Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2023 ▲▼ | Q4 2023 ▲▼ | Change ▲▼ | Q3 2023 ▲▼ | Q4 2023 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| IMMUNOGEN INC | 13,322,288 | 23,750,601 | +10,428,313 | 211,425 | 704,205 | 11.00% | +492,781 |
| ASCENDIS PHARMA A/S - ADR(ASND) | 10,719,555 | 10,107,400 | -612,155 | 1,003,779 | 1,273,027 | 19.88% | +269,248 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 5,676,067 | 5,330,412 | -345,655 | 130,124 | 245,039 | 3.83% | +114,915 |
| VAXCYTE INC(PCVX) | 7,891,254 | 7,891,254 | 0 | 402,296 | 495,571 | 7.74% | +93,275 |
| INHIBRX INC | 4,724,207 | 4,724,207 | 0 | 86,689 | 179,520 | 2.80% | +92,831 |
| AEROVATE THERAPEUTICS INC | 8,263,982 | 8,263,982 | 0 | 112,142 | 187,014 | 2.92% | +74,872 |
| CYMABAY THERAPEUTICS INC | 6,940,000 | 6,940,000 | 0 | 103,475 | 163,923 | 2.56% | +60,447 |
| RXSIGHT INC(RXST) | 3,052,796 | 3,404,285 | +351,489 | 85,142 | 137,261 | 2.14% | +52,118 |
| ICOSAVAX INC | 5,963,565 | 5,963,565 | 0 | 46,218 | 93,986 | 1.47% | +47,768 |
| NKARTA INC(NKTX) | 7,805,129 | 7,805,129 | 0 | 10,849 | 51,514 | 0.80% | +40,665 |
| ALPINE IMMUNE SCIENCES INC | 4,691,178 | 4,909,763 | +218,585 | 53,714 | 93,580 | 1.46% | +39,866 |
| MACROGENICS INC(MGNX) | 342,000 | 4,053,077 | +3,711,077 | 1,594 | 38,991 | 0.61% | +37,397 |
| 4D MOLECULAR THERAPEUTICS IN | 4,163,211 | 4,163,211 | 0 | 52,998 | 84,347 | 1.32% | +31,349 |
| C4 THERAPEUTICS INC(CCCC) | 0 | 4,878,000 | +4,878,000 | 0 | 27,561 | 0.43% | +27,561 |
| FULCRUM THERAPEUTICS INC(FULC) | 11,609,704 | 11,609,704 | 0 | 51,547 | 78,366 | 1.22% | +26,818 |
| UROGEN PHARMA LTD(URGN) | 1,483,697 | 3,083,430 | +1,599,733 | 20,787 | 46,251 | 0.72% | +25,465 |
| CYTEK BIOSCIENCES INC(CTKB) | 6,809,404 | 6,809,404 | 0 | 37,588 | 62,102 | 0.97% | +24,514 |
| AN2 THERAPEUTICS INC | 5,551,295 | 5,551,295 | 0 | 89,265 | 113,746 | 1.78% | +24,481 |
| VERONA PHARMA PLC - ADR | 6,317,990 | 6,317,990 | 0 | 102,983 | 125,602 | 1.96% | +22,618 |
| STRUCTURE THERAPEUTICS INC | 0 | 486,832 | +486,832 | 0 | 19,843 | 0.31% | +19,843 |
| DAY ONE BIOPHARMACEUTICALS I COM | 7,809,852 | 7,809,852 | 0 | 95,827 | 114,024 | 1.78% | +18,197 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 204,500 | 204,500 | 0 | 29,865 | 47,317 | 0.74% | +17,452 |
| ARVINAS INC(ARVN) | 0 | 421,348 | +421,348 | 0 | 17,343 | 0.27% | +17,343 |
| HARPOON THERAPEUTICS INC | 0 | 1,500,000 | +1,500,000 | 0 | 17,055 | 0.27% | +17,055 |
| THIRD HARMONIC BIO INC | 961,863 | 2,033,056 | +1,071,193 | 6,146 | 22,303 | 0.35% | +16,156 |
| ARS PHARMACEUTICALS INC(SPRY) | 9,459,678 | 9,459,678 | 0 | 35,758 | 51,839 | 0.81% | +16,081 |
| PEPGEN INC(PEPG) | 8,131,952 | 8,131,952 | 0 | 41,310 | 55,297 | 0.86% | +13,987 |
| APOGEE THERAPEUTICS INC(APGE) | 1,977,901 | 1,977,901 | 0 | 42,129 | 55,263 | 0.86% | +13,133 |
| SOLID BIOSCIENCES INC | 3,426,286 | 3,426,286 | 0 | 8,634 | 21,037 | 0.33% | +12,403 |
| WEREWOLF THERAPEUTICS INC(HOWL) | 6,144,881 | 6,144,881 | 0 | 13,150 | 23,719 | 0.37% | +10,569 |
| AXSOME THERAPEUTICS INC(AXSM) | 1,000,000 | 1,000,000 | 0 | 69,890 | 79,590 | 1.24% | +9,700 |
| EVOLENT HEALTH INC - A(EVH) | 2,736,680 | 2,549,132 | -187,548 | 74,520 | 84,198 | 1.32% | +9,678 |
| JANUX THERAPEUTICS INC(JANX) | 9,165,652 | 9,165,652 | 0 | 92,390 | 98,347 | 1.54% | +5,958 |
| NEWAMSTERDAM PHARMA CO NV ORDINARY SHARES | 9,000,000 | 7,864,000 | -1,136,000 | 83,250 | 87,841 | 1.37% | +4,591 |
| VOR BIOPHARMA INC(VOR) | 22,748,880 | 22,748,880 | 0 | 48,228 | 51,185 | 0.80% | +2,957 |
| CHIMERIX INC | 6,501,624 | 8,800,000 | +2,298,376 | 6,240 | 8,470 | 0.13% | +2,230 |
| COMPASS PATHWAYS PLC(CMPS) | 1,286,000 | 1,286,000 | 0 | 9,516 | 11,253 | 0.18% | +1,736 |
| SAB BIOTHERAPEUTICS INC(SABS) | 0 | 2,374,081 | +2,374,081 | 0 | 1,632 | 0.03% | +1,632 |
| BIOGEN INC(BIIB) | 532,892 | 532,892 | 0 | 136,959 | 137,896 | 2.15% | +938 |
| ELIEM THERAPEUTICS INC(CLYM) | 13,150,849 | 13,150,849 | 0 | 34,587 | 35,507 | 0.55% | +921 |
| TENAYA THERAPEUTICS INC(TNYA) | 6,718,483 | 5,507,347 | -1,211,136 | 17,132 | 17,844 | 0.28% | +712 |
| TYRA BIOSCIENCES INC(TYRA) | 7,236,454 | 7,236,454 | 0 | 99,646 | 100,225 | 1.57% | +579 |
| NEWAMSTERDAM PHARMA CO NV-27 *W EXP 99/99/999 | 333,333 | 333,333 | 0 | 633 | 1,043 | 0.02% | +410 |
| ENLIVEN THERAPEUTICS INC | 2,122,465 | 2,122,465 | 0 | 28,993 | 29,375 | 0.46% | +382 |
| UNICYCIVE THERAPEUTICS INC | 3,470,688 | 3,470,688 | 0 | 2,985 | 3,012 | 0.05% | +27 |
| ITEOS THERAPEUTICS INC | 4,417,259 | 4,417,259 | 0 | 48,369 | 48,369 | 0.76% | 0 |
| IGM BIOSCIENCES INC | 937,500 | 937,500 | 0 | 7,828 | 7,791 | 0.12% | -37 |
| BLACK DIAMOND THERAPEUTICS I | 3,525,754 | 3,525,754 | 0 | 10,119 | 9,907 | 0.15% | -212 |
| GERON CORP(GERN) | 46,202,425 | 46,202,425 | 0 | 97,949 | 97,487 | 1.52% | -462 |
| BICYCLE THERAPEUTICS PLC-ADR | 800,000 | 800,000 | 0 | 16,072 | 14,464 | 0.23% | -1,608 |
| CONNECT BIOPHARMA HOLDINGS L | 6,991,003 | 3,062,871 | -3,928,132 | 5,726 | 3,614 | 0.06% | -2,111 |
| MINERALYS THERAPEUTICS INC(MLYS) | 3,178,476 | 3,178,476 | 0 | 30,227 | 27,335 | 0.43% | -2,892 |
| NANOSTRING TECHNOLOGIES INC | 1,723,373 | 0 | -1,723,373 | 2,964 | 0 | — | -2,964 |
| ACUMEN PHARMACEUTICALS INC(ABOS) | 14,932,063 | 14,932,063 | 0 | 61,968 | 57,339 | 0.90% | -4,629 |
| TALARIS THERAPEUTICS INC | 2,403,238 | 0 | -2,403,238 | 6,753 | 0 | — | -6,753 |
| WAVE LIFE SCIENCES LTD(WVE) | 17,202,009 | 18,202,009 | +1,000,000 | 98,912 | 91,920 | 1.44% | -6,991 |
| PLIANT THERAPEUTICS INC(PLRX) | 1,762,000 | 1,281,000 | -481,000 | 30,553 | 23,199 | 0.36% | -7,354 |
| NEKTAR THERAPEUTICS(NKTR) | 18,700,000 | 0 | -18,700,000 | 11,138 | 0 | — | -11,138 |
| CELCUITY INC(CELC) | 1,400,001 | 0 | -1,400,001 | 12,796 | 0 | — | -12,796 |
| AVIDITY BIOSCIENCES INC | 6,416,998 | 2,454,533 | -3,962,465 | 40,940 | 22,214 | 0.35% | -18,727 |
| ACRIVON THERAPEUTICS INC | 4,810,508 | 4,810,508 | 0 | 45,988 | 23,668 | 0.37% | -22,321 |
| GH RESEARCH PLC(GHRS) | 5,587,333 | 5,587,333 | 0 | 56,153 | 32,407 | 0.51% | -23,746 |
| TAYSHA GENE THERAPIES INC(TSHA) | 18,472,503 | 18,472,503 | 0 | 58,373 | 32,696 | 0.51% | -25,677 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 3,370,506 | 0 | -3,370,506 | 26,930 | 0 | — | -26,930 |
| ACLARIS THERAPEUTICS INC(ACRS) | 4,398,453 | 0 | -4,398,453 | 30,129 | 0 | — | -30,129 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 2,007,946 | 0 | -2,007,946 | 30,802 | 0 | — | -30,802 |
| SOLENO THERAPEUTICS INC | 1,239,000 | 0 | -1,239,000 | 36,563 | 0 | — | -36,563 |
| LEGEND BIOTECH CORP-ADR(LEGN) | 6,264,707 | 6,264,707 | 0 | 420,800 | 376,947 | 5.89% | -43,853 |
| 89BIO INC | 11,416,948 | 11,416,948 | 0 | 176,278 | 127,527 | 1.99% | -48,750 |
| CUREVAC NV | 10,604,344 | 2,744,270 | -7,860,074 | 72,428 | 11,553 | 0.18% | -60,874 |
| COGENT BIOSCIENCES INC(COGT) | 6,416,147 | 0 | -6,416,147 | 62,557 | 0 | — | -62,557 |