Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| PTC THERAPEUTICS INC(PTCT) | 406,469 | 862,613 | +456,144 | 19,852 | 52,939 | 9.80% | +33,087 |
| DYNE THERAPEUTICS INC(DYN) | 264,976 | 1,262,674 | +997,698 | 2,523 | 15,973 | 2.96% | +13,450 |
| IOVANCE BIOTHERAPEUTICS INC(IOVA) | 3,429,329 | 7,618,132 | +4,188,803 | 5,898 | 16,531 | 3.06% | +10,633 |
| AMICUS THERAPEUTICS INC COM | 5,610,513 | 5,367,798 | -242,715 | 32,148 | 42,298 | 7.83% | +10,150 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 48,750 | 369,531 | +320,781 | 1,773 | 11,115 | 2.06% | +9,343 |
| GOSSAMER BIO INC(GOSS) | 5,739,013 | 5,464,349 | -274,664 | 7,059 | 14,371 | 2.66% | +7,312 |
| DISC MEDICINE INC(IRON) | 145,691 | 224,300 | +78,609 | 7,716 | 14,822 | 2.74% | +7,106 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 444,367 | 654,930 | +210,563 | 4,161 | 10,076 | 1.86% | +5,915 |
| PROTHENA CORP PLC SHS | 1,274,753 | 1,324,028 | +49,275 | 7,738 | 12,923 | 2.39% | +5,185 |
| CAREDX INC(CDNA) | 0 | 316,204 | +316,204 | 0 | 4,598 | 0.85% | +4,598 |
| ANAPTYSBIO INC | 812,821 | 673,520 | -139,301 | 18,045 | 20,623 | 3.82% | +2,579 |
| DENALI THERAPEUTICS INC(DNLI) | 239,809 | 408,006 | +168,197 | 3,355 | 5,924 | 1.10% | +2,569 |
| NUVATION BIO INC(NUVB) | 772,652 | 1,020,547 | +247,895 | 1,507 | 3,776 | 0.70% | +2,269 |
| AGIOS PHARMACEUTICALS INC(AGIO) | 268,783 | 265,497 | -3,286 | 8,940 | 10,657 | 1.97% | +1,717 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 64,700 | 64,700 | 0 | 3,293 | 4,743 | 0.88% | +1,451 |
| AVIDITY BIOSCIENCES INC | 118,886 | 109,831 | -9,055 | 3,376 | 4,785 | 0.89% | +1,409 |
| TAYSHA GENE THERAPIES INC(TSHA) | 1,246,033 | 1,246,033 | 0 | 2,878 | 4,075 | 0.75% | +1,196 |
| PYXIS ONCOLOGY INC(PYXS) | 1,037,421 | 1,037,421 | 0 | 1,141 | 2,303 | 0.43% | +1,162 |
| STOKE THERAPEUTICS INC(STOK) | 125,861 | 105,427 | -20,434 | 1,429 | 2,478 | 0.46% | +1,049 |
| TRAVERE THERAPEUTICS INC(TVTX) | 110,719 | 110,719 | 0 | 1,639 | 2,646 | 0.49% | +1,008 |
| ACLARIS THERAPEUTICS INC(ACRS) | 1,390,028 | 1,566,840 | +176,812 | 1,974 | 2,977 | 0.55% | +1,003 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 13,334 | 18,117 | +4,783 | 1,676 | 2,543 | 0.47% | +867 |
| ORUKA THERAPEUTICS INC(ORKA) | 0 | 59,985 | +59,985 | 0 | 791 | 0.15% | +791 |
| CRISPR THERAPEUTICS AG(CRSP) | 44,625 | 41,226 | -3,399 | 2,171 | 2,672 | 0.49% | +501 |
| PROQR THERAPEUTICS NV SHS EURO | 0 | 188,807 | +188,807 | 0 | 402 | 0.07% | +402 |
| ALDEYRA THERAPEUTICS INC(ALDX) | 225,465 | 225,465 | 0 | 864 | 1,177 | 0.22% | +313 |
| BIOGEN INC(BIIB) | 205,759 | 185,661 | -20,098 | 25,841 | 26,007 | 4.81% | +166 |
| UROGEN PHARMA LTD(URGN) | 24,500 | 24,500 | 0 | 336 | 489 | 0.09% | +153 |
| HUMANA INC(HUM) | 3,985 | 3,985 | 0 | 974 | 1,037 | 0.19% | +63 |
| GENERATION BIO CO | 150,475 | 15,047 | -135,428 | 48 | 92 | 0.02% | +44 |
| BICYCLE THERAPEUTICS PLC-ADR | 248,934 | 221,071 | -27,863 | 1,730 | 1,711 | 0.32% | -19 |
| AKARI THERAPEUTICS PLC-ADR(AKTX) | 146,024 | 146,024 | 0 | 171 | 147 | 0.03% | -23 |
| ABEONA THERAPEUTICS INC(ABEO) | 108,865 | 108,865 | 0 | 618 | 575 | 0.11% | -44 |
| EHEALTH INC(EHTH) | 1,577,850 | 1,544,619 | -33,231 | 6,864 | 6,657 | 1.23% | -206 |
| ALUMIS INC | 143,437 | 0 | -143,437 | 430 | 0 | — | -430 |
| EDWARDS LIFESCIENCES CORP | 39,473 | 33,640 | -5,833 | 3,087 | 2,616 | 0.48% | -471 |
| VYNE THERAPEUTICS INC PIPE(YARW) | 445,434 | 0 | -445,434 | 735 | 0 | — | -735 |
| BIONTECH SE-ADR(BNTX) | 25,206 | 19,614 | -5,592 | 2,684 | 1,934 | 0.36% | -749 |
| ALKERMES PLC(ALKS) | 221,021 | 183,938 | -37,083 | 6,323 | 5,518 | 1.02% | -805 |
| KARYOPHARM THERAPEUTICS INC(KPTI) | 187,911 | 0 | -187,911 | 810 | 0 | — | -810 |
| NOVOCURE LTD(NVCR) | 962,396 | 1,256,159 | +293,763 | 17,131 | 16,230 | 3.00% | -901 |
| ALIGN TECHNOLOGY INC | 37,772 | 45,735 | +7,963 | 7,151 | 5,727 | 1.06% | -1,424 |
| ACADIA PHARMACEUTICALS INC | 2,563,209 | 2,466,684 | -96,525 | 55,288 | 52,639 | 9.74% | -2,649 |
| UNITED THERAPEUTICS CORP(UTHR) | 95,482 | 58,186 | -37,296 | 27,437 | 24,392 | 4.51% | -3,045 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 840,470 | 754,007 | -86,463 | 46,201 | 40,837 | 7.56% | -5,364 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 75,535 | 32,320 | -43,215 | 24,631 | 14,738 | 2.73% | -9,893 |
| STAAR SURGICAL CO(STAA) | 791,879 | 0 | -791,879 | 13,288 | 0 | — | -13,288 |
| INSMED INC(INSM) | 865,113 | 491,805 | -373,308 | 87,065 | 70,825 | 13.11% | -16,240 |