Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2023 ▲▼ | Q4 2023 ▲▼ | Change ▲▼ | Q3 2023 ▲▼ | Q4 2023 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 0 | 154,437 | +154,437 | 0 | 29,561 | 2.66% | +29,561 |
| ACADIA PHARMACEUTICALS INC | 2,405,793 | 2,409,556 | +3,763 | 50,137 | 75,443 | 6.80% | +25,306 |
| INSMED INC(INSM) | 5,889,491 | 5,511,721 | -377,770 | 148,710 | 170,808 | 15.39% | +22,099 |
| AMICUS THERAPEUTICS INC COM | 10,524,022 | 10,373,715 | -150,307 | 127,972 | 147,203 | 13.26% | +19,231 |
| IOVANCE BIOTHERAPEUTICS INC(IOVA) | 0 | 2,106,792 | +2,106,792 | 0 | 17,128 | 1.54% | +17,128 |
| NEVRO CORP | 386,832 | 750,371 | +363,539 | 7,435 | 16,148 | 1.45% | +8,713 |
| VERVE THERAPEUTICS INC | 0 | 575,817 | +575,817 | 0 | 8,027 | 0.72% | +8,027 |
| SAREPTA THERAPEUTICS INC(SRPT) | 94,030 | 200,905 | +106,875 | 11,398 | 19,373 | 1.75% | +7,975 |
| ANAPTYSBIO INC | 431,224 | 686,882 | +255,658 | 7,745 | 14,713 | 1.33% | +6,968 |
| CYTOKINETICS INC(CYTK) | 111,717 | 111,717 | 0 | 3,291 | 9,327 | 0.84% | +6,036 |
| BLUEBIRD BIO INC | 0 | 3,333,333 | +3,333,333 | 0 | 4,600 | 0.41% | +4,600 |
| EHEALTH INC(EHTH) | 2,739,379 | 2,739,379 | 0 | 20,271 | 23,887 | 2.15% | +3,616 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 472,600 | 472,600 | 0 | 6,862 | 10,213 | 0.92% | +3,351 |
| GOSSAMER BIO INC(GOSS) | 6,530,288 | 5,958,888 | -571,400 | 5,438 | 6,530 | 0.59% | +1,092 |
| VYNE THERAPEUTICS INC PIPE(YARW) | 0 | 445,434 | +445,434 | 0 | 1,038 | 0.09% | +1,038 |
| TAYSHA GENE THERAPIES INC(TSHA) | 0 | 529,861 | +529,861 | 0 | 938 | 0.08% | +938 |
| SIGHT SCIENCES INC(SGHT) | 0 | 173,790 | +173,790 | 0 | 897 | 0.08% | +897 |
| RELMADA THERAPEUTICS INC(RLMD) | 732,400 | 732,400 | 0 | 2,197 | 3,032 | 0.27% | +835 |
| SAGE THERAPEUTICS INC | 1,005,776 | 991,525 | -14,251 | 20,699 | 21,486 | 1.94% | +787 |
| BIOGEN INC(BIIB) | 381,282 | 380,417 | -865 | 97,993 | 98,441 | 8.87% | +447 |
| UROGEN PHARMA LTD(URGN) | 24,500 | 24,500 | 0 | 343 | 368 | 0.03% | +24 |
| VANDA PHARMACEUTICALS INC(VNDA) | 278,985 | 278,985 | 0 | 1,205 | 1,177 | 0.11% | -28 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 64,700 | 64,700 | 0 | 2,045 | 1,910 | 0.17% | -135 |
| ALKERMES PLC(ALKS) | 603,400 | 603,400 | 0 | 16,901 | 16,738 | 1.51% | -163 |
| ALDEYRA THERAPEUTICS INC(ALDX) | 160,800 | 225,465 | +64,665 | 1,074 | 791 | 0.07% | -283 |
| TACTILE SYSTEMS TECHNOLOGY I(TCMD) | 27,100 | 0 | -27,100 | 381 | 0 | — | -381 |
| TRAVERE THERAPEUTICS INC(TVTX) | 166,069 | 110,719 | -55,350 | 1,485 | 995 | 0.09% | -489 |
| KEZAR LIFE SCIENCES INC | 656,200 | 0 | -656,200 | 781 | 0 | — | -781 |
| ALIGN TECHNOLOGY INC | 55,705 | 55,705 | 0 | 17,008 | 15,263 | 1.38% | -1,745 |
| NOVOCURE LTD(NVCR) | 660,275 | 561,908 | -98,367 | 10,663 | 8,389 | 0.76% | -2,274 |
| KARYOPHARM THERAPEUTICS INC(KPTI) | 5,675,876 | 5,102,193 | -573,683 | 7,606 | 4,413 | 0.40% | -3,192 |
| STAAR SURGICAL CO(STAA) | 1,374,822 | 1,376,950 | +2,128 | 55,240 | 42,975 | 3.87% | -12,266 |
| REVANCE THERAPEUTICS INC | 5,228,609 | 5,237,284 | +8,675 | 59,972 | 46,036 | 4.15% | -13,936 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 1,831,035 | 1,500,749 | -330,286 | 162,010 | 144,702 | 13.04% | -17,308 |
| PROTHENA CORP PLC SHS | 1,657,458 | 1,660,057 | +2,599 | 79,972 | 60,326 | 5.44% | -19,646 |
| UNITED THERAPEUTICS CORP(UTHR) | 575,907 | 395,784 | -180,123 | 130,080 | 87,029 | 7.84% | -43,051 |