Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| MIRUM PHARMACEUTICALS INC(MIRM) | 156,421 | 325,175 | +168,754 | 12,356 | 30,040 | 4.59% | +17,684 |
| CELLDEX THERAPEUTICS INC(CLDX) | 0 | 296,408 | +296,408 | 0 | 9,402 | 1.44% | +9,402 |
| UNITED THERAPEUTICS CORP(UTHR) | 58,186 | 62,809 | +4,623 | 28,351 | 37,244 | 5.70% | +8,893 |
| BICARA THERAPEUTICS INC | 298,575 | 550,408 | +251,833 | 5,025 | 10,948 | 1.67% | +5,923 |
| ANNEXON INC(ANNX) | 2,384,192 | 2,948,090 | +563,898 | 11,969 | 16,332 | 2.50% | +4,364 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 794,507 | 864,986 | +70,479 | 16,693 | 20,206 | 3.09% | +3,513 |
| IOVANCE BIOTHERAPEUTICS INC(IOVA) | 7,116,676 | 6,349,563 | -767,113 | 19,429 | 22,287 | 3.41% | +2,858 |
| TRAVERE THERAPEUTICS INC(TVTX) | 110,719 | 230,453 | +119,734 | 4,231 | 6,847 | 1.05% | +2,616 |
| CYTOKINETICS INC(CYTK) | 0 | 32,195 | +32,195 | 0 | 2,122 | 0.32% | +2,122 |
| ANAPTYSBIO INC | 690,032 | 638,161 | -51,871 | 33,453 | 35,392 | 5.41% | +1,940 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 461,294 | 596,495 | +135,201 | 10,610 | 12,497 | 1.91% | +1,887 |
| ALKERMES PLC(ALKS) | 242,560 | 242,560 | 0 | 6,787 | 8,577 | 1.31% | +1,790 |
| AGIOS PHARMACEUTICALS INC(AGIO) | 212,499 | 213,601 | +1,102 | 5,784 | 7,226 | 1.11% | +1,442 |
| ACLARIS THERAPEUTICS INC(ACRS) | 1,566,840 | 1,613,430 | +46,590 | 4,716 | 6,050 | 0.93% | +1,334 |
| VERASTEM INC(VSTM) | 0 | 246,093 | +246,093 | 0 | 1,304 | 0.20% | +1,304 |
| DYNE THERAPEUTICS INC(DYN) | 1,472,197 | 1,652,972 | +180,775 | 28,796 | 29,968 | 4.58% | +1,172 |
| ORUKA THERAPEUTICS INC(ORKA) | 59,985 | 59,985 | 0 | 1,818 | 2,942 | 0.45% | +1,124 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 0 | 1,787 | +1,787 | 0 | 935 | 0.14% | +935 |
| ALIGN TECHNOLOGY INC | 41,520 | 41,520 | 0 | 6,483 | 7,118 | 1.09% | +634 |
| XERIS BIOPHARMA HOLDINGS INC | 0 | 104,410 | +104,410 | 0 | 606 | 0.09% | +606 |
| DISC MEDICINE INC(IRON) | 317,456 | 401,719 | +84,263 | 25,209 | 25,686 | 3.93% | +477 |
| STOKE THERAPEUTICS INC(STOK) | 72,022 | 84,631 | +12,609 | 2,286 | 2,756 | 0.42% | +470 |
| CAPRICOR THERAPEUTICS INC(CAPR) | 226,304 | 229,763 | +3,459 | 6,531 | 6,985 | 1.07% | +454 |
| PYXIS ONCOLOGY INC(PYXS) | 1,037,421 | 1,010,510 | -26,911 | 1,193 | 1,475 | 0.23% | +282 |
| CAREDX INC(CDNA) | 478,220 | 531,870 | +53,650 | 9,010 | 9,233 | 1.41% | +224 |
| AKARI THERAPEUTICS PLC-ADR(AKTX) | 146,024 | 0 | -146,024 | 42 | 0 | — | -42 |
| PROQR THERAPEUTICS NV SHS EURO | 188,807 | 188,807 | 0 | 381 | 306 | 0.05% | -76 |
| GENERATION BIO CO | 15,047 | 0 | -15,047 | 85 | 0 | — | -85 |
| ABEONA THERAPEUTICS INC(ABEO) | 108,865 | 108,865 | 0 | 574 | 488 | 0.07% | -86 |
| BIONTECH SE-ADR(BNTX) | 19,614 | 19,614 | 0 | 1,867 | 1,743 | 0.27% | -124 |
| UROGEN PHARMA LTD(URGN) | 24,500 | 24,500 | 0 | 574 | 441 | 0.07% | -133 |
| COMPASS PATHWAYS PLC ADR(CMPS) | 115,616 | 115,616 | 0 | 798 | 639 | 0.10% | -158 |
| EDWARDS LIFESCIENCES CORP | 33,640 | 33,640 | 0 | 2,868 | 2,694 | 0.41% | -174 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 18,117 | 18,117 | 0 | 2,570 | 2,387 | 0.37% | -183 |
| CRISPR THERAPEUTICS AG(CRSP) | 41,226 | 39,605 | -1,621 | 2,162 | 1,884 | 0.29% | -278 |
| TAYSHA GENE THERAPIES INC(TSHA) | 1,183,195 | 1,391,382 | +208,187 | 6,508 | 6,219 | 0.95% | -288 |
| HUMANA INC(HUM) | 3,985 | 3,985 | 0 | 1,021 | 691 | 0.11% | -330 |
| INSPIRE MEDICAL SYSTEMS INC(INSP) | 8,772 | 8,772 | 0 | 809 | 452 | 0.07% | -357 |
| BICYCLE THERAPEUTICS PLC-ADR | 221,071 | 201,890 | -19,181 | 1,565 | 937 | 0.14% | -628 |
| PROTHENA CORP PLC SHS | 1,320,510 | 1,208,568 | -111,942 | 12,611 | 11,747 | 1.80% | -864 |
| ALDEYRA THERAPEUTICS INC(ALDX) | 225,465 | 155,709 | -69,756 | 1,168 | 263 | 0.04% | -905 |
| XENON PHARMACEUTICALS INC(XENE) | 96,519 | 51,345 | -45,174 | 4,326 | 2,986 | 0.46% | -1,340 |
| ACADIA PHARMACEUTICALS INC | 2,484,031 | 2,872,695 | +388,664 | 66,348 | 63,946 | 9.78% | -2,402 |
| NUVATION BIO INC(NUVB) | 538,079 | 508,846 | -29,233 | 4,821 | 2,183 | 0.33% | -2,638 |
| NOVOCURE LTD(NVCR) | 1,298,964 | 1,280,439 | -18,525 | 16,796 | 13,957 | 2.13% | -2,839 |
| EHEALTH INC(EHTH) | 1,531,429 | 1,482,797 | -48,632 | 7,045 | 1,913 | 0.29% | -5,132 |
| COMPASS THERAPEUTICS INC(CMPX) | 2,532,419 | 1,514,504 | -1,017,915 | 13,599 | 8,012 | 1.23% | -5,587 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 746,256 | 685,182 | -61,074 | 44,350 | 38,706 | 5.92% | -5,644 |
| PTC THERAPEUTICS INC(PTCT) | 903,916 | 921,607 | +17,691 | 68,661 | 62,789 | 9.60% | -5,872 |
| DENALI THERAPEUTICS INC(DNLI) | 641,239 | 234,582 | -406,657 | 10,587 | 4,504 | 0.69% | -6,083 |
| BIOGEN INC(BIIB) | 183,571 | 140,719 | -42,852 | 32,307 | 25,798 | 3.95% | -6,509 |
| GOSSAMER BIO INC(GOSS) | 4,471,592 | 0 | -4,471,592 | 13,862 | 0 | — | -13,862 |
| INSMED INC(INSM) | 489,482 | 415,269 | -74,213 | 85,189 | 67,905 | 10.39% | -17,285 |
| AMICUS THERAPEUTICS INC COM | 5,205,767 | 1,113,045 | -4,092,722 | 74,130 | 16,095 | 2.46% | -58,035 |