Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Insmed Incorporated(INSM) | 491,805 | 489,482 | -2,323 | $70.82M | $85.19M | 11.86% | +$14.36M |
| Amicus Therapeutics Inc COM | 5,367,798 | 5,205,767 | -162,031 | $42.30M | $74.13M | 10.32% | +$31.83M |
| PTC Therapeutics, Inc.(PTCT) | 862,613 | 903,916 | +41,303 | $52.94M | $68.66M | 9.56% | +$15.72M |
| Acadia Pharmaceuticals Inc | 2,466,684 | 2,484,031 | +17,347 | $52.64M | $66.35M | 9.24% | +$13.71M |
| BioMarin Pharmaceutical Inc.(BMRN) | 754,007 | 746,256 | -7,751 | $40.84M | $44.35M | 6.17% | +$3.51M |
| Anaptysbio Inc | 673,520 | 690,032 | +16,512 | $20.62M | $33.45M | 4.66% | +$12.83M |
| Biogen Inc.ADS(BIIB) | 185,661 | 183,571 | -2,090 | $26.01M | $32.31M | 4.50% | +$6.30M |
| Dyne Therapeutics, Inc.ADS(DYN) | 1,262,674 | 1,472,197 | +209,523 | $15.97M | $28.80M | 4.01% | +$12.82M |
| United Therapeutics Corporation(UTHR) | 58,186 | 58,186 | 0 | $24.39M | $28.35M | 3.95% | +$3.96M |
| Disc Medicine, Inc.(IRON) | 224,300 | 317,456 | +93,156 | $14.82M | $25.21M | 3.51% | +$10.39M |
| Iovance Biotherapeutics, Inc.(IOVA) | 7,618,132 | 7,116,676 | -501,456 | $16.53M | $19.43M | 2.70% | +$2.90M |
| NovoCure Limited(NVCR) | 1,256,159 | 1,298,964 | +42,805 | $16.23M | $16.80M | 2.34% | +$566.0K |
| Syndax Pharmaceuticals, Inc.(SNDX) | 654,930 | 794,507 | +139,577 | $10.08M | $16.69M | 2.32% | +$6.62M |
| Gossamer Bio, Inc.(GOSS) | 5,464,349 | 4,471,592 | -992,757 | $14.37M | $13.86M | 1.93% | -$509.3K |
| Compass Therapeutics, Inc.(CMPX) | 0 | 2,532,419 | +2,532,419 | $0 | $13.60M | 1.89% | +$13.60M |
| Prothena Corp PlcCL A SHS | 1,324,028 | 1,320,510 | -3,518 | $12.92M | $12.61M | 1.76% | -$311.6K |
| Mirum Pharmaceuticals, Inc.(MIRM) | 64,700 | 156,421 | +91,721 | $4.74M | $12.36M | 1.72% | +$7.61M |
| Annexon, Inc.(ANNX) | 0 | 2,384,192 | +2,384,192 | $0 | $11.97M | 1.67% | +$11.97M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 369,531 | 461,294 | +91,763 | $11.12M | $10.61M | 1.48% | -$505.7K |
| Denali Therapeutics Inc.(DNLI) | 408,006 | 641,239 | +233,233 | $5.92M | $10.59M | 1.47% | +$4.66M |
| CareDx, Inc.(CDNA) | 316,204 | 478,220 | +162,016 | $4.60M | $9.01M | 1.25% | +$4.41M |
| eHealth, Inc.(EHTH) | 1,544,619 | 1,531,429 | -13,190 | $6.66M | $7.04M | 0.98% | +$387.3K |
| Alkermes plc(ALKS) | 183,938 | 242,560 | +58,622 | $5.52M | $6.79M | 0.94% | +$1.27M |
| Capricor Therapeutics, Inc.(CAPR) | 0 | 226,304 | +226,304 | $0 | $6.53M | 0.91% | +$6.53M |
| Taysha Gene Therapies, Inc.(TSHA) | 1,246,033 | 1,183,195 | -62,838 | $4.07M | $6.51M | 0.91% | +$2.43M |
| Align Technology Inc | 45,735 | 41,520 | -4,215 | $5.73M | $6.48M | 0.90% | +$756.4K |
| Agios Pharmaceuticals, Inc.(AGIO) | 265,497 | 212,499 | -52,998 | $10.66M | $5.78M | 0.81% | -$4.87M |
| Bicara Therapeutics Inc | 0 | 298,575 | +298,575 | $0 | $5.03M | 0.70% | +$5.03M |
| Nuvation Bio Inc.CL A(NUVB) | 1,020,547 | 538,079 | -482,468 | $3.78M | $4.82M | 0.67% | +$1.05M |
| Aclaris Therapeutics, Inc.(ACRS) | 1,566,840 | 1,566,840 | 0 | $2.98M | $4.72M | 0.66% | +$1.74M |
| Xenon Pharmaceuticals Inc.(XENE) | 0 | 96,519 | +96,519 | $0 | $4.33M | 0.60% | +$4.33M |
| Travere Therapeutics, Inc.(TVTX) | 110,719 | 110,719 | 0 | $2.65M | $4.23M | 0.59% | +$1.58M |
| Edwards Lifesciences Corp | 33,640 | 33,640 | 0 | $2.62M | $2.87M | 0.40% | +$251.6K |
| Neurocrine Biosciences, Inc.(NBIX) | 18,117 | 18,117 | 0 | $2.54M | $2.57M | 0.36% | +$26.3K |
| Stoke Therapeutics, Inc.(STOK) | 105,427 | 72,022 | -33,405 | $2.48M | $2.29M | 0.32% | -$191.6K |
| CRISPR Therapeutics AGNAMEN AKT(CRSP) | 41,226 | 41,226 | 0 | $2.67M | $2.16M | 0.30% | -$510.0K |
| BioNTech SE(BNTX) | 19,614 | 19,614 | 0 | $1.93M | $1.87M | 0.26% | -$67.1K |
| Oruka Therapeutics, Inc.(ORKA) | 59,985 | 59,985 | 0 | $791.3K | $1.82M | 0.25% | +$1.03M |
| Bicycle Therapeutics Plc-Adr | 221,071 | 221,071 | 0 | $1.71M | $1.57M | 0.22% | -$145.9K |
| Pyxis Oncology, Inc.(PYXS) | 1,037,421 | 1,037,421 | 0 | $2.30M | $1.19M | 0.17% | -$1.11M |
| Aldeyra Therapeutics, Inc.ADR(ALDX) | 225,465 | 225,465 | 0 | $1.18M | $1.17M | 0.16% | -$9.0K |
| Humana Inc.(HUM) | 3,985 | 3,985 | 0 | $1.04M | $1.02M | 0.14% | -$16.1K |
| Inspire Medical Systems, Inc.(INSP) | 0 | 8,772 | +8,772 | $0 | $809.0K | 0.11% | +$809.0K |
| COMPASS Pathways plcADS(CMPS) | 0 | 115,616 | +115,616 | $0 | $797.8K | 0.11% | +$797.8K |
| UroGen Pharma Ltd.(URGN) | 24,500 | 24,500 | 0 | $488.8K | $573.8K | 0.08% | +$85.0K |
| Abeona Therapeutics Inc.(ABEO) | 108,865 | 108,865 | 0 | $574.8K | $573.7K | 0.08% | -$1.1K |
| Proqr Therapeutics NvSHS EURO SHS EURO | 188,807 | 188,807 | 0 | $402.2K | $381.4K | 0.05% | -$20.8K |
| Generation Bio Co | 0 | 15,047 | +15,047 | $0 | $85.5K | 0.01% | +$85.5K |
| Akari Therapeutics, Plc(AKTX) | 146,024 | 146,024 | 0 | $147.5K | $42.2K | 0.01% | -$105.3K |
| Alnylam Pharmaceuticals, Inc.(ALNY) | 32,320 | 0 | -32,320 | $14.74M | $0 | — | -$14.74M |
| Avidity Biosciences Inc | 109,831 | 0 | -109,831 | $4.79M | $0 | — | -$4.79M |
| Generation Bio Co | 15,047 | 0 | -15,047 | $92.1K | $0 | — | -$92.1K |