Fund Holdings — DAFNA Capital Management LLC

Total Portfolio Value:
$439.59M
Total Bought:
$45.30M
Total Sold:
$62.72M
Net Transaction:
-$17.42M
Notable People:
Nathan Fischel, Fariba Fischel Ghodsian, Dafna Holdings, L.P.
Securities
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SharesValue
Q4 2025
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Q1 2026
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Change
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Q4 2025
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Q1 2026
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Weight (%)
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Change
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Revolution Medicines, Inc.(RVMD)604,514580,678-23,836$48.15M$56.47M12.85%+$8.32M
Spdr S&p Biotech EtfETF
ST STR SP BIOT
336,505318,505-18,000$41.03M$40.68M9.25%-$347.4K
Stereotaxis, Inc.(STXS)13,680,55413,680,5540$31.47M$25.17M5.73%-$6.29M
Day One Biopharmaceuticals I
COM
999,163978,463-20,700$9.31M$20.98M4.77%+$11.67M
AtriCure, Inc.(ATRC)597,431597,4310$23.63M$17.04M3.88%-$6.59M
IDEAYA Biosciences, Inc.(IDYA)506,740476,740-30,000$17.52M$15.88M3.61%-$1.63M
Xenon Pharmaceuticals Inc.(XENE)287,939250,772-37,167$12.91M$14.58M3.32%+$1.68M
Cytokinetics, Incorporated(CYTK)370,997217,497-153,500$23.57M$14.34M3.26%-$9.24M
COMPASS Pathways plcADS(CMPS)811,0462,418,882+1,607,836$5.60M$13.38M3.04%+$7.78M
Nektar Therapeutics(NKTR)74,998165,178+90,180$3.17M$11.88M2.70%+$8.71M
Ishares Nasdaq Biotech IndxETF68,09562,095-6,000$11.49M$10.48M2.39%-$1.01M
Arcus Biosciences, Inc.(RCUS)431,329443,829+12,500$10.28M$9.59M2.18%-$691.9K
Neurocrine Biosciences, Inc.(NBIX)70,61570,6150$10.02M$9.30M2.12%-$712.5K
Larimar Therapeutics, Inc.(LRMR)939,1642,029,164+1,090,000$3.58M$9.13M2.08%+$5.55M
Bicara Therapeutics Inc261,583421,733+160,150$4.40M$8.39M1.91%+$3.99M
Axogen, Inc.(AXGN)476,826249,960-226,866$15.61M$8.28M1.88%-$7.33M
Biohaven Ltd.(BHVN)955,235845,735-109,500$10.78M$7.15M1.63%-$3.63M
Tandem Diabetes Care, Inc.(TNDM)355,208355,2080$7.81M$6.81M1.55%-$998.1K
Denali Therapeutics Inc.(DNLI)318,500318,5000$5.26M$6.12M1.39%+$856.8K
Ascendis Pharma A/SNOTE 2 250 4 0(ASND)000$5.46M$5.92M1.35%+$456.5K
Century Therapeutics, Inc.(IPSC)2,793,5862,434,353-359,233$2.78M$5.50M1.25%+$2.72M
DexCom, Inc.(DXCM)88,27986,279-2,000$5.86M$5.42M1.23%-$440.8K
Kalvista Pharmaceuticals Inc356,802267,402-89,400$5.76M$5.38M1.22%-$379.6K
Ascendis Pharma A/SADR(ASND)28,17723,177-5,000$6.01M$5.30M1.21%-$707.2K
MBX Biosciences, Inc.(MBX)165,265175,465+10,200$5.21M$5.24M1.19%+$25.2K
Inogen, Inc.(INGN)827,071845,179+18,108$5.56M$5.22M1.19%-$334.7K
Syndax Pharmaceuticals, Inc.(SNDX)277,855217,355-60,500$5.84M$5.08M1.16%-$760.3K
Alkermes plcSHS(ALKS)130,248139,482+9,234$3.64M$4.93M1.12%+$1.29M
Stoke Therapeutics, Inc.(STOK)108,875130,875+22,000$3.46M$4.26M0.97%+$805.6K
BioCryst Pharmaceuticals, Inc.(BCRX)418,255430,248+11,993$3.26M$4.10M0.93%+$833.6K
Lakefront Biotherapeutics NVADR(LKFT)130,175130,1750$4.26M$3.91M0.89%-$351.5K
Immunovant, Inc.(IMVT)150,524150,5240$3.83M$3.74M0.85%-$87.3K
Edgewise Therapeutics, Inc.(EWTX)159,736112,236-47,500$3.96M$3.54M0.80%-$428.4K
MapLight Therapeutics, Inc.(MPLT)143,764171,006+27,242$2.53M$3.48M0.79%+$951.3K
Allogene Therapeutics Inc1,380,1181,370,118-10,000$1.89M$3.34M0.76%+$1.45M
PROCEPT BioRobotics Corporation(PRCT)120,000120,0000$3.78M$3.00M0.68%-$774.0K
Align Technology Inc16,00015,000-1,000$2.50M$2.57M0.58%+$73.0K
Proqr Therapeutics N VSHS EURO
SHS EURO
1,567,5611,567,5610$3.17M$2.54M0.58%-$627.0K
Cybin D/B/A Helus Pharma(HELP)455,018498,361+43,343$3.72M$2.39M0.54%-$1.33M
Rapport Therapeutics, Inc.(RAPP)75,00075,0000$2.28M$2.35M0.53%+$71.3K
Insulet Corporation(PODD)6,87010,870+4,000$1.95M$2.28M0.52%+$328.2K
Structure Therapeutics IncADS37,00046,500+9,500$2.57M$2.24M0.51%-$332.1K
Immatics N.V.SHS(IMTX)261,138225,860-35,278$2.74M$2.22M0.51%-$519.5K
Celldex Therapeutics, Inc.(CLDX)68,51868,5180$1.86M$2.17M0.49%+$312.4K
Lexeo Therapeutics, Inc.(LXEO)340,859377,059+36,200$3.38M$2.16M0.49%-$1.22M
Alector Inc908,351908,3510$1.42M$1.95M0.44%+$535.9K
Viking Therapeutics, Inc.(VKTX)59,51659,5160$2.09M$1.94M0.44%-$157.1K
Kura Oncology, Inc.(KURA)235,868235,8680$2.45M$1.92M0.44%-$533.1K
Profound Medical Corp.(PROF)285,710263,005-22,705$2.25M$1.70M0.39%-$544.3K
Fulcrum Therapeutics, Inc.(FULC)0205,000+205,000$0$1.57M0.36%+$1.57M
Aquestive Therapeutics Inc375,915368,415-7,500$2.43M$1.53M0.35%-$899.5K
MediWound Ltd.SHS NEW(MDWD)113,61294,405-19,207$2.10M$1.52M0.35%-$576.4K
OrthoPediatrics Corp.(KIDS)095,659+95,659$0$1.52M0.35%+$1.52M
Ultragenyx Pharmaceutical Inc.(RARE)16,00061,100+45,100$368.0K$1.28M0.29%+$912.0K
Engene Holdings Inc
COM
163,645187,353+23,708$1.48M$1.28M0.29%-$201.8K
Neurogene Inc.(NGNE)27,97456,635+28,661$576.3K$1.14M0.26%+$565.5K
ARS Pharmaceuticals, Inc.(SPRY)190,065139,285-50,780$2.21M$1.12M0.25%-$1.10M
CytomX Therapeutics, Inc.(CTMX)0230,000+230,000$0$1.08M0.25%+$1.08M
Maze Therapeutics, Inc.(MAZE)035,000+35,000$0$1.04M0.24%+$1.04M
Mineralys Therapeutics, Inc.(MLYS)38,49038,4900$1.40M$1.04M0.24%-$354.1K
SCYNEXIS, Inc.(SCYX)01,086,956+1,086,956$0$996.6K0.23%+$996.6K
ORIC Pharmaceuticals, Inc.(ORIC)141,04598,724-42,321$1.15M$945.5K0.22%-$208.3K
Inspire Medical Systems, Inc.(INSP)8,60018,200+9,600$793.2K$938.8K0.21%+$145.6K
PolyPid Ltd.(PYPD)207,900207,9000$902.3K$910.6K0.21%+$8.3K
TELA Bio, Inc.(TELA)1,441,0291,441,0290$1.70M$893.4K0.20%-$807.0K
Zenas BioPharma, Inc.(ZBIO)042,500+42,500$0$830.9K0.19%+$830.9K
Verrica Pharmaceuticals Inc.(VRCA)173,451153,712-19,739$1.44M$813.1K0.18%-$628.2K
Fate Therapeutics, Inc.(FATE)550,000550,0000$540.4K$660.0K0.15%+$119.6K
Annexon, Inc.(ANNX)272,812117,812-155,000$1.37M$652.7K0.15%-$716.8K
Accuray Inc1,395,5081,680,508+285,000$1.15M$652.2K0.15%-$498.5K
Newamsterdam Pharma Co
ORDINARY SHARES
020,000+20,000$0$640.2K0.15%+$640.2K
Adicet Bio Inc93,81293,8120$789.9K$638.9K0.15%-$151.0K
BioNTech SEADS(BNTX)7,0007,0000$666.4K$622.2K0.14%-$44.2K
Pliant Therapeutics, Inc.(PLRX)0487,000+487,000$0$613.6K0.14%+$613.6K
Compugen Ltd.(CGEN)272,402257,783-14,619$416.8K$549.1K0.12%+$132.3K
Orchestra BioMed Holdings, Inc.(OBIO)126,841126,8410$526.4K$539.1K0.12%+$12.7K
Foghorn Therapeutics Inc.(FHTX)126,859111,859-15,000$685.0K$534.7K0.12%-$150.4K
iBio, Inc.(IBIO)0193,638+193,638$0$367.9K0.08%+$367.9K
Bicycle Therapeutics PlcADS64,49264,4920$456.6K$299.2K0.07%-$157.4K
ADC Therapeutics SASHS(ADCT)77,08172,081-5,000$272.1K$270.3K0.06%-$1.8K
Karyopharm Therapeutics Inc.(KPTI)51,00045,800-5,200$375.4K$255.1K0.06%-$120.3K
Autolus Therapeutics plcADS(AUTL)179,316179,3160$356.8K$247.5K0.06%-$109.4K
Neumora Therapeutics, Inc.(NMRA)070,000+70,000$0$136.5K0.03%+$136.5K
Astria Therapeutics Inc304,7750-304,775$3.99M$0—-$3.99M
BrainsWay Ltd.ADS(BWAY)12,9650-12,965$246.6K$0—-$246.6K
Erasca, Inc.(ERAS)254,4360-254,436$946.5K$0—-$946.5K
Perspective Therapeutics, Inc.(CATX)50,0000-50,000$137.5K$0—-$137.5K
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DAFNA Capital Management LLC — 13F Holdings — Q1 2026 | TickerTrail