Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q1 2025 ▲▼ | Q2 2025 ▲▼ | Change ▲▼ | Q1 2025 ▲▼ | Q2 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| INSMED INC(INSM) | 0 | 865,113 | +865,113 | 0 | 87,065 | 18.52% | +87,065 |
| BIOGEN INC(BIIB) | 0 | 205,759 | +205,759 | 0 | 25,841 | 5.50% | +25,841 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 0 | 75,535 | +75,535 | 0 | 24,631 | 5.24% | +24,631 |
| PTC THERAPEUTICS INC(PTCT) | 0 | 406,469 | +406,469 | 0 | 19,852 | 4.22% | +19,852 |
| NOVOCURE LTD(NVCR) | 0 | 962,396 | +962,396 | 0 | 17,131 | 3.64% | +17,131 |
| STAAR SURGICAL CO(STAA) | 0 | 791,879 | +791,879 | 0 | 13,288 | 2.83% | +13,288 |
| ACADIA PHARMACEUTICALS INC | 2,663,925 | 2,563,209 | -100,716 | 44,248 | 55,288 | 11.76% | +11,041 |
| PROTHENA CORP PLC SHS | 0 | 1,274,753 | +1,274,753 | 0 | 7,738 | 1.65% | +7,738 |
| DISC MEDICINE INC(IRON) | 0 | 145,691 | +145,691 | 0 | 7,716 | 1.64% | +7,716 |
| ALKERMES PLC(ALKS) | 0 | 221,021 | +221,021 | 0 | 6,323 | 1.35% | +6,323 |
| IOVANCE BIOTHERAPEUTICS INC(IOVA) | 0 | 3,429,329 | +3,429,329 | 0 | 5,898 | 1.25% | +5,898 |
| AVIDITY BIOSCIENCES INC | 0 | 118,886 | +118,886 | 0 | 3,376 | 0.72% | +3,376 |
| DENALI THERAPEUTICS INC(DNLI) | 0 | 239,809 | +239,809 | 0 | 3,355 | 0.71% | +3,355 |
| TAYSHA GENE THERAPIES INC(TSHA) | 0 | 1,246,033 | +1,246,033 | 0 | 2,878 | 0.61% | +2,878 |
| BIONTECH SE-ADR(BNTX) | 0 | 25,206 | +25,206 | 0 | 2,684 | 0.57% | +2,684 |
| DYNE THERAPEUTICS INC(DYN) | 0 | 264,976 | +264,976 | 0 | 2,523 | 0.54% | +2,523 |
| CRISPR THERAPEUTICS AG(CRSP) | 0 | 44,625 | +44,625 | 0 | 2,171 | 0.46% | +2,171 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 0 | 48,750 | +48,750 | 0 | 1,773 | 0.38% | +1,773 |
| BICYCLE THERAPEUTICS PLC-ADR | 0 | 248,934 | +248,934 | 0 | 1,730 | 0.37% | +1,730 |
| TRAVERE THERAPEUTICS INC(TVTX) | 0 | 110,719 | +110,719 | 0 | 1,639 | 0.35% | +1,639 |
| NUVATION BIO INC(NUVB) | 0 | 772,652 | +772,652 | 0 | 1,507 | 0.32% | +1,507 |
| STOKE THERAPEUTICS INC(STOK) | 0 | 125,861 | +125,861 | 0 | 1,429 | 0.30% | +1,429 |
| ALIGN TECHNOLOGY INC | 37,772 | 37,772 | 0 | 6,000 | 7,151 | 1.52% | +1,151 |
| PYXIS ONCOLOGY INC | 0 | 1,037,421 | +1,037,421 | 0 | 1,141 | 0.24% | +1,141 |
| ALDEYRA THERAPEUTICS INC | 0 | 225,465 | +225,465 | 0 | 864 | 0.18% | +864 |
| AGIOS PHARMACEUTICALS INC(AGIO) | 276,578 | 268,783 | -7,795 | 8,104 | 8,940 | 1.90% | +836 |
| KARYOPHARM THERAPEUTICS INC | 0 | 187,911 | +187,911 | 0 | 810 | 0.17% | +810 |
| ACLARIS THERAPEUTICS INC(ACRS) | 776,028 | 1,390,028 | +614,000 | 1,187 | 1,974 | 0.42% | +787 |
| ALUMIS INC | 0 | 143,437 | +143,437 | 0 | 430 | 0.09% | +430 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 64,700 | 64,700 | 0 | 2,915 | 3,293 | 0.70% | +378 |
| EDWARDS LIFESCIENCES CORP | 39,473 | 39,473 | 0 | 2,861 | 3,087 | 0.66% | +226 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 13,334 | 13,334 | 0 | 1,475 | 1,676 | 0.36% | +201 |
| AKARI THERAPEUTICS PLC-ADR | 0 | 146,024 | +146,024 | 0 | 171 | 0.04% | +171 |
| GOSSAMER BIO INC | 6,276,893 | 5,739,013 | -537,880 | 6,905 | 7,059 | 1.50% | +154 |
| ABEONA THERAPEUTICS INC | 108,865 | 108,865 | 0 | 518 | 618 | 0.13% | +100 |
| UROGEN PHARMA LTD(URGN) | 24,500 | 24,500 | 0 | 271 | 336 | 0.07% | +65 |
| VYNE THERAPEUTICS INC PIPE | 445,434 | 445,434 | 0 | 704 | 735 | 0.16% | +31 |
| GENERATION BIO CO | 150,475 | 150,475 | 0 | 61 | 48 | 0.01% | -13 |
| HUMANA INC(HUM) | 3,985 | 3,985 | 0 | 1,054 | 974 | 0.21% | -80 |
| RELMADA THERAPEUTICS INC | 495,146 | 0 | -495,146 | 134 | 0 | — | -134 |
| AKARI THERAPEUTICS PLC-ADR | 146,024 | 0 | -146,024 | 181 | 0 | — | -181 |
| INSTIL BIO INC | 11,165 | 0 | -11,165 | 194 | 0 | — | -194 |
| STOKE THERAPEUTICS INC(STOK) | 125,861 | 0 | -125,861 | 837 | 0 | — | -837 |
| ANAPTYSBIO INC | 1,020,713 | 812,821 | -207,892 | 18,975 | 18,045 | 3.84% | -930 |
| PYXIS ONCOLOGY INC | 1,037,421 | 0 | -1,037,421 | 1,017 | 0 | — | -1,017 |
| KARYOPHARM THERAPEUTICS INC | 324,032 | 0 | -324,032 | 1,212 | 0 | — | -1,212 |
| ALDEYRA THERAPEUTICS INC | 225,465 | 0 | -225,465 | 1,296 | 0 | — | -1,296 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 444,367 | 444,367 | 0 | 5,459 | 4,161 | 0.89% | -1,298 |
| NUVATION BIO INC(NUVB) | 772,652 | 0 | -772,652 | 1,360 | 0 | — | -1,360 |
| TAYSHA GENE THERAPIES INC(TSHA) | 1,419,468 | 0 | -1,419,468 | 1,973 | 0 | — | -1,973 |
| TRAVERE THERAPEUTICS INC(TVTX) | 110,719 | 0 | -110,719 | 1,984 | 0 | — | -1,984 |
| BICYCLE THERAPEUTICS PLC-ADR | 248,934 | 0 | -248,934 | 2,113 | 0 | — | -2,113 |
| BIONTECH SE-ADR(BNTX) | 25,206 | 0 | -25,206 | 2,295 | 0 | — | -2,295 |
| VERVE THERAPEUTICS INC | 575,817 | 0 | -575,817 | 2,631 | 0 | — | -2,631 |
| DYNE THERAPEUTICS INC(DYN) | 333,391 | 0 | -333,391 | 3,487 | 0 | — | -3,487 |
| EHEALTH INC | 1,684,336 | 1,577,850 | -106,486 | 11,251 | 6,864 | 1.46% | -4,388 |
| ACELYRIN INC | 1,792,895 | 0 | -1,792,895 | 4,428 | 0 | — | -4,428 |
| UNITED THERAPEUTICS CORP(UTHR) | 105,228 | 95,482 | -9,746 | 32,439 | 27,437 | 5.84% | -5,002 |
| ALKERMES PLC(ALKS) | 221,513 | 0 | -221,513 | 7,314 | 0 | — | -7,314 |
| STAAR SURGICAL CO(STAA) | 525,017 | 0 | -525,017 | 9,256 | 0 | — | -9,256 |
| IOVANCE BIOTHERAPEUTICS INC(IOVA) | 3,211,314 | 0 | -3,211,314 | 10,694 | 0 | — | -10,694 |
| SAREPTA THERAPEUTICS INC(SRPT) | 210,258 | 0 | -210,258 | 13,419 | 0 | — | -13,419 |
| NOVOCURE LTD(NVCR) | 1,002,061 | 0 | -1,002,061 | 17,857 | 0 | — | -17,857 |
| PROTHENA CORP PLC SHS | 1,659,734 | 0 | -1,659,734 | 20,539 | 0 | — | -20,539 |
| PTC THERAPEUTICS INC(PTCT) | 404,196 | 0 | -404,196 | 20,598 | 0 | — | -20,598 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 83,488 | 0 | -83,488 | 22,543 | 0 | — | -22,543 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 991,207 | 840,470 | -150,737 | 70,068 | 46,201 | 9.83% | -23,868 |
| AMICUS THERAPEUTICS INC COM | 7,345,002 | 5,610,513 | -1,734,489 | 59,935 | 32,148 | 6.84% | -27,787 |
| BIOGEN INC(BIIB) | 204,923 | 0 | -204,923 | 28,042 | 0 | — | -28,042 |
| INSMED INC(INSM) | 987,153 | 0 | -987,153 | 75,310 | 0 | — | -75,310 |