Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2024 ▲▼ | Q4 2024 ▲▼ | Change ▲▼ | Q3 2024 ▲▼ | Q4 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| SEPTERNA INC(SEPN) | 0 | 6,995,858 | +6,995,858 | 0 | 160,205 | 2.13% | +160,205 |
| JANUX THERAPEUTICS INC(JANX) | 9,165,652 | 10,365,652 | +1,200,000 | 416,396 | 554,977 | 7.39% | +138,581 |
| SPDR S&P BIOTECH ETF ST STR SP BIOT | 0 | 1,228,240 | +1,228,240 | 0 | 110,615 | 1.47% | +110,615 |
| NEWAMSTERDAM PHARMA CO NV ORDINARY SHARES | 8,064,000 | 8,845,000 | +781,000 | 133,862 | 227,317 | 3.03% | +93,454 |
| WAVE LIFE SCIENCES LTD(WVE) | 18,202,009 | 18,202,009 | 0 | 149,256 | 225,159 | 3.00% | +75,902 |
| ARCELLX INC COMMON STOCK | 1,851,479 | 2,787,327 | +935,848 | 154,617 | 213,760 | 2.84% | +59,143 |
| 10X GENOMICS INC-CLASS A(TXG) | 0 | 3,279,401 | +3,279,401 | 0 | 47,092 | 0.63% | +47,092 |
| KURA ONCOLOGY INC(KURA) | 0 | 4,451,041 | +4,451,041 | 0 | 38,769 | 0.52% | +38,769 |
| ZAI LAB LTD-ADR(ZLAB) | 0 | 1,295,040 | +1,295,040 | 0 | 33,917 | 0.45% | +33,917 |
| VOR BIOPHARMA INC(VOR) | 22,748,880 | 39,646,039 | +16,897,159 | 15,924 | 44,007 | 0.59% | +28,083 |
| NURIX THERAPEUTICS INC(NRIX) | 0 | 1,333,333 | +1,333,333 | 0 | 25,120 | 0.33% | +25,120 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 0 | 3,181,818 | +3,181,818 | 0 | 23,705 | 0.32% | +23,705 |
| CHIMERIX INC | 8,800,000 | 8,800,000 | 0 | 8,184 | 30,624 | 0.41% | +22,440 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 6,084,412 | 6,084,412 | 0 | 318,762 | 340,605 | 4.53% | +21,843 |
| CIDARA THERAPEUTICS INC | 703,080 | 1,092,796 | +389,716 | 7,558 | 29,374 | 0.39% | +21,816 |
| LENZ THERAPEUTICS INC | 4,178,823 | 4,178,823 | 0 | 99,205 | 120,643 | 1.61% | +21,437 |
| CERIBELL INC | 0 | 824,582 | +824,582 | 0 | 21,340 | 0.28% | +21,340 |
| TRAVERE THERAPEUTICS INC(TVTX) | 0 | 1,150,000 | +1,150,000 | 0 | 20,033 | 0.27% | +20,033 |
| ALECTOR INC | 0 | 9,695,228 | +9,695,228 | 0 | 18,324 | 0.24% | +18,324 |
| Bright Minds Biosciences Inc | 0 | 460,829 | +460,829 | 0 | 16,599 | 0.22% | +16,599 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 761,955 | 761,955 | 0 | 43,843 | 58,640 | 0.78% | +14,797 |
| ELEDON PHARMACEUTICALS INC | 0 | 3,566,338 | +3,566,338 | 0 | 14,693 | 0.20% | +14,693 |
| PROTARA THERAPEUTIC INC | 1,900,000 | 3,400,000 | +1,500,000 | 3,477 | 17,952 | 0.24% | +14,475 |
| ACLARIS THERAPEUTICS INC(ACRS) | 0 | 4,666,667 | +4,666,667 | 0 | 11,573 | 0.15% | +11,573 |
| FULCRUM THERAPEUTICS INC | 10,229,099 | 10,229,099 | 0 | 36,518 | 48,077 | 0.64% | +11,559 |
| MONOPAR THERAPEUTICS INC | 0 | 511,207 | +511,207 | 0 | 11,247 | 0.15% | +11,247 |
| ENANTA PHARMACEUTICALS INC | 0 | 1,038,000 | +1,038,000 | 0 | 5,969 | 0.08% | +5,969 |
| 89BIO INC | 14,175,398 | 14,175,398 | 0 | 104,898 | 110,852 | 1.48% | +5,954 |
| AEROVATE THERAPEUTICS INC | 9,192,092 | 9,192,092 | 0 | 19,211 | 24,359 | 0.32% | +5,148 |
| PLIANT THERAPEUTICS INC | 1,281,000 | 1,281,000 | 0 | 14,360 | 16,871 | 0.22% | +2,511 |
| NEWAMSTERDAM PHARMA CO NV-27 *W EXP 99/99/999 | 333,333 | 333,333 | 0 | 2,333 | 4,750 | 0.06% | +2,417 |
| GH RESEARCH PLC(GHRS) | 6,686,689 | 6,686,689 | 0 | 44,734 | 46,807 | 0.62% | +2,073 |
| XENCOR INC(XNCR) | 575,000 | 575,000 | 0 | 11,563 | 13,214 | 0.18% | +1,650 |
| ALLAKOS INC | 0 | 1,129,931 | +1,129,931 | 0 | 1,367 | 0.02% | +1,367 |
| SERA PROGNOSTICS INC-A | 3,032,808 | 3,032,808 | 0 | 23,656 | 24,687 | 0.33% | +1,031 |
| MINERALYS THERAPEUTICS INC(MLYS) | 4,850,984 | 4,850,984 | 0 | 58,745 | 59,716 | 0.79% | +970 |
| SCHOLAR ROCK HOLDING CORP(SRRK) | 0 | 17,616 | +17,616 | 0 | 761 | 0.01% | +761 |
| SURROZEN INC | 282,580 | 282,580 | 0 | 3,385 | 4,055 | 0.05% | +670 |
| SCILEX HOLDING CO | 261,179 | 1,036,218 | +775,039 | 241 | 442 | 0.01% | +200 |
| PERCEPTIVE CAPITAL SOLUTIONS CL A ORD SHS | 750,000 | 750,000 | 0 | 7,515 | 7,635 | 0.10% | +120 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 8,909,091 | 8,909,091 | 0 | 237,784 | 237,873 | 3.17% | +89 |
| REGULUS THERAPEUTICS INC | 766,834 | 336,843 | -429,991 | 1,204 | 532 | 0.01% | -672 |
| INSMED INC(INSM) | 200,000 | 200,000 | 0 | 14,600 | 13,808 | 0.18% | -792 |
| BOUNDLESS BIO INC | 2,180,631 | 2,180,631 | 0 | 7,567 | 6,324 | 0.08% | -1,243 |
| LEXEO THERAPEUTICS INC | 546,554 | 546,554 | 0 | 4,941 | 3,596 | 0.05% | -1,345 |
| AVALO THERAPEUTICS INC(AVTX) | 967,000 | 967,000 | 0 | 9,187 | 7,185 | 0.10% | -2,002 |
| AN2 THERAPEUTICS INC | 1,999,997 | 0 | -1,999,997 | 2,140 | 0 | — | -2,140 |
| ARVINAS INC | 421,348 | 421,348 | 0 | 10,378 | 8,077 | 0.11% | -2,301 |
| METAGENOMI INC | 1,305,239 | 0 | -1,305,239 | 2,832 | 0 | — | -2,832 |
| TAYSHA GENE THERAPIES INC(TSHA) | 10,872,503 | 10,872,503 | 0 | 21,854 | 18,809 | 0.25% | -3,044 |
| ADAGIO MEDICAL HOLDINGS INC | 1,333,926 | 0 | -1,333,926 | 3,442 | 0 | — | -3,442 |
| ADICET BIO INC | 7,541,000 | 7,541,000 | 0 | 10,859 | 7,254 | 0.10% | -3,605 |
| WEREWOLF THERAPEUTICS INC | 6,144,881 | 6,144,881 | 0 | 13,027 | 9,094 | 0.12% | -3,933 |
| ZURA BIO LTD | 3,217,503 | 3,217,503 | 0 | 13,063 | 8,044 | 0.11% | -5,019 |
| AXSOME THERAPEUTICS INC(AXSM) | 1,000,000 | 1,000,000 | 0 | 89,870 | 84,610 | 1.13% | -5,260 |
| THIRD HARMONIC BIO INC | 1,280,826 | 960,620 | -320,206 | 17,355 | 9,885 | 0.13% | -7,470 |
| IMMATICS NV(IMTX) | 1,750,000 | 1,750,000 | 0 | 19,968 | 12,443 | 0.17% | -7,525 |
| ENLIVEN THERAPEUTICS INC | 1,061,233 | 848,986 | -212,247 | 27,104 | 19,102 | 0.25% | -8,002 |
| IDEAYA BIOSCIENCES INC(IDYA) | 1,347,252 | 1,347,252 | 0 | 42,681 | 34,624 | 0.46% | -8,057 |
| ACRIVON THERAPEUTICS INC | 8,340,508 | 8,340,508 | 0 | 58,384 | 50,210 | 0.67% | -8,174 |
| C4 THERAPEUTICS INC | 4,878,000 | 4,878,000 | 0 | 27,805 | 17,561 | 0.23% | -10,244 |
| ASTRIA THERAPEUTICS INC | 5,105,213 | 5,105,213 | 0 | 56,208 | 45,641 | 0.61% | -10,568 |
| ACUMEN PHARMACEUTICALS INC | 14,932,063 | 14,932,063 | 0 | 37,032 | 25,683 | 0.34% | -11,348 |
| MBX BIOSCIENCES INC(MBX) | 1,511,334 | 1,511,334 | 0 | 39,264 | 27,854 | 0.37% | -11,411 |
| CERVOMED INC | 817,120 | 0 | -817,120 | 11,930 | 0 | — | -11,930 |
| SOLID BIOSCIENCES INC | 4,330,446 | 4,330,446 | 0 | 30,183 | 17,322 | 0.23% | -12,861 |
| TENAYA THERAPEUTICS INC | 6,982,587 | 0 | -6,982,587 | 13,476 | 0 | — | -13,476 |
| TOURMALINE BIO INC | 2,538,925 | 2,538,925 | 0 | 65,276 | 51,489 | 0.69% | -13,786 |
| LARIMAR THERAPEUTICS INC | 6,045,351 | 6,045,351 | 0 | 39,597 | 23,396 | 0.31% | -16,202 |
| ITEOS THERAPEUTICS INC | 3,184,711 | 2,092,259 | -1,092,452 | 32,516 | 16,069 | 0.21% | -16,447 |
| NUVALENT INC-A | 176,281 | 0 | -176,281 | 18,034 | 0 | — | -18,034 |
| NKARTA INC | 10,805,129 | 10,805,129 | 0 | 48,839 | 26,905 | 0.36% | -21,934 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 2,333,000 | 1,866,400 | -466,600 | 63,878 | 40,688 | 0.54% | -23,190 |
| ALTO NEUROSCIENCE INC(ANRO) | 2,075,154 | 0 | -2,075,154 | 23,740 | 0 | — | -23,740 |
| 4D MOLECULAR THERAPEUTICS IN | 5,098,211 | 4,563,211 | -535,000 | 55,112 | 25,417 | 0.34% | -29,695 |
| BICYCLE THERAPEUTICS PLC-ADR | 2,253,000 | 1,093,477 | -1,159,523 | 50,985 | 15,309 | 0.20% | -35,677 |
| DAY ONE BIOPHARMACEUTICALS I COM | 7,871,721 | 5,755,577 | -2,116,144 | 109,653 | 72,923 | 0.97% | -36,730 |
| BIOAGE LABS INC | 2,210,589 | 1,310,589 | -900,000 | 45,980 | 7,588 | 0.10% | -38,392 |
| GERON CORP(GERN) | 32,285,755 | 30,009,536 | -2,276,219 | 146,577 | 106,234 | 1.41% | -40,344 |
| STRUCTURE THERAPEUTICS INC | 1,896,772 | 1,517,418 | -379,354 | 83,249 | 41,152 | 0.55% | -42,097 |
| ARS PHARMACEUTICALS INC | 10,860,977 | 10,860,977 | 0 | 157,484 | 114,583 | 1.52% | -42,901 |
| APOGEE THERAPEUTICS INC(APGE) | 1,961,863 | 1,569,491 | -392,372 | 115,240 | 71,098 | 0.95% | -44,142 |
| RECURSION PHARMACEUTICALS-A(RXRX) | 15,384,615 | 7,725,096 | -7,659,519 | 101,385 | 52,222 | 0.69% | -49,163 |
| PEPGEN INC | 10,689,545 | 10,689,545 | 0 | 91,396 | 40,513 | 0.54% | -50,882 |
| CG ONCOLOGY INC(CGON) | 1,397,433 | 0 | -1,397,433 | 52,725 | 0 | — | -52,725 |
| ARTIVA BIOTHERAPEUTICS INC | 9,853,302 | 9,853,302 | 0 | 152,234 | 99,321 | 1.32% | -52,912 |
| BICARA THERAPEUTICS INC | 6,955,993 | 6,955,993 | 0 | 177,169 | 121,173 | 1.61% | -55,996 |
| ASCENDIS PHARMA A/S - ADR(ASND) | 9,710,428 | 10,112,744 | +402,316 | 1,449,864 | 1,392,221 | 18.53% | -57,643 |
| VERONA PHARMA PLC - ADR | 5,009,653 | 1,766,830 | -3,242,823 | 144,128 | 82,052 | 1.09% | -62,076 |
| RXSIGHT INC | 3,916,825 | 3,743,018 | -173,807 | 193,609 | 128,685 | 1.71% | -64,924 |
| DYNE THERAPEUTICS INC(DYN) | 6,381,144 | 6,381,144 | 0 | 229,211 | 150,340 | 2.00% | -78,871 |
| TYRA BIOSCIENCES INC(TYRA) | 10,416,609 | 10,637,290 | +220,681 | 244,894 | 147,858 | 1.97% | -97,036 |
| CLIMB BIO INC | 31,419,267 | 31,419,267 | 0 | 159,924 | 56,555 | 0.75% | -103,369 |
| AVIDITY BIOSCIENCES INC | 6,300,408 | 6,300,408 | 0 | 289,378 | 183,216 | 2.44% | -106,162 |
| LEGEND BIOTECH CORP-ADR(LEGN) | 7,506,934 | 7,506,934 | 0 | 365,813 | 244,276 | 3.25% | -121,537 |
| EVOLENT HEALTH INC - A | 8,514,862 | 3,577,197 | -4,937,665 | 240,800 | 40,243 | 0.54% | -200,557 |
| BIOGEN INC(BIIB) | 1,184,456 | 0 | -1,184,456 | 229,595 | 0 | — | -229,595 |
| VAXCYTE INC(PCVX) | 8,689,190 | 8,689,190 | 0 | 992,914 | 711,297 | 9.47% | -281,617 |