Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2024 ▲▼ | Q4 2024 ▲▼ | Change ▲▼ | Q3 2024 ▲▼ | Q4 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 0 | 1,974,590 | +1,974,590 | 0 | 609,299 | 6.51% | +609,299 |
| ACADIA Pharmaceuticals Inc. | 42,877,916 | 42,877,916 | 0 | 659,462 | 786,810 | 8.40% | +127,347 |
| Kodiak Sciences Inc.(KOD) | 17,310,490 | 17,310,490 | 0 | 45,180 | 172,239 | 1.84% | +127,059 |
| Incyte Corporation(INCY) | 30,739,020 | 30,739,466 | +446 | 2,031,849 | 2,123,175 | 22.68% | +91,326 |
| Ionis Pharmaceuticals, Inc.(IONS) | 0 | 0 | 0 | 0 | 29,544 | 0.32% | +29,544 |
| GRAIL, Inc.(GRAL) | 0 | 1,630,125 | +1,630,125 | 0 | 29,098 | 0.31% | +29,098 |
| Candel Therapeutics, Inc. | 0 | 2,981,983 | +2,981,983 | 0 | 25,884 | 0.28% | +25,884 |
| Insmed Incorporated(INSM) | 4,415,918 | 5,006,863 | +590,945 | 322,362 | 345,674 | 3.69% | +23,312 |
| Replimune Group, Inc.(REPL) | 11,045,336 | 11,045,336 | 0 | 121,057 | 133,759 | 1.43% | +12,702 |
| Roivant Sciences Ltd.(ROIV) | 2,798,716 | 3,767,773 | +969,057 | 32,297 | 44,573 | 0.48% | +12,276 |
| CRISPR Therapeutics AG(CRSP) | 843,075 | 1,308,011 | +464,936 | 39,608 | 51,483 | 0.55% | +11,876 |
| AbCellera Biologics Inc.(ABCL) | 27,525,640 | 27,525,640 | 0 | 71,567 | 80,650 | 0.86% | +9,083 |
| Edgewise Therapeutics, Inc.(EWTX) | 5,840,059 | 6,155,940 | +315,881 | 155,871 | 164,364 | 1.76% | +8,492 |
| argenx SE(ARGX) | 111,904 | 111,904 | 0 | 60,661 | 68,821 | 0.74% | +8,160 |
| Monte Rosa Therapeutics, Inc.(GLUE) | 4,916,095 | 4,916,095 | 0 | 26,055 | 34,118 | 0.36% | +8,062 |
| Vir Biotechnology, Inc.(VIR) | 0 | 1,084,539 | +1,084,539 | 0 | 7,961 | 0.09% | +7,961 |
| Intellia Therapeutics, Inc.(NTLA) | 0 | 644,116 | +644,116 | 0 | 7,510 | 0.08% | +7,510 |
| Immunovant, Inc.(IMVT) | 1,225,410 | 1,707,881 | +482,471 | 34,936 | 42,304 | 0.45% | +7,368 |
| Celcuity Inc.(CELC) | 1,874,978 | 2,678,553 | +803,575 | 27,956 | 35,062 | 0.37% | +7,106 |
| Praxis Precision Medicines, Inc.(PRAX) | 323,105 | 331,533 | +8,428 | 18,591 | 25,515 | 0.27% | +6,923 |
| Entrada Therapeutics, Inc. | 4,865,819 | 4,865,819 | 0 | 77,756 | 84,130 | 0.90% | +6,374 |
| Structure Therapeutics Inc. | 85,500 | 361,565 | +276,065 | 3,753 | 9,806 | 0.10% | +6,053 |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 6,398,366 | 6,084,249 | -314,117 | 335,210 | 340,596 | 3.64% | +5,386 |
| BioNTech SE(BNTX) | 0 | 45,031 | +45,031 | 0 | 5,131 | 0.05% | +5,131 |
| Disc Medicine, Inc.(IRON) | 0 | 77,050 | +77,050 | 0 | 4,885 | 0.05% | +4,885 |
| DBV Technologies S.A.(DBVT) | 0 | 1,461,425 | +1,461,425 | 0 | 4,516 | 0.05% | +4,516 |
| Merus N.V. | 300,000 | 450,000 | +150,000 | 14,988 | 18,923 | 0.20% | +3,935 |
| Revolution Medicines, Inc.(RVMD) | 7,569,090 | 7,936,972 | +367,882 | 343,258 | 347,163 | 3.71% | +3,905 |
| Ionis Pharmaceuticals, Inc.(IONS) | 223,470 | 357,915 | +134,445 | 8,952 | 12,513 | 0.13% | +3,561 |
| KALA BIO, Inc. | 891,335 | 1,201,894 | +310,559 | 5,081 | 8,341 | 0.09% | +3,261 |
| Alkermes plc(ALKS) | 4,181,751 | 4,181,751 | 0 | 117,047 | 120,267 | 1.28% | +3,220 |
| Aligos Therapeutics, Inc. | 83,055 | 83,055 | 0 | 719 | 3,309 | 0.04% | +2,590 |
| Xencor, Inc.(XNCR) | 670,431 | 670,431 | 0 | 13,482 | 15,407 | 0.16% | +1,924 |
| Protara Therapeutics, Inc. | 536,832 | 536,832 | 0 | 982 | 2,834 | 0.03% | +1,852 |
| Sera Prognostics, Inc. | 5,434,399 | 5,434,399 | 0 | 42,388 | 44,236 | 0.47% | +1,848 |
| Wave Life Sciences Ltd.(WVE) | 344,063 | 344,063 | 0 | 2,821 | 4,256 | 0.05% | +1,435 |
| Design Therapeutics, Inc.(DSGN) | 1,743,725 | 1,743,725 | 0 | 9,381 | 10,759 | 0.11% | +1,378 |
| Verve Therapeutics, Inc. | 1,691,530 | 1,691,530 | 0 | 8,187 | 9,540 | 0.10% | +1,353 |
| Rocket Pharmaceuticals, Inc. | 0 | 97,079 | +97,079 | 0 | 1,220 | 0.01% | +1,220 |
| Centessa Pharmaceuticals plc | 1,227,178 | 1,227,178 | 0 | 19,623 | 20,555 | 0.22% | +933 |
| PTC Therapeutics, Inc.(PTCT) | 0 | 20,400 | +20,400 | 0 | 921 | 0.01% | +921 |
| Sagimet Biosciences Inc. | 1,381,898 | 952,996 | -428,902 | 3,828 | 4,288 | 0.05% | +461 |
| Mirum Pharmaceuticals, Inc.(MIRM) | 190,476 | 190,476 | 0 | 7,429 | 7,876 | 0.08% | +448 |
| Leap Therapeutics, Inc. | 1,172,175 | 1,172,175 | 0 | 3,012 | 3,370 | 0.04% | +358 |
| vTv Therapeutics, Inc. | 97,314 | 97,314 | 0 | 1,320 | 1,344 | 0.01% | +24 |
| Surrozen, Inc. | 833,333 | 833,333 | 0 | 9 | 18 | 0.00% | +9 |
| PMV Pharmaceuticals, Inc. | 322,024 | 322,024 | 0 | 480 | 486 | 0.01% | +6 |
| Acrivon Therapeutics, Inc. | 52,885 | 52,885 | 0 | 370 | 318 | 0.00% | -52 |
| Tyra Biosciences, Inc.(TYRA) | 10,607 | 10,607 | 0 | 249 | 147 | 0.00% | -102 |
| Xenon Pharmaceuticals Inc.(XENE) | 993,679 | 993,679 | 0 | 39,121 | 38,952 | 0.42% | -169 |
| Foghorn Therapeutics Inc. | 45,027 | 45,027 | 0 | 419 | 213 | 0.00% | -207 |
| Opthea Limited | 2,173,622 | 2,173,622 | 0 | 8,847 | 8,537 | 0.09% | -310 |
| Enliven Therapeutics, Inc. | 114,833 | 114,833 | 0 | 2,933 | 2,584 | 0.03% | -349 |
| Mersana Therapeutics, Inc. | 1,086,115 | 1,086,115 | 0 | 2,053 | 1,553 | 0.02% | -500 |
| Century Therapeutics, Inc. | 797,460 | 797,460 | 0 | 1,364 | 805 | 0.01% | -558 |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 75,778 | 0 | -75,778 | 576 | 0 | — | -576 |
| Compass Therapeutics, Inc. | 1,557,630 | 1,557,630 | 0 | 2,866 | 2,259 | 0.02% | -607 |
| Arcturus Therapeutics Holdings Inc. | 151,329 | 151,329 | 0 | 3,512 | 2,568 | 0.03% | -944 |
| Akero Therapeutics, Inc. | 1,097,082 | 1,097,082 | 0 | 31,475 | 30,521 | 0.33% | -954 |
| Prime Medicine, Inc. | 1,028,466 | 1,028,466 | 0 | 3,980 | 3,003 | 0.03% | -977 |
| Pfizer Inc.(PFE) | 35,000 | 0 | -35,000 | 1,013 | 0 | — | -1,013 |
| Taysha Gene Therapies, Inc.(TSHA) | 4,004,756 | 4,004,756 | 0 | 8,050 | 6,928 | 0.07% | -1,121 |
| Aerovate Therapeutics, Inc. | 628,939 | 0 | -628,939 | 1,314 | 0 | — | -1,314 |
| Contineum Therapeutics, Inc. | 312,500 | 312,500 | 0 | 5,981 | 4,578 | 0.05% | -1,403 |
| Skye Bioscience, Inc. | 1,434,634 | 1,450,638 | +16,004 | 5,609 | 4,105 | 0.04% | -1,504 |
| Vaxcyte, Inc.(PCVX) | 48,885 | 48,885 | 0 | 5,586 | 4,002 | 0.04% | -1,584 |
| NewAmsterdam Pharma Company N.V. ORDINARY SHARES | 96,711 | 0 | -96,711 | 1,605 | 0 | — | -1,605 |
| HOOKIPA Pharma Inc. | 812,814 | 812,814 | 0 | 3,495 | 1,634 | 0.02% | -1,861 |
| Celldex Therapeutics, Inc.(CLDX) | 247,644 | 247,644 | 0 | 8,417 | 6,258 | 0.07% | -2,159 |
| Arvinas, Inc. | 405,576 | 405,576 | 0 | 9,989 | 7,775 | 0.08% | -2,214 |
| Immunocore Holdings plc(IMCR) | 1,515,318 | 1,515,318 | 0 | 47,172 | 44,702 | 0.48% | -2,470 |
| Stoke Therapeutics, Inc.(STOK) | 4,368,443 | 4,633,838 | +265,395 | 53,688 | 51,111 | 0.55% | -2,577 |
| Neumora Therapeutics, Inc. | 1,034,600 | 1,034,600 | 0 | 13,667 | 10,967 | 0.12% | -2,700 |
| Generation Bio Co. | 1,944,945 | 1,944,945 | 0 | 4,804 | 2,062 | 0.02% | -2,742 |
| Relay Therapeutics, Inc.(RLAY) | 1,160,117 | 1,160,117 | 0 | 8,214 | 4,780 | 0.05% | -3,434 |
| Neurogene Inc. | 456,015 | 674,450 | +218,435 | 19,134 | 15,418 | 0.16% | -3,716 |
| Cerus Corporation | 19,477,339 | 19,477,339 | 0 | 33,891 | 29,995 | 0.32% | -3,895 |
| Krystal Biotech, Inc.(KRYS) | 169,934 | 169,934 | 0 | 30,933 | 26,622 | 0.28% | -4,311 |
| Alector, Inc. | 927,264 | 0 | -927,264 | 4,321 | 0 | — | -4,321 |
| Alumis Inc. | 1,562,500 | 1,562,500 | 0 | 16,688 | 12,281 | 0.13% | -4,406 |
| 2seventy bio, Inc. | 2,497,526 | 2,497,526 | 0 | 11,788 | 7,343 | 0.08% | -4,446 |
| DBV Technologies S.A. | 7,307,131 | 0 | -7,307,131 | 5,115 | 0 | — | -5,115 |
| Fate Therapeutics, Inc. | 2,997,772 | 3,258,402 | +260,630 | 10,492 | 5,376 | 0.06% | -5,116 |
| Crinetics Pharmaceuticals, Inc.(CRNX) | 103,927 | 0 | -103,927 | 5,311 | 0 | — | -5,311 |
| Insmed Incorporated(INSM) | 0 | 0 | 0 | 98,325 | 92,929 | 0.99% | -5,397 |
| TScan Therapeutics, Inc. | 2,784,792 | 2,784,792 | 0 | 13,868 | 8,466 | 0.09% | -5,402 |
| Tango Therapeutics, Inc.(TNGX) | 750,000 | 0 | -750,000 | 5,775 | 0 | — | -5,775 |
| Sana Biotechnology, Inc.(SANA) | 2,380,949 | 2,380,949 | 0 | 9,905 | 3,881 | 0.04% | -6,024 |
| IDEAYA Biosciences, Inc.(IDYA) | 1,062,123 | 1,062,123 | 0 | 33,648 | 27,297 | 0.29% | -6,351 |
| Bicara Therapeutics Inc. | 833,333 | 833,333 | 0 | 21,225 | 14,517 | 0.16% | -6,708 |
| Prelude Therapeutics Inc. | 10,123,824 | 10,123,824 | 0 | 20,956 | 12,908 | 0.14% | -8,048 |
| Dyne Therapeutics, Inc.(DYN) | 672,096 | 672,096 | 0 | 24,142 | 15,835 | 0.17% | -8,307 |
| Nurix Therapeutics, Inc.(NRIX) | 3,882,125 | 3,882,125 | 0 | 87,231 | 73,139 | 0.78% | -14,092 |
| Kiniksa Pharmaceuticals International, plc(KNSA) | 2,818,323 | 2,818,323 | 0 | 70,430 | 55,746 | 0.60% | -14,683 |
| Biomea Fusion, Inc. | 2,108,949 | 1,451,990 | -656,959 | 21,300 | 5,634 | 0.06% | -15,667 |
| Ultragenyx Pharmaceutical Inc.(RARE) | 1,576,114 | 1,576,114 | 0 | 87,553 | 66,307 | 0.71% | -21,246 |
| Immatics N.V.(IMTX) | 6,443,398 | 7,275,830 | +832,432 | 73,519 | 51,731 | 0.55% | -21,788 |
| Denali Therapeutics Inc.(DNLI) | 3,731,695 | 3,731,695 | 0 | 108,704 | 76,052 | 0.81% | -32,652 |
| Kymera Therapeutics, Inc.(KYMR) | 5,995,929 | 5,995,929 | 0 | 283,787 | 241,216 | 2.58% | -42,571 |
| IGM Biosciences, Inc. | 4,092,310 | 4,094,304 | +1,994 | 67,687 | 25,016 | 0.27% | -42,671 |