Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q3 2024 ▲▼ | Q4 2024 ▲▼ | Change ▲▼ | Q3 2024 ▲▼ | Q4 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Ascendis Pharma A/SSH(ASND) | 9,710,428 | 10,112,744 | +402,316 | $1.45B | $1.39B | 18.53% | -$57.64M |
| Vaxcyte, Inc.SH(PCVX) | 8,689,190 | 8,689,190 | 0 | $992.91M | $711.30M | 9.47% | -$281.62M |
| Janux Therapeutics, Inc.SH(JANX) | 9,165,652 | 10,365,652 | +1,200,000 | $416.40M | $554.98M | 7.39% | +$138.58M |
| Rhythm Pharmaceuticals, Inc.SH(RYTM) | 6,084,412 | 6,084,412 | 0 | $318.76M | $340.61M | 4.53% | +$21.84M |
| Legend Biotech CorporationSH(LEGN) | 7,506,934 | 7,506,934 | 0 | $365.81M | $244.28M | 3.25% | -$121.54M |
| Edgewise Therapeutics, Inc.SH(EWTX) | 8,909,091 | 8,909,091 | 0 | $237.78M | $237.87M | 3.17% | +$89.1K |
| Newamsterdam Pharma Co NvSH ORDINARY SHARES | 8,064,000 | 8,845,000 | +781,000 | $133.86M | $227.32M | 3.03% | +$93.45M |
| Wave Life Sciences, Inc.SH(WVE) | 18,202,009 | 18,202,009 | 0 | $149.26M | $225.16M | 3.00% | +$75.90M |
| Arcellx IncSH COMMON STOCK | 1,851,479 | 2,787,327 | +935,848 | $154.62M | $213.76M | 2.84% | +$59.14M |
| Avidity Biosciences IncSH | 6,300,408 | 6,300,408 | 0 | $289.38M | $183.22M | 2.44% | -$106.16M |
| Septerna, Inc.SH(SEPN) | 0 | 6,995,858 | +6,995,858 | $0 | $160.21M | 2.13% | +$160.21M |
| Dyne Therapeutics, Inc.SH(DYN) | 6,381,144 | 6,381,144 | 0 | $229.21M | $150.34M | 2.00% | -$78.87M |
| Tyra Biosciences, Inc.SH(TYRA) | 10,416,609 | 10,637,290 | +220,681 | $244.89M | $147.86M | 1.97% | -$97.04M |
| RxSight, Inc.SH(RXST) | 3,916,825 | 3,743,018 | -173,807 | $193.61M | $128.68M | 1.71% | -$64.92M |
| Bicara Therapeutics IncSH | 6,955,993 | 6,955,993 | 0 | $177.17M | $121.17M | 1.61% | -$56.00M |
| LENZ Therapeutics, Inc.SH(LENZ) | 4,178,823 | 4,178,823 | 0 | $99.21M | $120.64M | 1.61% | +$21.44M |
| ARS Pharmaceuticals, Inc.SH(SPRY) | 10,860,977 | 10,860,977 | 0 | $157.48M | $114.58M | 1.52% | -$42.90M |
| 89bio IncSH | 14,175,398 | 14,175,398 | 0 | $104.90M | $110.85M | 1.48% | +$5.95M |
| Spdr S&p Biotech EtfSH ST STR SP BIOT | 0 | 1,228,240 | +1,228,240 | $0 | $110.62M | 1.47% | +$110.62M |
| Geron CorporationSH(GERN) | 32,285,755 | 30,009,536 | -2,276,219 | $146.58M | $106.23M | 1.41% | -$40.34M |
| Artiva Biotherapeutics, Inc.SH(ARTV) | 9,853,302 | 9,853,302 | 0 | $152.23M | $99.32M | 1.32% | -$52.91M |
| Axsome Therapeutics, Inc.SH(AXSM) | 1,000,000 | 1,000,000 | 0 | $89.87M | $84.61M | 1.13% | -$5.26M |
| Verona Pharma Plc - AdrSH | 5,009,653 | 1,766,830 | -3,242,823 | $144.13M | $82.05M | 1.09% | -$62.08M |
| Day One Biopharmaceuticals ISH COM | 7,871,721 | 5,755,577 | -2,116,144 | $109.65M | $72.92M | 0.97% | -$36.73M |
| Apogee Therapeutics IncSH | 1,961,863 | 1,569,491 | -392,372 | $115.24M | $71.10M | 0.95% | -$44.14M |
| Mineralys Therapeutics, Inc.SH(MLYS) | 4,850,984 | 4,850,984 | 0 | $58.75M | $59.72M | 0.79% | +$970.2K |
| Praxis Precision Medicines, Inc.SH(PRAX) | 761,955 | 761,955 | 0 | $43.84M | $58.64M | 0.78% | +$14.80M |
| Climb Bio, Inc.SH(CLYM) | 31,419,267 | 31,419,267 | 0 | $159.92M | $56.55M | 0.75% | -$103.37M |
| Recursion Pharmaceuticals, Inc.SH(RXRX) | 15,384,615 | 7,725,096 | -7,659,519 | $101.38M | $52.22M | 0.69% | -$49.16M |
| Tourmaline Bio IncSH | 2,538,925 | 2,538,925 | 0 | $65.28M | $51.49M | 0.69% | -$13.79M |
| Acrivon Therapeutics IncSH | 8,340,508 | 8,340,508 | 0 | $58.38M | $50.21M | 0.67% | -$8.17M |
| Fulcrum Therapeutics, Inc.SH(FULC) | 10,229,099 | 10,229,099 | 0 | $36.52M | $48.08M | 0.64% | +$11.56M |
| 10x Genomics, Inc.SH(TXG) | 0 | 3,279,401 | +3,279,401 | $0 | $47.09M | 0.63% | +$47.09M |
| GH Research PLCSH(GHRS) | 6,686,689 | 6,686,689 | 0 | $44.73M | $46.81M | 0.62% | +$2.07M |
| Astria Therapeutics IncSH | 5,105,213 | 5,105,213 | 0 | $56.21M | $45.64M | 0.61% | -$10.57M |
| Vor Biopharma Inc.SH(VOR) | 22,748,880 | 39,646,039 | +16,897,159 | $15.92M | $44.01M | 0.59% | +$28.08M |
| Structure Therapeutics IncSH | 1,896,772 | 1,517,418 | -379,354 | $83.25M | $41.15M | 0.55% | -$42.10M |
| Dianthus Therapeutics, Inc.SH(DNTH) | 2,333,000 | 1,866,400 | -466,600 | $63.88M | $40.69M | 0.54% | -$23.19M |
| PepGen Inc.SH(PEPG) | 10,689,545 | 10,689,545 | 0 | $91.40M | $40.51M | 0.54% | -$50.88M |
| Evolent Health, Inc.SH(EVH) | 8,514,862 | 3,577,197 | -4,937,665 | $240.80M | $40.24M | 0.54% | -$200.56M |
| Kura Oncology, Inc.SH(KURA) | 0 | 4,451,041 | +4,451,041 | $0 | $38.77M | 0.52% | +$38.77M |
| IDEAYA Biosciences, Inc.SH(IDYA) | 1,347,252 | 1,347,252 | 0 | $42.68M | $34.62M | 0.46% | -$8.06M |
| Zai Lab LimitedSH(ZLAB) | 0 | 1,295,040 | +1,295,040 | $0 | $33.92M | 0.45% | +$33.92M |
| Chimerix IncSH | 8,800,000 | 8,800,000 | 0 | $8.18M | $30.62M | 0.41% | +$22.44M |
| Cidara Therapeutics IncSH | 703,080 | 1,092,796 | +389,716 | $7.56M | $29.37M | 0.39% | +$21.82M |
| MBX Biosciences, Inc.SH(MBX) | 1,511,334 | 1,511,334 | 0 | $39.26M | $27.85M | 0.37% | -$11.41M |
| Nkarta, Inc.SH(NKTX) | 10,805,129 | 10,805,129 | 0 | $48.84M | $26.90M | 0.36% | -$21.93M |
| Acumen Pharmaceuticals, Inc.SH(ABOS) | 14,932,063 | 14,932,063 | 0 | $37.03M | $25.68M | 0.34% | -$11.35M |
| 4d Molecular Therapeutics InSH | 5,098,211 | 4,563,211 | -535,000 | $55.11M | $25.42M | 0.34% | -$29.69M |
| Nurix Therapeutics, Inc.SH(NRIX) | 0 | 1,333,333 | +1,333,333 | $0 | $25.12M | 0.33% | +$25.12M |
| Sera Prognostics, Inc.SH(SERA) | 3,032,808 | 3,032,808 | 0 | $23.66M | $24.69M | 0.33% | +$1.03M |
| Aerovate Therapeutics IncSH | 9,192,092 | 9,192,092 | 0 | $19.21M | $24.36M | 0.32% | +$5.15M |
| EyePoint, Inc.SH(EYPT) | 0 | 3,181,818 | +3,181,818 | $0 | $23.70M | 0.32% | +$23.70M |
| Larimar Therapeutics, Inc.SH(LRMR) | 6,045,351 | 6,045,351 | 0 | $39.60M | $23.40M | 0.31% | -$16.20M |
| CeriBell, Inc.SH(CBLL) | 0 | 824,582 | +824,582 | $0 | $21.34M | 0.28% | +$21.34M |
| Travere Therapeutics, Inc.SH(TVTX) | 0 | 1,150,000 | +1,150,000 | $0 | $20.03M | 0.27% | +$20.03M |
| Enliven Therapeutics IncSH | 1,061,233 | 848,986 | -212,247 | $27.10M | $19.10M | 0.25% | -$8.00M |
| Taysha Gene Therapies, Inc.SH(TSHA) | 10,872,503 | 10,872,503 | 0 | $21.85M | $18.81M | 0.25% | -$3.04M |
| Alector IncSH | 0 | 9,695,228 | +9,695,228 | $0 | $18.32M | 0.24% | +$18.32M |
| Protara Therapeutics, Inc.SH(TARA) | 1,900,000 | 3,400,000 | +1,500,000 | $3.48M | $17.95M | 0.24% | +$14.47M |
| C4 Therapeutics, Inc.SH(CCCC) | 4,878,000 | 4,878,000 | 0 | $27.80M | $17.56M | 0.23% | -$10.24M |
| Solid Biosciences IncSH | 4,330,446 | 4,330,446 | 0 | $30.18M | $17.32M | 0.23% | -$12.86M |
| Pliant Therapeutics, Inc.SH(PLRX) | 1,281,000 | 1,281,000 | 0 | $14.36M | $16.87M | 0.22% | +$2.51M |
| Bright Minds Biosciences Inc.SH(DRUG) | 0 | 460,829 | +460,829 | $0 | $16.60M | 0.22% | +$16.60M |
| Iteos Therapeutics IncSH | 3,184,711 | 2,092,259 | -1,092,452 | $32.52M | $16.07M | 0.21% | -$16.45M |
| Bicycle Therapeutics Plc-AdrSH | 2,253,000 | 1,093,477 | -1,159,523 | $50.99M | $15.31M | 0.20% | -$35.68M |
| Eledon Pharmaceuticals, Inc.SH(ELDN) | 0 | 3,566,338 | +3,566,338 | $0 | $14.69M | 0.20% | +$14.69M |
| Insmed IncorporatedSH(INSM) | 200,000 | 200,000 | 0 | $14.60M | $13.81M | 0.18% | -$792.0K |
| Xencor, Inc.SH(XNCR) | 575,000 | 575,000 | 0 | $11.56M | $13.21M | 0.18% | +$1.65M |
| Immatics N.V.SH(IMTX) | 1,750,000 | 1,750,000 | 0 | $19.97M | $12.44M | 0.17% | -$7.53M |
| Aclaris Therapeutics, Inc.SH(ACRS) | 0 | 4,666,667 | +4,666,667 | $0 | $11.57M | 0.15% | +$11.57M |
| Monopar Therapeutics Inc.SH(MNPR) | 0 | 511,207 | +511,207 | $0 | $11.25M | 0.15% | +$11.25M |
| Third Harmonic Bio IncSH | 1,280,826 | 960,620 | -320,206 | $17.36M | $9.88M | 0.13% | -$7.47M |
| Werewolf Therapeutics, Inc.SH(HOWL) | 6,144,881 | 6,144,881 | 0 | $13.03M | $9.09M | 0.12% | -$3.93M |
| Arvinas, Inc.SH(ARVN) | 421,348 | 421,348 | 0 | $10.38M | $8.08M | 0.11% | -$2.30M |
| Zura Bio LimitedSH(ZURA) | 3,217,503 | 3,217,503 | 0 | $13.06M | $8.04M | 0.11% | -$5.02M |
| Perceptive Capital SolutionsSH CL A ORD SHS | 750,000 | 750,000 | 0 | $7.51M | $7.63M | 0.10% | +$120.0K |
| BioAge Labs, Inc.SH(BIOA) | 2,210,589 | 1,310,589 | -900,000 | $45.98M | $7.59M | 0.10% | -$38.39M |
| Adicet Bio IncSH | 7,541,000 | 7,541,000 | 0 | $10.86M | $7.25M | 0.10% | -$3.60M |
| Avalo Therapeutics, Inc.SH(AVTX) | 967,000 | 967,000 | 0 | $9.19M | $7.18M | 0.10% | -$2.00M |
| Boundless Bio, Inc.SH(BOLD) | 2,180,631 | 2,180,631 | 0 | $7.57M | $6.32M | 0.08% | -$1.24M |
| Enanta Pharmaceuticals, Inc.SH(ENTA) | 0 | 1,038,000 | +1,038,000 | $0 | $5.97M | 0.08% | +$5.97M |
| Newamsterdam Pharma Co Nv-27SH *W EXP 99/99/999 | 333,333 | 333,333 | 0 | $2.33M | $4.75M | 0.06% | +$2.42M |
| Surrozen, Inc.SH(SRZN) | 282,580 | 282,580 | 0 | $3.39M | $4.06M | 0.05% | +$669.7K |
| Lexeo Therapeutics, Inc.SH(LXEO) | 546,554 | 546,554 | 0 | $4.94M | $3.60M | 0.05% | -$1.34M |
| Allakos IncSH | 0 | 1,129,931 | +1,129,931 | $0 | $1.37M | 0.02% | +$1.37M |
| Scholar Rock Holding CorporationSH(SRRK) | 0 | 17,616 | +17,616 | $0 | $761.4K | 0.01% | +$761.4K |
| Regulus Therapeutics IncSH | 766,834 | 336,843 | -429,991 | $1.20M | $532.2K | 0.01% | -$671.7K |
| Scilex Holding CompanySH(SCLX) | 261,179 | 1,036,218 | +775,039 | $241.5K | $441.8K | 0.01% | +$200.4K |
| Adagio Medical Holdings, Inc.SH(ADGM) | 1,333,926 | 0 | -1,333,926 | $3.44M | $0 | — | -$3.44M |
| Alto Neuroscience, Inc.SH(ANRO) | 2,075,154 | 0 | -2,075,154 | $23.74M | $0 | — | -$23.74M |
| An2 Therapeutics IncSH | 1,999,997 | 0 | -1,999,997 | $2.14M | $0 | — | -$2.14M |
| Biogen Inc.SH(BIIB) | 1,184,456 | 0 | -1,184,456 | $229.59M | $0 | — | -$229.59M |
| CervoMed Inc.SH(CRVO) | 817,120 | 0 | -817,120 | $11.93M | $0 | — | -$11.93M |
| CG Oncology, Inc.SH(CGON) | 1,397,433 | 0 | -1,397,433 | $52.73M | $0 | — | -$52.73M |
| Metagenomi Therapeutics, Inc.SH(MGX) | 1,305,239 | 0 | -1,305,239 | $2.83M | $0 | — | -$2.83M |
| Nuvalent Inc-ASH | 176,281 | 0 | -176,281 | $18.03M | $0 | — | -$18.03M |
| Tenaya Therapeutics, Inc.SH(TNYA) | 6,982,587 | 0 | -6,982,587 | $13.48M | $0 | — | -$13.48M |