Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2023 ▲▼ | Q4 2023 ▲▼ | Change ▲▼ | Q3 2023 ▲▼ | Q4 2023 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ACADIA Pharmaceuticals Inc. | 42,864,612 | 42,864,612 | 0 | 893,299 | 1,342,091 | 15.27% | +448,792 |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 1,545,113 | 1,969,798 | +424,685 | 225,648 | 455,772 | 5.19% | +230,124 |
| Incyte Corporation(INCY) | 36,178,566 | 36,179,122 | +556 | 2,090,036 | 2,271,687 | 25.85% | +181,651 |
| Mirati Therapeutics, Inc. | 1,409,784 | 4,121,440 | +2,711,656 | 61,410 | 242,135 | 2.76% | +180,724 |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 6,702,349 | 6,398,365 | -303,984 | 153,651 | 294,133 | 3.35% | +140,481 |
| Kymera Therapeutics, Inc.(KYMR) | 4,750,400 | 5,995,928 | +1,245,528 | 66,031 | 152,656 | 1.74% | +86,626 |
| Revolution Medicines, Inc.(RVMD) | 2,691,493 | 5,148,657 | +2,457,164 | 74,501 | 147,663 | 1.68% | +73,163 |
| Cerevel Therapeutics Holdings, Inc. | 0 | 1,600,000 | +1,600,000 | 0 | 67,840 | 0.77% | +67,840 |
| Immunocore Holdings plc(IMCR) | 2,520,731 | 2,520,731 | 0 | 130,826 | 172,216 | 1.96% | +41,390 |
| AbCellera Biologics Inc.(ABCL) | 20,763,323 | 22,909,753 | +2,146,430 | 95,511 | 130,815 | 1.49% | +35,303 |
| Sera Prognostics, Inc.(SERA) | 1,515,342 | 5,434,399 | +3,919,057 | 2,819 | 32,498 | 0.37% | +29,679 |
| Edgewise Therapeutics, Inc.(EWTX) | 1,049,699 | 3,112,786 | +2,063,087 | 6,015 | 34,054 | 0.39% | +28,039 |
| Kodiak Sciences Inc.(KOD) | 17,310,490 | 17,310,490 | 0 | 31,159 | 52,624 | 0.60% | +21,465 |
| Ultragenyx Pharmaceutical Inc.(RARE) | 1,366,547 | 1,466,547 | +100,000 | 48,717 | 70,130 | 0.80% | +21,413 |
| Xenon Pharmaceuticals Inc.(XENE) | 751,639 | 993,679 | +242,040 | 25,676 | 45,769 | 0.52% | +20,093 |
| Gracell Biotechnologies Inc. | 1,000,000 | 2,080,000 | +1,080,000 | 2,880 | 20,883 | 0.24% | +18,003 |
| Bicycle Therapeutics plc | 843,814 | 1,790,390 | +946,576 | 16,952 | 32,370 | 0.37% | +15,418 |
| Cerus Corporation(CERS) | 17,239,501 | 19,477,339 | +2,237,838 | 27,928 | 42,071 | 0.48% | +14,143 |
| Prelude Therapeutics Inc.(PRLD) | 10,123,824 | 10,123,824 | 0 | 31,283 | 43,229 | 0.49% | +11,946 |
| Aerovate Therapeutics, Inc. | 1,963,479 | 1,680,517 | -282,962 | 26,644 | 38,030 | 0.43% | +11,386 |
| Celldex Therapeutics, Inc.(CLDX) | 0 | 247,644 | +247,644 | 0 | 9,822 | 0.11% | +9,822 |
| Nurix Therapeutics, Inc.(NRIX) | 3,882,125 | 3,882,125 | 0 | 30,514 | 40,064 | 0.46% | +9,550 |
| IDEAYA Biosciences, Inc.(IDYA) | 1,062,123 | 1,062,123 | 0 | 28,656 | 37,790 | 0.43% | +9,134 |
| TScan Therapeutics, Inc.(TCRX) | 2,784,792 | 2,784,792 | 0 | 7,129 | 16,235 | 0.18% | +9,106 |
| Neurogene Inc.(NGNE) | 0 | 453,516 | +453,516 | 0 | 8,789 | 0.10% | +8,789 |
| Denali Therapeutics Inc.(DNLI) | 2,292,003 | 2,607,196 | +315,193 | 47,284 | 55,950 | 0.64% | +8,666 |
| Stoke Therapeutics, Inc.(STOK) | 1,485,915 | 2,030,134 | +544,219 | 5,855 | 10,679 | 0.12% | +4,824 |
| Verve Therapeutics, Inc. | 1,416,530 | 1,691,530 | +275,000 | 18,783 | 23,580 | 0.27% | +4,797 |
| IGM Biosciences, Inc. | 3,157,764 | 3,691,011 | +533,247 | 26,367 | 30,672 | 0.35% | +4,305 |
| Monte Rosa Therapeutics, Inc.(GLUE) | 4,916,095 | 4,916,095 | 0 | 23,548 | 27,776 | 0.32% | +4,228 |
| ARS Pharmaceuticals, Inc.(SPRY) | 2,006,451 | 2,006,451 | 0 | 7,584 | 10,995 | 0.13% | +3,411 |
| Leap Therapeutics, Inc.(CYPH) | 1,172,175 | 1,172,175 | 0 | 1,618 | 4,859 | 0.06% | +3,241 |
| Relay Therapeutics, Inc.(RLAY) | 1,160,117 | 1,160,117 | 0 | 9,757 | 12,773 | 0.15% | +3,016 |
| Opthea Limited(CKDXF) | 2,690,891 | 2,588,645 | -102,246 | 4,688 | 7,637 | 0.09% | +2,949 |
| Celcuity Inc.(CELC) | 535,478 | 535,478 | 0 | 4,894 | 7,802 | 0.09% | +2,908 |
| Xencor, Inc.(XNCR) | 123,127 | 245,431 | +122,304 | 2,481 | 5,211 | 0.06% | +2,729 |
| Day One Biopharmaceuticals, Inc. COM | 1,000,000 | 1,000,000 | 0 | 12,270 | 14,600 | 0.17% | +2,330 |
| Replimune Group, Inc.(REPL) | 4,578,280 | 9,545,336 | +4,967,056 | 78,334 | 80,467 | 0.92% | +2,133 |
| Insmed Incorporated(INSM) | 343,000 | 343,000 | 0 | 8,661 | 10,630 | 0.12% | +1,969 |
| HOOKIPA Pharma Inc. | 8,065,398 | 8,128,151 | +62,753 | 4,968 | 6,584 | 0.07% | +1,616 |
| Biomea Fusion, Inc.(BMEA) | 2,108,949 | 2,108,949 | 0 | 29,019 | 30,622 | 0.35% | +1,603 |
| Immunovant, Inc.(IMVT) | 425,009 | 425,009 | 0 | 16,316 | 17,906 | 0.20% | +1,590 |
| Krystal Biotech, Inc.(KRYS) | 169,934 | 169,934 | 0 | 19,712 | 21,082 | 0.24% | +1,370 |
| Athira Pharma, Inc. | 3,153,807 | 3,153,807 | 0 | 6,371 | 7,664 | 0.09% | +1,293 |
| Mersana Therapeutics, Inc. | 1,086,115 | 1,086,115 | 0 | 1,379 | 2,520 | 0.03% | +1,140 |
| Pfizer Inc.(PFE) | 0 | 35,000 | +35,000 | 0 | 1,008 | 0.01% | +1,008 |
| Perspective Therapeutics, Inc.(CATX) | 7,639,703 | 7,639,703 | 0 | 2,091 | 3,071 | 0.03% | +980 |
| 2seventy bio, Inc. | 2,497,526 | 2,497,526 | 0 | 9,790 | 10,664 | 0.12% | +874 |
| Talis Biomedical Corporation | 508,323 | 508,323 | 0 | 2,933 | 3,787 | 0.04% | +854 |
| Invitae Corporation | 0 | 0 | 0 | 130,373 | 131,153 | 1.49% | +780 |
| Sagimet Biosciences Inc.(SGMT) | 815,359 | 1,456,518 | +641,159 | 7,175 | 7,894 | 0.09% | +719 |
| Vaxcyte, Inc.(PCVX) | 48,885 | 48,885 | 0 | 2,492 | 3,070 | 0.03% | +578 |
| Kiniksa Pharmaceuticals, Ltd. | 2,809,577 | 2,809,577 | 0 | 48,802 | 49,280 | 0.56% | +478 |
| Design Therapeutics, Inc.(DSGN) | 1,500,000 | 1,500,000 | 0 | 3,540 | 3,975 | 0.05% | +435 |
| Sana Biotechnology, Inc.(SANA) | 2,000,000 | 2,000,000 | 0 | 7,740 | 8,160 | 0.09% | +420 |
| Century Therapeutics, Inc.(IPSC) | 1,149,340 | 797,460 | -351,880 | 2,299 | 2,648 | 0.03% | +349 |
| Tyra Biosciences, Inc.(TYRA) | 0 | 10,607 | +10,607 | 0 | 147 | 0.00% | +147 |
| Adaptimmune Therapeutics plc(ADAPY) | 10,969,282 | 10,969,282 | 0 | 8,556 | 8,699 | 0.10% | +143 |
| Foghorn Therapeutics Inc.(FHTX) | 45,027 | 45,027 | 0 | 225 | 290 | 0.00% | +65 |
| Invitae Corporation | 0 | 0 | 0 | 6,208 | 6,273 | 0.07% | +64 |
| Protara Therapeutics, Inc.(TARA) | 199,671 | 199,671 | 0 | 333 | 374 | 0.00% | +41 |
| Invitae Corporation | 1,764,546 | 1,764,546 | 0 | 1,068 | 1,106 | 0.01% | +38 |
| Surrozen, Inc.(SRZN) | 833,333 | 833,333 | 0 | 34 | 16 | 0.00% | -18 |
| Aligos Therapeutics, Inc. | 2,076,400 | 2,076,400 | 0 | 1,551 | 1,379 | 0.02% | -172 |
| Praxis Precision Medicines, Inc. | 1,879,915 | 131,533 | -1,748,382 | 3,215 | 2,931 | 0.03% | -284 |
| Genetron Holdings Limited | 455,306 | 0 | -455,306 | 370 | 0 | — | -370 |
| Mirum Pharmaceuticals, Inc.(MIRM) | 190,476 | 190,476 | 0 | 6,019 | 5,623 | 0.06% | -396 |
| Achilles Therapeutics plc | 2,557,149 | 2,102,792 | -454,357 | 2,327 | 1,869 | 0.02% | -457 |
| KALA BIO, Inc.(KALA) | 266,613 | 266,613 | 0 | 2,373 | 1,866 | 0.02% | -507 |
| Atreca, Inc. | 3,532,760 | 2,177,499 | -1,355,261 | 922 | 287 | 0.00% | -635 |
| Compass Therapeutics, Inc.(CMPX) | 1,557,630 | 1,557,630 | 0 | 3,069 | 2,430 | 0.03% | -639 |
| Prime Medicine, Inc.(PRME) | 1,028,466 | 1,028,466 | 0 | 9,812 | 9,112 | 0.10% | -699 |
| Taysha Gene Therapies, Inc.(TSHA) | 2,504,756 | 4,004,756 | +1,500,000 | 7,915 | 7,088 | 0.08% | -827 |
| PMV Pharmaceuticals, Inc.(PMVP) | 322,024 | 322,024 | 0 | 1,977 | 998 | 0.01% | -979 |
| Tango Therapeutics, Inc.(TNGX) | 750,000 | 750,000 | 0 | 8,445 | 7,425 | 0.08% | -1,020 |
| Avidity Biosciences, Inc. | 166,347 | 0 | -166,347 | 1,061 | 0 | — | -1,061 |
| Vor Biopharma Inc.(VOR) | 633,848 | 0 | -633,848 | 1,344 | 0 | — | -1,344 |
| iTeos Therapeutics, Inc. | 150,346 | 0 | -150,346 | 1,646 | 0 | — | -1,646 |
| POINT Biopharma Global Inc. | 249,968 | 0 | -249,968 | 1,667 | 0 | — | -1,667 |
| AnaptysBio, Inc. | 106,197 | 0 | -106,197 | 1,907 | 0 | — | -1,907 |
| Instil Bio, Inc.(TIL) | 4,704,395 | 0 | -4,704,395 | 2,013 | 0 | — | -2,013 |
| Affimed N.V. | 4,448,644 | 0 | -4,448,644 | 2,126 | 0 | — | -2,126 |
| Entrada Therapeutics, Inc.(TRDA) | 4,865,819 | 4,865,819 | 0 | 76,880 | 73,425 | 0.84% | -3,455 |
| Immatics N.V.(IMTX) | 5,640,816 | 5,838,853 | +198,037 | 65,321 | 61,483 | 0.70% | -3,838 |
| Aadi Bioscience, Inc.(WHWK) | 989,928 | 251,727 | -738,201 | 4,791 | 508 | 0.01% | -4,283 |
| Natera, Inc.(NTRA) | 100,000 | 0 | -100,000 | 4,425 | 0 | — | -4,425 |
| Neoleukin Therapeutics, Inc. | 1,221,414 | 0 | -1,221,414 | 4,825 | 0 | — | -4,825 |
| Morphic Holding, Inc. | 215,800 | 0 | -215,800 | 4,944 | 0 | — | -4,944 |
| Summit Therapeutics Inc.(SMMT) | 3,140,473 | 0 | -3,140,473 | 5,873 | 0 | — | -5,873 |
| DBV Technologies S.A. | 14,614,264 | 14,614,264 | 0 | 19,875 | 13,924 | 0.16% | -5,951 |
| Alector, Inc. | 964,851 | 0 | -964,851 | 6,252 | 0 | — | -6,252 |
| Geron Corporation(GERN) | 3,061,224 | 0 | -3,061,224 | 6,490 | 0 | — | -6,490 |
| bluebird bio, Inc. | 2,499,715 | 0 | -2,499,715 | 7,599 | 0 | — | -7,599 |
| Arvinas, Inc.(ARVN) | 413,481 | 0 | -413,481 | 8,121 | 0 | — | -8,121 |
| Heron Therapeutics, Inc.(HRTX) | 8,131,678 | 0 | -8,131,678 | 8,376 | 0 | — | -8,376 |
| Pacific Biosciences of California, Inc.(PACB) | 1,127,782 | 0 | -1,127,782 | 9,417 | 0 | — | -9,417 |
| Cogent Biosciences, Inc.(COGT) | 1,292,966 | 0 | -1,292,966 | 12,606 | 0 | — | -12,606 |
| argenx SE(ARGX) | 151,215 | 151,215 | 0 | 74,342 | 57,527 | 0.65% | -16,815 |
| Cabaletta Bio, Inc.(CABA) | 1,594,000 | 13,331 | -1,580,669 | 24,261 | 303 | 0.00% | -23,958 |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 12,710,818 | 10,126,176 | -2,584,642 | 89,993 | 60,656 | 0.69% | -29,337 |