Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Incyte Corporation(INCY) | 30,743,663 | 30,743,991 | +328 | 2,607,370 | 3,036,584 | 17.78% | +429,214 |
| Celcuity Inc.(CELC) | 7,915,792 | 7,915,792 | 0 | 391,040 | 789,521 | 4.62% | +398,481 |
| Revolution Medicines, Inc.(RVMD) | 9,455,357 | 9,455,357 | 0 | 441,565 | 753,119 | 4.41% | +311,554 |
| Kymera Therapeutics, Inc.(KYMR) | 6,651,429 | 8,657,242 | +2,005,813 | 376,471 | 673,620 | 3.94% | +297,149 |
| Praxis Precision Medicines, Inc.(PRAX) | 689,488 | 1,126,488 | +437,000 | 36,543 | 332,021 | 1.94% | +295,478 |
| Kodiak Sciences Inc.(KOD) | 17,310,490 | 19,919,186 | +2,608,696 | 283,373 | 556,940 | 3.26% | +273,568 |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 2,141,701 | 2,141,701 | 0 | 982,313 | 1,247,198 | 7.30% | +264,886 |
| ACADIA Pharmaceuticals Inc. | 42,896,690 | 42,896,690 | 0 | 915,415 | 1,145,771 | 6.71% | +230,355 |
| Insmed Incorporated(INSM) | 6,703,484 | 6,592,746 | -110,738 | 965,369 | 1,147,402 | 6.72% | +182,033 |
| Ionis Pharmaceuticals, Inc.(IONS) | 566,798 | 1,791,841 | +1,225,043 | 37,080 | 141,753 | 0.83% | +104,673 |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | 1,670,762 | 2,175,645 | +504,883 | 57,625 | 144,441 | 0.85% | +86,816 |
| GRAIL, Inc.(GRAL) | 1,630,125 | 2,085,333 | +455,208 | 96,389 | 178,484 | 1.05% | +82,094 |
| Crinetics Pharmaceuticals, Inc.(CRNX) | 280,000 | 1,648,869 | +1,368,869 | 11,662 | 76,755 | 0.45% | +65,093 |
| Roivant Sciences Ltd.(ROIV) | 3,767,773 | 5,555,017 | +1,787,244 | 57,006 | 120,544 | 0.71% | +63,537 |
| Replimune Group, Inc.(REPL) | 0 | 11,045,336 | +11,045,336 | 0 | 107,361 | 0.63% | +107,361 |
| Structure Therapeutics Inc. | 1,556,109 | 1,432,529 | -123,580 | 43,571 | 99,632 | 0.58% | +56,061 |
| Nurix Therapeutics, Inc.(NRIX) | 3,882,125 | 4,658,556 | +776,431 | 35,871 | 88,373 | 0.52% | +52,502 |
| Immunovant, Inc.(IMVT) | 5,457,881 | 5,457,881 | 0 | 87,981 | 138,739 | 0.81% | +50,758 |
| Edgewise Therapeutics, Inc.(EWTX) | 7,305,940 | 6,575,940 | -730,000 | 118,502 | 163,182 | 0.96% | +44,680 |
| Abivax S.A.(ABVX) | 875,796 | 875,796 | 0 | 74,355 | 118,105 | 0.69% | +43,750 |
| Terns Pharmaceuticals, Inc. | 0 | 950,000 | +950,000 | 0 | 38,380 | 0.22% | +38,380 |
| Alkermes plc(ALKS) | 8,091,351 | 10,012,267 | +1,920,916 | 242,741 | 280,143 | 1.64% | +37,403 |
| IDEAYA Biosciences, Inc.(IDYA) | 3,275,444 | 3,618,826 | +343,382 | 89,125 | 125,103 | 0.73% | +35,978 |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 5,604,483 | 5,604,483 | 0 | 565,997 | 599,904 | 3.51% | +33,907 |
| Monte Rosa Therapeutics, Inc.(GLUE) | 4,916,095 | 4,345,736 | -570,359 | 36,428 | 68,141 | 0.40% | +31,713 |
| Celcuity Inc.(CELC) | 0 | 0 | 0 | 40,905 | 66,580 | 0.39% | +25,675 |
| Jade Biosciences, Inc. | 0 | 1,641,137 | +1,641,137 | 0 | 25,323 | 0.15% | +25,323 |
| Immatics N.V.(IMTX) | 12,094,094 | 12,094,094 | 0 | 103,042 | 126,988 | 0.74% | +23,946 |
| Entrada Therapeutics, Inc. | 4,865,819 | 5,072,730 | +206,911 | 28,222 | 52,148 | 0.31% | +23,926 |
| Viridian Therapeutics, Inc.(VRDN) | 1,744,406 | 1,971,678 | +227,272 | 37,644 | 61,359 | 0.36% | +23,714 |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 0 | 2,822,727 | +2,822,727 | 0 | 22,017 | 0.13% | +22,017 |
| Ventyx Biosciences, Inc. | 1,023,130 | 2,349,280 | +1,326,150 | 3,182 | 21,214 | 0.12% | +18,032 |
| Tectonic Therapeutic, Inc. | 100,000 | 903,400 | +803,400 | 1,569 | 18,845 | 0.11% | +17,276 |
| Centessa Pharmaceuticals plc | 0 | 670,751 | +670,751 | 0 | 16,775 | 0.10% | +16,775 |
| Spyre Therapeutics, Inc.(SYRE) | 1,000,000 | 1,000,000 | 0 | 16,760 | 32,760 | 0.19% | +16,000 |
| Dyne Therapeutics, Inc.(DYN) | 0 | 813,449 | +813,449 | 0 | 15,911 | 0.09% | +15,911 |
| Contineum Therapeutics, Inc. | 77,670 | 1,420,838 | +1,343,168 | 913 | 16,240 | 0.10% | +15,328 |
| Prelude Therapeutics Inc. | 10,123,824 | 10,123,824 | 0 | 14,578 | 29,359 | 0.17% | +14,781 |
| DBV Technologies S.A.(DBVT) | 1,461,425 | 1,461,425 | 0 | 14,614 | 28,016 | 0.16% | +13,401 |
| Alumis Inc. | 1,562,500 | 1,562,500 | 0 | 6,234 | 15,250 | 0.09% | +9,016 |
| Taysha Gene Therapies, Inc.(TSHA) | 4,004,756 | 4,004,756 | 0 | 13,096 | 22,026 | 0.13% | +8,931 |
| Design Therapeutics, Inc.(DSGN) | 1,712,882 | 2,233,099 | +520,217 | 12,898 | 20,946 | 0.12% | +8,048 |
| Absci Corporation | 0 | 2,134,803 | +2,134,803 | 0 | 7,450 | 0.04% | +7,450 |
| Denali Therapeutics Inc.(DNLI) | 3,731,695 | 3,731,695 | 0 | 54,184 | 61,610 | 0.36% | +7,426 |
| Kiniksa Pharmaceuticals International, plc(KNSA) | 2,824,669 | 2,826,246 | +1,577 | 109,682 | 116,583 | 0.68% | +6,901 |
| Arcus Biosciences, Inc.(RCUS) | 0 | 270,000 | +270,000 | 0 | 6,434 | 0.04% | +6,434 |
| MapLight Therapeutics, Inc. | 0 | 364,705 | +364,705 | 0 | 6,406 | 0.04% | +6,406 |
| Cerus Corporation | 10,008,345 | 10,008,345 | 0 | 15,913 | 20,617 | 0.12% | +4,704 |
| Sionna Therapeutics, Inc. | 400,000 | 400,000 | 0 | 11,764 | 16,456 | 0.10% | +4,692 |
| CytomX Therapeutics, Inc. | 4,250,826 | 4,250,826 | 0 | 13,560 | 18,109 | 0.11% | +4,548 |
| Disc Medicine, Inc.(IRON) | 337,050 | 337,050 | 0 | 22,272 | 26,765 | 0.16% | +4,493 |
| Xencor, Inc.(XNCR) | 1,102,106 | 1,102,106 | 0 | 12,928 | 16,873 | 0.10% | +3,946 |
| Relay Therapeutics, Inc.(RLAY) | 1,160,117 | 1,160,117 | 0 | 6,056 | 9,815 | 0.06% | +3,759 |
| 4D Molecular Therapeutics, Inc. | 0 | 475,737 | +475,737 | 0 | 3,568 | 0.02% | +3,568 |
| Wave Life Sciences Ltd.(WVE) | 344,063 | 344,063 | 0 | 2,519 | 5,849 | 0.03% | +3,331 |
| Neurogene Inc. | 991,691 | 991,691 | 0 | 17,186 | 20,429 | 0.12% | +3,243 |
| Protara Therapeutics, Inc. | 536,832 | 971,614 | +434,782 | 2,335 | 5,179 | 0.03% | +2,843 |
| vTv Therapeutics, Inc. | 148,314 | 148,314 | 0 | 3,463 | 5,931 | 0.03% | +2,468 |
| Nuvalent, Inc. | 143,937 | 143,937 | 0 | 12,448 | 14,479 | 0.08% | +2,031 |
| Enliven Therapeutics, Inc. | 114,833 | 271,406 | +156,573 | 2,351 | 4,180 | 0.02% | +1,829 |
| Xenon Pharmaceuticals Inc.(XENE) | 370,208 | 370,208 | 0 | 14,864 | 16,593 | 0.10% | +1,729 |
| Dianthus Therapeutics, Inc.(DNTH) | 789,759 | 789,759 | 0 | 31,077 | 32,546 | 0.19% | +1,469 |
| LB Pharmaceuticals Inc.(LBRX) | 200,000 | 200,000 | 0 | 3,158 | 4,452 | 0.03% | +1,294 |
| Pharvaris N.V. COM | 375,000 | 375,000 | 0 | 9,356 | 10,406 | 0.06% | +1,050 |
| Rapport Therapeutics, Inc.(RAPP) | 1,547,090 | 1,547,090 | 0 | 45,949 | 46,939 | 0.27% | +990 |
| Celldex Therapeutics, Inc.(CLDX) | 665,370 | 665,370 | 0 | 17,213 | 18,071 | 0.11% | +858 |
| Vir Biotechnology, Inc.(VIR) | 542,539 | 542,539 | 0 | 3,098 | 3,272 | 0.02% | +174 |
| Tyra Biosciences, Inc.(TYRA) | 10,607 | 10,607 | 0 | 148 | 279 | 0.00% | +130 |
| Acrivon Therapeutics, Inc. | 22,809 | 22,809 | 0 | 41 | 55 | 0.00% | +14 |
| Surrozen, Inc. | 833,333 | 833,333 | 0 | 15 | 17 | 0.00% | +2 |
| Opthea Limited | 2,087,320 | 0 | -2,087,320 | 0 | 0 | — | 0 |
| Aligos Therapeutics, Inc. | 83,055 | 83,055 | 0 | 814 | 774 | 0.00% | -40 |
| VYNE Therapeutics Inc. | 851,353 | 0 | -851,353 | 285 | 0 | — | -285 |
| KALA BIO, Inc. | 985,093 | 1,804,055 | +818,962 | 1,507 | 1,003 | 0.01% | -504 |
| Sera Prognostics, Inc. | 5,498,170 | 5,498,170 | 0 | 16,824 | 16,220 | 0.09% | -605 |
| Sagimet Biosciences Inc. | 952,996 | 952,996 | 0 | 6,538 | 5,642 | 0.03% | -896 |
| Generation Bio Co. | 194,493 | 0 | -194,493 | 1,190 | 0 | — | -1,190 |
| BioNTech SE(BNTX) | 368,923 | 368,923 | 0 | 36,383 | 35,121 | 0.21% | -1,262 |
| TScan Therapeutics, Inc. | 2,784,792 | 2,784,792 | 0 | 5,068 | 2,785 | 0.02% | -2,284 |
| Stoke Therapeutics, Inc.(STOK) | 4,633,838 | 3,336,697 | -1,297,141 | 108,895 | 105,907 | 0.62% | -2,988 |
| Immunocore Holdings plc(IMCR) | 2,322,656 | 2,322,656 | 0 | 84,382 | 80,619 | 0.47% | -3,763 |
| Skye Bioscience, Inc. | 1,450,638 | 1,450,638 | 0 | 5,701 | 1,088 | 0.01% | -4,613 |
| MBX Biosciences, Inc.(MBX) | 277,777 | 0 | -277,777 | 4,861 | 0 | — | -4,861 |
| Heron Therapeutics, Inc. | 4,251,951 | 0 | -4,251,951 | 5,357 | 0 | — | -5,357 |
| Sana Biotechnology, Inc.(SANA) | 2,030,949 | 310,483 | -1,720,466 | 7,210 | 1,264 | 0.01% | -5,946 |
| argenx SE(ARGX) | 37,760 | 25,174 | -12,586 | 27,850 | 21,170 | 0.12% | -6,680 |
| Bicycle Therapeutics plc | 10,885,357 | 10,885,357 | 0 | 84,253 | 77,068 | 0.45% | -7,184 |
| Agios Pharmaceuticals, Inc.(AGIO) | 189,866 | 0 | -189,866 | 7,621 | 0 | — | -7,621 |
| Viking Therapeutics, Inc.(VKTX) | 366,083 | 0 | -366,083 | 9,621 | 0 | — | -9,621 |
| Arcellx, Inc. COMMON STOCK | 166,825 | 0 | -166,825 | 13,696 | 0 | — | -13,696 |
| Akero Therapeutics, Inc. | 324,630 | 0 | -324,630 | 15,413 | 0 | — | -15,413 |
| Ultragenyx Pharmaceutical Inc.(RARE) | 2,772,692 | 2,772,692 | 0 | 83,403 | 63,772 | 0.37% | -19,631 |
| Cidara Therapeutics, Inc. | 227,272 | 0 | -227,272 | 21,764 | 0 | — | -21,764 |
| Vaxcyte, Inc.(PCVX) | 640,885 | 0 | -640,885 | 23,085 | 0 | — | -23,085 |
| Avidity Biosciences, Inc. | 625,000 | 0 | -625,000 | 27,231 | 0 | — | -27,231 |
| AbCellera Biologics Inc.(ABCL) | 27,525,640 | 27,525,640 | 0 | 138,454 | 94,138 | 0.55% | -44,316 |
| Intellia Therapeutics, Inc.(NTLA) | 2,746,674 | 0 | -2,746,674 | 47,435 | 0 | — | -47,435 |
| Merus N.V. | 574,377 | 0 | -574,377 | 54,078 | 0 | — | -54,078 |
| Summit Therapeutics Inc.(SMMT) | 33,722,974 | 36,391,063 | +2,668,089 | 696,717 | 636,480 | 3.73% | -60,237 |
| BeOne Medicines Ltd.(ONC) | 8,799,053 | 8,799,053 | 0 | 2,997,837 | 2,673,240 | 15.65% | -324,597 |