Fund Holdings

DAFNA Capital Management LLC

Filing Period:
Securities
SharesValue ($K)
Q4 2025
Q1 2026
Change
Q4 2025
Q1 2026
Weight (%)
Change
DAY ONE BIOPHARMACEUTICALS I
COM
999,163978,463-20,7009,312,19920,978,2474.77%+11,666,048
NEKTAR THERAPEUTICS(NKTR)74,998165,178+90,1803,170,91511,884,5572.70%+8,713,642
REVOLUTION MEDICINES INC(RVMD)604,514580,678-23,83648,149,54056,470,93612.85%+8,321,396
COMPASS PATHWAYS PLC(CMPS)811,0462,418,882+1,607,8365,596,21713,376,4173.04%+7,780,200
LARIMAR THERAPEUTICS INC939,1642,029,164+1,090,0003,578,2159,131,2382.08%+5,553,023
BICARA THERAPEUTICS INC261,583421,733+160,1504,402,4428,388,2691.91%+3,985,827
CENTURY THERAPEUTICS INC2,793,5862,434,353-359,2332,779,0595,501,6381.25%+2,722,579
XENON PHARMACEUTICALS INC(XENE)287,939250,772-37,16712,905,42614,582,3923.32%+1,676,966
FULCRUM THERAPEUTICS INC0205,000+205,00001,572,3500.36%+1,572,350
ORTHOPEDIATRICS CORP095,659+95,65901,518,1080.35%+1,518,108
ALLOGENE THERAPEUTICS INC1,380,1181,370,118-10,0001,890,7623,343,0880.76%+1,452,326
ALKERMES PLC(ALKS)130,248139,482+9,2343,644,3394,932,0841.12%+1,287,745
CYTOMX THERAPEUTICS INC0230,000+230,00001,081,0000.25%+1,081,000
MAZE THERAPEUTICS INC(MAZE)035,000+35,00001,044,7500.24%+1,044,750
SCYNEXIS INC01,086,956+1,086,9560996,6300.23%+996,630
MAPLIGHT THERAPEUTICS INC(MPLT)143,764171,006+27,2422,525,2153,476,5520.79%+951,337
ULTRAGENYX PHARMACEUTICAL INC(RARE)16,00061,100+45,100368,0001,280,0450.29%+912,045
DENALI THERAPEUTICS INC(DNLI)318,500318,50005,258,4356,115,2001.39%+856,765
BIOCRYST PHARMACEUTICALS INC(BCRX)418,255430,248+11,9933,262,3894,095,9610.93%+833,572
ZENAS BIOPHARMA INC(ZBIO)042,500+42,5000830,8750.19%+830,875
STOKE THERAPEUTICS INC(STOK)108,875130,875+22,0003,455,6934,261,2900.97%+805,597
NEWAMSTERDAM PHARMA CO
ORDINARY SHARES
020,000+20,0000640,2000.15%+640,200
PLIANT THERAPEUTICS INC0487,000+487,0000613,6200.14%+613,620
NEUROGENE INC27,97456,635+28,661576,2641,141,7620.26%+565,498
ALECTOR INC908,351908,35101,417,0281,952,9550.44%+535,927
ASCENDIS PHARMA A/S(ASND)0005,460,0005,916,5001.35%+456,500
IBIO INC0193,638+193,6380367,9120.08%+367,912
INSULET CORP(PODD)6,87010,870+4,0001,952,7292,280,9610.52%+328,232
CELLDEX THERAPEUTICS INC(CLDX)68,51868,51801,860,9492,173,3910.49%+312,442
INSPIRE MEDICAL SYSTEMS INC(INSP)8,60018,200+9,600793,178938,7560.21%+145,578
NEUMORA THERAPEUTICS INC070,000+70,0000136,5000.03%+136,500
COMPUGEN LTD272,402257,783-14,619416,775549,0780.12%+132,303
FATE THERAPEUTICS INC550,000550,0000540,430660,0000.15%+119,570
ALIGN TECHNOLOGY INC16,00015,000-1,0002,498,4002,571,4500.58%+73,050
RAPPORT THERAPEUTICS INC(RAPP)75,00075,00002,275,5002,346,7500.53%+71,250
MBX BIOSCIENCES INC(MBX)165,265175,465+10,2005,212,4585,237,6301.19%+25,172
ORCHESTRA BIOMED HOLDINGS INC126,841126,8410526,390539,0740.12%+12,684
POLYPID LTD207,900207,9000902,286910,6020.21%+8,316
ADC THERAPEUTICS SA77,08172,081-5,000272,096270,3040.06%-1,792
BIONTECH SE(BNTX)7,0007,0000666,400622,1600.14%-44,240
IMMUNOVANT INC(IMVT)150,524150,52403,826,3203,739,0160.85%-87,304
AUTOLUS THERAPEUTICS LTD179,316179,3160356,839247,4560.06%-109,383
KARYOPHARM THERAPEUTICS INC51,00045,800-5,200375,360255,1060.06%-120,254
PERSPECTIVE THERAPEUTICS INC50,0000-50,000137,5000-137,500
FOGHORN THERAPEUTICS INC126,859111,859-15,000685,039534,6860.12%-150,353
ADICET BIO INC93,81293,8120789,897638,8600.15%-151,037
VIKING THERAPEUTICS INC(VKTX)59,51659,51602,093,7731,936,6510.44%-157,122
BICYCLE THERAPEUTICS PLC64,49264,4920456,603299,2430.07%-157,360
ENGENE HOLDINGS INC
COM
163,645187,353+23,7081,477,7141,275,8740.29%-201,840
ORIC PHARMACEUTICALS INC(ORIC)141,04598,724-42,3211,153,748945,4600.22%-208,288
BRAINSWAY LTD12,9650-12,965246,5940-246,594
STRUCTURE THERAPEUTICS INC37,00046,500+9,5002,573,3502,241,3000.51%-332,050
INOGEN INC827,071845,179+18,1085,557,9175,223,2061.19%-334,711
SPDR S&P BIOTECH ETF
ST STR SP BIOT
336,505318,505-18,00041,030,05540,682,6449.25%-347,411
GALAPAGOS NV(LKFT)130,175130,17504,256,7233,905,2500.89%-351,473
MINERALYS THERAPEUTICS INC(MLYS)38,49038,49001,396,8021,042,6940.24%-354,108
KALVISTA PHARMACEUTICALS INC356,802267,402-89,4005,762,3525,382,8021.22%-379,550
EDGEWISE THERAPEUTICS INC(EWTX)159,736112,236-47,5003,963,8493,535,4340.80%-428,415
DEXCOM INC(DXCM)88,27986,279-2,0005,859,0775,418,3211.23%-440,756
ACCURAY INC1,395,5081,680,508+285,0001,150,736652,2050.15%-498,531
IMMATICS NV(IMTX)261,138225,860-35,2782,741,9492,222,4620.51%-519,487
KURA ONCOLOGY INC(KURA)235,868235,86802,450,6691,917,6070.44%-533,062
PROFOUND MEDICAL CORP285,710263,005-22,7052,248,5381,704,2720.39%-544,266
MEDIWOUND LTD113,61294,405-19,2072,097,2781,520,8650.35%-576,413
PROQR THERAPEUTICS N V
SHS EURO
1,567,5611,567,56103,166,4732,539,4490.58%-627,024
VERRICA PHARMACEUTICALS INC173,451153,712-19,7391,441,378813,1360.18%-628,242
ARCUS BIOSCIENCES INC(RCUS)431,329443,829+12,50010,278,5709,586,7062.18%-691,864
ASCENDIS PHARMA A/S(ASND)28,17723,177-5,0006,008,4635,301,2751.21%-707,188
NEUROCRINE BIOSCIENCES INC(NBIX)70,61570,615010,015,3259,302,8202.12%-712,505
ANNEXON INC(ANNX)272,812117,812-155,0001,369,516652,6780.15%-716,838
SYNDAX PHARMACEUTICALS INC(SNDX)277,855217,355-60,5005,837,7345,077,4131.16%-760,321
PROCEPT BIOROBOTICS CORP(PRCT)120,000120,00003,775,2003,001,2000.68%-774,000
TELA BIO INC1,441,0291,441,02901,700,414893,4380.20%-806,976
AQUESTIVE THERAPEUTICS INC375,915368,415-7,5002,428,4111,528,9220.35%-899,489
ERASCA INC(ERAS)254,4360-254,436946,5020-946,502
TANDEM DIABETES CARE INC(TNDM)355,208355,20807,807,4726,809,3371.55%-998,135
ISHARES NASDAQ BIOTECH INDX68,09562,095-6,00011,492,39310,484,7412.39%-1,007,652
ARS PHARMACEUTICALS INC190,065139,285-50,7802,214,2571,118,4590.25%-1,095,798
LEXEO THERAPEUTICS INC340,859377,059+36,2003,384,7302,164,3190.49%-1,220,411
CYBIN INC455,018498,361+43,3433,722,0472,392,1330.54%-1,329,914
IDEAYA BIOSCIENCES INC(IDYA)506,740476,740-30,00017,518,00215,884,9773.61%-1,633,025
BIOHAVEN LTD(BHVN)955,235845,735-109,50010,784,6037,154,9181.63%-3,629,685
ASTRIA THERAPEUTICS INC304,7750-304,7753,989,5050-3,989,505
STEREOTAXIS INC13,680,55413,680,554031,465,27425,172,2195.73%-6,293,055
ATRICURE INC(ATRC)597,431597,431023,634,37017,044,7063.88%-6,589,664
AXOGEN INC(AXGN)476,826249,960-226,86615,606,5158,281,1751.88%-7,325,340
CYTOKINETICS INC(CYTK)370,997217,497-153,50023,573,14914,335,2273.26%-9,237,922
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