Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| BeOne Medicines AGADS(ONC) | 8,799,053 | 8,799,053 | 0 | $2.13B | $3.00B | 21.66% | +$867.85M |
| Incyte Corporation(INCY) | 30,743,275 | 30,743,663 | +388 | $2.09B | $2.61B | 18.84% | +$513.75M |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 1,976,018 | 2,141,701 | +165,683 | $598.02M | $982.31M | 7.10% | +$384.29M |
| Insmed Incorporated(INSM) | 7,712,900 | 6,703,484 | -1,009,416 | $776.23M | $965.37M | 6.98% | +$189.14M |
| ACADIA Pharmaceuticals Inc. | 42,896,690 | 42,896,690 | 0 | $925.28M | $915.42M | 6.61% | -$9.87M |
| Summit Therapeutics Inc.(SMMT) | 33,722,974 | 33,722,974 | 0 | $717.62M | $696.72M | 5.03% | -$20.91M |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 5,604,483 | 5,604,483 | 0 | $354.15M | $566.00M | 4.09% | +$211.85M |
| Revolution Medicines, Inc.(RVMD) | 9,364,972 | 9,455,357 | +90,385 | $344.54M | $441.57M | 3.19% | +$97.03M |
| Celcuity Inc.(CELC) | 5,450,445 | 7,915,792 | +2,465,347 | $72.76M | $391.04M | 2.83% | +$318.28M |
| Kymera Therapeutics, Inc.(KYMR) | 6,651,429 | 6,651,429 | 0 | $290.27M | $376.47M | 2.72% | +$86.20M |
| Kodiak Sciences Inc.(KOD) | 17,310,490 | 17,310,490 | 0 | $64.57M | $283.37M | 2.05% | +$218.80M |
| Alkermes plcSHS(ALKS) | 6,410,603 | 8,091,351 | +1,680,748 | $183.41M | $242.74M | 1.75% | +$59.33M |
| AbCellera Biologics Inc.(ABCL) | 27,525,640 | 27,525,640 | 0 | $94.41M | $138.45M | 1.00% | +$44.04M |
| Edgewise Therapeutics, Inc.(EWTX) | 7,305,940 | 7,305,940 | 0 | $95.78M | $118.50M | 0.86% | +$22.72M |
| Kiniksa Pharmaceuticals International, plcCL A(KNSA) | 2,824,669 | 2,824,669 | 0 | $78.16M | $109.68M | 0.79% | +$31.52M |
| Stoke Therapeutics, Inc.(STOK) | 4,633,838 | 4,633,838 | 0 | $52.59M | $108.90M | 0.79% | +$56.30M |
| Immatics N.V.SHS(IMTX) | 10,168,901 | 12,094,094 | +1,925,193 | $54.71M | $103.04M | 0.74% | +$48.33M |
| GRAIL, Inc.(GRAL) | 1,630,125 | 1,630,125 | 0 | $83.82M | $96.39M | 0.70% | +$12.57M |
| IDEAYA Biosciences, Inc.(IDYA) | 2,118,728 | 3,275,444 | +1,156,716 | $44.54M | $89.12M | 0.64% | +$44.59M |
| Immunovant, Inc.(IMVT) | 5,457,881 | 5,457,881 | 0 | $87.33M | $87.98M | 0.64% | +$654.9K |
| Immunocore Holdings plcADS(IMCR) | 2,322,656 | 2,322,656 | 0 | $72.88M | $84.38M | 0.61% | +$11.50M |
| Bicycle Therapeutics plcADS | 10,885,357 | 10,885,357 | 0 | $75.65M | $84.25M | 0.61% | +$8.60M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 2,772,692 | 2,772,692 | 0 | $100.82M | $83.40M | 0.60% | -$17.41M |
| ABIVAX Société AnonymeADS(ABVX) | 0 | 875,796 | +875,796 | $0 | $74.36M | 0.54% | +$74.36M |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | 939,174 | 1,670,762 | +731,588 | $14.84M | $57.62M | 0.42% | +$42.79M |
| Roivant Sciences Ltd.SHS(ROIV) | 3,767,773 | 3,767,773 | 0 | $42.46M | $57.01M | 0.41% | +$14.54M |
| Denali Therapeutics Inc.(DNLI) | 3,731,695 | 3,731,695 | 0 | $52.21M | $54.18M | 0.39% | +$1.98M |
| Merus N.V. | 574,377 | 574,377 | 0 | $30.21M | $54.08M | 0.39% | +$23.87M |
| Intellia Therapeutics, Inc.(NTLA) | 2,675,674 | 2,746,674 | +71,000 | $25.10M | $47.44M | 0.34% | +$22.34M |
| Replimune Group, Inc.(REPL) | 11,045,336 | 11,045,336 | 0 | $102.61M | $46.28M | 0.33% | -$56.33M |
| Rapport Therapeutics, Inc.(RAPP) | 550,090 | 1,547,090 | +997,000 | $6.25M | $45.95M | 0.33% | +$39.69M |
| Structure Therapeutics Inc.ADS | 2,508,767 | 1,556,109 | -952,658 | $52.03M | $43.57M | 0.31% | -$8.46M |
| Celcuity Inc.NOTE 2 75 8 1 2031(CELC) | 0 | 0 | 0 | $0 | $40.91M | 0.30% | +$40.91M |
| Viridian Therapeutics, Inc.(VRDN) | 1,744,406 | 1,744,406 | 0 | $24.39M | $37.64M | 0.27% | +$13.26M |
| Ionis Pharmaceuticals, Inc.(IONS) | 0 | 566,798 | +566,798 | $0 | $37.08M | 0.27% | +$37.08M |
| Praxis Precision Medicines, Inc.(PRAX) | 689,488 | 689,488 | 0 | $28.99M | $36.54M | 0.26% | +$7.55M |
| Monte Rosa Therapeutics, Inc.(GLUE) | 4,916,095 | 4,916,095 | 0 | $22.17M | $36.43M | 0.26% | +$14.26M |
| BioNTech SEADS(BNTX) | 368,923 | 368,923 | 0 | $39.28M | $36.38M | 0.26% | -$2.90M |
| Nurix Therapeutics, Inc.(NRIX) | 3,882,125 | 3,882,125 | 0 | $44.22M | $35.87M | 0.26% | -$8.35M |
| Dianthus Therapeutics, Inc.(DNTH) | 789,759 | 789,759 | 0 | $14.71M | $31.08M | 0.22% | +$16.36M |
| Entrada Therapeutics, Inc.(TRDA) | 4,865,819 | 4,865,819 | 0 | $32.70M | $28.22M | 0.20% | -$4.48M |
| argenx SEADR(ARGX) | 37,760 | 37,760 | 0 | $20.81M | $27.85M | 0.20% | +$7.04M |
| Avidity Biosciences, Inc. | 0 | 625,000 | +625,000 | $0 | $27.23M | 0.20% | +$27.23M |
| Vaxcyte, Inc.(PCVX) | 640,885 | 640,885 | 0 | $20.84M | $23.08M | 0.17% | +$2.25M |
| Disc Medicine, Inc.(IRON) | 337,050 | 337,050 | 0 | $17.85M | $22.27M | 0.16% | +$4.42M |
| Cidara Therapeutics, Inc. | 227,272 | 227,272 | 0 | $11.07M | $21.76M | 0.16% | +$10.69M |
| Celldex Therapeutics, Inc.(CLDX) | 665,370 | 665,370 | 0 | $13.54M | $17.21M | 0.12% | +$3.67M |
| Neurogene Inc.(NGNE) | 991,691 | 991,691 | 0 | $14.83M | $17.19M | 0.12% | +$2.36M |
| Sera Prognostics, Inc.CL A(SERA) | 5,498,170 | 5,498,170 | 0 | $15.23M | $16.82M | 0.12% | +$1.59M |
| Spyre Therapeutics, Inc.(SYRE) | 626,703 | 1,000,000 | +373,297 | $9.38M | $16.76M | 0.12% | +$7.38M |
| Cerus Corporation(CERS) | 12,883,844 | 10,008,345 | -2,875,499 | $18.17M | $15.91M | 0.11% | -$2.25M |
| Akero Therapeutics, Inc. | 324,630 | 324,630 | 0 | $17.32M | $15.41M | 0.11% | -$1.91M |
| Xenon Pharmaceuticals Inc.(XENE) | 370,208 | 370,208 | 0 | $11.59M | $14.86M | 0.11% | +$3.28M |
| DBV Technologies S.A.ADS(DBVT) | 1,461,425 | 1,461,425 | 0 | $13.39M | $14.61M | 0.11% | +$1.23M |
| Prelude Therapeutics Incorporated(PRLD) | 10,123,824 | 10,123,824 | 0 | $8.19M | $14.58M | 0.11% | +$6.38M |
| Arcellx, Inc. COMMON STOCK | 166,825 | 166,825 | 0 | $10.99M | $13.70M | 0.10% | +$2.71M |
| CytomX Therapeutics, Inc.(CTMX) | 3,484,226 | 4,250,826 | +766,600 | $7.91M | $13.56M | 0.10% | +$5.65M |
| Taysha Gene Therapies, Inc.(TSHA) | 4,004,756 | 4,004,756 | 0 | $9.25M | $13.10M | 0.09% | +$3.84M |
| Xencor, Inc.(XNCR) | 670,431 | 1,102,106 | +431,675 | $5.27M | $12.93M | 0.09% | +$7.66M |
| Design Therapeutics, Inc.(DSGN) | 1,712,882 | 1,712,882 | 0 | $5.77M | $12.90M | 0.09% | +$7.13M |
| Nuvalent, Inc. | 143,937 | 143,937 | 0 | $10.98M | $12.45M | 0.09% | +$1.47M |
| Sionna Therapeutics, Inc.(SION) | 400,000 | 400,000 | 0 | $6.94M | $11.76M | 0.09% | +$4.82M |
| Crinetics Pharmaceuticals, Inc. | 280,000 | 280,000 | 0 | $8.05M | $11.66M | 0.08% | +$3.61M |
| Viking Therapeutics, Inc.(VKTX) | 0 | 366,083 | +366,083 | $0 | $9.62M | 0.07% | +$9.62M |
| Pharvaris N.V. COM | 0 | 375,000 | +375,000 | $0 | $9.36M | 0.07% | +$9.36M |
| Agios Pharmaceuticals, Inc.(AGIO) | 189,866 | 189,866 | 0 | $6.31M | $7.62M | 0.06% | +$1.31M |
| Sana Biotechnology, Inc.(SANA) | 2,030,949 | 2,030,949 | 0 | $5.54M | $7.21M | 0.05% | +$1.67M |
| Sagimet Biosciences Inc.COM SER A(SGMT) | 952,996 | 952,996 | 0 | $7.26M | $6.54M | 0.05% | -$724.3K |
| Alumis Inc. | 1,562,500 | 1,562,500 | 0 | $4.69M | $6.23M | 0.05% | +$1.55M |
| Relay Therapeutics, Inc.(RLAY) | 1,160,117 | 1,160,117 | 0 | $4.01M | $6.06M | 0.04% | +$2.04M |
| Skye Bioscience, Inc.(SKYE) | 1,450,638 | 1,450,638 | 0 | $6.06M | $5.70M | 0.04% | -$362.7K |
| Heron Therapeutics, Inc.(HRTX) | 0 | 4,251,951 | +4,251,951 | $0 | $5.36M | 0.04% | +$5.36M |
| TScan Therapeutics, Inc.(TCRX) | 2,784,792 | 2,784,792 | 0 | $4.04M | $5.07M | 0.04% | +$1.03M |
| MBX Biosciences, Inc.(MBX) | 0 | 277,777 | +277,777 | $0 | $4.86M | 0.04% | +$4.86M |
| vTv Therapeutics Inc.CL A(VTVT) | 97,314 | 148,314 | +51,000 | $1.46M | $3.46M | 0.03% | +$2.00M |
| Ventyx Biosciences, Inc. | 0 | 1,023,130 | +1,023,130 | $0 | $3.18M | 0.02% | +$3.18M |
| LB Pharmaceuticals Inc(LBRX) | 0 | 200,000 | +200,000 | $0 | $3.16M | 0.02% | +$3.16M |
| Vir Biotechnology, Inc.(VIR) | 542,539 | 542,539 | 0 | $2.73M | $3.10M | 0.02% | +$363.5K |
| Wave Life Sciences, Inc.SHS(WVE) | 344,063 | 344,063 | 0 | $2.24M | $2.52M | 0.02% | +$282.1K |
| Enliven Therapeutics, Inc. | 114,833 | 114,833 | 0 | $2.30M | $2.35M | 0.02% | +$47.1K |
| Protara Therapeutics, Inc.(TARA) | 536,832 | 536,832 | 0 | $1.63M | $2.34M | 0.02% | +$708.6K |
| Tectonic Therapeutic, Inc.(TECX) | 100,000 | 100,000 | 0 | $1.99M | $1.57M | 0.01% | -$418.0K |
| KALA BIO, Inc.(KALA) | 1,201,894 | 985,093 | -216,801 | $5.72M | $1.51M | 0.01% | -$4.21M |
| Generation Bio Co. | 0 | 194,493 | +194,493 | $0 | $1.19M | 0.01% | +$1.19M |
| Contineum Therapeutics, Inc.CL A(CTNM) | 312,500 | 77,670 | -234,830 | $1.24M | $912.6K | 0.01% | -$328.0K |
| Aligos Therapeutics, Inc.(ALGS) | 83,055 | 83,055 | 0 | $598.8K | $813.9K | 0.01% | +$215.1K |
| Yarrow Bioscience Inc(YARW) | 0 | 851,353 | +851,353 | $0 | $285.2K | 0.00% | +$285.2K |
| Tyra Biosciences, Inc.(TYRA) | 10,607 | 10,607 | 0 | $101.5K | $148.4K | 0.00% | +$46.9K |
| Acrivon Therapeutics, Inc. | 22,809 | 22,809 | 0 | $27.1K | $41.3K | 0.00% | +$14.1K |
| Surrozen, Inc.W EXP 8 11 2026(SRZN) | 833,333 | 833,333 | 0 | $15.1K | $14.8K | 0.00% | -$250 |
| Ceryvyn Therapeutics LimitedADS(CKDXF) | 2,087,320 | 2,087,320 | 0 | $0 | $0 | — | $0 |
| Blueprint Medicines Corporation | 125,538 | 0 | -125,538 | $16.09M | $0 | — | -$16.09M |
| Candel Therapeutics, Inc.(CADL) | 355,112 | 0 | -355,112 | $1.80M | $0 | — | -$1.80M |
| Fate Therapeutics, Inc.(FATE) | 2,485,018 | 0 | -2,485,018 | $2.78M | $0 | — | -$2.78M |
| Generation Bio Co. | 1,944,945 | 0 | -1,944,945 | $622.6K | $0 | — | -$622.6K |
| HOOKIPA Pharma Inc. | 812,814 | 0 | -812,814 | $1.02M | $0 | — | -$1.02M |
| IGM Biosciences, Inc. | 4,096,210 | 0 | -4,096,210 | $4.59M | $0 | — | -$4.59M |
| Neumora Therapeutics, Inc.(NMRA) | 1,034,600 | 0 | -1,034,600 | $758.7K | $0 | — | -$758.7K |
| Rocket Pharmaceuticals, Inc.(RCKT) | 552,079 | 0 | -552,079 | $1.35M | $0 | — | -$1.35M |
| Verona Pharma plcADS | 223,843 | 0 | -223,843 | $21.17M | $0 | — | -$21.17M |