Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| CIDARA THERAPEUTICS INC | 3,365,523 | 3,365,523 | 0 | 322,282 | 743,410 | 7.62% | +421,128 |
| AVIDITY BIOSCIENCES INC | 8,641,031 | 8,641,031 | 0 | 376,490 | 623,278 | 6.39% | +246,788 |
| WAVE LIFE SCIENCES LTD(WVE) | 18,202,009 | 18,203,009 | +1,000 | 133,239 | 309,451 | 3.17% | +176,212 |
| TYRA BIOSCIENCES INC(TYRA) | 12,198,625 | 12,198,625 | 0 | 170,659 | 320,702 | 3.29% | +150,043 |
| ASCENDIS PHARMA A/S - ADR(ASND) | 10,281,496 | 10,281,496 | 0 | 2,044,064 | 2,192,426 | 22.46% | +148,362 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 5,681,359 | 6,666,837 | +985,478 | 573,760 | 713,618 | 7.31% | +139,858 |
| BIOCRYST PHARMACEUTICALS INC(BCRX) | 0 | 15,827,186 | +15,827,186 | 0 | 123,452 | 1.26% | +123,452 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 0 | 373,787 | +373,787 | 0 | 110,170 | 1.13% | +110,170 |
| SIONNA THERAPEUTICS INC | 10,445,322 | 9,905,045 | -540,277 | 307,197 | 407,494 | 4.17% | +100,297 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 10,428,437 | 10,428,437 | 0 | 169,149 | 258,782 | 2.65% | +89,632 |
| NUVALENT INC-A | 1,246,456 | 1,880,057 | +633,601 | 107,794 | 189,115 | 1.94% | +81,321 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 0 | 2,600,000 | +2,600,000 | 0 | 65,000 | 0.67% | +65,000 |
| VAXCYTE INC(PCVX) | 11,965,991 | 10,724,599 | -1,241,392 | 431,015 | 494,833 | 5.07% | +63,818 |
| SEPTERNA INC(SEPN) | 6,995,858 | 6,995,858 | 0 | 131,592 | 195,045 | 2.00% | +63,452 |
| EVOMMUNE INC | 0 | 3,458,770 | +3,458,770 | 0 | 59,214 | 0.61% | +59,214 |
| SPYRE THERAPEUTICS INC(SYRE) | 0 | 1,621,620 | +1,621,620 | 0 | 53,124 | 0.54% | +53,124 |
| DISC MEDICINE INC(IRON) | 1,577,106 | 1,976,132 | +399,026 | 104,215 | 156,925 | 1.61% | +52,709 |
| TAYSHA GENE THERAPIES INC(TSHA) | 23,555,648 | 23,555,648 | 0 | 77,027 | 129,556 | 1.33% | +52,529 |
| LEXEO THERAPEUTICS INC | 0 | 5,000,000 | +5,000,000 | 0 | 49,650 | 0.51% | +49,650 |
| JADE BIOSCIENCES INC | 1,062,326 | 3,671,083 | +2,608,757 | 9,168 | 56,645 | 0.58% | +47,477 |
| NEWAMSTERDAM PHARMA CO NV ORDINARY SHARES | 10,138,938 | 9,550,191 | -588,747 | 288,351 | 335,021 | 3.43% | +46,669 |
| CAPRICOR THERAPEUTICS INC | 0 | 1,507,844 | +1,507,844 | 0 | 43,516 | 0.45% | +43,516 |
| PEPGEN INC | 20,064,545 | 20,064,545 | 0 | 92,698 | 130,620 | 1.34% | +37,922 |
| GRAIL INC(GRAL) | 0 | 428,266 | +428,266 | 0 | 36,655 | 0.38% | +36,655 |
| BENITEC BIOPHARMA INC | 0 | 1,850,000 | +1,850,000 | 0 | 24,920 | 0.26% | +24,920 |
| INVIVYD INC | 17,119,096 | 17,119,096 | 0 | 18,831 | 42,284 | 0.43% | +23,453 |
| REZOLUTE INC | 0 | 9,180,000 | +9,180,000 | 0 | 21,665 | 0.22% | +21,665 |
| LB PHARMACEUTICALS INC(LBRX) | 1,776,958 | 2,208,604 | +431,646 | 28,058 | 49,164 | 0.50% | +21,105 |
| OVID THERAPEUTICS INC | 0 | 10,714,000 | +10,714,000 | 0 | 17,464 | 0.18% | +17,464 |
| ARS PHARMACEUTICALS INC | 10,860,977 | 10,860,977 | 0 | 109,153 | 126,530 | 1.30% | +17,378 |
| PALISADE BIO INC | 0 | 7,124,116 | +7,124,116 | 0 | 16,742 | 0.17% | +16,742 |
| C4 THERAPEUTICS INC | 0 | 8,000,000 | +8,000,000 | 0 | 15,280 | 0.16% | +15,280 |
| CLIMB BIO INC | 31,419,267 | 11,293,828 | -20,125,439 | 63,153 | 77,711 | 0.80% | +14,559 |
| MEDLINE INC-CL A(MDLN) | 0 | 335,000 | +335,000 | 0 | 14,070 | 0.14% | +14,070 |
| ARTIVA BIOTHERAPEUTICS INC | 9,853,302 | 9,853,302 | 0 | 28,279 | 42,271 | 0.43% | +13,992 |
| RANI THERAPEUTICS HOLDINGS-A | 0 | 8,500,000 | +8,500,000 | 0 | 11,475 | 0.12% | +11,475 |
| DESIGN THERAPEUTICS INC(DSGN) | 475,699 | 1,461,381 | +985,682 | 3,582 | 13,708 | 0.14% | +10,126 |
| ASSEMBLY BIOSCIENCES INC | 1,020,410 | 1,020,410 | 0 | 26,122 | 34,704 | 0.36% | +8,582 |
| ADICET BIO INC | 0 | 948,249 | +948,249 | 0 | 7,984 | 0.08% | +7,984 |
| SAB BIOTHERAPEUTICS INC | 4,401,500 | 4,401,500 | 0 | 8,847 | 16,462 | 0.17% | +7,615 |
| BICARA THERAPEUTICS INC | 6,955,993 | 6,955,993 | 0 | 109,835 | 117,069 | 1.20% | +7,234 |
| ACUMEN PHARMACEUTICALS INC | 14,932,063 | 14,932,063 | 0 | 25,534 | 31,507 | 0.32% | +5,973 |
| ACRIVON THERAPEUTICS INC | 8,340,508 | 8,340,508 | 0 | 15,096 | 20,101 | 0.21% | +5,004 |
| WAYSTAR HOLDING CORP(WAY) | 0 | 144,400 | +144,400 | 0 | 4,729 | 0.05% | +4,729 |
| INSPIRE MEDICAL SYSTEMS INC(INSP) | 114,901 | 141,964 | +27,063 | 8,526 | 13,093 | 0.13% | +4,568 |
| BELITE BIO INC - ADR(BLTE) | 875,000 | 432,484 | -442,516 | 64,750 | 69,180 | 0.71% | +4,430 |
| HINGE HEALTH INC-A(HNGE) | 0 | 80,113 | +80,113 | 0 | 3,721 | 0.04% | +3,721 |
| AVALO THERAPEUTICS INC(AVTX) | 662,968 | 662,968 | 0 | 8,426 | 12,039 | 0.12% | +3,613 |
| 4D MOLECULAR THERAPEUTICS IN | 4,563,211 | 5,653,211 | +1,090,000 | 39,654 | 42,399 | 0.43% | +2,745 |
| QIAGEN N.V.(QGEN) | 0 | 43,976 | +43,976 | 0 | 2,082 | 0.02% | +2,082 |
| NEWAMSTERDAM PHARMA CO NV-27 *W EXP 99/99/999 | 333,333 | 333,333 | 0 | 5,703 | 7,667 | 0.08% | +1,963 |
| ORTHOPEDIATRICS CORP | 0 | 109,959 | +109,959 | 0 | 1,953 | 0.02% | +1,953 |
| HEALTH CATALYST INC | 0 | 793,749 | +793,749 | 0 | 1,897 | 0.02% | +1,897 |
| PERCEPTIVE CAPITAL SOLUTIONS CL A ORD SHS | 750,000 | 750,000 | 0 | 7,950 | 9,773 | 0.10% | +1,823 |
| MONOPAR THERAPEUTICS INC | 511,207 | 667,207 | +156,000 | 41,750 | 43,569 | 0.45% | +1,818 |
| GERON CORP(GERN) | 60,379,366 | 63,771,366 | +3,392,000 | 82,720 | 84,178 | 0.86% | +1,458 |
| GENEDX HOLDINGS CORP(WGS) | 58,044 | 58,044 | 0 | 6,254 | 7,549 | 0.08% | +1,296 |
| PALATIN TECHNOLOGIES INC | 0 | 70,000 | +70,000 | 0 | 1,077 | 0.01% | +1,077 |
| PROGYNY INC | 96,628 | 96,628 | 0 | 2,079 | 2,481 | 0.03% | +402 |
| CONTINEUM THERAPEUTICS INC-A | 2,122,000 | 2,179,711 | +57,711 | 24,934 | 24,914 | 0.26% | -19 |
| NKARTA INC | 10,805,129 | 10,805,129 | 0 | 22,367 | 19,989 | 0.20% | -2,377 |
| INFLARX NV | 1,973,233 | 0 | -1,973,233 | 2,644 | 0 | — | -2,644 |
| EXACT SCIENCES CORP(EXK) | 54,939 | 0 | -54,939 | 3,006 | 0 | — | -3,006 |
| SOLID BIOSCIENCES INC | 5,811,423 | 5,811,423 | 0 | 35,856 | 32,776 | 0.34% | -3,080 |
| GLAUKOS CORP(GKOS) | 54,180 | 0 | -54,180 | 4,418 | 0 | — | -4,418 |
| EVOLENT HEALTH INC - A | 579,052 | 0 | -579,052 | 4,899 | 0 | — | -4,899 |
| ADICET BIO INC | 7,541,000 | 0 | -7,541,000 | 6,110 | 0 | — | -6,110 |
| SURROZEN INC | 602,626 | 0 | -602,626 | 7,765 | 0 | — | -7,765 |
| CYTOMX THERAPEUTICS INC | 2,661,331 | 0 | -2,661,331 | 8,490 | 0 | — | -8,490 |
| WEREWOLF THERAPEUTICS INC | 6,681,307 | 6,681,307 | 0 | 13,162 | 4,233 | 0.04% | -8,930 |
| ELEDON PHARMACEUTICALS INC | 3,566,338 | 0 | -3,566,338 | 9,237 | 0 | — | -9,237 |
| UNIQURE NV(QURE) | 200,000 | 0 | -200,000 | 11,674 | 0 | — | -11,674 |
| MINERALYS THERAPEUTICS INC(MLYS) | 7,323,750 | 7,323,750 | 0 | 277,717 | 265,779 | 2.72% | -11,938 |
| GH RESEARCH PLC(GHRS) | 7,676,697 | 7,676,697 | 0 | 109,777 | 97,494 | 1.00% | -12,283 |
| ARCUS BIOSCIENCES INC(RCUS) | 1,136,364 | 0 | -1,136,364 | 15,455 | 0 | — | -15,455 |
| PRIME MEDICINE INC | 3,000,000 | 0 | -3,000,000 | 16,620 | 0 | — | -16,620 |
| TANGO THERAPEUTICS INC(TNGX) | 2,000,000 | 0 | -2,000,000 | 16,800 | 0 | — | -16,800 |
| LARIMAR THERAPEUTICS INC | 6,045,351 | 0 | -6,045,351 | 19,526 | 0 | — | -19,526 |
| FULCRUM THERAPEUTICS INC | 10,229,099 | 6,053,960 | -4,175,139 | 94,108 | 68,470 | 0.70% | -25,637 |
| VOR BIOPHARMA INC(VOR) | 1,982,301 | 5,404,998 | +3,422,697 | 96,578 | 70,697 | 0.72% | -25,880 |
| TRAVERE THERAPEUTICS INC(TVTX) | 1,150,000 | 0 | -1,150,000 | 27,485 | 0 | — | -27,485 |
| METSERA INC | 675,525 | 0 | -675,525 | 35,350 | 0 | — | -35,350 |
| STRUCTURE THERAPEUTICS INC | 1,517,418 | 0 | -1,517,418 | 42,488 | 0 | — | -42,488 |
| SCHOLAR ROCK HOLDING CORP(SRRK) | 1,166,788 | 0 | -1,166,788 | 43,451 | 0 | — | -43,451 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 2,866,733 | 1,611,733 | -1,255,000 | 112,806 | 66,420 | 0.68% | -46,386 |
| JANUX THERAPEUTICS INC(JANX) | 11,189,693 | 11,189,693 | 0 | 273,476 | 154,418 | 1.58% | -119,058 |
| LENZ THERAPEUTICS INC | 4,178,823 | 4,178,823 | 0 | 194,650 | 66,861 | 0.68% | -127,788 |
| ARCELLX INC COMMON STOCK | 3,036,527 | 1,267,156 | -1,769,371 | 249,299 | 82,619 | 0.85% | -166,680 |
| 89BIO INC | 19,889,683 | 0 | -19,889,683 | 292,378 | 0 | — | -292,378 |