Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Insmed Incorporated(INSM) | 489,482 | 415,269 | -74,213 | $85.19M | $67.90M | 10.39% | -$17.28M |
| Acadia Pharmaceuticals Inc | 2,484,031 | 2,872,695 | +388,664 | $66.35M | $63.95M | 9.78% | -$2.40M |
| PTC Therapeutics, Inc.(PTCT) | 903,916 | 921,607 | +17,691 | $68.66M | $62.79M | 9.60% | -$5.87M |
| BioMarin Pharmaceutical Inc.(BMRN) | 746,256 | 685,182 | -61,074 | $44.35M | $38.71M | 5.92% | -$5.64M |
| United Therapeutics Corporation(UTHR) | 58,186 | 62,809 | +4,623 | $28.35M | $37.24M | 5.70% | +$8.89M |
| Anaptysbio Inc | 690,032 | 638,161 | -51,871 | $33.45M | $35.39M | 5.41% | +$1.94M |
| Mirum Pharmaceuticals, Inc.(MIRM) | 156,421 | 325,175 | +168,754 | $12.36M | $30.04M | 4.59% | +$17.68M |
| Dyne Therapeutics, Inc.(DYN) | 1,472,197 | 1,652,972 | +180,775 | $28.80M | $29.97M | 4.58% | +$1.17M |
| Biogen Inc.(BIIB) | 183,571 | 140,719 | -42,852 | $32.31M | $25.80M | 3.95% | -$6.51M |
| Disc Medicine, Inc.(IRON) | 317,456 | 401,719 | +84,263 | $25.21M | $25.69M | 3.93% | +$476.7K |
| Iovance Biotherapeutics, Inc.(IOVA) | 7,116,676 | 6,349,563 | -767,113 | $19.43M | $22.29M | 3.41% | +$2.86M |
| Syndax Pharmaceuticals, Inc.(SNDX) | 794,507 | 864,986 | +70,479 | $16.69M | $20.21M | 3.09% | +$3.51M |
| Annexon, Inc.(ANNX) | 2,384,192 | 2,948,090 | +563,898 | $11.97M | $16.33M | 2.50% | +$4.36M |
| Amicus Therapeutics Inc COM | 5,205,767 | 1,113,045 | -4,092,722 | $74.13M | $16.09M | 2.46% | -$58.04M |
| NovoCure Limited(NVCR) | 1,298,964 | 1,280,439 | -18,525 | $16.80M | $13.96M | 2.13% | -$2.84M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 461,294 | 596,495 | +135,201 | $10.61M | $12.50M | 1.91% | +$1.89M |
| Prothena Corp PlcSHS SHS | 1,320,510 | 1,208,568 | -111,942 | $12.61M | $11.75M | 1.80% | -$863.6K |
| Bicara Therapeutics Inc | 298,575 | 550,408 | +251,833 | $5.03M | $10.95M | 1.67% | +$5.92M |
| Celldex Therapeutics, Inc.(CLDX) | 0 | 296,408 | +296,408 | $0 | $9.40M | 1.44% | +$9.40M |
| CareDx, Inc.(CDNA) | 478,220 | 531,870 | +53,650 | $9.01M | $9.23M | 1.41% | +$223.6K |
| Alkermes plcSHS(ALKS) | 242,560 | 242,560 | 0 | $6.79M | $8.58M | 1.31% | +$1.79M |
| Compass Therapeutics, Inc.(CMPX) | 2,532,419 | 1,514,504 | -1,017,915 | $13.60M | $8.01M | 1.23% | -$5.59M |
| Agios Pharmaceuticals, Inc.(AGIO) | 212,499 | 213,601 | +1,102 | $5.78M | $7.23M | 1.11% | +$1.44M |
| Align Technology Inc | 41,520 | 41,520 | 0 | $6.48M | $7.12M | 1.09% | +$634.4K |
| Capricor Therapeutics, Inc.(CAPR) | 226,304 | 229,763 | +3,459 | $6.53M | $6.98M | 1.07% | +$453.7K |
| Travere Therapeutics, Inc.(TVTX) | 110,719 | 230,453 | +119,734 | $4.23M | $6.85M | 1.05% | +$2.62M |
| Taysha Gene Therapies, Inc.(TSHA) | 1,183,195 | 1,391,382 | +208,187 | $6.51M | $6.22M | 0.95% | -$288.1K |
| Aclaris Therapeutics, Inc.(ACRS) | 1,566,840 | 1,613,430 | +46,590 | $4.72M | $6.05M | 0.93% | +$1.33M |
| Denali Therapeutics Inc.(DNLI) | 641,239 | 234,582 | -406,657 | $10.59M | $4.50M | 0.69% | -$6.08M |
| Xenon Pharmaceuticals Inc.(XENE) | 96,519 | 51,345 | -45,174 | $4.33M | $2.99M | 0.46% | -$1.34M |
| Oruka Therapeutics, Inc.(ORKA) | 59,985 | 59,985 | 0 | $1.82M | $2.94M | 0.45% | +$1.12M |
| Stoke Therapeutics, Inc.(STOK) | 72,022 | 84,631 | +12,609 | $2.29M | $2.76M | 0.42% | +$469.6K |
| Edwards Lifesciences Corp | 33,640 | 33,640 | 0 | $2.87M | $2.69M | 0.41% | -$173.9K |
| Neurocrine Biosciences, Inc.(NBIX) | 18,117 | 18,117 | 0 | $2.57M | $2.39M | 0.37% | -$182.8K |
| Nuvation Bio Inc.CL A(NUVB) | 538,079 | 508,846 | -29,233 | $4.82M | $2.18M | 0.33% | -$2.64M |
| Cytokinetics, Incorporated(CYTK) | 0 | 32,195 | +32,195 | $0 | $2.12M | 0.32% | +$2.12M |
| eHealth, Inc.(EHTH) | 1,531,429 | 1,482,797 | -48,632 | $7.04M | $1.91M | 0.29% | -$5.13M |
| CRISPR Therapeutics AGNAMEN AKT(CRSP) | 41,226 | 39,605 | -1,621 | $2.16M | $1.88M | 0.29% | -$277.9K |
| BioNTech SEADS(BNTX) | 19,614 | 19,614 | 0 | $1.87M | $1.74M | 0.27% | -$124.0K |
| Pyxis Oncology, Inc.(PYXS) | 1,037,421 | 1,010,510 | -26,911 | $1.19M | $1.48M | 0.23% | +$282.3K |
| Verastem, Inc.(VSTM) | 0 | 246,093 | +246,093 | $0 | $1.30M | 0.20% | +$1.30M |
| Bicycle Therapeutics Plc-AdrADS | 221,071 | 201,890 | -19,181 | $1.57M | $936.8K | 0.14% | -$628.4K |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 0 | 1,787 | +1,787 | $0 | $935.4K | 0.14% | +$935.4K |
| Humana Inc.(HUM) | 3,985 | 3,985 | 0 | $1.02M | $691.0K | 0.11% | -$329.7K |
| COMPASS Pathways plcADS(CMPS) | 115,616 | 115,616 | 0 | $797.8K | $639.4K | 0.10% | -$158.4K |
| Xeris Biopharma Holdings Inc | 0 | 104,410 | +104,410 | $0 | $605.6K | 0.09% | +$605.6K |
| Abeona Therapeutics Inc.(ABEO) | 108,865 | 108,865 | 0 | $573.7K | $487.7K | 0.07% | -$86.0K |
| Inspire Medical Systems, Inc.(INSP) | 8,772 | 8,772 | 0 | $809.0K | $452.5K | 0.07% | -$356.6K |
| UroGen Pharma Ltd.(URGN) | 24,500 | 24,500 | 0 | $573.8K | $440.5K | 0.07% | -$133.3K |
| Proqr Therapeutics NvSHS EURO SHS EURO | 188,807 | 188,807 | 0 | $381.4K | $305.9K | 0.05% | -$75.5K |
| Aldeyra Therapeutics, Inc.(ALDX) | 225,465 | 155,709 | -69,756 | $1.17M | $263.1K | 0.04% | -$904.8K |
| Akari Therapeutics, Plc(AKTX) | 146,024 | 0 | -146,024 | $42.2K | $0 | — | -$42.2K |
| Generation Bio Co | 15,047 | 0 | -15,047 | $85.5K | $0 | — | -$85.5K |
| Gossamer Bio, Inc.(GOSS) | 4,471,592 | 0 | -4,471,592 | $13.86M | $0 | — | -$13.86M |