Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| AMICUS THERAPEUTICS INC COM | 5,367,798 | 5,205,767 | -162,031 | 42,298 | 74,130 | 10.32% | +31,832 |
| PTC THERAPEUTICS INC(PTCT) | 862,613 | 903,916 | +41,303 | 52,939 | 68,661 | 9.56% | +15,723 |
| INSMED INC(INSM) | 491,805 | 489,482 | -2,323 | 70,825 | 85,189 | 11.86% | +14,365 |
| ACADIA PHARMACEUTICALS INC | 2,466,684 | 2,484,031 | +17,347 | 52,639 | 66,348 | 9.24% | +13,709 |
| COMPASS THERAPEUTICS INC | 0 | 2,532,419 | +2,532,419 | 0 | 13,599 | 1.89% | +13,599 |
| ANAPTYSBIO INC | 673,520 | 690,032 | +16,512 | 20,623 | 33,453 | 4.66% | +12,830 |
| DYNE THERAPEUTICS INC(DYN) | 1,262,674 | 1,472,197 | +209,523 | 15,973 | 28,796 | 4.01% | +12,823 |
| ANNEXON INC(ANNX) | 0 | 2,384,192 | +2,384,192 | 0 | 11,969 | 1.67% | +11,969 |
| DISC MEDICINE INC(IRON) | 224,300 | 317,456 | +93,156 | 14,822 | 25,209 | 3.51% | +10,387 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 64,700 | 156,421 | +91,721 | 4,743 | 12,356 | 1.72% | +7,613 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 654,930 | 794,507 | +139,577 | 10,076 | 16,693 | 2.32% | +6,616 |
| CAPRICOR THERAPEUTICS INC | 0 | 226,304 | +226,304 | 0 | 6,531 | 0.91% | +6,531 |
| BIOGEN INC(BIIB) | 185,661 | 183,571 | -2,090 | 26,007 | 32,307 | 4.50% | +6,299 |
| BICARA THERAPEUTICS INC | 0 | 298,575 | +298,575 | 0 | 5,025 | 0.70% | +5,025 |
| DENALI THERAPEUTICS INC(DNLI) | 408,006 | 641,239 | +233,233 | 5,924 | 10,587 | 1.47% | +4,663 |
| CAREDX INC(CDNA) | 316,204 | 478,220 | +162,016 | 4,598 | 9,010 | 1.25% | +4,412 |
| XENON PHARMACEUTICALS INC(XENE) | 0 | 96,519 | +96,519 | 0 | 4,326 | 0.60% | +4,326 |
| UNITED THERAPEUTICS CORP(UTHR) | 58,186 | 58,186 | 0 | 24,392 | 28,351 | 3.95% | +3,959 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 754,007 | 746,256 | -7,751 | 40,837 | 44,350 | 6.17% | +3,513 |
| IOVANCE BIOTHERAPEUTICS INC(IOVA) | 7,618,132 | 7,116,676 | -501,456 | 16,531 | 19,429 | 2.70% | +2,897 |
| TAYSHA GENE THERAPIES INC(TSHA) | 1,246,033 | 1,183,195 | -62,838 | 4,075 | 6,508 | 0.91% | +2,433 |
| ACLARIS THERAPEUTICS INC(ACRS) | 1,566,840 | 1,566,840 | 0 | 2,977 | 4,716 | 0.66% | +1,739 |
| TRAVERE THERAPEUTICS INC(TVTX) | 110,719 | 110,719 | 0 | 2,646 | 4,231 | 0.59% | +1,584 |
| ALKERMES PLC(ALKS) | 183,938 | 242,560 | +58,622 | 5,518 | 6,787 | 0.94% | +1,269 |
| NUVATION BIO INC(NUVB) | 1,020,547 | 538,079 | -482,468 | 3,776 | 4,821 | 0.67% | +1,045 |
| ORUKA THERAPEUTICS INC(ORKA) | 59,985 | 59,985 | 0 | 791 | 1,818 | 0.25% | +1,027 |
| INSPIRE MEDICAL SYSTEMS INC(INSP) | 0 | 8,772 | +8,772 | 0 | 809 | 0.11% | +809 |
| COMPASS PATHWAYS PLC ADR(CMPS) | 0 | 115,616 | +115,616 | 0 | 798 | 0.11% | +798 |
| ALIGN TECHNOLOGY INC | 45,735 | 41,520 | -4,215 | 5,727 | 6,483 | 0.90% | +756 |
| NOVOCURE LTD(NVCR) | 1,256,159 | 1,298,964 | +42,805 | 16,230 | 16,796 | 2.34% | +566 |
| EHEALTH INC | 1,544,619 | 1,531,429 | -13,190 | 6,657 | 7,045 | 0.98% | +387 |
| EDWARDS LIFESCIENCES CORP | 33,640 | 33,640 | 0 | 2,616 | 2,868 | 0.40% | +252 |
| GENERATION BIO CO | 0 | 15,047 | +15,047 | 0 | 85 | 0.01% | +85 |
| UROGEN PHARMA LTD(URGN) | 24,500 | 24,500 | 0 | 489 | 574 | 0.08% | +85 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 18,117 | 18,117 | 0 | 2,543 | 2,570 | 0.36% | +26 |
| ABEONA THERAPEUTICS INC | 108,865 | 108,865 | 0 | 575 | 574 | 0.08% | -1 |
| ALDEYRA THERAPEUTICS INC | 225,465 | 225,465 | 0 | 1,177 | 1,168 | 0.16% | -9 |
| HUMANA INC(HUM) | 3,985 | 3,985 | 0 | 1,037 | 1,021 | 0.14% | -16 |
| PROQR THERAPEUTICS NV SHS EURO | 188,807 | 188,807 | 0 | 402 | 381 | 0.05% | -21 |
| BIONTECH SE-ADR(BNTX) | 19,614 | 19,614 | 0 | 1,934 | 1,867 | 0.26% | -67 |
| GENERATION BIO CO | 15,047 | 0 | -15,047 | 92 | 0 | — | -92 |
| AKARI THERAPEUTICS PLC-ADR | 146,024 | 146,024 | 0 | 147 | 42 | 0.01% | -105 |
| BICYCLE THERAPEUTICS PLC-ADR | 221,071 | 221,071 | 0 | 1,711 | 1,565 | 0.22% | -146 |
| STOKE THERAPEUTICS INC(STOK) | 105,427 | 72,022 | -33,405 | 2,478 | 2,286 | 0.32% | -192 |
| PROTHENA CORP PLC SHS | 1,324,028 | 1,320,510 | -3,518 | 12,923 | 12,611 | 1.76% | -312 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 369,531 | 461,294 | +91,763 | 11,115 | 10,610 | 1.48% | -506 |
| GOSSAMER BIO INC | 5,464,349 | 4,471,592 | -992,757 | 14,371 | 13,862 | 1.93% | -509 |
| CRISPR THERAPEUTICS AG(CRSP) | 41,226 | 41,226 | 0 | 2,672 | 2,162 | 0.30% | -510 |
| PYXIS ONCOLOGY INC | 1,037,421 | 1,037,421 | 0 | 2,303 | 1,193 | 0.17% | -1,110 |
| AVIDITY BIOSCIENCES INC | 109,831 | 0 | -109,831 | 4,785 | 0 | — | -4,785 |
| AGIOS PHARMACEUTICALS INC(AGIO) | 265,497 | 212,499 | -52,998 | 10,657 | 5,784 | 0.81% | -4,873 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 32,320 | 0 | -32,320 | 14,738 | 0 | — | -14,738 |