Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2023 ▲▼ | Q4 2023 ▲▼ | Change ▲▼ | Q3 2023 ▲▼ | Q4 2023 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| EDGEWISE THERAPEUTIC(EWTX) | 0 | 327,801 | +327,801 | 0 | 3,586 | 1.54% | +3,586 |
| ARGENX SE(ARGX) | 1,227 | 10,027 | +8,800 | 603 | 3,815 | 1.64% | +3,211 |
| MERCK & CO INC(MRK) | 55,000 | 79,500 | +24,500 | 5,662 | 8,667 | 3.73% | +3,005 |
| LILLY ELI & CO(LLY) | 23,265 | 26,565 | +3,300 | 12,496 | 15,485 | 6.67% | +2,989 |
| 4D MOLECULAR THERA | 0 | 142,510 | +142,510 | 0 | 2,887 | 1.24% | +2,887 |
| ARVINAS INC(ARVN) | 7,010 | 66,000 | +58,990 | 138 | 2,717 | 1.17% | +2,579 |
| ABBOTT LABS | 52,498 | 68,998 | +16,500 | 5,084 | 7,595 | 3.27% | +2,510 |
| TRAVERE THERAPEUTICS(TVTX) | 0 | 274,623 | +274,623 | 0 | 2,469 | 1.06% | +2,469 |
| ACELYRIN INC | 0 | 325,549 | +325,549 | 0 | 2,429 | 1.05% | +2,429 |
| SYNDAX PHARMACEUTI(SNDX) | 0 | 92,060 | +92,060 | 0 | 1,989 | 0.86% | +1,989 |
| UNIQURE N.V.(QURE) | 0 | 292,592 | +292,592 | 0 | 1,981 | 0.85% | +1,981 |
| ALTIMMUNE INC(ALT) | 0 | 170,800 | +170,800 | 0 | 1,922 | 0.83% | +1,922 |
| UNITEDHEALTH GRP INC(UNH) | 16,925 | 18,925 | +2,000 | 8,533 | 9,963 | 4.29% | +1,430 |
| ABBVIE INC(ABBV) | 39,300 | 46,300 | +7,000 | 5,858 | 7,175 | 3.09% | +1,317 |
| SUTRO BIOPHARMA IN(STRO) | 432,339 | 623,684 | +191,345 | 1,500 | 2,676 | 1.15% | +1,175 |
| THERMO FISHER SCI(TMO) | 7,165 | 9,015 | +1,850 | 3,627 | 4,785 | 2.06% | +1,158 |
| GRAPHITE BIO INC | 0 | 441,829 | +441,829 | 0 | 1,158 | 0.50% | +1,158 |
| ANNEXON INC(ANNX) | 898,785 | 650,911 | -247,874 | 2,121 | 2,955 | 1.27% | +834 |
| DANAHER CORP(DHR) | 10,975 | 14,975 | +4,000 | 2,723 | 3,464 | 1.49% | +741 |
| AMGEN INC(AMGN) | 28,065 | 28,685 | +620 | 7,543 | 8,262 | 3.56% | +719 |
| ITEOS THERAPEUTICS | 155,075 | 220,056 | +64,981 | 1,698 | 2,410 | 1.04% | +712 |
| VERTEX PHARMACEUTICL(VRTX) | 8,769 | 9,219 | +450 | 3,049 | 3,751 | 1.62% | +702 |
| DEXCOM INC(DXCM) | 31,700 | 29,400 | -2,300 | 2,958 | 3,648 | 1.57% | +691 |
| BIOATLA INC(BCAB) | 706,062 | 706,062 | 0 | 1,200 | 1,737 | 0.75% | +537 |
| EYEPOINT PHARMA(EYPT) | 176,080 | 81,160 | -94,920 | 1,407 | 1,876 | 0.81% | +469 |
| GILEAD SCIENCES INC(GILD) | 38,150 | 40,905 | +2,755 | 2,859 | 3,314 | 1.43% | +455 |
| FUSION PHARMACEUTI | 57,297 | 57,297 | 0 | 149 | 551 | 0.24% | +402 |
| IONIS PHARMACEUTICAL(IONS) | 0 | 6,480 | +6,480 | 0 | 328 | 0.14% | +328 |
| REGENERON PHARMCTCLS(REGN) | 3,720 | 3,835 | +115 | 3,061 | 3,368 | 1.45% | +307 |
| ALLAKOS INC | 770,132 | 752,381 | -17,751 | 1,748 | 2,054 | 0.88% | +306 |
| PMV PHARMACEUTICALS(PMVP) | 303,824 | 685,985 | +382,161 | 1,865 | 2,127 | 0.92% | +261 |
| BIOGEN INC(BIIB) | 15,012 | 15,827 | +815 | 3,858 | 4,096 | 1.76% | +237 |
| PFIZER INC(PFE) | 157,400 | 189,400 | +32,000 | 5,221 | 5,453 | 2.35% | +232 |
| HUMANA INC(HUM) | 7,325 | 8,225 | +900 | 3,564 | 3,765 | 1.62% | +202 |
| ASCENDIS PHARMA A S(ASND) | 4,241 | 4,441 | +200 | 397 | 559 | 0.24% | +162 |
| MEDTRONIC PLC(MDT) | 40,051 | 40,051 | 0 | 3,138 | 3,299 | 1.42% | +161 |
| STRUCTURE THERAPEU | 0 | 3,400 | +3,400 | 0 | 139 | 0.06% | +139 |
| MEDPACE HOLDINGS(MEDP) | 1,181 | 1,371 | +190 | 286 | 420 | 0.18% | +134 |
| NEUROCRINE BIOSCIENC(NBIX) | 4,035 | 4,445 | +410 | 454 | 586 | 0.25% | +132 |
| APELLIS PHARMACEUTIC COM | 5,220 | 5,220 | 0 | 199 | 312 | 0.13% | +114 |
| IQVIA HOLDINGS INC(IQV) | 19,000 | 16,600 | -2,400 | 3,738 | 3,841 | 1.65% | +103 |
| ROYALTY PHARMA PLC(RPRX) | 17,950 | 20,570 | +2,620 | 487 | 578 | 0.25% | +91 |
| ASTRAZENECA(AZN) | 24,820 | 26,130 | +1,310 | 1,681 | 1,760 | 0.76% | +79 |
| BEIGENE LIMITED(ONC) | 3,332 | 3,752 | +420 | 599 | 677 | 0.29% | +77 |
| INCYTE CORPORATION(INCY) | 9,645 | 10,105 | +460 | 557 | 634 | 0.27% | +77 |
| EXELIXIS INC(EXEL) | 12,480 | 13,990 | +1,510 | 273 | 336 | 0.14% | +63 |
| BOSTON SCIENTIFIC(BSX) | 98,976 | 91,476 | -7,500 | 5,226 | 5,288 | 2.28% | +62 |
| ILLUMINA INC(ILMN) | 6,300 | 6,600 | +300 | 865 | 919 | 0.40% | +54 |
| ROIVANT SCIENCES LTD(ROIV) | 30,447 | 36,457 | +6,010 | 356 | 409 | 0.18% | +54 |
| MODERNA INC(MRNA) | 15,000 | 16,100 | +1,100 | 1,549 | 1,601 | 0.69% | +52 |
| SUMMIT THERAPEUTICS(SMMT) | 20,000 | 30,000 | +10,000 | 37 | 78 | 0.03% | +41 |
| ZAI LAB LTD(ZLAB) | 3,000 | 4,000 | +1,000 | 73 | 109 | 0.05% | +36 |
| UNITED THERAPEUTICS(UTHR) | 2,615 | 2,815 | +200 | 591 | 619 | 0.27% | +28 |
| SPDR SER TR ST STR SP BIOT | 24,675 | 20,439 | -4,236 | 1,802 | 1,825 | 0.79% | +23 |
| BIONTECH SE(BNTX) | 3,445 | 3,725 | +280 | 374 | 393 | 0.17% | +19 |
| SANOFI(SNY) | 12,830 | 14,090 | +1,260 | 688 | 701 | 0.30% | +12 |
| DR REDDYS LABS LTD(RDY) | 4,500 | 4,500 | 0 | 301 | 313 | 0.13% | +12 |
| VERASTEM INC(VSTM) | 203,327 | 203,327 | 0 | 1,653 | 1,655 | 0.71% | +2 |
| JAZZ PHARMA PLC(JAZZ) | 3,914 | 4,094 | +180 | 507 | 504 | 0.22% | -3 |
| ARCUTIS BIOTHERAPEUTICS(ARQT) | 4,357 | 0 | -4,357 | 23 | 0 | — | -23 |
| SAREPTA THERAPEUTICS(SRPT) | 18,006 | 21,541 | +3,535 | 2,183 | 2,077 | 0.89% | -105 |
| AMYLYX PHARMACEUTIC(AMLX) | 73,655 | 84,055 | +10,400 | 1,349 | 1,237 | 0.53% | -111 |
| LEGEND BIOTECH CORP(LEGN) | 6,670 | 3,000 | -3,670 | 448 | 181 | 0.08% | -268 |
| HORIZON THERAPEUTICS | 2,515 | 0 | -2,515 | 291 | 0 | — | -291 |
| VERALTO CORPORATION(VLTO) | 3,658 | 0 | -3,658 | 309 | 0 | — | -309 |
| EFFECTOR THERAPEUTCS | 2,382,644 | 2,382,644 | 0 | 1,429 | 1,114 | 0.48% | -316 |
| JOHNSON & JOHNSON(JNJ) | 56,850 | 53,850 | -3,000 | 8,854 | 8,440 | 3.63% | -414 |
| TURNSTONE BIOLOGICS | 517,648 | 517,648 | 0 | 2,040 | 1,317 | 0.57% | -722 |
| ALNYLAM PHARMACUETCL(ALNY) | 28,960 | 22,640 | -6,320 | 5,129 | 4,334 | 1.87% | -795 |
| RALLYBIO CORP(RLYB) | 375,960 | 0 | -375,960 | 1,267 | 0 | — | -1,267 |
| GENERATION BIO CO | 356,740 | 0 | -356,740 | 1,352 | 0 | — | -1,352 |
| EDWARDS LIFESCIENCE | 49,200 | 21,900 | -27,300 | 3,409 | 1,670 | 0.72% | -1,739 |
| ATEA PHARMACEUTICALS(AVIR) | 600,461 | 0 | -600,461 | 1,801 | 0 | — | -1,801 |
| MACROGENICS INC(MGNX) | 387,001 | 0 | -387,001 | 1,803 | 0 | — | -1,803 |
| STAAR SURGICAL CO(STAA) | 47,000 | 0 | -47,000 | 1,888 | 0 | — | -1,888 |
| SEAGEN INC | 9,210 | 0 | -9,210 | 1,954 | 0 | — | -1,954 |
| ARS PHARMACEUTICALS(SPRY) | 1,049,191 | 354,641 | -694,550 | 3,966 | 1,943 | 0.84% | -2,023 |
| REPLIMUNE GROUP INC(REPL) | 271,056 | 305,412 | +34,356 | 4,638 | 2,575 | 1.11% | -2,063 |
| SCHOLAR ROCK HLDG(SRRK) | 310,398 | 0 | -310,398 | 2,204 | 0 | — | -2,204 |
| MADRIGAL PHARMACEUTI(MDGL) | 20,901 | 1,201 | -19,700 | 3,052 | 278 | 0.12% | -2,774 |
| MINERALYS THERAPEUTI(MLYS) | 840,759 | 605,606 | -235,153 | 7,996 | 5,208 | 2.24% | -2,787 |
| IOVANCE BIOTHERAPEUT(IOVA) | 985,000 | 198,800 | -786,200 | 4,482 | 1,616 | 0.70% | -2,866 |
| CYTOKINETICS INC(CYTK) | 118,303 | 7,013 | -111,290 | 3,485 | 586 | 0.25% | -2,900 |
| VERA THERAPEUTICS(VERA) | 357,139 | 124,151 | -232,988 | 4,896 | 1,909 | 0.82% | -2,987 |
| OCULAR THERAPEUTIX(OCUL) | 969,350 | 0 | -969,350 | 3,044 | 0 | — | -3,044 |
| INSULET CORP(PODD) | 36,725 | 12,950 | -23,775 | 5,857 | 2,810 | 1.21% | -3,047 |
| VENTYX BIOSCIENCES I | 88,000 | 0 | -88,000 | 3,056 | 0 | — | -3,056 |
| IRHYTHM TECHNOLOGIES(IRTC) | 33,000 | 0 | -33,000 | 3,111 | 0 | — | -3,111 |
| ALPHATEC HOLDINGS IN(ATEC) | 246,345 | 0 | -246,345 | 3,195 | 0 | — | -3,195 |
| GOODRX HLDGS INC(GDRX) | 1,007,000 | 364,000 | -643,000 | 5,669 | 2,439 | 1.05% | -3,231 |
| INTELLIA THERAPEUT(NTLA) | 112,332 | 9,300 | -103,032 | 3,552 | 284 | 0.12% | -3,268 |
| SHOCKWAVE MEDICAL | 17,400 | 0 | -17,400 | 3,464 | 0 | — | -3,464 |
| DOCGO INC(DCGO) | 651,400 | 0 | -651,400 | 3,472 | 0 | — | -3,472 |
| REVOLUTION MEDICIN(RVMD) | 142,650 | 13,710 | -128,940 | 3,949 | 393 | 0.17% | -3,555 |
| KARUNA THERAPEUTICS | 25,980 | 2,235 | -23,745 | 4,393 | 707 | 0.30% | -3,686 |
| MOONLAKE IMMUNOTHERA(MLTX) | 97,965 | 30,005 | -67,960 | 5,584 | 1,812 | 0.78% | -3,772 |
| ACADIA PHARMACEUTCLS | 209,960 | 15,060 | -194,900 | 4,376 | 472 | 0.20% | -3,904 |
| ARROWHEAD PHARMACEUT(ARWR) | 157,552 | 8,182 | -149,370 | 4,233 | 250 | 0.11% | -3,983 |
| PROGYNY INC | 120,000 | 0 | -120,000 | 4,082 | 0 | — | -4,082 |
| PTC THERAPEUTICS I(PTCT) | 187,016 | 0 | -187,016 | 4,191 | 0 | — | -4,191 |