Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Ascendis Pharma A/SSH(ASND) | 10,281,496 | 10,281,496 | 0 | $2.04B | $2.19B | 22.46% | +$148.36M |
| Cidara Therapeutics IncSH | 3,365,523 | 3,365,523 | 0 | $322.28M | $743.41M | 7.62% | +$421.13M |
| Rhythm Pharmaceuticals, Inc.SH(RYTM) | 5,681,359 | 6,666,837 | +985,478 | $573.76M | $713.62M | 7.31% | +$139.86M |
| Avidity Biosciences IncSH | 8,641,031 | 8,641,031 | 0 | $376.49M | $623.28M | 6.39% | +$246.79M |
| Vaxcyte, Inc.SH(PCVX) | 11,965,991 | 10,724,599 | -1,241,392 | $431.01M | $494.83M | 5.07% | +$63.82M |
| Sionna Therapeutics, Inc.SH(SION) | 10,445,322 | 9,905,045 | -540,277 | $307.20M | $407.49M | 4.17% | +$100.30M |
| Newamsterdam Pharma Co NvSH ORDINARY SHARES | 10,138,938 | 9,550,191 | -588,747 | $288.35M | $335.02M | 3.43% | +$46.67M |
| Tyra Biosciences, Inc.SH(TYRA) | 12,198,625 | 12,198,625 | 0 | $170.66M | $320.70M | 3.29% | +$150.04M |
| Wave Life Sciences, Inc.SH(WVE) | 18,202,009 | 18,203,009 | +1,000 | $133.24M | $309.45M | 3.17% | +$176.21M |
| Mineralys Therapeutics, Inc.SH(MLYS) | 7,323,750 | 7,323,750 | 0 | $277.72M | $265.78M | 2.72% | -$11.94M |
| Edgewise Therapeutics, Inc.SH(EWTX) | 10,428,437 | 10,428,437 | 0 | $169.15M | $258.78M | 2.65% | +$89.63M |
| Septerna, Inc.SH(SEPN) | 6,995,858 | 6,995,858 | 0 | $131.59M | $195.04M | 2.00% | +$63.45M |
| Nuvalent Inc-ASH | 1,246,456 | 1,880,057 | +633,601 | $107.79M | $189.11M | 1.94% | +$81.32M |
| Disc Medicine, Inc.SH(IRON) | 1,577,106 | 1,976,132 | +399,026 | $104.22M | $156.92M | 1.61% | +$52.71M |
| Janux Therapeutics, Inc.SH(JANX) | 11,189,693 | 11,189,693 | 0 | $273.48M | $154.42M | 1.58% | -$119.06M |
| PepGen Inc.SH(PEPG) | 20,064,545 | 20,064,545 | 0 | $92.70M | $130.62M | 1.34% | +$37.92M |
| Taysha Gene Therapies, Inc.SH(TSHA) | 23,555,648 | 23,555,648 | 0 | $77.03M | $129.56M | 1.33% | +$52.53M |
| ARS Pharmaceuticals, Inc.SH(SPRY) | 10,860,977 | 10,860,977 | 0 | $109.15M | $126.53M | 1.30% | +$17.38M |
| BioCryst Pharmaceuticals, Inc.SH(BCRX) | 0 | 15,827,186 | +15,827,186 | $0 | $123.45M | 1.26% | +$123.45M |
| Bicara Therapeutics IncSH | 6,955,993 | 6,955,993 | 0 | $109.84M | $117.07M | 1.20% | +$7.23M |
| Praxis Precision Medicines, Inc.SH(PRAX) | 0 | 373,787 | +373,787 | $0 | $110.17M | 1.13% | +$110.17M |
| GH Research PLCSH(GHRS) | 7,676,697 | 7,676,697 | 0 | $109.78M | $97.49M | 1.00% | -$12.28M |
| Geron CorporationSH(GERN) | 60,379,366 | 63,771,366 | +3,392,000 | $82.72M | $84.18M | 0.86% | +$1.46M |
| Arcellx IncSH COMMON STOCK | 3,036,527 | 1,267,156 | -1,769,371 | $249.30M | $82.62M | 0.85% | -$166.68M |
| Climb Bio, Inc.SH(CLYM) | 31,419,267 | 11,293,828 | -20,125,439 | $63.15M | $77.71M | 0.80% | +$14.56M |
| Vor Biopharma Inc.SH(VOR) | 1,982,301 | 5,404,998 | +3,422,697 | $96.58M | $70.70M | 0.72% | -$25.88M |
| Belite Bio, IncSH(BLTE) | 875,000 | 432,484 | -442,516 | $64.75M | $69.18M | 0.71% | +$4.43M |
| Fulcrum Therapeutics, Inc.SH(FULC) | 10,229,099 | 6,053,960 | -4,175,139 | $94.11M | $68.47M | 0.70% | -$25.64M |
| LENZ Therapeutics, Inc.SH(LENZ) | 4,178,823 | 4,178,823 | 0 | $194.65M | $66.86M | 0.68% | -$127.79M |
| Dianthus Therapeutics, Inc.SH(DNTH) | 2,866,733 | 1,611,733 | -1,255,000 | $112.81M | $66.42M | 0.68% | -$46.39M |
| Olema Pharmaceuticals, Inc.SH(OLMA) | 0 | 2,600,000 | +2,600,000 | $0 | $65.00M | 0.67% | +$65.00M |
| Evommune, Inc.SH(EVMN) | 0 | 3,458,770 | +3,458,770 | $0 | $59.21M | 0.61% | +$59.21M |
| Jade Biosciences IncSH | 1,062,326 | 3,671,083 | +2,608,757 | $9.17M | $56.64M | 0.58% | +$47.48M |
| Spyre Therapeutics, Inc.SH(SYRE) | 0 | 1,621,620 | +1,621,620 | $0 | $53.12M | 0.54% | +$53.12M |
| Lexeo Therapeutics, Inc.SH(LXEO) | 0 | 5,000,000 | +5,000,000 | $0 | $49.65M | 0.51% | +$49.65M |
| LB Pharmaceuticals IncSH(LBRX) | 1,776,958 | 2,208,604 | +431,646 | $28.06M | $49.16M | 0.50% | +$21.11M |
| Monopar Therapeutics Inc.SH(MNPR) | 511,207 | 667,207 | +156,000 | $41.75M | $43.57M | 0.45% | +$1.82M |
| Capricor Therapeutics, Inc.SH(CAPR) | 0 | 1,507,844 | +1,507,844 | $0 | $43.52M | 0.45% | +$43.52M |
| 4d Molecular Therapeutics InSH | 4,563,211 | 5,653,211 | +1,090,000 | $39.65M | $42.40M | 0.43% | +$2.74M |
| Invivyd, Inc.SH(IVVD) | 17,119,096 | 17,119,096 | 0 | $18.83M | $42.28M | 0.43% | +$23.45M |
| Artiva Biotherapeutics, Inc.SH(ARTV) | 9,853,302 | 9,853,302 | 0 | $28.28M | $42.27M | 0.43% | +$13.99M |
| GRAIL, Inc.SH(GRAL) | 0 | 428,266 | +428,266 | $0 | $36.66M | 0.38% | +$36.66M |
| Assembly Biosciences IncSH | 1,020,410 | 1,020,410 | 0 | $26.12M | $34.70M | 0.36% | +$8.58M |
| Solid Biosciences IncSH | 5,811,423 | 5,811,423 | 0 | $35.86M | $32.78M | 0.34% | -$3.08M |
| Acumen Pharmaceuticals, Inc.SH(ABOS) | 14,932,063 | 14,932,063 | 0 | $25.53M | $31.51M | 0.32% | +$5.97M |
| Benitec Biopharma Inc.SH(BNTC) | 0 | 1,850,000 | +1,850,000 | $0 | $24.92M | 0.26% | +$24.92M |
| Contineum Therapeutics, Inc.SH(CTNM) | 2,122,000 | 2,179,711 | +57,711 | $24.93M | $24.91M | 0.26% | -$19.4K |
| Rezolute, Inc.SH(RZLT) | 0 | 9,180,000 | +9,180,000 | $0 | $21.66M | 0.22% | +$21.66M |
| Acrivon Therapeutics IncSH | 8,340,508 | 8,340,508 | 0 | $15.10M | $20.10M | 0.21% | +$5.00M |
| Nkarta, Inc.SH(NKTX) | 10,805,129 | 10,805,129 | 0 | $22.37M | $19.99M | 0.20% | -$2.38M |
| Ovid Therapeutics Inc.SH(OVID) | 0 | 10,714,000 | +10,714,000 | $0 | $17.46M | 0.18% | +$17.46M |
| Palisade Bio, Inc.SH(PALI) | 0 | 7,124,116 | +7,124,116 | $0 | $16.74M | 0.17% | +$16.74M |
| SAB Biotherapeutics, Inc.SH(SABS) | 4,401,500 | 4,401,500 | 0 | $8.85M | $16.46M | 0.17% | +$7.61M |
| C4 Therapeutics, Inc.SH(CCCC) | 0 | 8,000,000 | +8,000,000 | $0 | $15.28M | 0.16% | +$15.28M |
| Medline Inc.SH(MDLN) | 0 | 335,000 | +335,000 | $0 | $14.07M | 0.14% | +$14.07M |
| Design Therapeutics, Inc.SH(DSGN) | 475,699 | 1,461,381 | +985,682 | $3.58M | $13.71M | 0.14% | +$10.13M |
| Inspire Medical Systems, Inc.SH(INSP) | 114,901 | 141,964 | +27,063 | $8.53M | $13.09M | 0.13% | +$4.57M |
| Avalo Therapeutics, Inc.SH(AVTX) | 662,968 | 662,968 | 0 | $8.43M | $12.04M | 0.12% | +$3.61M |
| Rani Therapeutics Holdings, Inc.SH(RANI) | 0 | 8,500,000 | +8,500,000 | $0 | $11.47M | 0.12% | +$11.47M |
| Perceptive Capital SolutionsSH CL A ORD SHS | 750,000 | 750,000 | 0 | $7.95M | $9.77M | 0.10% | +$1.82M |
| Adicet Bio IncSH | 0 | 948,249 | +948,249 | $0 | $7.98M | 0.08% | +$7.98M |
| Newamsterdam Pharma Co Nv-27SH *W EXP 99/99/999 | 333,333 | 333,333 | 0 | $5.70M | $7.67M | 0.08% | +$1.96M |
| GeneDx Holdings Corp.SH(WGS) | 58,044 | 58,044 | 0 | $6.25M | $7.55M | 0.08% | +$1.30M |
| Waystar Holding Corp.SH(WAY) | 0 | 144,400 | +144,400 | $0 | $4.73M | 0.05% | +$4.73M |
| Werewolf Therapeutics, Inc.SH(HOWL) | 6,681,307 | 6,681,307 | 0 | $13.16M | $4.23M | 0.04% | -$8.93M |
| Hinge Health, Inc.SH(HNGE) | 0 | 80,113 | +80,113 | $0 | $3.72M | 0.04% | +$3.72M |
| Progyny IncSH | 96,628 | 96,628 | 0 | $2.08M | $2.48M | 0.03% | +$402.0K |
| Qiagen N.V.SH(QGEN) | 0 | 43,976 | +43,976 | $0 | $2.08M | 0.02% | +$2.08M |
| OrthoPediatrics Corp.SH(KIDS) | 0 | 109,959 | +109,959 | $0 | $1.95M | 0.02% | +$1.95M |
| Health Catalyst, Inc.SH(HCAT) | 0 | 793,749 | +793,749 | $0 | $1.90M | 0.02% | +$1.90M |
| Palatin Technologies, Inc.SH(PTN) | 0 | 70,000 | +70,000 | $0 | $1.08M | 0.01% | +$1.08M |
| Adicet Bio IncSH | 7,541,000 | 0 | -7,541,000 | $6.11M | $0 | — | -$6.11M |
| 89bio IncSH | 19,889,683 | 0 | -19,889,683 | $292.38M | $0 | — | -$292.38M |
| Arcus Biosciences, Inc.SH(RCUS) | 1,136,364 | 0 | -1,136,364 | $15.45M | $0 | — | -$15.45M |
| CytomX Therapeutics, Inc.SH(CTMX) | 2,661,331 | 0 | -2,661,331 | $8.49M | $0 | — | -$8.49M |
| Eledon Pharmaceuticals, Inc.SH(ELDN) | 3,566,338 | 0 | -3,566,338 | $9.24M | $0 | — | -$9.24M |
| Larimar Therapeutics, Inc.SH(LRMR) | 6,045,351 | 0 | -6,045,351 | $19.53M | $0 | — | -$19.53M |
| Metsera IncSH | 675,525 | 0 | -675,525 | $35.35M | $0 | — | -$35.35M |
| Scholar Rock Holding CorporationSH(SRRK) | 1,166,788 | 0 | -1,166,788 | $43.45M | $0 | — | -$43.45M |
| Structure Therapeutics IncSH | 1,517,418 | 0 | -1,517,418 | $42.49M | $0 | — | -$42.49M |
| Surrozen, Inc.SH(SRZN) | 602,626 | 0 | -602,626 | $7.76M | $0 | — | -$7.76M |
| Tango Therapeutics, Inc.SH(TNGX) | 2,000,000 | 0 | -2,000,000 | $16.80M | $0 | — | -$16.80M |
| Travere Therapeutics, Inc.SH(TVTX) | 1,150,000 | 0 | -1,150,000 | $27.48M | $0 | — | -$27.48M |
| InflaRx N.V.SH(IFRX) | 1,973,233 | 0 | -1,973,233 | $2.64M | $0 | — | -$2.64M |
| Prime Medicine, Inc.SH(PRME) | 3,000,000 | 0 | -3,000,000 | $16.62M | $0 | — | -$16.62M |
| Evolent Health, Inc.SH(EVH) | 579,052 | 0 | -579,052 | $4.90M | $0 | — | -$4.90M |
| Endeavour Silver Corp.SH(EXK) | 54,939 | 0 | -54,939 | $3.01M | $0 | — | -$3.01M |
| Glaukos CorporationSH(GKOS) | 54,180 | 0 | -54,180 | $4.42M | $0 | — | -$4.42M |
| uniQure N.V.SH(QURE) | 200,000 | 0 | -200,000 | $11.67M | $0 | — | -$11.67M |