Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q1 2025 ▲▼ | Q2 2025 ▲▼ | Change ▲▼ | Q1 2025 ▲▼ | Q2 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Ascendis Pharma A/SSH(ASND) | 10,281,496 | 10,281,496 | 0 | $1.60B | $1.77B | 29.90% | +$172.11M |
| Vaxcyte, Inc.SH(PCVX) | 12,189,149 | 11,965,991 | -223,158 | $460.26M | $389.01M | 6.55% | -$71.25M |
| Rhythm Pharmaceuticals, Inc.SH(RYTM) | 6,084,412 | 5,561,359 | -523,053 | $322.29M | $351.42M | 5.92% | +$29.13M |
| Janux Therapeutics, Inc.SH(JANX) | 11,189,693 | 11,189,693 | 0 | $302.12M | $258.48M | 4.35% | -$43.64M |
| Avidity Biosciences IncSH | 6,300,408 | 7,266,031 | +965,623 | $185.99M | $206.36M | 3.48% | +$20.37M |
| Arcellx IncSH COMMON STOCK | 3,036,527 | 3,036,527 | 0 | $199.20M | $199.96M | 3.37% | +$759.1K |
| 89bio IncSH | 19,889,683 | 19,889,683 | 0 | $144.60M | $195.32M | 3.29% | +$50.72M |
| ARS Pharmaceuticals, Inc.SH(SPRY) | 10,860,977 | 10,860,977 | 0 | $136.63M | $189.52M | 3.19% | +$52.89M |
| Newamsterdam Pharma Co NvSH ORDINARY SHARES | 10,138,938 | 10,138,938 | 0 | $207.54M | $183.62M | 3.09% | -$23.93M |
| Sionna Therapeutics, Inc.SH(SION) | 10,445,322 | 10,445,322 | 0 | $109.26M | $181.23M | 3.05% | +$71.97M |
| Cidara Therapeutics IncSH | 1,092,796 | 3,365,523 | +2,272,727 | $23.54M | $163.93M | 2.76% | +$140.40M |
| Edgewise Therapeutics, Inc.SH(EWTX) | 8,909,091 | 9,902,633 | +993,542 | $196.00M | $129.82M | 2.19% | -$66.18M |
| LENZ Therapeutics, Inc.SH(LENZ) | 4,178,823 | 4,178,823 | 0 | $107.44M | $122.48M | 2.06% | +$15.04M |
| Wave Life Sciences, Inc.SH(WVE) | 18,202,009 | 18,202,009 | 0 | $147.07M | $118.31M | 1.99% | -$28.76M |
| Tyra Biosciences, Inc.SH(TYRA) | 10,637,290 | 12,198,625 | +1,561,335 | $98.93M | $116.74M | 1.97% | +$17.81M |
| GH Research PLCSH(GHRS) | 6,944,648 | 7,676,697 | +732,049 | $76.60M | $93.58M | 1.58% | +$16.98M |
| Dyne Therapeutics, Inc.SH(DYN) | 9,714,392 | 9,714,392 | 0 | $101.61M | $92.48M | 1.56% | -$9.13M |
| Geron CorporationSH(GERN) | 60,379,366 | 60,379,366 | 0 | $96.00M | $85.13M | 1.43% | -$10.87M |
| Disc Medicine, Inc.SH(IRON) | 1,577,106 | 1,577,106 | 0 | $78.29M | $83.52M | 1.41% | +$5.24M |
| Mineralys Therapeutics, Inc.SH(MLYS) | 6,147,280 | 6,147,280 | 0 | $97.62M | $83.17M | 1.40% | -$14.45M |
| Septerna, Inc.SH(SEPN) | 6,995,858 | 6,995,858 | 0 | $40.51M | $73.95M | 1.25% | +$33.44M |
| Fulcrum Therapeutics, Inc.SH(FULC) | 10,229,099 | 10,229,099 | 0 | $29.46M | $70.38M | 1.19% | +$40.92M |
| Bicara Therapeutics IncSH | 6,955,993 | 6,955,993 | 0 | $90.64M | $64.62M | 1.09% | -$26.02M |
| Vor Biopharma Inc.SH(VOR) | 39,646,039 | 39,646,039 | 0 | $28.45M | $64.23M | 1.08% | +$35.78M |
| Taysha Gene Therapies, Inc.SH(TSHA) | 10,872,503 | 23,555,648 | +12,683,145 | $15.11M | $54.41M | 0.92% | +$39.30M |
| Dianthus Therapeutics, Inc.SH(DNTH) | 2,866,733 | 2,866,733 | 0 | $52.00M | $53.41M | 0.90% | +$1.40M |
| RxSight, Inc.SH(RXST) | 3,743,018 | 3,702,967 | -40,051 | $94.51M | $48.14M | 0.81% | -$46.37M |
| Tourmaline Bio IncSH | 2,538,925 | 2,538,925 | 0 | $38.62M | $40.60M | 0.68% | +$1.98M |
| Scholar Rock Holding CorporationSH(SRRK) | 1,136,453 | 1,136,453 | 0 | $36.54M | $40.25M | 0.68% | +$3.72M |
| Climb Bio, Inc.SH(CLYM) | 31,419,267 | 31,419,267 | 0 | $38.33M | $38.96M | 0.66% | +$628.4K |
| Structure Therapeutics IncSH | 1,517,418 | 1,517,418 | 0 | $26.27M | $31.47M | 0.53% | +$5.20M |
| Solid Biosciences IncSH | 4,330,446 | 5,811,323 | +1,480,877 | $16.02M | $28.30M | 0.48% | +$12.28M |
| Metsera IncSH | 675,525 | 675,525 | 0 | $18.39M | $19.22M | 0.32% | +$830.9K |
| Monopar Therapeutics Inc.SH(MNPR) | 511,207 | 511,207 | 0 | $18.61M | $18.29M | 0.31% | -$322.1K |
| Nkarta, Inc.SH(NKTX) | 10,805,129 | 10,805,129 | 0 | $19.88M | $17.94M | 0.30% | -$1.94M |
| Larimar Therapeutics, Inc.SH(LRMR) | 6,045,351 | 6,045,351 | 0 | $13.00M | $17.47M | 0.29% | +$4.47M |
| Acumen Pharmaceuticals, Inc.SH(ABOS) | 14,932,063 | 14,932,063 | 0 | $16.43M | $17.32M | 0.29% | +$895.9K |
| Enliven Therapeutics IncSH | 848,986 | 848,986 | 0 | $16.71M | $17.03M | 0.29% | +$322.6K |
| Travere Therapeutics, Inc.SH(TVTX) | 1,150,000 | 1,150,000 | 0 | $20.61M | $17.02M | 0.29% | -$3.59M |
| 4d Molecular Therapeutics InSH | 4,563,211 | 4,563,211 | 0 | $14.74M | $16.93M | 0.29% | +$2.19M |
| Hinge Health, Inc.SH(HNGE) | 0 | 300,000 | +300,000 | $0 | $15.53M | 0.26% | +$15.53M |
| Artiva Biotherapeutics, Inc.SH(ARTV) | 9,853,302 | 9,853,302 | 0 | $29.56M | $14.88M | 0.25% | -$14.68M |
| PepGen Inc.SH(PEPG) | 10,689,545 | 10,689,545 | 0 | $15.02M | $11.87M | 0.20% | -$3.15M |
| Jade Biosciences IncSH | 0 | 1,062,326 | +1,062,326 | $0 | $10.61M | 0.18% | +$10.61M |
| Tango Therapeutics, Inc.SH(TNGX) | 0 | 2,000,000 | +2,000,000 | $0 | $10.24M | 0.17% | +$10.24M |
| Acrivon Therapeutics IncSH | 8,340,508 | 8,340,508 | 0 | $16.93M | $9.93M | 0.17% | -$7.01M |
| Eledon Pharmaceuticals, Inc.SH(ELDN) | 3,566,338 | 3,566,338 | 0 | $12.09M | $9.66M | 0.16% | -$2.43M |
| Arcus Biosciences, Inc.SH(RCUS) | 1,136,364 | 1,136,364 | 0 | $8.92M | $9.25M | 0.16% | +$329.5K |
| Perceptive Capital SolutionsSH CL A ORD SHS | 750,000 | 750,000 | 0 | $7.72M | $7.96M | 0.13% | +$240.0K |
| Omada Health, Inc.SH(OMDA) | 0 | 400,000 | +400,000 | $0 | $7.32M | 0.12% | +$7.32M |
| Werewolf Therapeutics, Inc.SH(HOWL) | 6,144,881 | 6,681,307 | +536,426 | $5.97M | $7.28M | 0.12% | +$1.31M |
| Beta Bionics, Inc.SH(BBNX) | 500,000 | 500,000 | 0 | $6.12M | $7.28M | 0.12% | +$1.16M |
| CytomX Therapeutics, Inc.SH(CTMX) | 1,000,000 | 2,661,331 | +1,661,331 | $635.8K | $6.04M | 0.10% | +$5.41M |
| 10x Genomics, Inc.SH(TXG) | 1,944,247 | 475,343 | -1,468,904 | $16.97M | $5.50M | 0.09% | -$11.47M |
| Surrozen, Inc.SH(SRZN) | 679,130 | 602,626 | -76,504 | $7.92M | $5.39M | 0.09% | -$2.53M |
| GeneDx Holdings Corp.SH(WGS) | 0 | 58,044 | +58,044 | $0 | $5.36M | 0.09% | +$5.36M |
| Avalo Therapeutics, Inc.SH(AVTX) | 967,000 | 932,973 | -34,027 | $7.75M | $4.66M | 0.08% | -$3.09M |
| Adicet Bio IncSH | 7,541,000 | 7,541,000 | 0 | $5.69M | $4.60M | 0.08% | -$1.09M |
| MBX Biosciences, Inc.SH(MBX) | 1,511,334 | 377,841 | -1,133,493 | $11.15M | $4.31M | 0.07% | -$6.84M |
| Protara Therapeutics, Inc.SH(TARA) | 3,400,000 | 1,039,295 | -2,360,705 | $14.48M | $3.15M | 0.05% | -$11.33M |
| Newamsterdam Pharma Co Nv-27SH *W EXP 99/99/999 | 333,333 | 333,333 | 0 | $3.00M | $2.67M | 0.04% | -$330.0K |
| Acadia Healthcare Company, Inc.SH(ACHC) | 217,000 | 89,262 | -127,738 | $6.58M | $2.03M | 0.03% | -$4.55M |
| InflaRx N.V.SH(IFRX) | 0 | 1,973,233 | +1,973,233 | $0 | $1.56M | 0.03% | +$1.56M |
| Alector IncSH | 9,695,228 | 0 | -9,695,228 | $11.93M | $0 | — | -$11.93M |
| Apogee Therapeutics IncSH | 1,569,491 | 0 | -1,569,491 | $58.64M | $0 | — | -$58.64M |
| Astria Therapeutics IncSH | 5,105,213 | 0 | -5,105,213 | $27.26M | $0 | — | -$27.26M |
| Aerovate Therapeutics IncSH | 9,192,092 | 0 | -9,192,092 | $23.07M | $0 | — | -$23.07M |
| Bicycle Therapeutics Plc-AdrSH | 1,093,477 | 0 | -1,093,477 | $9.28M | $0 | — | -$9.28M |
| Boundless Bio, Inc.SH(BOLD) | 2,180,631 | 0 | -2,180,631 | $3.29M | $0 | — | -$3.29M |
| Day One Biopharmaceuticals ISH COM | 5,755,577 | 0 | -5,755,577 | $45.64M | $0 | — | -$45.64M |
| EyePoint, Inc.SH(EYPT) | 3,181,818 | 0 | -3,181,818 | $17.25M | $0 | — | -$17.25M |
| IDEAYA Biosciences, Inc.SH(IDYA) | 1,347,252 | 0 | -1,347,252 | $22.07M | $0 | — | -$22.07M |
| Immatics N.V.SH(IMTX) | 1,750,000 | 0 | -1,750,000 | $7.89M | $0 | — | -$7.89M |
| Insmed IncorporatedSH(INSM) | 200,000 | 0 | -200,000 | $15.26M | $0 | — | -$15.26M |
| Iteos Therapeutics IncSH | 3,649,057 | 0 | -3,649,057 | $21.78M | $0 | — | -$21.78M |
| Kura Oncology, Inc.SH(KURA) | 4,004,610 | 0 | -4,004,610 | $26.43M | $0 | — | -$26.43M |
| Lexeo Therapeutics, Inc.SH(LXEO) | 546,554 | 0 | -546,554 | $1.90M | $0 | — | -$1.90M |
| Nurix Therapeutics, Inc.SH(NRIX) | 1,333,333 | 0 | -1,333,333 | $15.84M | $0 | — | -$15.84M |
| Scilex Holding CompanySH(SCLX) | 1,036,218 | 0 | -1,036,218 | $257.5K | $0 | — | -$257.5K |
| Sera Prognostics, Inc.SH(SERA) | 3,032,808 | 0 | -3,032,808 | $11.16M | $0 | — | -$11.16M |
| Xencor, Inc.SH(XNCR) | 575,000 | 0 | -575,000 | $6.12M | $0 | — | -$6.12M |
| Zai Lab LimitedSH(ZLAB) | 1,295,040 | 0 | -1,295,040 | $46.80M | $0 | — | -$46.80M |
| Zura Bio LimitedSH(ZURA) | 3,217,503 | 0 | -3,217,503 | $4.15M | $0 | — | -$4.15M |
| Bright Minds Biosciences Inc.SH(DRUG) | 206,427 | 0 | -206,427 | $7.45M | $0 | — | -$7.45M |
| Aclaris Therapeutics, Inc.SH(ACRS) | 4,666,667 | 0 | -4,666,667 | $7.14M | $0 | — | -$7.14M |
| CeriBell, Inc.SH(CBLL) | 824,582 | 0 | -824,582 | $15.84M | $0 | — | -$15.84M |
| BioAge Labs, Inc.SH(BIOA) | 1,052,494 | 0 | -1,052,494 | $3.96M | $0 | — | -$3.96M |
| UroGen Pharma Ltd.SH(URGN) | 3,206,271 | 0 | -3,206,271 | $35.46M | $0 | — | -$35.46M |
| Humacyte, Inc.SH(HUMA) | 3,312,356 | 0 | -3,312,356 | $5.65M | $0 | — | -$5.65M |
| Glaukos CorporationSH(GKOS) | 190,256 | 0 | -190,256 | $18.72M | $0 | — | -$18.72M |
| Sutro Biopharma, Inc.SH(STRO) | 4,434,637 | 0 | -4,434,637 | $2.89M | $0 | — | -$2.89M |