Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2023 ▲▼ | Q1 2024 ▲▼ | Change ▲▼ | Q4 2023 ▲▼ | Q1 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ASCENDIS PHARMA A/S - ADR(ASND) | 10,107,400 | 10,108,400 | +1,000 | 1,273,027 | 1,528,087 | 19.44% | +255,060 |
| JANUX THERAPEUTICS INC(JANX) | 9,165,652 | 9,165,652 | 0 | 98,347 | 345,087 | 4.39% | +246,739 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 0 | 8,909,091 | +8,909,091 | 0 | 162,502 | 2.07% | +162,502 |
| DYNE THERAPEUTICS INC(DYN) | 0 | 4,954,779 | +4,954,779 | 0 | 140,666 | 1.79% | +140,666 |
| EVOLENT HEALTH INC - A(EVH) | 2,549,132 | 5,736,132 | +3,187,000 | 84,198 | 188,088 | 2.39% | +103,890 |
| PEPGEN INC(PEPG) | 8,131,952 | 10,689,545 | +2,557,593 | 55,297 | 157,136 | 2.00% | +101,839 |
| NEWAMSTERDAM PHARMA CO NV ORDINARY SHARES | 7,864,000 | 7,864,000 | 0 | 87,841 | 185,984 | 2.37% | +98,143 |
| LENZ THERAPEUTICS INC(LENZ) | 0 | 4,178,823 | +4,178,823 | 0 | 93,313 | 1.19% | +93,313 |
| 4D MOLECULAR THERAPEUTICS IN | 4,163,211 | 5,051,511 | +888,300 | 84,347 | 160,941 | 2.05% | +76,594 |
| APOGEE THERAPEUTICS INC(APGE) | 1,977,901 | 1,977,901 | 0 | 55,263 | 131,432 | 1.67% | +76,169 |
| LONGBOARD PHARMACEUTICALS IN | 0 | 3,289,119 | +3,289,119 | 0 | 71,045 | 0.90% | +71,045 |
| TYRA BIOSCIENCES INC(TYRA) | 7,236,454 | 10,416,609 | +3,180,155 | 100,225 | 170,832 | 2.17% | +70,608 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 0 | 2,333,000 | +2,333,000 | 0 | 69,990 | 0.89% | +69,990 |
| NKARTA INC(NKTX) | 7,805,129 | 10,805,129 | +3,000,000 | 51,514 | 116,803 | 1.49% | +65,290 |
| VAXCYTE INC(PCVX) | 7,891,254 | 8,203,754 | +312,500 | 495,571 | 560,398 | 7.13% | +64,828 |
| ASTRIA THERAPEUTICS INC | 0 | 4,413,150 | +4,413,150 | 0 | 62,115 | 0.79% | +62,115 |
| AVIDITY BIOSCIENCES INC | 2,454,533 | 3,282,180 | +827,647 | 22,214 | 83,761 | 1.07% | +61,548 |
| CG ONCOLOGY INC(CGON) | 0 | 1,397,433 | +1,397,433 | 0 | 61,347 | 0.78% | +61,347 |
| ARS PHARMACEUTICALS INC(SPRY) | 9,459,678 | 10,860,977 | +1,401,299 | 51,839 | 110,999 | 1.41% | +59,160 |
| AEROVATE THERAPEUTICS INC | 8,263,982 | 8,263,982 | 0 | 187,014 | 244,366 | 3.11% | +57,352 |
| GERON CORP(GERN) | 46,202,425 | 46,202,425 | 0 | 97,487 | 152,468 | 1.94% | +54,981 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 0 | 828,380 | +828,380 | 0 | 50,548 | 0.64% | +50,548 |
| LARIMAR THERAPEUTICS INC(LRMR) | 0 | 6,045,351 | +6,045,351 | 0 | 45,884 | 0.58% | +45,884 |
| STRUCTURE THERAPEUTICS INC | 486,832 | 1,510,362 | +1,023,530 | 19,843 | 64,734 | 0.82% | +44,891 |
| RXSIGHT INC(RXST) | 3,404,285 | 3,442,825 | +38,540 | 137,261 | 177,581 | 2.26% | +40,320 |
| SOLID BIOSCIENCES INC | 3,426,286 | 4,330,446 | +904,160 | 21,037 | 57,682 | 0.73% | +36,644 |
| MINERALYS THERAPEUTICS INC(MLYS) | 3,178,476 | 4,850,984 | +1,672,508 | 27,335 | 62,626 | 0.80% | +35,291 |
| GH RESEARCH PLC(GHRS) | 5,587,333 | 6,251,714 | +664,381 | 32,407 | 66,643 | 0.85% | +34,237 |
| FULCRUM THERAPEUTICS INC(FULC) | 11,609,704 | 11,609,704 | 0 | 78,366 | 109,596 | 1.39% | +31,230 |
| BOUNDLESS BIO INC(BOLD) | 0 | 2,180,631 | +2,180,631 | 0 | 31,074 | 0.40% | +31,074 |
| CYBIN INC(HELP) | 0 | 58,139,535 | +58,139,535 | 0 | 24,041 | 0.31% | +24,041 |
| BIOGEN INC(BIIB) | 532,892 | 740,727 | +207,835 | 137,896 | 159,723 | 2.03% | +21,827 |
| ALTO NEUROSCIENCE INC(ANRO) | 0 | 1,385,491 | +1,385,491 | 0 | 21,267 | 0.27% | +21,267 |
| 89BIO INC | 11,416,948 | 12,766,948 | +1,350,000 | 127,527 | 148,607 | 1.89% | +21,080 |
| WAVE LIFE SCIENCES LTD(WVE) | 18,202,009 | 18,202,009 | 0 | 91,920 | 112,306 | 1.43% | +20,386 |
| CERVOMED INC(CRVO) | 0 | 861,573 | +861,573 | 0 | 20,075 | 0.26% | +20,075 |
| VAXART INC(VXRT) | 0 | 15,384,615 | +15,384,615 | 0 | 20,000 | 0.25% | +20,000 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 0 | 938,591 | +938,591 | 0 | 19,401 | 0.25% | +19,401 |
| SERA PROGNOSTICS INC-A(SERA) | 0 | 2,024,221 | +2,024,221 | 0 | 18,420 | 0.23% | +18,420 |
| METAGENOMI INC(MGX) | 0 | 1,744,415 | +1,744,415 | 0 | 18,404 | 0.23% | +18,404 |
| IMMATICS NV(IMTX) | 0 | 1,750,000 | +1,750,000 | 0 | 18,393 | 0.23% | +18,393 |
| REGULUS THERAPEUTICS INC | 0 | 6,250,000 | +6,250,000 | 0 | 18,000 | 0.23% | +18,000 |
| ADICET BIO INC | 0 | 7,541,000 | +7,541,000 | 0 | 17,721 | 0.23% | +17,721 |
| WEREWOLF THERAPEUTICS INC(HOWL) | 6,144,881 | 6,144,881 | 0 | 23,719 | 39,819 | 0.51% | +16,100 |
| DAY ONE BIOPHARMACEUTICALS I COM | 7,809,852 | 7,809,852 | 0 | 114,024 | 129,019 | 1.64% | +14,995 |
| C4 THERAPEUTICS INC(CCCC) | 4,878,000 | 4,878,000 | 0 | 27,561 | 39,853 | 0.51% | +12,293 |
| TENAYA THERAPEUTICS INC(TNYA) | 5,507,347 | 5,755,050 | +247,703 | 17,844 | 30,099 | 0.38% | +12,255 |
| ITEOS THERAPEUTICS INC | 4,417,259 | 4,417,259 | 0 | 48,369 | 60,251 | 0.77% | +11,882 |
| ACRIVON THERAPEUTICS INC | 4,810,508 | 4,810,508 | 0 | 23,668 | 34,395 | 0.44% | +10,727 |
| LEXEO THERAPEUTICS INC(LXEO) | 0 | 660,938 | +660,938 | 0 | 10,364 | 0.13% | +10,364 |
| BLACK DIAMOND THERAPEUTICS I | 3,525,754 | 3,525,754 | 0 | 9,907 | 17,876 | 0.23% | +7,968 |
| ENLIVEN THERAPEUTICS INC | 2,122,465 | 2,122,465 | 0 | 29,375 | 37,334 | 0.47% | +7,959 |
| LEGEND BIOTECH CORP-ADR(LEGN) | 6,264,707 | 6,861,097 | +596,390 | 376,947 | 384,839 | 4.90% | +7,892 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 204,500 | 204,500 | 0 | 47,317 | 54,610 | 0.69% | +7,292 |
| BICYCLE THERAPEUTICS PLC-ADR | 800,000 | 800,000 | 0 | 14,464 | 19,920 | 0.25% | +5,456 |
| ACUMEN PHARMACEUTICALS INC(ABOS) | 14,932,063 | 14,932,063 | 0 | 57,339 | 60,475 | 0.77% | +3,136 |
| VOR BIOPHARMA INC(VOR) | 22,748,880 | 22,748,880 | 0 | 51,185 | 53,915 | 0.69% | +2,730 |
| NEWAMSTERDAM PHARMA CO NV-27 *W EXP 99/99/999 | 333,333 | 333,333 | 0 | 1,043 | 3,680 | 0.05% | +2,637 |
| UNICYCIVE THERAPEUTICS INC | 3,470,688 | 3,470,688 | 0 | 3,012 | 4,790 | 0.06% | +1,778 |
| IGM BIOSCIENCES INC | 937,500 | 937,500 | 0 | 7,791 | 9,047 | 0.12% | +1,256 |
| CHIMERIX INC | 8,800,000 | 8,800,000 | 0 | 8,470 | 9,328 | 0.12% | +858 |
| ELIEM THERAPEUTICS INC(CLYM) | 13,150,849 | 13,150,849 | 0 | 35,507 | 36,033 | 0.46% | +526 |
| AXSOME THERAPEUTICS INC(AXSM) | 1,000,000 | 1,000,000 | 0 | 79,590 | 79,800 | 1.02% | +210 |
| ARVINAS INC(ARVN) | 421,348 | 421,348 | 0 | 17,343 | 17,393 | 0.22% | +51 |
| UROGEN PHARMA LTD(URGN) | 3,083,430 | 3,083,430 | 0 | 46,251 | 46,251 | 0.59% | 0 |
| TAYSHA GENE THERAPIES INC(TSHA) | 18,472,503 | 10,872,503 | -7,600,000 | 32,696 | 31,204 | 0.40% | -1,492 |
| SAB BIOTHERAPEUTICS INC(SABS) | 2,374,081 | 0 | -2,374,081 | 1,632 | 0 | — | -1,632 |
| THIRD HARMONIC BIO INC | 2,033,056 | 2,033,056 | 0 | 22,303 | 19,192 | 0.24% | -3,111 |
| CONNECT BIOPHARMA HOLDINGS L | 3,062,871 | 0 | -3,062,871 | 3,614 | 0 | — | -3,614 |
| PLIANT THERAPEUTICS INC(PLRX) | 1,281,000 | 1,281,000 | 0 | 23,199 | 19,087 | 0.24% | -4,112 |
| COMPASS PATHWAYS PLC(CMPS) | 1,286,000 | 791,359 | -494,641 | 11,253 | 6,584 | 0.08% | -4,668 |
| CUREVAC NV | 2,744,270 | 1,965,707 | -778,563 | 11,553 | 5,956 | 0.08% | -5,597 |
| MACROGENICS INC(MGNX) | 4,053,077 | 2,082,021 | -1,971,056 | 38,991 | 30,647 | 0.39% | -8,343 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 5,330,412 | 5,330,412 | 0 | 245,039 | 230,967 | 2.94% | -14,072 |
| CYTEK BIOSCIENCES INC(CTKB) | 6,809,404 | 6,809,404 | 0 | 62,102 | 45,691 | 0.58% | -16,411 |
| HARPOON THERAPEUTICS INC | 1,500,000 | 0 | -1,500,000 | 17,055 | 0 | — | -17,055 |
| VERONA PHARMA PLC - ADR | 6,317,990 | 6,317,990 | 0 | 125,602 | 101,656 | 1.29% | -23,945 |
| INHIBRX INC | 4,724,207 | 2,629,837 | -2,094,370 | 179,520 | 91,939 | 1.17% | -87,581 |
| ALPINE IMMUNE SCIENCES INC | 4,909,763 | 0 | -4,909,763 | 93,580 | 0 | — | -93,580 |
| ICOSAVAX INC | 5,963,565 | 0 | -5,963,565 | 93,986 | 0 | — | -93,986 |
| AN2 THERAPEUTICS INC | 5,551,295 | 5,551,295 | 0 | 113,746 | 18,042 | 0.23% | -95,704 |
| CYMABAY THERAPEUTICS INC | 6,940,000 | 0 | -6,940,000 | 163,923 | 0 | — | -163,923 |
| IMMUNOGEN INC | 23,750,601 | 0 | -23,750,601 | 704,205 | 0 | — | -704,205 |