Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q1 2025 ▲▼ | Q2 2025 ▲▼ | Change ▲▼ | Q1 2025 ▲▼ | Q2 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ASCENDIS PHARMA A/S - ADR(ASND) | 10,281,496 | 10,281,496 | 0 | 1,602,474 | 1,774,586 | 29.90% | +172,112 |
| CIDARA THERAPEUTICS INC | 1,092,796 | 3,365,523 | +2,272,727 | 23,539 | 163,935 | 2.76% | +140,396 |
| SIONNA THERAPEUTICS INC(SION) | 10,445,322 | 10,445,322 | 0 | 109,258 | 181,226 | 3.05% | +71,968 |
| ARS PHARMACEUTICALS INC(SPRY) | 10,860,977 | 10,860,977 | 0 | 136,631 | 189,524 | 3.19% | +52,893 |
| 89BIO INC | 19,889,683 | 19,889,683 | 0 | 144,598 | 195,317 | 3.29% | +50,719 |
| FULCRUM THERAPEUTICS INC(FULC) | 10,229,099 | 10,229,099 | 0 | 29,460 | 70,376 | 1.19% | +40,916 |
| TAYSHA GENE THERAPIES INC(TSHA) | 10,872,503 | 23,555,648 | +12,683,145 | 15,113 | 54,414 | 0.92% | +39,301 |
| VOR BIOPHARMA INC(VOR) | 39,646,039 | 39,646,039 | 0 | 28,446 | 64,227 | 1.08% | +35,781 |
| SEPTERNA INC(SEPN) | 6,995,858 | 6,995,858 | 0 | 40,506 | 73,946 | 1.25% | +33,440 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 6,084,412 | 5,561,359 | -523,053 | 322,291 | 351,422 | 5.92% | +29,131 |
| AVIDITY BIOSCIENCES INC | 6,300,408 | 7,266,031 | +965,623 | 185,988 | 206,355 | 3.48% | +20,367 |
| TYRA BIOSCIENCES INC(TYRA) | 10,637,290 | 12,198,625 | +1,561,335 | 98,927 | 116,741 | 1.97% | +17,814 |
| GH RESEARCH PLC(GHRS) | 6,944,648 | 7,676,697 | +732,049 | 76,599 | 93,579 | 1.58% | +16,979 |
| HINGE HEALTH INC-A(HNGE) | 0 | 300,000 | +300,000 | 0 | 15,525 | 0.26% | +15,525 |
| LENZ THERAPEUTICS INC(LENZ) | 4,178,823 | 4,178,823 | 0 | 107,438 | 122,481 | 2.06% | +15,044 |
| SOLID BIOSCIENCES INC | 4,330,446 | 5,811,323 | +1,480,877 | 16,023 | 28,301 | 0.48% | +12,278 |
| JADE BIOSCIENCES INC | 0 | 1,062,326 | +1,062,326 | 0 | 10,613 | 0.18% | +10,613 |
| TANGO THERAPEUTICS INC(TNGX) | 0 | 2,000,000 | +2,000,000 | 0 | 10,240 | 0.17% | +10,240 |
| OMADA HEALTH INC(OMDA) | 0 | 400,000 | +400,000 | 0 | 7,320 | 0.12% | +7,320 |
| CYTOMX THERAPEUTICS INC(CTMX) | 1,000,000 | 2,661,331 | +1,661,331 | 636 | 6,041 | 0.10% | +5,405 |
| GENEDX HOLDINGS CORP(WGS) | 0 | 58,044 | +58,044 | 0 | 5,358 | 0.09% | +5,358 |
| DISC MEDICINE INC(IRON) | 1,577,106 | 1,577,106 | 0 | 78,288 | 83,524 | 1.41% | +5,236 |
| STRUCTURE THERAPEUTICS INC | 1,517,418 | 1,517,418 | 0 | 26,267 | 31,471 | 0.53% | +5,205 |
| LARIMAR THERAPEUTICS INC(LRMR) | 6,045,351 | 6,045,351 | 0 | 12,998 | 17,471 | 0.29% | +4,474 |
| SCHOLAR ROCK HOLDING CORP(SRRK) | 1,136,453 | 1,136,453 | 0 | 36,537 | 40,253 | 0.68% | +3,716 |
| 4D MOLECULAR THERAPEUTICS IN | 4,563,211 | 4,563,211 | 0 | 14,739 | 16,930 | 0.29% | +2,190 |
| TOURMALINE BIO INC | 2,538,925 | 2,538,925 | 0 | 38,617 | 40,597 | 0.68% | +1,980 |
| INFLARX NV(IFRX) | 0 | 1,973,233 | +1,973,233 | 0 | 1,559 | 0.03% | +1,559 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 2,866,733 | 2,866,733 | 0 | 52,003 | 53,407 | 0.90% | +1,405 |
| WEREWOLF THERAPEUTICS INC(HOWL) | 6,144,881 | 6,681,307 | +536,426 | 5,974 | 7,283 | 0.12% | +1,309 |
| BETA BIONICS INC(BBNX) | 500,000 | 500,000 | 0 | 6,120 | 7,280 | 0.12% | +1,160 |
| ACUMEN PHARMACEUTICALS INC(ABOS) | 14,932,063 | 14,932,063 | 0 | 16,425 | 17,321 | 0.29% | +896 |
| METSERA INC | 675,525 | 675,525 | 0 | 18,388 | 19,219 | 0.32% | +831 |
| ARCELLX INC COMMON STOCK | 3,036,527 | 3,036,527 | 0 | 199,196 | 199,955 | 3.37% | +759 |
| CLIMB BIO INC(CLYM) | 31,419,267 | 31,419,267 | 0 | 38,332 | 38,960 | 0.66% | +628 |
| ARCUS BIOSCIENCES INC(RCUS) | 1,136,364 | 1,136,364 | 0 | 8,920 | 9,250 | 0.16% | +330 |
| ENLIVEN THERAPEUTICS INC | 848,986 | 848,986 | 0 | 16,708 | 17,031 | 0.29% | +323 |
| PERCEPTIVE CAPITAL SOLUTIONS CL A ORD SHS | 750,000 | 750,000 | 0 | 7,725 | 7,965 | 0.13% | +240 |
| SCILEX HOLDING CO(SCLX) | 1,036,218 | 0 | -1,036,218 | 258 | 0 | — | -257 |
| MONOPAR THERAPEUTICS INC(MNPR) | 511,207 | 511,207 | 0 | 18,613 | 18,291 | 0.31% | -322 |
| NEWAMSTERDAM PHARMA CO NV-27 *W EXP 99/99/999 | 333,333 | 333,333 | 0 | 2,997 | 2,667 | 0.04% | -330 |
| ADICET BIO INC | 7,541,000 | 7,541,000 | 0 | 5,693 | 4,600 | 0.08% | -1,093 |
| LEXEO THERAPEUTICS INC(LXEO) | 546,554 | 0 | -546,554 | 1,897 | 0 | — | -1,897 |
| NKARTA INC(NKTX) | 10,805,129 | 10,805,129 | 0 | 19,881 | 17,937 | 0.30% | -1,945 |
| ELEDON PHARMACEUTICALS INC(ELDN) | 3,566,338 | 3,566,338 | 0 | 12,090 | 9,665 | 0.16% | -2,425 |
| SURROZEN INC(SRZN) | 679,130 | 602,626 | -76,504 | 7,919 | 5,387 | 0.09% | -2,531 |
| SUTRO BIOPHARMA INC(STRO) | 4,434,637 | 0 | -4,434,637 | 2,885 | 0 | — | -2,885 |
| AVALO THERAPEUTICS INC(AVTX) | 967,000 | 932,973 | -34,027 | 7,746 | 4,656 | 0.08% | -3,090 |
| PEPGEN INC(PEPG) | 10,689,545 | 10,689,545 | 0 | 15,019 | 11,865 | 0.20% | -3,153 |
| BOUNDLESS BIO INC(BOLD) | 2,180,631 | 0 | -2,180,631 | 3,293 | 0 | — | -3,293 |
| TRAVERE THERAPEUTICS INC(TVTX) | 1,150,000 | 1,150,000 | 0 | 20,608 | 17,020 | 0.29% | -3,588 |
| BIOAGE LABS INC(BIOA) | 1,052,494 | 0 | -1,052,494 | 3,957 | 0 | — | -3,957 |
| ZURA BIO LTD(ZURA) | 3,217,503 | 0 | -3,217,503 | 4,151 | 0 | — | -4,151 |
| ACADIA HEALTHCARE CO INC(ACHC) | 217,000 | 89,262 | -127,738 | 6,579 | 2,025 | 0.03% | -4,554 |
| HUMACYTE INC(HUMA) | 3,312,356 | 0 | -3,312,356 | 5,648 | 0 | — | -5,648 |
| XENCOR INC(XNCR) | 575,000 | 0 | -575,000 | 6,118 | 0 | — | -6,118 |
| MBX BIOSCIENCES INC(MBX) | 1,511,334 | 377,841 | -1,133,493 | 11,154 | 4,311 | 0.07% | -6,842 |
| ACRIVON THERAPEUTICS INC | 8,340,508 | 8,340,508 | 0 | 16,931 | 9,925 | 0.17% | -7,006 |
| ACLARIS THERAPEUTICS INC(ACRS) | 4,666,667 | 0 | -4,666,667 | 7,140 | 0 | — | -7,140 |
| Bright Minds Biosciences Inc(DRUG) | 206,427 | 0 | -206,427 | 7,446 | 0 | — | -7,446 |
| IMMATICS NV(IMTX) | 1,750,000 | 0 | -1,750,000 | 7,893 | 0 | — | -7,892 |
| DYNE THERAPEUTICS INC(DYN) | 9,714,392 | 9,714,392 | 0 | 101,613 | 92,481 | 1.56% | -9,132 |
| BICYCLE THERAPEUTICS PLC-ADR | 1,093,477 | 0 | -1,093,477 | 9,284 | 0 | — | -9,284 |
| GERON CORP(GERN) | 60,379,366 | 60,379,366 | 0 | 96,003 | 85,135 | 1.43% | -10,868 |
| SERA PROGNOSTICS INC-A(SERA) | 3,032,808 | 0 | -3,032,808 | 11,161 | 0 | — | -11,161 |
| PROTARA THERAPEUTIC INC(TARA) | 3,400,000 | 1,039,295 | -2,360,705 | 14,484 | 3,149 | 0.05% | -11,335 |
| 10X GENOMICS INC-CLASS A(TXG) | 1,944,247 | 475,343 | -1,468,904 | 16,973 | 5,504 | 0.09% | -11,469 |
| ALECTOR INC | 9,695,228 | 0 | -9,695,228 | 11,925 | 0 | — | -11,925 |
| MINERALYS THERAPEUTICS INC(MLYS) | 6,147,280 | 6,147,280 | 0 | 97,619 | 83,173 | 1.40% | -14,446 |
| ARTIVA BIOTHERAPEUTICS INC(ARTV) | 9,853,302 | 9,853,302 | 0 | 29,560 | 14,878 | 0.25% | -14,681 |
| INSMED INC(INSM) | 200,000 | 0 | -200,000 | 15,258 | 0 | — | -15,258 |
| NURIX THERAPEUTICS INC(NRIX) | 1,333,333 | 0 | -1,333,333 | 15,840 | 0 | — | -15,840 |
| CERIBELL INC(CBLL) | 824,582 | 0 | -824,582 | 15,840 | 0 | — | -15,840 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 3,181,818 | 0 | -3,181,818 | 17,245 | 0 | — | -17,245 |
| GLAUKOS CORP(GKOS) | 190,256 | 0 | -190,256 | 18,725 | 0 | — | -18,725 |
| ITEOS THERAPEUTICS INC | 3,649,057 | 0 | -3,649,057 | 21,785 | 0 | — | -21,785 |
| IDEAYA BIOSCIENCES INC(IDYA) | 1,347,252 | 0 | -1,347,252 | 22,068 | 0 | — | -22,068 |
| AEROVATE THERAPEUTICS INC | 9,192,092 | 0 | -9,192,092 | 23,072 | 0 | — | -23,072 |
| NEWAMSTERDAM PHARMA CO NV ORDINARY SHARES | 10,138,938 | 10,138,938 | 0 | 207,544 | 183,616 | 3.09% | -23,928 |
| BICARA THERAPEUTICS INC | 6,955,993 | 6,955,993 | 0 | 90,637 | 64,621 | 1.09% | -26,015 |
| KURA ONCOLOGY INC(KURA) | 4,004,610 | 0 | -4,004,610 | 26,430 | 0 | — | -26,430 |
| ASTRIA THERAPEUTICS INC | 5,105,213 | 0 | -5,105,213 | 27,262 | 0 | — | -27,262 |
| WAVE LIFE SCIENCES LTD(WVE) | 18,202,009 | 18,202,009 | 0 | 147,072 | 118,313 | 1.99% | -28,759 |
| UROGEN PHARMA LTD(URGN) | 3,206,271 | 0 | -3,206,271 | 35,461 | 0 | — | -35,461 |
| JANUX THERAPEUTICS INC(JANX) | 11,189,693 | 11,189,693 | 0 | 302,122 | 258,482 | 4.35% | -43,640 |
| DAY ONE BIOPHARMACEUTICALS I COM | 5,755,577 | 0 | -5,755,577 | 45,642 | 0 | — | -45,642 |
| RXSIGHT INC(RXST) | 3,743,018 | 3,702,967 | -40,051 | 94,511 | 48,139 | 0.81% | -46,373 |
| ZAI LAB LTD-ADR(ZLAB) | 1,295,040 | 0 | -1,295,040 | 46,803 | 0 | — | -46,803 |
| APOGEE THERAPEUTICS INC(APGE) | 1,569,491 | 0 | -1,569,491 | 58,636 | 0 | — | -58,636 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 8,909,091 | 9,902,633 | +993,542 | 196,000 | 129,824 | 2.19% | -66,176 |
| VAXCYTE INC(PCVX) | 12,189,149 | 11,965,991 | -223,158 | 460,262 | 389,014 | 6.55% | -71,248 |