Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q1 2025 ▲▼ | Q2 2025 ▲▼ | Change ▲▼ | Q1 2025 ▲▼ | Q2 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Insmed Incorporated(INSM) | 987,153 | 865,113 | -122,040 | $75.31M | $87.06M | 18.52% | +$11.76M |
| Acadia Pharmaceuticals Inc | 2,663,925 | 2,563,209 | -100,716 | $44.25M | $55.29M | 11.76% | +$11.04M |
| BioMarin Pharmaceutical Inc.(BMRN) | 991,207 | 840,470 | -150,737 | $70.07M | $46.20M | 9.83% | -$23.87M |
| Amicus Therapeutics Inc COM | 7,345,002 | 5,610,513 | -1,734,489 | $59.94M | $32.15M | 6.84% | -$27.79M |
| United Therapeutics Corporation(UTHR) | 105,228 | 95,482 | -9,746 | $32.44M | $27.44M | 5.84% | -$5.00M |
| Biogen Inc.ADS(BIIB) | 204,923 | 205,759 | +836 | $28.04M | $25.84M | 5.50% | -$2.20M |
| Alnylam Pharmaceuticals, Inc.SHS(ALNY) | 83,488 | 75,535 | -7,953 | $22.54M | $24.63M | 5.24% | +$2.09M |
| PTC Therapeutics, Inc.SHS(PTCT) | 404,196 | 406,469 | +2,273 | $20.60M | $19.85M | 4.22% | -$745.9K |
| Anaptysbio Inc | 1,020,713 | 812,821 | -207,892 | $18.98M | $18.04M | 3.84% | -$930.4K |
| NovoCure Limited(NVCR) | 1,002,061 | 962,396 | -39,665 | $17.86M | $17.13M | 3.64% | -$726.1K |
| STAAR Surgical Company(STAA) | 525,017 | 791,879 | +266,862 | $9.26M | $13.29M | 2.83% | +$4.03M |
| Agios Pharmaceuticals, Inc.(AGIO) | 276,578 | 268,783 | -7,795 | $8.10M | $8.94M | 1.90% | +$836.0K |
| Prothena Corp PlcCL A SHS | 1,659,734 | 1,274,753 | -384,981 | $20.54M | $7.74M | 1.65% | -$12.80M |
| Disc Medicine, Inc.(IRON) | 0 | 145,691 | +145,691 | $0 | $7.72M | 1.64% | +$7.72M |
| Align Technology Inc | 37,772 | 37,772 | 0 | $6.00M | $7.15M | 1.52% | +$1.15M |
| Gossamer Bio, Inc.(GOSS) | 6,276,893 | 5,739,013 | -537,880 | $6.90M | $7.06M | 1.50% | +$154.4K |
| eHealth, Inc.(EHTH) | 1,684,336 | 1,577,850 | -106,486 | $11.25M | $6.86M | 1.46% | -$4.39M |
| Alkermes plc(ALKS) | 221,513 | 221,021 | -492 | $7.31M | $6.32M | 1.35% | -$990.9K |
| Iovance Biotherapeutics, Inc.(IOVA) | 3,211,314 | 3,429,329 | +218,015 | $10.69M | $5.90M | 1.25% | -$4.80M |
| Syndax Pharmaceuticals, Inc.(SNDX) | 444,367 | 444,367 | 0 | $5.46M | $4.16M | 0.89% | -$1.30M |
| Avidity Biosciences Inc | 0 | 118,886 | +118,886 | $0 | $3.38M | 0.72% | +$3.38M |
| Denali Therapeutics Inc.(DNLI) | 0 | 239,809 | +239,809 | $0 | $3.35M | 0.71% | +$3.35M |
| Mirum Pharmaceuticals, Inc.(MIRM) | 64,700 | 64,700 | 0 | $2.91M | $3.29M | 0.70% | +$377.8K |
| Edwards Lifesciences Corp | 39,473 | 39,473 | 0 | $2.86M | $3.09M | 0.66% | +$226.2K |
| Taysha Gene Therapies, Inc.(TSHA) | 1,419,468 | 1,246,033 | -173,435 | $1.97M | $2.88M | 0.61% | +$905.3K |
| BioNTech SE(BNTX) | 25,206 | 25,206 | 0 | $2.30M | $2.68M | 0.57% | +$388.4K |
| Dyne Therapeutics, Inc.ADS(DYN) | 333,391 | 264,976 | -68,415 | $3.49M | $2.52M | 0.54% | -$964.7K |
| CRISPR Therapeutics AGNAMEN AKT(CRSP) | 0 | 44,625 | +44,625 | $0 | $2.17M | 0.46% | +$2.17M |
| Aclaris Therapeutics, Inc.(ACRS) | 776,028 | 1,390,028 | +614,000 | $1.19M | $1.97M | 0.42% | +$786.5K |
| Ultragenyx Pharmaceutical Inc.(RARE) | 0 | 48,750 | +48,750 | $0 | $1.77M | 0.38% | +$1.77M |
| Bicycle Therapeutics Plc-Adr | 248,934 | 248,934 | 0 | $2.11M | $1.73M | 0.37% | -$383.4K |
| Neurocrine Biosciences, Inc.(NBIX) | 13,334 | 13,334 | 0 | $1.47M | $1.68M | 0.36% | +$201.2K |
| Travere Therapeutics, Inc.(TVTX) | 110,719 | 110,719 | 0 | $1.98M | $1.64M | 0.35% | -$345.4K |
| Nuvation Bio Inc.(NUVB) | 772,652 | 772,652 | 0 | $1.36M | $1.51M | 0.32% | +$146.8K |
| Stoke Therapeutics, Inc.(STOK) | 125,861 | 125,861 | 0 | $837.0K | $1.43M | 0.30% | +$591.5K |
| Pyxis Oncology, Inc.(PYXS) | 1,037,421 | 1,037,421 | 0 | $1.02M | $1.14M | 0.24% | +$124.6K |
| Humana Inc.(HUM) | 3,985 | 3,985 | 0 | $1.05M | $974.3K | 0.21% | -$80.2K |
| Aldeyra Therapeutics, Inc.ADR(ALDX) | 225,465 | 225,465 | 0 | $1.30M | $863.5K | 0.18% | -$432.9K |
| Karyopharm Therapeutics Inc.(KPTI) | 0 | 187,911 | +187,911 | $0 | $809.9K | 0.17% | +$809.9K |
| Yarrow Bioscience Inc(YARW) | 445,434 | 445,434 | 0 | $703.8K | $735.0K | 0.16% | +$31.2K |
| Abeona Therapeutics Inc.(ABEO) | 108,865 | 108,865 | 0 | $518.2K | $618.4K | 0.13% | +$100.2K |
| Alumis Inc | 0 | 143,437 | +143,437 | $0 | $430.3K | 0.09% | +$430.3K |
| UroGen Pharma Ltd.(URGN) | 24,500 | 24,500 | 0 | $271.0K | $335.6K | 0.07% | +$64.7K |
| Akari Therapeutics, Plc(AKTX) | 146,024 | 146,024 | 0 | $181.1K | $170.8K | 0.04% | -$10.2K |
| Generation Bio Co | 150,475 | 150,475 | 0 | $60.9K | $48.2K | 0.01% | -$12.8K |
| Acelyrin Inc | 1,792,895 | 0 | -1,792,895 | $4.43M | $0 | — | -$4.43M |
| Instil Bio, Inc.(TIL) | 11,165 | 0 | -11,165 | $193.8K | $0 | — | -$193.8K |
| Karyopharm Therapeutics Inc.(KPTI) | 324,032 | 0 | -324,032 | $1.21M | $0 | — | -$1.21M |
| Relmada Therapeutics, Inc.(RLMD) | 495,146 | 0 | -495,146 | $133.7K | $0 | — | -$133.7K |
| Sarepta Therapeutics, Inc.(SRPT) | 210,258 | 0 | -210,258 | $13.42M | $0 | — | -$13.42M |
| Verve Therapeutics Inc | 575,817 | 0 | -575,817 | $2.63M | $0 | — | -$2.63M |