Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2024 ▲▼ | Q1 2025 ▲▼ | Change ▲▼ | Q4 2024 ▲▼ | Q1 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ASCENDIS PHARMA A/S - ADR(ASND) | 10,112,744 | 10,281,496 | +168,752 | 1,392,221 | 1,602,474 | 26.76% | +210,253 |
| SIONNA THERAPEUTICS INC | 0 | 10,445,322 | +10,445,322 | 0 | 109,258 | 1.82% | +109,258 |
| DISC MEDICINE INC(IRON) | 0 | 1,577,106 | +1,577,106 | 0 | 78,288 | 1.31% | +78,288 |
| MINERALYS THERAPEUTICS INC(MLYS) | 4,850,984 | 6,147,280 | +1,296,296 | 59,716 | 97,619 | 1.63% | +37,903 |
| SCHOLAR ROCK HOLDING CORP(SRRK) | 17,616 | 1,136,453 | +1,118,837 | 761 | 36,537 | 0.61% | +35,776 |
| UROGEN PHARMA LTD(URGN) | 0 | 3,206,271 | +3,206,271 | 0 | 35,461 | 0.59% | +35,461 |
| 89BIO INC | 14,175,398 | 19,889,683 | +5,714,285 | 110,852 | 144,598 | 2.41% | +33,746 |
| GH RESEARCH PLC(GHRS) | 6,686,689 | 6,944,648 | +257,959 | 46,807 | 76,599 | 1.28% | +29,793 |
| ARS PHARMACEUTICALS INC | 10,860,977 | 10,860,977 | 0 | 114,583 | 136,631 | 2.28% | +22,048 |
| GLAUKOS CORP(GKOS) | 0 | 190,256 | +190,256 | 0 | 18,725 | 0.31% | +18,725 |
| METSERA INC | 0 | 675,525 | +675,525 | 0 | 18,388 | 0.31% | +18,388 |
| ZAI LAB LTD-ADR(ZLAB) | 1,295,040 | 1,295,040 | 0 | 33,917 | 46,803 | 0.78% | +12,886 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 1,866,400 | 2,866,733 | +1,000,333 | 40,688 | 52,003 | 0.87% | +11,315 |
| ARCUS BIOSCIENCES INC(RCUS) | 0 | 1,136,364 | +1,136,364 | 0 | 8,920 | 0.15% | +8,920 |
| MONOPAR THERAPEUTICS INC | 511,207 | 511,207 | 0 | 11,247 | 18,613 | 0.31% | +7,366 |
| ACADIA HEALTHCARE CO INC(ACHC) | 0 | 217,000 | +217,000 | 0 | 6,579 | 0.11% | +6,579 |
| BETA BIONICS INC | 0 | 500,000 | +500,000 | 0 | 6,120 | 0.10% | +6,120 |
| ITEOS THERAPEUTICS INC | 2,092,259 | 3,649,057 | +1,556,798 | 16,069 | 21,785 | 0.36% | +5,716 |
| HUMACYTE INC | 0 | 3,312,356 | +3,312,356 | 0 | 5,648 | 0.09% | +5,648 |
| SURROZEN INC | 282,580 | 679,130 | +396,550 | 4,055 | 7,919 | 0.13% | +3,864 |
| SUTRO BIOPHARMA INC | 0 | 4,434,637 | +4,434,637 | 0 | 2,885 | 0.05% | +2,885 |
| AVIDITY BIOSCIENCES INC | 6,300,408 | 6,300,408 | 0 | 183,216 | 185,988 | 3.11% | +2,772 |
| INSMED INC(INSM) | 200,000 | 200,000 | 0 | 13,808 | 15,258 | 0.25% | +1,450 |
| CYTOMX THERAPEUTICS INC | 0 | 1,000,000 | +1,000,000 | 0 | 636 | 0.01% | +636 |
| TRAVERE THERAPEUTICS INC(TVTX) | 1,150,000 | 1,150,000 | 0 | 20,033 | 20,608 | 0.34% | +575 |
| AVALO THERAPEUTICS INC(AVTX) | 967,000 | 967,000 | 0 | 7,185 | 7,746 | 0.13% | +561 |
| PERCEPTIVE CAPITAL SOLUTIONS CL A ORD SHS | 750,000 | 750,000 | 0 | 7,635 | 7,725 | 0.13% | +90 |
| SCILEX HOLDING CO | 1,036,218 | 1,036,218 | 0 | 442 | 258 | 0.00% | -184 |
| REGULUS THERAPEUTICS INC | 336,843 | 0 | -336,843 | 532 | 0 | — | -532 |
| AEROVATE THERAPEUTICS INC | 9,192,092 | 9,192,092 | 0 | 24,359 | 23,072 | 0.39% | -1,287 |
| SOLID BIOSCIENCES INC | 4,330,446 | 4,330,446 | 0 | 17,322 | 16,023 | 0.27% | -1,299 |
| ALLAKOS INC | 1,129,931 | 0 | -1,129,931 | 1,367 | 0 | — | -1,367 |
| ADICET BIO INC | 7,541,000 | 7,541,000 | 0 | 7,254 | 5,693 | 0.10% | -1,561 |
| LEXEO THERAPEUTICS INC | 546,554 | 546,554 | 0 | 3,596 | 1,897 | 0.03% | -1,700 |
| NEWAMSTERDAM PHARMA CO NV-27 *W EXP 99/99/999 | 333,333 | 333,333 | 0 | 4,750 | 2,997 | 0.05% | -1,753 |
| ENLIVEN THERAPEUTICS INC | 848,986 | 848,986 | 0 | 19,102 | 16,708 | 0.28% | -2,394 |
| ELEDON PHARMACEUTICALS INC | 3,566,338 | 3,566,338 | 0 | 14,693 | 12,090 | 0.20% | -2,603 |
| BOUNDLESS BIO INC | 2,180,631 | 2,180,631 | 0 | 6,324 | 3,293 | 0.05% | -3,031 |
| WEREWOLF THERAPEUTICS INC | 6,144,881 | 6,144,881 | 0 | 9,094 | 5,974 | 0.10% | -3,120 |
| PROTARA THERAPEUTIC INC | 3,400,000 | 3,400,000 | 0 | 17,952 | 14,484 | 0.24% | -3,468 |
| BIOAGE LABS INC | 1,310,589 | 1,052,494 | -258,095 | 7,588 | 3,957 | 0.07% | -3,631 |
| TAYSHA GENE THERAPIES INC(TSHA) | 10,872,503 | 10,872,503 | 0 | 18,809 | 15,113 | 0.25% | -3,697 |
| ZURA BIO LTD | 3,217,503 | 3,217,503 | 0 | 8,044 | 4,151 | 0.07% | -3,893 |
| ACLARIS THERAPEUTICS INC(ACRS) | 4,666,667 | 4,666,667 | 0 | 11,573 | 7,140 | 0.12% | -4,433 |
| IMMATICS NV(IMTX) | 1,750,000 | 1,750,000 | 0 | 12,443 | 7,893 | 0.13% | -4,550 |
| CERIBELL INC | 824,582 | 824,582 | 0 | 21,340 | 15,840 | 0.26% | -5,500 |
| CIDARA THERAPEUTICS INC | 1,092,796 | 1,092,796 | 0 | 29,374 | 23,539 | 0.39% | -5,836 |
| ENANTA PHARMACEUTICALS INC | 1,038,000 | 0 | -1,038,000 | 5,969 | 0 | — | -5,968 |
| BICYCLE THERAPEUTICS PLC-ADR | 1,093,477 | 1,093,477 | 0 | 15,309 | 9,284 | 0.16% | -6,025 |
| ALECTOR INC | 9,695,228 | 9,695,228 | 0 | 18,324 | 11,925 | 0.20% | -6,399 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 3,181,818 | 3,181,818 | 0 | 23,705 | 17,245 | 0.29% | -6,459 |
| NKARTA INC | 10,805,129 | 10,805,129 | 0 | 26,905 | 19,881 | 0.33% | -7,023 |
| XENCOR INC(XNCR) | 575,000 | 575,000 | 0 | 13,214 | 6,118 | 0.10% | -7,095 |
| ARVINAS INC | 421,348 | 0 | -421,348 | 8,077 | 0 | — | -8,077 |
| Bright Minds Biosciences Inc | 460,829 | 206,427 | -254,402 | 16,599 | 7,446 | 0.12% | -9,153 |
| ACUMEN PHARMACEUTICALS INC | 14,932,063 | 14,932,063 | 0 | 25,683 | 16,425 | 0.27% | -9,258 |
| NURIX THERAPEUTICS INC(NRIX) | 1,333,333 | 1,333,333 | 0 | 25,120 | 15,840 | 0.26% | -9,280 |
| THIRD HARMONIC BIO INC | 960,620 | 0 | -960,620 | 9,885 | 0 | — | -9,885 |
| GERON CORP(GERN) | 30,009,536 | 60,379,366 | +30,369,830 | 106,234 | 96,003 | 1.60% | -10,231 |
| LARIMAR THERAPEUTICS INC | 6,045,351 | 6,045,351 | 0 | 23,396 | 12,998 | 0.22% | -10,398 |
| 4D MOLECULAR THERAPEUTICS IN | 4,563,211 | 4,563,211 | 0 | 25,417 | 14,739 | 0.25% | -10,678 |
| KURA ONCOLOGY INC(KURA) | 4,451,041 | 4,004,610 | -446,431 | 38,769 | 26,430 | 0.44% | -12,338 |
| APOGEE THERAPEUTICS INC(APGE) | 1,569,491 | 1,569,491 | 0 | 71,098 | 58,636 | 0.98% | -12,462 |
| IDEAYA BIOSCIENCES INC(IDYA) | 1,347,252 | 1,347,252 | 0 | 34,624 | 22,068 | 0.37% | -12,556 |
| TOURMALINE BIO INC | 2,538,925 | 2,538,925 | 0 | 51,489 | 38,617 | 0.64% | -12,872 |
| LENZ THERAPEUTICS INC | 4,178,823 | 4,178,823 | 0 | 120,643 | 107,438 | 1.79% | -13,205 |
| SERA PROGNOSTICS INC-A | 3,032,808 | 3,032,808 | 0 | 24,687 | 11,161 | 0.19% | -13,526 |
| ARCELLX INC COMMON STOCK | 2,787,327 | 3,036,527 | +249,200 | 213,760 | 199,196 | 3.33% | -14,564 |
| STRUCTURE THERAPEUTICS INC | 1,517,418 | 1,517,418 | 0 | 41,152 | 26,267 | 0.44% | -14,886 |
| VOR BIOPHARMA INC(VOR) | 39,646,039 | 39,646,039 | 0 | 44,007 | 28,446 | 0.48% | -15,561 |
| MBX BIOSCIENCES INC(MBX) | 1,511,334 | 1,511,334 | 0 | 27,854 | 11,154 | 0.19% | -16,700 |
| PLIANT THERAPEUTICS INC | 1,281,000 | 0 | -1,281,000 | 16,871 | 0 | — | -16,871 |
| C4 THERAPEUTICS INC | 4,878,000 | 0 | -4,878,000 | 17,561 | 0 | — | -17,561 |
| CLIMB BIO INC | 31,419,267 | 31,419,267 | 0 | 56,555 | 38,332 | 0.64% | -18,223 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 6,084,412 | 6,084,412 | 0 | 340,605 | 322,291 | 5.38% | -18,314 |
| ASTRIA THERAPEUTICS INC | 5,105,213 | 5,105,213 | 0 | 45,641 | 27,262 | 0.46% | -18,379 |
| FULCRUM THERAPEUTICS INC | 10,229,099 | 10,229,099 | 0 | 48,077 | 29,460 | 0.49% | -18,617 |
| NEWAMSTERDAM PHARMA CO NV ORDINARY SHARES | 8,845,000 | 10,138,938 | +1,293,938 | 227,317 | 207,544 | 3.47% | -19,772 |
| PEPGEN INC | 10,689,545 | 10,689,545 | 0 | 40,513 | 15,019 | 0.25% | -25,495 |
| DAY ONE BIOPHARMACEUTICALS I COM | 5,755,577 | 5,755,577 | 0 | 72,923 | 45,642 | 0.76% | -27,281 |
| 10X GENOMICS INC-CLASS A(TXG) | 3,279,401 | 1,944,247 | -1,335,154 | 47,092 | 16,973 | 0.28% | -30,119 |
| BICARA THERAPEUTICS INC | 6,955,993 | 6,955,993 | 0 | 121,173 | 90,637 | 1.51% | -30,537 |
| CHIMERIX INC | 8,800,000 | 0 | -8,800,000 | 30,624 | 0 | — | -30,624 |
| ACRIVON THERAPEUTICS INC | 8,340,508 | 8,340,508 | 0 | 50,210 | 16,931 | 0.28% | -33,279 |
| RXSIGHT INC | 3,743,018 | 3,743,018 | 0 | 128,685 | 94,511 | 1.58% | -34,174 |
| EVOLENT HEALTH INC - A | 3,577,197 | 0 | -3,577,197 | 40,243 | 0 | — | -40,243 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 8,909,091 | 8,909,091 | 0 | 237,873 | 196,000 | 3.27% | -41,873 |
| DYNE THERAPEUTICS INC(DYN) | 6,381,144 | 9,714,392 | +3,333,248 | 150,340 | 101,613 | 1.70% | -48,727 |
| TYRA BIOSCIENCES INC(TYRA) | 10,637,290 | 10,637,290 | 0 | 147,858 | 98,927 | 1.65% | -48,932 |
| RECURSION PHARMACEUTICALS-A(RXRX) | 7,725,096 | 0 | -7,725,096 | 52,222 | 0 | — | -52,222 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 761,955 | 0 | -761,955 | 58,640 | 0 | — | -58,640 |
| ARTIVA BIOTHERAPEUTICS INC | 9,853,302 | 9,853,302 | 0 | 99,321 | 29,560 | 0.49% | -69,761 |
| WAVE LIFE SCIENCES LTD(WVE) | 18,202,009 | 18,202,009 | 0 | 225,159 | 147,072 | 2.46% | -78,087 |
| VERONA PHARMA PLC - ADR | 1,766,830 | 0 | -1,766,830 | 82,052 | 0 | — | -82,052 |
| AXSOME THERAPEUTICS INC(AXSM) | 1,000,000 | 0 | -1,000,000 | 84,610 | 0 | — | -84,610 |
| SPDR S&P BIOTECH ETF ST STR SP BIOT | 1,228,240 | 0 | -1,228,240 | 110,615 | 0 | — | -110,615 |
| SEPTERNA INC(SEPN) | 6,995,858 | 6,995,858 | 0 | 160,205 | 40,506 | 0.68% | -119,699 |
| LEGEND BIOTECH CORP-ADR(LEGN) | 7,506,934 | 0 | -7,506,934 | 244,276 | 0 | — | -244,276 |
| VAXCYTE INC(PCVX) | 8,689,190 | 12,189,149 | +3,499,959 | 711,297 | 460,262 | 7.69% | -251,035 |
| JANUX THERAPEUTICS INC(JANX) | 10,365,652 | 11,189,693 | +824,041 | 554,977 | 302,122 | 5.05% | -252,855 |