 0 | 10,982 | 12,448 | 0.09% | +1,465 |
| Agios Pharmaceuticals, Inc.(AGIO) | 189,866 | 189,866 | 0 | 6,315 | 7,621 | 0.06% | +1,306 |
| DBV Technologies S.A.(DBVT) | 1,461,425 | 1,461,425 | 0 | 13,387 | 14,614 | 0.11% | +1,228 |
| Generation Bio Co. | 0 | 194,493 | +194,493 | 0 | 1,190 | 0.01% | +1,190 |
| TScan Therapeutics, Inc.(TCRX) | 2,784,792 | 2,784,792 | 0 | 4,038 | 5,068 | 0.04% | +1,030 |
| Protara Therapeutics, Inc.(TARA) | 536,832 | 536,832 | 0 | 1,627 | 2,335 | 0.02% | +709 |
| Immunovant, Inc.(IMVT) | 5,457,881 | 5,457,881 | 0 | 87,326 | 87,981 | 0.64% | +655 |
| Vir Biotechnology, Inc.(VIR) | 542,539 | 542,539 | 0 | 2,734 | 3,098 | 0.02% | +364 |
| VYNE Therapeutics Inc.(YARW) | 0 | 851,353 | +851,353 | 0 | 285 | 0.00% | +285 |
| Wave Life Sciences Ltd.(WVE) | 344,063 | 344,063 | 0 | 2,236 | 2,519 | 0.02% | +282 |
| Aligos Therapeutics, Inc.(ALGS) | 83,055 | 83,055 | 0 | 599 | 814 | 0.01% | +215 |
| Enliven Therapeutics, Inc. | 114,833 | 114,833 | 0 | 2,304 | 2,351 | 0.02% | +47 |
| Tyra Biosciences, Inc.(TYRA) | 10,607 | 10,607 | 0 | 102 | 148 | 0.00% | +47 |
| Acrivon Therapeutics, Inc. | 22,809 | 22,809 | 0 | 27 | 41 | 0.00% | +14 |
| Opthea Limited(CKDXF) | 2,087,320 | 2,087,320 | 0 | 0 | 0 | — | 0 |
| Surrozen, Inc.(SRZN) | 833,333 | 833,333 | 0 | 15 | 15 | 0.00% | -0 |
| Contineum Therapeutics, Inc.(CTNM) | 312,500 | 77,670 | -234,830 | 1,241 | 913 | 0.01% | -328 |
| Skye Bioscience, Inc.(SKYE) | 1,450,638 | 1,450,638 | 0 | 6,064 | 5,701 | 0.04% | -363 |
| Tectonic Therapeutic, Inc.(TECX) | 100,000 | 100,000 | 0 | 1,987 | 1,569 | 0.01% | -418 |
| Generation Bio Co. | 1,944,945 | 0 | -1,944,945 | 623 | 0 | — | -623 |
| Sagimet Biosciences Inc.(SGMT) | 952,996 | 952,996 | 0 | 7,262 | 6,538 | 0.05% | -724 |
| Neumora Therapeutics, Inc.(NMRA) | 1,034,600 | 0 | -1,034,600 | 759 | 0 | — | -759 |
| HOOKIPA Pharma Inc. | 812,814 | 0 | -812,814 | 1,020 | 0 | — | -1,020 |
| Rocket Pharmaceuticals, Inc.(RCKT) | 552,079 | 0 | -552,079 | 1,353 | 0 | — | -1,353 |
| Candel Therapeutics, Inc.(CADL) | 355,112 | 0 | -355,112 | 1,797 | 0 | — | -1,797 |
| Akero Therapeutics, Inc. | 324,630 | 324,630 | 0 | 17,322 | 15,413 | 0.11% | -1,909 |
| Cerus Corporation(CERS) | 12,883,844 | 10,008,345 | -2,875,499 | 18,166 | 15,913 | 0.11% | -2,253 |
| Fate Therapeutics, Inc.(FATE) | 2,485,018 | 0 | -2,485,018 | 2,783 | 0 | — | -2,783 |
| BioNTech SE(BNTX) | 368,923 | 368,923 | 0 | 39,279 | 36,383 | 0.26% | -2,896 |
| KALA BIO, Inc.(KALA) | 1,201,894 | 985,093 | -216,801 | 5,721 | 1,507 | 0.01% | -4,214 |
| Entrada Therapeutics, Inc.(TRDA) | 4,865,819 | 4,865,819 | 0 | 32,698 | 28,222 | 0.20% | -4,477 |
| IGM Biosciences, Inc. | 4,096,210 | 0 | -4,096,210 | 4,588 | 0 | — | -4,588 |
| Nurix Therapeutics, Inc.(NRIX) | 3,882,125 | 3,882,125 | 0 | 44,217 | 35,871 | 0.26% | -8,347 |
| Structure Therapeutics Inc. | 2,508,767 | 1,556,109 | -952,658 | 52,032 | 43,571 | 0.31% | -8,461 |
| ACADIA Pharmaceuticals Inc. | 42,896,690 | 42,896,690 | 0 | 925,282 | 915,415 | 6.61% | -9,866 |
| Blueprint Medicines Corporation | 125,538 | 0 | -125,538 | 16,091 | 0 | — | -16,091 |
| Ultragenyx Pharmaceutical Inc.(RARE) | 2,772,692 | 2,772,692 | 0 | 100,815 | 83,403 | 0.60% | -17,413 |
| Verve Therapeutics, Inc. | 1,691,530 | 0 | -1,691,530 | 18,996 | 0 | — | -18,996 |
| Summit Therapeutics Inc.(SMMT) | 33,722,974 | 33,722,974 | 0 | 717,625 | 696,717 | 5.03% | -20,908 |
| Verona Pharma plc | 223,843 | 0 | -223,843 | 21,171 | 0 | — | -21,171 |