Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Ascendis Pharma A/SSH(ASND) | 10,281,496 | 10,281,496 | 0 | $1.77B | $2.04B | 25.19% | +$269.48M |
| Rhythm Pharmaceuticals, Inc.SH(RYTM) | 5,561,359 | 5,681,359 | +120,000 | $351.42M | $573.76M | 7.07% | +$222.34M |
| Vaxcyte, Inc.SH(PCVX) | 11,965,991 | 11,965,991 | 0 | $389.01M | $431.01M | 5.31% | +$42.00M |
| Avidity Biosciences IncSH | 7,266,031 | 8,641,031 | +1,375,000 | $206.36M | $376.49M | 4.64% | +$170.13M |
| Cidara Therapeutics IncSH | 3,365,523 | 3,365,523 | 0 | $163.93M | $322.28M | 3.97% | +$158.35M |
| Sionna Therapeutics, Inc.SH(SION) | 10,445,322 | 10,445,322 | 0 | $181.23M | $307.20M | 3.79% | +$125.97M |
| 89bio IncSH | 19,889,683 | 19,889,683 | 0 | $195.32M | $292.38M | 3.60% | +$97.06M |
| Newamsterdam Pharma Co NvSH ORDINARY SHARES | 10,138,938 | 10,138,938 | 0 | $183.62M | $288.35M | 3.55% | +$104.74M |
| Mineralys Therapeutics, Inc.SH(MLYS) | 6,147,280 | 7,323,750 | +1,176,470 | $83.17M | $277.72M | 3.42% | +$194.54M |
| Janux Therapeutics, Inc.SH(JANX) | 11,189,693 | 11,189,693 | 0 | $258.48M | $273.48M | 3.37% | +$14.99M |
| Arcellx IncSH COMMON STOCK | 3,036,527 | 3,036,527 | 0 | $199.96M | $249.30M | 3.07% | +$49.34M |
| LENZ Therapeutics, Inc.SH(LENZ) | 4,178,823 | 4,178,823 | 0 | $122.48M | $194.65M | 2.40% | +$72.17M |
| Tyra Biosciences, Inc.SH(TYRA) | 12,198,625 | 12,198,625 | 0 | $116.74M | $170.66M | 2.10% | +$53.92M |
| Edgewise Therapeutics, Inc.SH(EWTX) | 9,902,633 | 10,428,437 | +525,804 | $129.82M | $169.15M | 2.08% | +$39.33M |
| Wave Life Sciences, Inc.SH(WVE) | 18,202,009 | 18,202,009 | 0 | $118.31M | $133.24M | 1.64% | +$14.93M |
| Septerna, Inc.SH(SEPN) | 6,995,858 | 6,995,858 | 0 | $73.95M | $131.59M | 1.62% | +$57.65M |
| Dianthus Therapeutics, Inc.SH(DNTH) | 2,866,733 | 2,866,733 | 0 | $53.41M | $112.81M | 1.39% | +$59.40M |
| Bicara Therapeutics IncSH | 6,955,993 | 6,955,993 | 0 | $64.62M | $109.84M | 1.35% | +$45.21M |
| GH Research PLCSH(GHRS) | 7,676,697 | 7,676,697 | 0 | $93.58M | $109.78M | 1.35% | +$16.20M |
| ARS Pharmaceuticals, Inc.SH(SPRY) | 10,860,977 | 10,860,977 | 0 | $189.52M | $109.15M | 1.34% | -$80.37M |
| Nuvalent Inc-ASH | 0 | 1,246,456 | +1,246,456 | $0 | $107.79M | 1.33% | +$107.79M |
| Disc Medicine, Inc.SH(IRON) | 1,577,106 | 1,577,106 | 0 | $83.52M | $104.22M | 1.28% | +$20.69M |
| Vor Biopharma Inc.SH(VOR) | 0 | 1,982,301 | +1,982,301 | $0 | $96.58M | 1.19% | +$96.58M |
| Fulcrum Therapeutics, Inc.SH(FULC) | 10,229,099 | 10,229,099 | 0 | $70.38M | $94.11M | 1.16% | +$23.73M |
| PepGen Inc.SH(PEPG) | 10,689,545 | 20,064,545 | +9,375,000 | $11.87M | $92.70M | 1.14% | +$80.83M |
| Geron CorporationSH(GERN) | 60,379,366 | 60,379,366 | 0 | $85.13M | $82.72M | 1.02% | -$2.42M |
| Taysha Gene Therapies, Inc.SH(TSHA) | 23,555,648 | 23,555,648 | 0 | $54.41M | $77.03M | 0.95% | +$22.61M |
| Belite Bio, IncSH(BLTE) | 0 | 875,000 | +875,000 | $0 | $64.75M | 0.80% | +$64.75M |
| Climb Bio, Inc.SH(CLYM) | 31,419,267 | 31,419,267 | 0 | $38.96M | $63.15M | 0.78% | +$24.19M |
| Scholar Rock Holding CorporationSH(SRRK) | 1,136,453 | 1,166,788 | +30,335 | $40.25M | $43.45M | 0.54% | +$3.20M |
| Structure Therapeutics IncSH | 1,517,418 | 1,517,418 | 0 | $31.47M | $42.49M | 0.52% | +$11.02M |
| Monopar Therapeutics Inc.SH(MNPR) | 511,207 | 511,207 | 0 | $18.29M | $41.75M | 0.51% | +$23.46M |
| 4d Molecular Therapeutics InSH | 4,563,211 | 4,563,211 | 0 | $16.93M | $39.65M | 0.49% | +$22.72M |
| Solid Biosciences IncSH | 5,811,323 | 5,811,423 | +100 | $28.30M | $35.86M | 0.44% | +$7.56M |
| Metsera IncSH | 675,525 | 675,525 | 0 | $19.22M | $35.35M | 0.44% | +$16.13M |
| Artiva Biotherapeutics, Inc.SH(ARTV) | 9,853,302 | 9,853,302 | 0 | $14.88M | $28.28M | 0.35% | +$13.40M |
| LB Pharmaceuticals IncSH(LBRX) | 0 | 1,776,958 | +1,776,958 | $0 | $28.06M | 0.35% | +$28.06M |
| Travere Therapeutics, Inc.SH(TVTX) | 1,150,000 | 1,150,000 | 0 | $17.02M | $27.48M | 0.34% | +$10.46M |
| Assembly Biosciences IncSH | 0 | 1,020,410 | +1,020,410 | $0 | $26.12M | 0.32% | +$26.12M |
| Acumen Pharmaceuticals, Inc.SH(ABOS) | 14,932,063 | 14,932,063 | 0 | $17.32M | $25.53M | 0.31% | +$8.21M |
| Contineum Therapeutics, Inc.SH(CTNM) | 0 | 2,122,000 | +2,122,000 | $0 | $24.93M | 0.31% | +$24.93M |
| Nkarta, Inc.SH(NKTX) | 10,805,129 | 10,805,129 | 0 | $17.94M | $22.37M | 0.28% | +$4.43M |
| Larimar Therapeutics, Inc.SH(LRMR) | 6,045,351 | 6,045,351 | 0 | $17.47M | $19.53M | 0.24% | +$2.06M |
| Invivyd, Inc.SH(IVVD) | 0 | 17,119,096 | +17,119,096 | $0 | $18.83M | 0.23% | +$18.83M |
| Tango Therapeutics, Inc.SH(TNGX) | 2,000,000 | 2,000,000 | 0 | $10.24M | $16.80M | 0.21% | +$6.56M |
| Prime Medicine, Inc.SH(PRME) | 0 | 3,000,000 | +3,000,000 | $0 | $16.62M | 0.20% | +$16.62M |
| Arcus Biosciences, Inc.SH(RCUS) | 1,136,364 | 1,136,364 | 0 | $9.25M | $15.45M | 0.19% | +$6.20M |
| Acrivon Therapeutics IncSH | 8,340,508 | 8,340,508 | 0 | $9.93M | $15.10M | 0.19% | +$5.17M |
| Werewolf Therapeutics, Inc.SH(HOWL) | 6,681,307 | 6,681,307 | 0 | $7.28M | $13.16M | 0.16% | +$5.88M |
| uniQure N.V.SH(QURE) | 0 | 200,000 | +200,000 | $0 | $11.67M | 0.14% | +$11.67M |
| Eledon Pharmaceuticals, Inc.SH(ELDN) | 3,566,338 | 3,566,338 | 0 | $9.66M | $9.24M | 0.11% | -$428.0K |
| Jade Biosciences IncSH | 1,062,326 | 1,062,326 | 0 | $10.61M | $9.17M | 0.11% | -$1.44M |
| SAB Biotherapeutics, Inc.SH(SABS) | 0 | 4,401,500 | +4,401,500 | $0 | $8.85M | 0.11% | +$8.85M |
| Inspire Medical Systems, Inc.SH(INSP) | 0 | 114,901 | +114,901 | $0 | $8.53M | 0.11% | +$8.53M |
| CytomX Therapeutics, Inc.SH(CTMX) | 2,661,331 | 2,661,331 | 0 | $6.04M | $8.49M | 0.10% | +$2.45M |
| Avalo Therapeutics, Inc.SH(AVTX) | 932,973 | 662,968 | -270,005 | $4.66M | $8.43M | 0.10% | +$3.77M |
| Perceptive Capital SolutionsSH CL A ORD SHS | 750,000 | 750,000 | 0 | $7.96M | $7.95M | 0.10% | -$15.0K |
| Surrozen, Inc.SH(SRZN) | 602,626 | 602,626 | 0 | $5.39M | $7.76M | 0.10% | +$2.38M |
| GeneDx Holdings Corp.SH(WGS) | 58,044 | 58,044 | 0 | $5.36M | $6.25M | 0.08% | +$895.6K |
| Adicet Bio IncSH | 7,541,000 | 7,541,000 | 0 | $4.60M | $6.11M | 0.08% | +$1.51M |
| Newamsterdam Pharma Co Nv-27SH *W EXP 99/99/999 | 333,333 | 333,333 | 0 | $2.67M | $5.70M | 0.07% | +$3.04M |
| Evolent Health, Inc.SH(EVH) | 0 | 579,052 | +579,052 | $0 | $4.90M | 0.06% | +$4.90M |
| Glaukos CorporationSH(GKOS) | 0 | 54,180 | +54,180 | $0 | $4.42M | 0.05% | +$4.42M |
| Design Therapeutics, Inc.SH(DSGN) | 0 | 475,699 | +475,699 | $0 | $3.58M | 0.04% | +$3.58M |
| Endeavour Silver Corp.SH(EXK) | 0 | 54,939 | +54,939 | $0 | $3.01M | 0.04% | +$3.01M |
| InflaRx N.V.SH(IFRX) | 1,973,233 | 1,973,233 | 0 | $1.56M | $2.64M | 0.03% | +$1.09M |
| Progyny IncSH | 0 | 96,628 | +96,628 | $0 | $2.08M | 0.03% | +$2.08M |
| Acadia Healthcare Company, Inc.SH(ACHC) | 89,262 | 0 | -89,262 | $2.03M | $0 | — | -$2.03M |
| Beta Bionics, Inc.SH(BBNX) | 500,000 | 0 | -500,000 | $7.28M | $0 | — | -$7.28M |
| Dyne Therapeutics, Inc.SH(DYN) | 9,714,392 | 0 | -9,714,392 | $92.48M | $0 | — | -$92.48M |
| Enliven Therapeutics IncSH | 848,986 | 0 | -848,986 | $17.03M | $0 | — | -$17.03M |
| Hinge Health, Inc.SH(HNGE) | 300,000 | 0 | -300,000 | $15.53M | $0 | — | -$15.53M |
| MBX Biosciences, Inc.SH(MBX) | 377,841 | 0 | -377,841 | $4.31M | $0 | — | -$4.31M |
| Omada Health, Inc.SH(OMDA) | 400,000 | 0 | -400,000 | $7.32M | $0 | — | -$7.32M |
| Protara Therapeutics, Inc.SH(TARA) | 1,039,295 | 0 | -1,039,295 | $3.15M | $0 | — | -$3.15M |
| RxSight, Inc.SH(RXST) | 3,702,967 | 0 | -3,702,967 | $48.14M | $0 | — | -$48.14M |
| 10x Genomics, Inc.SH(TXG) | 475,343 | 0 | -475,343 | $5.50M | $0 | — | -$5.50M |
| Tourmaline Bio IncSH | 2,538,925 | 0 | -2,538,925 | $40.60M | $0 | — | -$40.60M |
| Vor Biopharma Inc.SH(VOR) | 39,646,039 | 0 | -39,646,039 | $64.23M | $0 | — | -$64.23M |