Fund Holdings — DAFNA Capital Management LLC

Total Portfolio Value:
$430.52M
Total Bought:
$46.78M
Total Sold:
$80.57M
Net Transaction:
-$33.79M
Notable People:
Nathan Fischel, Fariba Fischel Ghodsian, Dafna Holdings, L.P.
Securities
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SharesValue
Q3 2025
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Q4 2025
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Change
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Q3 2025
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Q4 2025
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Weight (%)
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Change
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Revolution Medicines, Inc.(RVMD)657,176604,514-52,662$30.69M$48.15M11.18%+$17.46M
Spdr S&p Biotech EtfETF
ST STR SP BIOT
401,505336,505-65,000$40.23M$41.03M9.53%+$799.3K
Stereotaxis, Inc.(STXS)13,680,55413,680,5540$42.55M$31.47M7.31%-$11.08M
AtriCure, Inc.(ATRC)592,273597,431+5,158$20.88M$23.63M5.49%+$2.76M
Cytokinetics, Incorporated(CYTK)394,940370,997-23,943$21.71M$23.57M5.48%+$1.87M
IDEAYA Biosciences, Inc.(IDYA)539,923506,740-33,183$14.69M$17.52M4.07%+$2.83M
Axogen, Inc.(AXGN)742,282476,826-265,456$13.24M$15.61M3.63%+$2.36M
Xenon Pharmaceuticals Inc.(XENE)287,939287,9390$11.56M$12.91M3.00%+$1.34M
Ishares Nasdaq Biotech IndxETF102,50068,095-34,405$14.80M$11.49M2.67%-$3.31M
Biohaven Ltd.(BHVN)235,235955,235+720,000$3.53M$10.78M2.51%+$7.25M
Arcus Biosciences, Inc.(RCUS)627,626431,329-196,297$8.54M$10.28M2.39%+$1.74M
Neurocrine Biosciences, Inc.(NBIX)70,61570,6150$9.91M$10.02M2.33%+$102.4K
Day One Biopharmaceuticals I
COM
999,163999,1630$7.04M$9.31M2.16%+$2.27M
Tandem Diabetes Care, Inc.(TNDM)355,208355,2080$4.31M$7.81M1.81%+$3.50M
Ascendis Pharma A/SADR(ASND)33,17728,177-5,000$6.60M$6.01M1.40%-$587.5K
DexCom, Inc.(DXCM)65,55288,279+22,727$4.41M$5.86M1.36%+$1.45M
Syndax Pharmaceuticals, Inc.(SNDX)500,702277,855-222,847$7.70M$5.84M1.36%-$1.87M
Kalvista Pharmaceuticals Inc422,731356,802-65,929$5.15M$5.76M1.34%+$613.5K
COMPASS Pathways plcADS(CMPS)811,046811,0460$4.65M$5.60M1.30%+$948.9K
Inogen, Inc.(INGN)605,625827,071+221,446$4.95M$5.56M1.29%+$610.0K
Ascendis Pharma A/SNOTE 2 250 4 0(ASND)000$5.44M$5.46M1.27%+$17.5K
Denali Therapeutics Inc.(DNLI)168,500318,500+150,000$2.45M$5.26M1.22%+$2.81M
MBX Biosciences, Inc.(MBX)85,000165,265+80,265$1.49M$5.21M1.21%+$3.72M
Bicara Therapeutics Inc317,001261,583-55,418$5.01M$4.40M1.02%-$603.0K
Lakefront Biotherapeutics NVADR(LKFT)130,175130,1750$4.51M$4.26M0.99%-$252.5K
Astria Therapeutics Inc319,775304,775-15,000$2.33M$3.99M0.93%+$1.66M
Edgewise Therapeutics, Inc.(EWTX)213,736159,736-54,000$3.47M$3.96M0.92%+$497.1K
Immunovant, Inc.(IMVT)191,493150,524-40,969$3.09M$3.83M0.89%+$739.5K
PROCEPT BioRobotics Corporation(PRCT)0120,000+120,000$0$3.78M0.88%+$3.78M
Cybin D/B/A Helus Pharma(HELP)0455,018+455,018$0$3.72M0.86%+$3.72M
Alkermes plcSHS(ALKS)134,748130,248-4,500$4.04M$3.64M0.85%-$398.1K
Larimar Therapeutics, Inc.(LRMR)1,027,764939,164-88,600$3.32M$3.58M0.83%+$258.5K
Stoke Therapeutics, Inc.(STOK)169,791108,875-60,916$3.99M$3.46M0.80%-$534.4K
Lexeo Therapeutics, Inc.(LXEO)358,083340,859-17,224$2.38M$3.38M0.79%+$1.01M
BioCryst Pharmaceuticals, Inc.(BCRX)218,255418,255+200,000$1.66M$3.26M0.76%+$1.61M
Nektar Therapeutics(NKTR)54,99874,998+20,000$3.13M$3.17M0.74%+$41.5K
Proqr Therapeutics N VSHS EURO
SHS EURO
1,567,5611,567,5610$3.34M$3.17M0.74%-$172.4K
Century Therapeutics, Inc.(IPSC)1,704,2322,793,586+1,089,354$848.7K$2.78M0.65%+$1.93M
Immatics N.V.SHS(IMTX)235,000261,138+26,138$2.00M$2.74M0.64%+$739.7K
Structure Therapeutics IncADS59,00037,000-22,000$1.65M$2.57M0.60%+$921.4K
MapLight Therapeutics, Inc.(MPLT)0143,764+143,764$0$2.53M0.59%+$2.53M
Align Technology Inc11,00016,000+5,000$1.38M$2.50M0.58%+$1.12M
Kura Oncology, Inc.(KURA)463,368235,868-227,500$4.10M$2.45M0.57%-$1.65M
Aquestive Therapeutics Inc512,589375,915-136,674$2.87M$2.43M0.56%-$437.0K
Rapport Therapeutics, Inc.(RAPP)75,00075,0000$2.23M$2.28M0.53%+$48.0K
Profound Medical Corp.(PROF)0285,710+285,710$0$2.25M0.52%+$2.25M
ARS Pharmaceuticals, Inc.(SPRY)140,500190,065+49,565$1.41M$2.21M0.51%+$802.2K
MediWound Ltd.SHS NEW(MDWD)113,612113,6120$2.05M$2.10M0.49%+$50.0K
Viking Therapeutics, Inc.(VKTX)64,51659,516-5,000$1.70M$2.09M0.49%+$398.3K
Insulet Corporation(PODD)6,8706,8700$2.12M$1.95M0.45%-$168.2K
Allogene Therapeutics Inc1,380,1181,380,1180$1.71M$1.89M0.44%+$179.4K
Celldex Therapeutics, Inc.(CLDX)24,51868,518+44,000$634.3K$1.86M0.43%+$1.23M
TELA Bio, Inc.(TELA)1,441,0291,441,0290$2.15M$1.70M0.39%-$446.7K
Engene Holdings Inc
COM
0163,645+163,645$0$1.48M0.34%+$1.48M
Verrica Pharmaceuticals Inc.(VRCA)0173,451+173,451$0$1.44M0.33%+$1.44M
Alector Inc798,351908,351+110,000$2.36M$1.42M0.33%-$946.1K
Mineralys Therapeutics, Inc.(MLYS)83,49038,490-45,000$3.17M$1.40M0.32%-$1.77M
Annexon, Inc.(ANNX)0272,812+272,812$0$1.37M0.32%+$1.37M
ORIC Pharmaceuticals, Inc.(ORIC)104,671141,045+36,374$1.26M$1.15M0.27%-$102.3K
Accuray Inc1,222,3581,395,508+173,150$2.04M$1.15M0.27%-$890.6K
Erasca, Inc.(ERAS)350,000254,436-95,564$763.0K$946.5K0.22%+$183.5K
PolyPid Ltd.(PYPD)207,900207,9000$693.3K$902.3K0.21%+$208.9K
Inspire Medical Systems, Inc.(INSP)17,2008,600-8,600$1.28M$793.2K0.18%-$483.1K
Adicet Bio Inc093,812+93,812$0$789.9K0.18%+$789.9K
Foghorn Therapeutics Inc.(FHTX)126,859126,8590$620.3K$685.0K0.16%+$64.7K
BioNTech SEADS(BNTX)7,0007,0000$690.3K$666.4K0.15%-$23.9K
Neurogene Inc.(NGNE)30,37527,974-2,401$526.4K$576.3K0.13%+$49.9K
Fate Therapeutics, Inc.(FATE)0550,000+550,000$0$540.4K0.13%+$540.4K
Orchestra BioMed Holdings, Inc.(OBIO)363,636126,841-236,795$901.8K$526.4K0.12%-$375.4K
Bicycle Therapeutics PlcADS64,49264,4920$499.2K$456.6K0.11%-$42.6K
Compugen Ltd.(CGEN)272,402272,4020$400.4K$416.8K0.10%+$16.3K
Karyopharm Therapeutics Inc.(KPTI)051,000+51,000$0$375.4K0.09%+$375.4K
Ultragenyx Pharmaceutical Inc.(RARE)016,000+16,000$0$368.0K0.09%+$368.0K
Autolus Therapeutics plcADS(AUTL)179,316179,3160$292.3K$356.8K0.08%+$64.6K
ADC Therapeutics SASHS(ADCT)122,08177,081-45,000$488.3K$272.1K0.06%-$216.2K
BrainsWay Ltd.ADS(BWAY)56,96612,965-44,001$858.5K$246.6K0.06%-$611.9K
Perspective Therapeutics, Inc.(CATX)050,000+50,000$0$137.5K0.03%+$137.5K
Aprea Therapeutics, Inc.(APRE)137,1740-137,174$202.3K$0—-$202.3K
Tessera Defense and Homeland Security Inc.(HLSQ)401,1360-401,136$210.6K$0—-$210.6K
Black Diamond Therapeutics I307,0700-307,070$1.16M$0—-$1.16M
Compass Therapeutics, Inc.(CMPX)946,6610-946,661$3.31M$0—-$3.31M
Keros Therapeutics, Inc.(KROS)80,7160-80,716$1.28M$0—-$1.28M
Korro Bio, Inc.(KRRO)60,8040-60,804$2.91M$0—-$2.91M
Merus Bv220,4510-220,451$20.76M$0—-$20.76M
Soleno Therapeutics Inc53,0000-53,000$3.58M$0—-$3.58M
Sutro Biopharma, Inc.(STRO)437,0790-437,079$379.6K$0—-$379.6K
UroGen Pharma Ltd.(URGN)27,5150-27,515$548.9K$0—-$548.9K
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DAFNA Capital Management LLC — 13F Holdings — Q4 2025 | TickerTrail