BAKER BROS. ADVISORS LP
Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| BeOne Medicines Ltd.(ONC) | 8,799,053 | 8,799,053 | 0 | 2,129,986,760 | 2,997,837,357 | 21.66% | +867,850,597 |
| Incyte Corporation(INCY) | 30,743,275 | 30,743,663 | +388 | 2,093,617,028 | 2,607,370,059 | 18.84% | +513,753,031 |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 1,976,018 | 2,141,701 | +165,683 | 598,022,088 | 982,312,581 | 7.10% | +384,290,493 |
| Celcuity Inc.(CELC) | 5,450,445 | 7,915,792 | +2,465,347 | 72,763,441 | 391,040,125 | 2.83% | +318,276,684 |
| Kodiak Sciences Inc.(KOD) | 17,310,490 | 17,310,490 | 0 | 64,568,128 | 283,372,721 | 2.05% | +218,804,593 |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 5,604,483 | 5,604,483 | 0 | 354,147,281 | 565,996,738 | 4.09% | +211,849,457 |
| Insmed Incorporated(INSM) | 7,712,900 | 6,703,484 | -1,009,416 | 776,226,256 | 965,368,731 | 6.98% | +189,142,475 |
| Revolution Medicines, Inc.(RVMD) | 9,364,972 | 9,455,357 | +90,385 | 344,537,320 | 441,565,172 | 3.19% | +97,027,852 |
| Kymera Therapeutics, Inc.(KYMR) | 6,651,429 | 6,651,429 | 0 | 290,268,362 | 376,470,881 | 2.72% | +86,202,519 |
| Abivax S.A.(ABVX) | 0 | 875,796 | +875,796 | 0 | 74,355,080 | 0.54% | +74,355,080 |
| Alkermes plc(ALKS) | 6,410,603 | 8,091,351 | +1,680,748 | 183,407,352 | 242,740,530 | 1.75% | +59,333,178 |
| Stoke Therapeutics, Inc.(STOK) | 4,633,838 | 4,633,838 | 0 | 52,594,061 | 108,895,193 | 0.79% | +56,301,132 |
| Immatics N.V.(IMTX) | 10,168,901 | 12,094,094 | +1,925,193 | 54,708,687 | 103,041,681 | 0.74% | +48,332,994 |
| IDEAYA Biosciences, Inc.(IDYA) | 2,118,728 | 3,275,444 | +1,156,716 | 44,535,663 | 89,124,831 | 0.64% | +44,589,168 |
| AbCellera Biologics Inc.(ABCL) | 27,525,640 | 27,525,640 | 0 | 94,412,945 | 138,453,969 | 1.00% | +44,041,024 |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | 939,174 | 1,670,762 | +731,588 | 14,838,949 | 57,624,581 | 0.42% | +42,785,632 |
| Celcuity Inc.(CELC) | 0 | 0 | 0 | 0 | 40,905,126 | 0.30% | +40,905,126 |
| Rapport Therapeutics, Inc.(RAPP) | 550,090 | 1,547,090 | +997,000 | 6,254,523 | 45,948,573 | 0.33% | +39,694,050 |
| Ionis Pharmaceuticals, Inc.(IONS) | 0 | 566,798 | +566,798 | 0 | 37,079,925 | 0.27% | +37,079,925 |
| Kiniksa Pharmaceuticals International, plc(KNSA) | 2,824,669 | 2,824,669 | 0 | 78,158,591 | 109,681,897 | 0.79% | +31,523,306 |
| Avidity Biosciences, Inc. | 0 | 625,000 | +625,000 | 0 | 27,231,250 | 0.20% | +27,231,250 |
| Merus N.V. | 574,377 | 574,377 | 0 | 30,212,230 | 54,077,595 | 0.39% | +23,865,365 |
| Edgewise Therapeutics, Inc.(EWTX) | 7,305,940 | 7,305,940 | 0 | 95,780,873 | 118,502,347 | 0.86% | +22,721,474 |
| Intellia Therapeutics, Inc.(NTLA) | 2,675,674 | 2,746,674 | +71,000 | 25,097,822 | 47,435,060 | 0.34% | +22,337,238 |
| Dianthus Therapeutics, Inc.(DNTH) | 789,759 | 789,759 | 0 | 14,713,210 | 31,077,017 | 0.22% | +16,363,807 |
| Roivant Sciences Ltd.(ROIV) | 3,767,773 | 3,767,773 | 0 | 42,462,802 | 57,006,405 | 0.41% | +14,543,603 |
| Monte Rosa Therapeutics, Inc.(GLUE) | 4,916,095 | 4,916,095 | 0 | 22,171,588 | 36,428,264 | 0.26% | +14,256,676 |
| Viridian Therapeutics, Inc.(VRDN) | 1,744,406 | 1,744,406 | 0 | 24,386,796 | 37,644,281 | 0.27% | +13,257,485 |
| GRAIL, Inc.(GRAL) | 1,630,125 | 1,630,125 | 0 | 83,821,028 | 96,389,291 | 0.70% | +12,568,263 |
| Immunocore Holdings plc(IMCR) | 2,322,656 | 2,322,656 | 0 | 72,884,945 | 84,382,092 | 0.61% | +11,497,147 |
| Cidara Therapeutics, Inc. | 227,272 | 227,272 | 0 | 11,070,419 | 21,763,567 | 0.16% | +10,693,148 |
| Viking Therapeutics, Inc.(VKTX) | 0 | 366,083 | +366,083 | 0 | 9,620,661 | 0.07% | +9,620,661 |
| Pharvaris N.V. | 0 | 375,000 | +375,000 | 0 | 9,356,250 | 0.07% | +9,356,250 |
| Bicycle Therapeutics plc | 10,885,357 | 10,885,357 | 0 | 75,653,231 | 84,252,663 | 0.61% | +8,599,432 |
| Xencor, Inc.(XNCR) | 670,431 | 1,102,106 | +431,675 | 5,269,588 | 12,927,703 | 0.09% | +7,658,115 |
| Praxis Precision Medicines, Inc.(PRAX) | 689,488 | 689,488 | 0 | 28,992,970 | 36,542,864 | 0.26% | +7,549,894 |
| Spyre Therapeutics, Inc.(SYRE) | 626,703 | 1,000,000 | +373,297 | 9,381,744 | 16,760,000 | 0.12% | +7,378,256 |
| Design Therapeutics, Inc. | 1,712,882 | 1,712,882 | 0 | 5,772,412 | 12,898,001 | 0.09% | +7,125,589 |
| argenx SE(ARGX) | 37,760 | 37,760 | 0 | 20,814,067 | 27,850,266 | 0.20% | +7,036,199 |
| Prelude Therapeutics Inc. | 10,123,824 | 10,123,824 | 0 | 8,194,223 | 14,578,307 | 0.11% | +6,384,084 |
| CytomX Therapeutics, Inc. | 3,484,226 | 4,250,826 | +766,600 | 7,909,193 | 13,560,135 | 0.10% | +5,650,942 |
| Heron Therapeutics, Inc. | 0 | 4,251,951 | +4,251,951 | 0 | 5,357,458 | 0.04% | +5,357,458 |
| MBX Biosciences, Inc.(MBX) | 0 | 277,777 | +277,777 | 0 | 4,861,098 | 0.04% | +4,861,098 |
| Sionna Therapeutics, Inc.(SION) | 400,000 | 400,000 | 0 | 6,940,000 | 11,764,000 | 0.09% | +4,824,000 |
| Disc Medicine, Inc.(IRON) | 337,050 | 337,050 | 0 | 17,850,168 | 22,272,264 | 0.16% | +4,422,096 |
| Taysha Gene Therapies, Inc.(TSHA) | 4,004,756 | 4,004,756 | 0 | 9,250,986 | 13,095,552 | 0.09% | +3,844,566 |
| Celldex Therapeutics, Inc.(CLDX) | 665,370 | 665,370 | 0 | 13,540,280 | 17,213,122 | 0.12% | +3,672,842 |
| Crinetics Pharmaceuticals, Inc.(CRNX) | 280,000 | 280,000 | 0 | 8,052,800 | 11,662,000 | 0.08% | +3,609,200 |
| Xenon Pharmaceuticals Inc.(XENE) | 370,208 | 370,208 | 0 | 11,587,510 | 14,863,851 | 0.11% | +3,276,341 |
| Ventyx Biosciences, Inc. | 0 | 1,023,130 | +1,023,130 | 0 | 3,181,934 | 0.02% | +3,181,934 |
| LB Pharmaceuticals Inc.(LBRX) | 0 | 200,000 | +200,000 | 0 | 3,158,000 | 0.02% | +3,158,000 |
| Arcellx, Inc. | 166,825 | 166,825 | 0 | 10,985,426 | 13,696,333 | 0.10% | +2,710,907 |
| Neurogene Inc. | 991,691 | 991,691 | 0 | 14,825,780 | 17,186,005 | 0.12% | +2,360,225 |
| Vaxcyte, Inc.(PCVX) | 640,885 | 640,885 | 0 | 20,835,171 | 23,084,678 | 0.17% | +2,249,507 |
| Relay Therapeutics, Inc.(RLAY) | 1,160,117 | 1,160,117 | 0 | 4,014,005 | 6,055,811 | 0.04% | +2,041,806 |
| vTv Therapeutics, Inc. | 97,314 | 148,314 | +51,000 | 1,459,710 | 3,463,132 | 0.03% | +2,003,422 |
| Denali Therapeutics Inc.(DNLI) | 3,731,695 | 3,731,695 | 0 | 52,206,413 | 54,184,211 | 0.39% | +1,977,798 |
| Sana Biotechnology, Inc.(SANA) | 2,030,949 | 2,030,949 | 0 | 5,544,491 | 7,209,869 | 0.05% | +1,665,378 |
| Sera Prognostics, Inc. | 5,498,170 | 5,498,170 | 0 | 15,229,931 | 16,824,400 | 0.12% | +1,594,469 |
| Alumis Inc. | 1,562,500 | 1,562,500 | 0 | 4,687,500 | 6,234,375 | 0.05% | +1,546,875 |
| Nuvalent, Inc.(NUVL) | 143,937 | 143,937 | 0 | 10,982,393 | 12,447,672 | 0.09% | +1,465,279 |
| Agios Pharmaceuticals, Inc.(AGIO) | 189,866 | 189,866 | 0 | 6,314,943 | 7,621,221 | 0.06% | +1,306,278 |
| DBV Technologies S.A. | 1,461,425 | 1,461,425 | 0 | 13,386,507 | 14,614,250 | 0.11% | +1,227,743 |
| Generation Bio Co. | 0 | 194,493 | +194,493 | 0 | 1,190,297 | 0.01% | +1,190,297 |
| TScan Therapeutics, Inc. | 2,784,792 | 2,784,792 | 0 | 4,037,948 | 5,068,321 | 0.04% | +1,030,373 |
| Protara Therapeutics, Inc. | 536,832 | 536,832 | 0 | 1,626,601 | 2,335,219 | 0.02% | +708,618 |
| Immunovant, Inc.(IMVT) | 5,457,881 | 5,457,881 | 0 | 87,326,096 | 87,981,042 | 0.64% | +654,946 |
| Vir Biotechnology, Inc.(VIR) | 542,539 | 542,539 | 0 | 2,734,397 | 3,097,898 | 0.02% | +363,501 |
| VYNE Therapeutics Inc. | 0 | 851,353 | +851,353 | 0 | 285,203 | 0.00% | +285,203 |
| Wave Life Sciences Ltd.(WVE) | 344,063 | 344,063 | 0 | 2,236,410 | 2,518,541 | 0.02% | +282,131 |
| Aligos Therapeutics, Inc. | 83,055 | 83,055 | 0 | 598,827 | 813,939 | 0.01% | +215,112 |
| Enliven Therapeutics, Inc. | 114,833 | 114,833 | 0 | 2,303,550 | 2,350,632 | 0.02% | +47,082 |
| Tyra Biosciences, Inc.(TYRA) | 10,607 | 10,607 | 0 | 101,509 | 148,392 | 0.00% | +46,883 |
| Acrivon Therapeutics, Inc. | 22,809 | 22,809 | 0 | 27,143 | 41,284 | 0.00% | +14,141 |
| Opthea Limited | 2,087,320 | 2,087,320 | 0 | 0 | 0 | — | 0 |
| Surrozen, Inc. | 833,333 | 833,333 | 0 | 15,083 | 14,833 | 0.00% | -250 |
| Contineum Therapeutics, Inc. | 312,500 | 77,670 | -234,830 | 1,240,625 | 912,623 | 0.01% | -328,002 |
| Skye Bioscience, Inc. | 1,450,638 | 1,450,638 | 0 | 6,063,667 | 5,701,007 | 0.04% | -362,660 |
| Tectonic Therapeutic, Inc. | 100,000 | 100,000 | 0 | 1,987,000 | 1,569,000 | 0.01% | -418,000 |
| Generation Bio Co. | 1,944,945 | 0 | -1,944,945 | 622,577 | 0 | — | -622,577 |
| Sagimet Biosciences Inc. | 952,996 | 952,996 | 0 | 7,261,830 | 6,537,553 | 0.05% | -724,277 |
| Neumora Therapeutics, Inc. | 1,034,600 | 0 | -1,034,600 | 758,672 | 0 | — | -758,672 |
| HOOKIPA Pharma Inc. | 812,814 | 0 | -812,814 | 1,020,082 | 0 | — | -1,020,082 |
| Rocket Pharmaceuticals, Inc. | 552,079 | 0 | -552,079 | 1,352,594 | 0 | — | -1,352,594 |
| Candel Therapeutics, Inc. | 355,112 | 0 | -355,112 | 1,796,867 | 0 | — | -1,796,867 |
| Akero Therapeutics, Inc. | 324,630 | 324,630 | 0 | 17,322,257 | 15,413,432 | 0.11% | -1,908,825 |
| Cerus Corporation | 12,883,844 | 10,008,345 | -2,875,499 | 18,166,220 | 15,913,269 | 0.11% | -2,252,951 |
| Fate Therapeutics, Inc. | 2,485,018 | 0 | -2,485,018 | 2,783,220 | 0 | — | -2,783,220 |
| BioNTech SE(BNTX) | 368,923 | 368,923 | 0 | 39,279,232 | 36,383,186 | 0.26% | -2,896,046 |
| KALA BIO, Inc. | 1,201,894 | 985,093 | -216,801 | 5,721,015 | 1,507,192 | 0.01% | -4,213,823 |
| Entrada Therapeutics, Inc. | 4,865,819 | 4,865,819 | 0 | 32,698,304 | 28,221,750 | 0.20% | -4,476,554 |
| IGM Biosciences, Inc. | 4,096,210 | 0 | -4,096,210 | 4,587,755 | 0 | — | -4,587,755 |
| Nurix Therapeutics, Inc.(NRIX) | 3,882,125 | 3,882,125 | 0 | 44,217,404 | 35,870,835 | 0.26% | -8,346,569 |
| Structure Therapeutics Inc. | 2,508,767 | 1,556,109 | -952,658 | 52,031,828 | 43,571,052 | 0.31% | -8,460,776 |
| ACADIA Pharmaceuticals Inc. | 42,896,690 | 42,896,690 | 0 | 925,281,603 | 915,415,365 | 6.61% | -9,866,238 |
| Blueprint Medicines Corporation | 125,538 | 0 | -125,538 | 16,091,461 | 0 | — | -16,091,461 |
| Ultragenyx Pharmaceutical Inc.(RARE) | 2,772,692 | 2,772,692 | 0 | 100,815,081 | 83,402,575 | 0.60% | -17,412,506 |
| Verve Therapeutics, Inc. | 1,691,530 | 0 | -1,691,530 | 18,995,882 | 0 | — | -18,995,882 |
| Summit Therapeutics Inc.(SMMT) | 33,722,974 | 33,722,974 | 0 | 717,624,887 | 696,716,643 | 5.03% | -20,908,244 |
| Verona Pharma plc | 223,843 | 0 | -223,843 | 21,171,071 | 0 | — | -21,171,071 |