Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Ascendis Pharma A/SADR(ASND) | 10,281,496 | 10,281,496 | 0 | $2.19B | $2.35B | 24.92% | +$159.26M |
| Vaxcyte, Inc.(PCVX) | 10,724,599 | 11,474,599 | +750,000 | $494.83M | $666.79M | 7.07% | +$171.96M |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 6,666,837 | 6,666,837 | 0 | $713.62M | $579.81M | 6.14% | -$133.80M |
| Tyra Biosciences, Inc.(TYRA) | 12,198,625 | 12,198,625 | 0 | $320.70M | $467.21M | 4.95% | +$146.51M |
| Sionna Therapeutics, Inc.(SION) | 9,905,045 | 9,905,045 | 0 | $407.49M | $397.09M | 4.21% | -$10.40M |
| Edgewise Therapeutics, Inc.(EWTX) | 10,428,437 | 10,428,437 | 0 | $258.78M | $328.50M | 3.48% | +$69.71M |
| Newamsterdam Pharma Co Nv ORDINARY SHARES | 9,550,191 | 9,550,191 | 0 | $335.02M | $305.70M | 3.24% | -$29.32M |
| Nuvalent Inc-A | 1,880,057 | 2,534,145 | +654,088 | $189.11M | $259.62M | 2.75% | +$70.51M |
| Dianthus Therapeutics, Inc.(DNTH) | 1,611,733 | 2,611,733 | +1,000,000 | $66.42M | $219.18M | 2.32% | +$152.76M |
| Mineralys Therapeutics, Inc.(MLYS) | 7,323,750 | 7,692,750 | +369,000 | $265.78M | $208.40M | 2.21% | -$57.38M |
| SpyGlass Pharma, Inc.(SGP) | 0 | 8,021,117 | +8,021,117 | $0 | $207.83M | 2.20% | +$207.83M |
| Wave Life Sciences, Inc.(WVE) | 18,203,009 | 26,975,505 | +8,772,496 | $309.45M | $195.57M | 2.07% | -$113.88M |
| Septerna, Inc.(SEPN) | 6,995,858 | 6,995,858 | 0 | $195.04M | $168.11M | 1.78% | -$26.93M |
| Disc Medicine, Inc.(IRON) | 1,976,132 | 2,450,221 | +474,089 | $156.92M | $156.67M | 1.66% | -$257.5K |
| Janux Therapeutics, Inc.(JANX) | 11,189,693 | 11,189,693 | 0 | $154.42M | $155.54M | 1.65% | +$1.12M |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 15,827,186 | 15,827,186 | 0 | $123.45M | $150.67M | 1.60% | +$27.22M |
| Bicara Therapeutics Inc | 6,955,993 | 7,255,993 | +300,000 | $117.07M | $144.32M | 1.53% | +$27.25M |
| Praxis Precision Medicines, Inc.(PRAX) | 373,787 | 373,787 | 0 | $110.17M | $120.43M | 1.28% | +$10.26M |
| GH Research PLC(GHRS) | 7,676,697 | 7,676,697 | 0 | $97.49M | $107.93M | 1.14% | +$10.44M |
| Zai Lab Limited(ZLAB) | 0 | 5,707,262 | +5,707,262 | $0 | $107.35M | 1.14% | +$107.35M |
| Taysha Gene Therapies, Inc.(TSHA) | 23,555,648 | 23,555,648 | 0 | $129.56M | $105.29M | 1.12% | -$24.26M |
| Vor Biopharma Inc.(VOR) | 5,404,998 | 5,404,998 | 0 | $70.70M | $96.43M | 1.02% | +$25.73M |
| Geron Corporation(GERN) | 63,771,366 | 63,771,366 | 0 | $84.18M | $95.02M | 1.01% | +$10.84M |
| ARS Pharmaceuticals, Inc.(SPRY) | 10,860,977 | 10,860,977 | 0 | $126.53M | $87.21M | 0.92% | -$39.32M |
| Sarepta Therapeutics, Inc.(SRPT) | 0 | 3,902,596 | +3,902,596 | $0 | $84.92M | 0.90% | +$84.92M |
| Spyre Therapeutics, Inc.(SYRE) | 1,621,620 | 1,621,620 | 0 | $53.12M | $81.79M | 0.87% | +$28.67M |
| Evommune, Inc.(EVMN) | 3,458,770 | 3,494,638 | +35,868 | $59.21M | $80.34M | 0.85% | +$21.13M |
| Climb Bio, Inc.(CLYM) | 11,293,828 | 11,300,939 | +7,111 | $77.71M | $77.41M | 0.82% | -$299.8K |
| Solid Biosciences Inc | 5,811,423 | 9,339,978 | +3,528,555 | $32.78M | $67.25M | 0.71% | +$34.47M |
| Artiva Biotherapeutics, Inc.(ARTV) | 9,853,302 | 9,853,302 | 0 | $42.27M | $63.46M | 0.67% | +$21.18M |
| Damora Therapeutics, Inc.(DMRA) | 0 | 2,399,310 | +2,399,310 | $0 | $62.14M | 0.66% | +$62.14M |
| Xencor, Inc.(XNCR) | 0 | 4,897,237 | +4,897,237 | $0 | $59.06M | 0.63% | +$59.06M |
| LB Pharmaceuticals Inc(LBRX) | 2,208,604 | 2,208,604 | 0 | $49.16M | $54.46M | 0.58% | +$5.30M |
| Jade Biosciences Inc | 3,671,083 | 3,671,083 | 0 | $56.64M | $51.58M | 0.55% | -$5.07M |
| Acumen Pharmaceuticals, Inc.(ABOS) | 14,932,063 | 20,992,669 | +6,060,606 | $31.51M | $49.54M | 0.52% | +$18.04M |
| 4d Molecular Therapeutics In | 5,653,211 | 5,049,779 | -603,432 | $42.40M | $47.01M | 0.50% | +$4.61M |
| Fulcrum Therapeutics, Inc.(FULC) | 6,053,960 | 6,053,960 | 0 | $68.47M | $46.43M | 0.49% | -$22.04M |
| Capricor Therapeutics, Inc.(CAPR) | 1,507,844 | 1,507,844 | 0 | $43.52M | $45.84M | 0.49% | +$2.32M |
| Century Therapeutics, Inc.(IPSC) | 0 | 17,754,430 | +17,754,430 | $0 | $40.13M | 0.43% | +$40.13M |
| Olema Pharmaceuticals, Inc.(OLMA) | 2,600,000 | 2,600,000 | 0 | $65.00M | $38.77M | 0.41% | -$26.23M |
| LENZ Therapeutics, Inc.(LENZ) | 4,178,823 | 4,178,823 | 0 | $66.86M | $38.24M | 0.41% | -$28.62M |
| Monopar Therapeutics Inc.(MNPR) | 667,207 | 667,207 | 0 | $43.57M | $36.56M | 0.39% | -$7.01M |
| PepGen Inc.(PEPG) | 20,064,545 | 20,064,545 | 0 | $130.62M | $35.51M | 0.38% | -$95.11M |
| Design Therapeutics, Inc.(DSGN) | 1,461,381 | 2,972,973 | +1,511,592 | $13.71M | $31.63M | 0.34% | +$17.92M |
| Mirum Pharmaceuticals, Inc.(MIRM) | 0 | 318,554 | +318,554 | $0 | $29.43M | 0.31% | +$29.43M |
| BioAge Labs, Inc.(BIOA) | 0 | 1,650,648 | +1,650,648 | $0 | $28.87M | 0.31% | +$28.87M |
| Lexeo Therapeutics, Inc.(LXEO) | 5,000,000 | 5,000,000 | 0 | $49.65M | $28.70M | 0.30% | -$20.95M |
| Assembly Biosciences Inc | 1,020,410 | 1,020,410 | 0 | $34.70M | $28.32M | 0.30% | -$6.39M |
| Rezolute, Inc.(RZLT) | 9,180,000 | 9,180,000 | 0 | $21.66M | $28.00M | 0.30% | +$6.33M |
| Aktis Oncology, Inc.(AKTS) | 0 | 1,503,084 | +1,503,084 | $0 | $26.89M | 0.28% | +$26.89M |
| ALX Oncology Holdings Inc.(ALXO) | 0 | 13,011,849 | +13,011,849 | $0 | $26.09M | 0.28% | +$26.09M |
| Aclaris Therapeutics, Inc.(ACRS) | 0 | 6,804,072 | +6,804,072 | $0 | $25.52M | 0.27% | +$25.52M |
| Ovid Therapeutics Inc.(OVID) | 10,714,000 | 10,714,000 | 0 | $17.46M | $23.79M | 0.25% | +$6.32M |
| Nkarta, Inc.(NKTX) | 10,805,129 | 10,805,129 | 0 | $19.99M | $22.80M | 0.24% | +$2.81M |
| Travere Therapeutics, Inc.(TVTX) | 0 | 746,841 | +746,841 | $0 | $22.19M | 0.24% | +$22.19M |
| GRAIL, Inc.(GRAL) | 428,266 | 428,266 | 0 | $36.66M | $22.13M | 0.23% | -$14.52M |
| C4 Therapeutics, Inc.(CCCC) | 8,000,000 | 8,000,000 | 0 | $15.28M | $21.04M | 0.22% | +$5.76M |
| Relmada Therapeutics, Inc.(RLMD) | 0 | 2,947,369 | +2,947,369 | $0 | $20.51M | 0.22% | +$20.51M |
| Benitec Biopharma Inc.(BNTC) | 1,850,000 | 1,850,000 | 0 | $24.92M | $19.70M | 0.21% | -$5.22M |
| Bright Minds Biosciences Inc.(DRUG) | 0 | 265,000 | +265,000 | $0 | $19.34M | 0.20% | +$19.34M |
| Sutro Biopharma, Inc.(STRO) | 0 | 715,307 | +715,307 | $0 | $17.82M | 0.19% | +$17.82M |
| Contineum Therapeutics, Inc.(CTNM) | 2,179,711 | 1,296,012 | -883,699 | $24.91M | $16.93M | 0.18% | -$7.99M |
| SAB Biotherapeutics, Inc.(SABS) | 4,401,500 | 4,401,500 | 0 | $16.46M | $16.86M | 0.18% | +$396.1K |
| Inspire Medical Systems, Inc.(INSP) | 141,964 | 325,663 | +183,699 | $13.09M | $16.80M | 0.18% | +$3.70M |
| Anteris Technologies Global Corp.(AVR) | 0 | 3,000,000 | +3,000,000 | $0 | $16.65M | 0.18% | +$16.65M |
| OnKure Therapeutics, Inc.(OKUR) | 0 | 3,998,333 | +3,998,333 | $0 | $16.55M | 0.18% | +$16.55M |
| Hinge Health, Inc.(HNGE) | 80,113 | 364,613 | +284,500 | $3.72M | $14.06M | 0.15% | +$10.34M |
| GeneDx Holdings Corp.(WGS) | 58,044 | 209,887 | +151,843 | $7.55M | $13.48M | 0.14% | +$5.93M |
| Waystar Holding Corp.(WAY) | 144,400 | 529,400 | +385,000 | $4.73M | $12.76M | 0.14% | +$8.03M |
| Helix Acquisition Corp. III(HLXC) | 0 | 1,250,000 | +1,250,000 | $0 | $12.70M | 0.13% | +$12.70M |
| Palisade Bio, Inc.(PALI) | 7,124,116 | 7,124,116 | 0 | $16.74M | $12.47M | 0.13% | -$4.27M |
| Acrivon Therapeutics Inc | 8,340,508 | 8,340,508 | 0 | $20.10M | $11.59M | 0.12% | -$8.51M |
| Atrium Therapeutics, Inc.(RNA) | 0 | 864,102 | +864,102 | $0 | $11.55M | 0.12% | +$11.55M |
| Karyopharm Therapeutics Inc.(KPTI) | 0 | 1,917,354 | +1,917,354 | $0 | $10.68M | 0.11% | +$10.68M |
| Avalo Therapeutics, Inc.(AVTX) | 662,968 | 662,968 | 0 | $12.04M | $9.90M | 0.10% | -$2.14M |
| Perceptive Capital Solutions CL A ORD SHS | 750,000 | 750,000 | 0 | $9.77M | $8.23M | 0.09% | -$1.54M |
| Adicet Bio Inc | 948,249 | 1,182,624 | +234,375 | $7.98M | $8.05M | 0.09% | +$69.4K |
| Newamsterdam Pharma Co Nv-27W EXP 99 99 999 *W EXP 99/99/999 | 333,333 | 333,333 | 0 | $7.67M | $6.68M | 0.07% | -$986.7K |
| Corvus Pharmaceuticals, Inc.(CRVS) | 0 | 450,000 | +450,000 | $0 | $6.58M | 0.07% | +$6.58M |
| Rani Therapeutics Holdings, Inc.(RANI) | 8,500,000 | 8,500,000 | 0 | $11.47M | $6.25M | 0.07% | -$5.23M |
| Equillium, Inc.(EQ) | 0 | 3,096,336 | +3,096,336 | $0 | $6.19M | 0.07% | +$6.19M |
| Werewolf Therapeutics, Inc.(HOWL) | 6,681,307 | 6,681,307 | 0 | $4.23M | $5.56M | 0.06% | +$1.33M |
| MacroGenics, Inc.(MGNX) | 0 | 1,864,176 | +1,864,176 | $0 | $5.39M | 0.06% | +$5.39M |
| MapLight Therapeutics, Inc.(MPLT) | 0 | 248,294 | +248,294 | $0 | $5.05M | 0.05% | +$5.05M |
| Palatin Technologies, Inc.(PTN) | 70,000 | 70,000 | 0 | $1.08M | $1.22M | 0.01% | +$142.8K |
| Arcellx IncSH COMMON STOCK | 1,267,156 | 0 | -1,267,156 | $82.62M | $0 | — | -$82.62M |
| Belite Bio, IncSH(BLTE) | 432,484 | 0 | -432,484 | $69.18M | $0 | — | -$69.18M |
| Cidara Therapeutics IncSH | 3,365,523 | 0 | -3,365,523 | $743.41M | $0 | — | -$743.41M |
| Health Catalyst, Inc.SH(HCAT) | 793,749 | 0 | -793,749 | $1.90M | $0 | — | -$1.90M |
| Invivyd, Inc.SH(IVVD) | 17,119,096 | 0 | -17,119,096 | $42.28M | $0 | — | -$42.28M |
| OrthoPediatrics Corp.SH(KIDS) | 109,959 | 0 | -109,959 | $1.95M | $0 | — | -$1.95M |
| Medline Inc.SH(MDLN) | 335,000 | 0 | -335,000 | $14.07M | $0 | — | -$14.07M |
| Progyny IncSH | 96,628 | 0 | -96,628 | $2.48M | $0 | — | -$2.48M |
| Qiagen N.V.SH(QGEN) | 43,976 | 0 | -43,976 | $2.08M | $0 | — | -$2.08M |
| Avidity Biosciences IncSH | 8,641,031 | 0 | -8,641,031 | $623.28M | $0 | — | -$623.28M |