Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q4 2023 ▲▼ | Q1 2024 ▲▼ | Change ▲▼ | Q4 2023 ▲▼ | Q1 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Rocket Pharmaceuticals, Inc.(RCKT) | 17,687,772 | 17,687,772 | 0 | $530.10M | $476.51M | 7.03% | -$53.59M |
| Immunocore Holdings plcADS(IMCR) | 6,096,387 | 6,019,641 | -76,746 | $416.51M | $391.28M | 5.78% | -$25.23M |
| Axsome Therapeutics, Inc.(AXSM) | 4,489,596 | 4,492,679 | +3,083 | $357.33M | $358.52M | 5.29% | +$1.19M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 6,887,086 | 7,087,115 | +200,029 | $329.34M | $330.90M | 4.88% | +$1.56M |
| Bruker Corporation(BRKR) | 3,344,095 | 3,344,095 | 0 | $245.72M | $314.14M | 4.64% | +$68.42M |
| argenx SEADR(ARGX) | 667,195 | 667,195 | 0 | $253.82M | $262.69M | 3.88% | +$8.87M |
| Acadia Pharmaceuticals Inc | 11,253,551 | 13,829,315 | +2,575,764 | $352.35M | $255.70M | 3.77% | -$96.64M |
| Natera, Inc.(NTRA) | 2,593,323 | 2,593,323 | 0 | $162.45M | $237.19M | 3.50% | +$74.74M |
| PTC Therapeutics, Inc.(PTCT) | 7,423,970 | 7,423,970 | 0 | $204.60M | $215.96M | 3.19% | +$11.36M |
| Masimo Corp | 1,462,400 | 1,462,400 | 0 | $171.41M | $214.75M | 3.17% | +$43.35M |
| Avidity Biosciences Inc | 6,689,789 | 7,970,269 | +1,280,480 | $60.54M | $203.40M | 3.00% | +$142.86M |
| Merus N V | 2,373,625 | 4,109,393 | +1,735,768 | $65.27M | $185.05M | 2.73% | +$119.77M |
| Cytokinetics, Incorporated(CYTK) | 2,525,080 | 2,525,080 | 0 | $210.82M | $177.03M | 2.61% | -$33.79M |
| Apogee Therapeutics Inc | 2,142,591 | 2,467,591 | +325,000 | $59.86M | $163.97M | 2.42% | +$104.11M |
| Alkermes plcSHS(ALKS) | 3,901,523 | 6,054,280 | +2,152,757 | $108.23M | $163.89M | 2.42% | +$55.66M |
| Protagonist Therapeutics Inc | 5,315,514 | 5,315,514 | 0 | $121.88M | $153.78M | 2.27% | +$31.89M |
| Penumbra, Inc.(PEN) | 662,664 | 675,888 | +13,224 | $166.69M | $150.84M | 2.23% | -$15.84M |
| Avadel Pharmaceuticals PlcADR | 6,947,918 | 8,798,558 | +1,850,640 | $98.10M | $148.61M | 2.19% | +$50.50M |
| Akero Therapeutics Inc | 3,592,759 | 5,431,985 | +1,839,226 | $83.89M | $137.21M | 2.03% | +$53.32M |
| Establishment Labs Holdings Inc.(ESTA) | 2,494,138 | 2,675,703 | +181,565 | $64.57M | $136.19M | 2.01% | +$71.62M |
| Arvinas, Inc.(ARVN) | 4,213,483 | 3,297,897 | -915,586 | $173.43M | $136.14M | 2.01% | -$37.29M |
| Tarsus Pharmaceuticals, Inc.(TARS) | 3,152,341 | 3,272,341 | +120,000 | $63.83M | $118.95M | 1.76% | +$55.11M |
| Stryker Corporation(SYK) | 0 | 321,000 | +321,000 | $0 | $114.88M | 1.70% | +$114.88M |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 815,191 | 397,047 | -418,144 | $188.62M | $106.03M | 1.57% | -$82.59M |
| Immatics N.V.SHS(IMTX) | 1,484,911 | 10,000,000 | +8,515,089 | $15.64M | $105.10M | 1.55% | +$89.46M |
| Sage Therapeutics Inc | 5,197,019 | 5,480,577 | +283,558 | $112.62M | $102.71M | 1.52% | -$9.91M |
| Shockwave Med Inc | 65,060 | 288,684 | +223,624 | $12.40M | $94.00M | 1.39% | +$81.61M |
| Dyne Therapeutics, Inc.(DYN) | 0 | 3,091,587 | +3,091,587 | $0 | $87.77M | 1.30% | +$87.77M |
| 89bio Inc | 5,578,931 | 7,378,548 | +1,799,617 | $62.32M | $85.89M | 1.27% | +$23.57M |
| Spyre Therapeutics, Inc.(SYRE) | 2,232,760 | 2,232,760 | 0 | $48.05M | $84.69M | 1.25% | +$36.64M |
| Vericel Corporation(VCEL) | 3,212,794 | 1,606,397 | -1,606,397 | $114.41M | $83.56M | 1.23% | -$30.84M |
| Cargo Therapeutics Inc | 5,175,832 | 3,735,619 | -1,440,213 | $119.82M | $83.38M | 1.23% | -$36.44M |
| RadNet, Inc.(RDNT) | 663,602 | 1,700,550 | +1,036,948 | $23.07M | $82.75M | 1.22% | +$59.68M |
| Thermo Fisher Scientific Inc.(TMO) | 50,000 | 110,500 | +60,500 | $26.54M | $64.22M | 0.95% | +$37.68M |
| 10x Genomics, Inc.CL A(TXG) | 1,549,951 | 1,554,856 | +4,905 | $86.74M | $58.35M | 0.86% | -$28.38M |
| Stoke Therapeutics, Inc.(STOK) | 4,131,045 | 4,224,838 | +93,793 | $21.73M | $57.04M | 0.84% | +$35.31M |
| Fulcrum Therapeutics, Inc.(FULC) | 5,469,956 | 5,845,956 | +376,000 | $36.92M | $55.19M | 0.81% | +$18.26M |
| Taysha Gene Therapies, Inc.(TSHA) | 16,893,185 | 18,593,185 | +1,700,000 | $29.90M | $53.36M | 0.79% | +$23.46M |
| Insmed Incorporated(INSM) | 1,865,108 | 1,865,108 | 0 | $57.80M | $50.60M | 0.75% | -$7.20M |
| UroGen Pharma Ltd.(URGN) | 1,726,808 | 3,257,347 | +1,530,539 | $25.90M | $48.86M | 0.72% | +$22.96M |
| Kyverna Therapeutics, Inc.(KYTX) | 0 | 1,852,711 | +1,852,711 | $0 | $46.02M | 0.68% | +$46.02M |
| Intuitive Surgical, Inc.(ISRG) | 0 | 99,000 | +99,000 | $0 | $39.51M | 0.58% | +$39.51M |
| Neurogene Inc.(NGNE) | 0 | 769,122 | +769,122 | $0 | $39.15M | 0.58% | +$39.15M |
| Janux Therapeutics, Inc.(JANX) | 0 | 1,000,000 | +1,000,000 | $0 | $37.65M | 0.56% | +$37.65M |
| GH Research PLC(GHRS) | 3,327,129 | 3,327,129 | 0 | $19.30M | $35.47M | 0.52% | +$16.17M |
| Orchestra BioMed Holdings, Inc.(OBIO) | 5,620,640 | 5,620,640 | 0 | $51.32M | $29.62M | 0.44% | -$21.70M |
| Dianthus Therapeutics, Inc.(DNTH) | 0 | 666,667 | +666,667 | $0 | $20.00M | 0.30% | +$20.00M |
| Essa Pharma Inc | 2,298,662 | 2,298,662 | 0 | $15.17M | $19.52M | 0.29% | +$4.34M |
| LENZ Therapeutics, Inc.(LENZ) | 0 | 863,389 | +863,389 | $0 | $19.28M | 0.28% | +$19.28M |
| CG Oncology, Inc.(CGON) | 0 | 413,670 | +413,670 | $0 | $18.16M | 0.27% | +$18.16M |
| Tourmaline Bio Inc | 398,850 | 741,656 | +342,806 | $10.44M | $16.98M | 0.25% | +$6.54M |
| Roivant Sciences Ltd.SHS(ROIV) | 1,454,273 | 1,454,273 | 0 | $16.33M | $15.33M | 0.23% | -$1.00M |
| Viridian Therapeutics, Inc.(VRDN) | 605,816 | 605,816 | 0 | $13.19M | $10.61M | 0.16% | -$2.59M |
| Adicet Bio Inc | 4,134,631 | 4,134,631 | 0 | $7.81M | $9.72M | 0.14% | +$1.90M |
| REGENXBIO Inc.(RGNX) | 0 | 350,000 | +350,000 | $0 | $7.37M | 0.11% | +$7.37M |
| Acelyrin Inc | 978,310 | 978,310 | 0 | $7.30M | $6.60M | 0.10% | -$694.6K |
| Endeavour Silver Corp.(EXK) | 0 | 95,000 | +95,000 | $0 | $6.56M | 0.10% | +$6.56M |
| Allurion Technologies Inc | 3,457,707 | 3,457,707 | 0 | $12.93M | $6.05M | 0.09% | -$6.88M |
| Immunic, Inc.(IMUX) | 4,335,255 | 4,567,717 | +232,462 | $6.50M | $6.03M | 0.09% | -$473.5K |
| Milestone Pharmaceuticals Inc.(MIST) | 3,256,102 | 3,256,102 | 0 | $5.44M | $5.83M | 0.09% | +$390.7K |
| Glaukos Corporation(GKOS) | 0 | 58,791 | +58,791 | $0 | $5.54M | 0.08% | +$5.54M |
| Sagimet Biosciences Inc.COM SER A(SGMT) | 0 | 999,147 | +999,147 | $0 | $5.42M | 0.08% | +$5.42M |
| Larimar Therapeutics, Inc.(LRMR) | 0 | 650,000 | +650,000 | $0 | $4.93M | 0.07% | +$4.93M |
| SAB Biotherapeutics, Inc.(SABS) | 0 | 917,827 | +917,827 | $0 | $4.17M | 0.06% | +$4.17M |
| Exagen Inc.(XGN) | 1,504,602 | 1,504,602 | 0 | $2.99M | $2.39M | 0.04% | -$601.8K |
| Beyond Air, Inc.(XAIR) | 0 | 1,204,820 | +1,204,820 | $0 | $2.10M | 0.03% | +$2.10M |
| Cutera Inc | 1,817,585 | 1,331,776 | -485,809 | $6.41M | $1.96M | 0.03% | -$4.45M |
| Arya Sciences Acqu Corp IvCL A | 127,970 | 127,970 | 0 | $1.39M | $1.44M | 0.02% | +$42.2K |
| Rocket Pharmaceuticals, Inc.W EXP 09 02 202(RCKT) | 350,000 | 350,000 | 0 | $171.5K | $104.7K | 0.00% | -$66.8K |
| Alnylam Pharmaceuticals, Inc.(ALNY) | 1,640,559 | 0 | -1,640,559 | $314.02M | $0 | — | -$314.02M |
| Apyx Medical Corporation(APYX) | 1,025,963 | 0 | -1,025,963 | $2.69M | $0 | — | -$2.69M |
| Celldex Therapeutics, Inc.(CLDX) | 3,463,201 | 0 | -3,463,201 | $137.35M | $0 | — | -$137.35M |
| Danaher Corporation(DHR) | 118,584 | 0 | -118,584 | $27.43M | $0 | — | -$27.43M |
| Guardant Health, Inc.(GH) | 492,977 | 0 | -492,977 | $13.34M | $0 | — | -$13.34M |
| Mirati Therapeutics Inc | 6,768,514 | 0 | -6,768,514 | $397.65M | $0 | — | -$397.65M |
| SAB Biotherapeutics, Inc.(SABS) | 9,178,282 | 0 | -9,178,282 | $6.31M | $0 | — | -$6.31M |
| Sientra Inc | 81,016 | 0 | -81,016 | $49.4K | $0 | — | -$49.4K |
| Sight Sciences, Inc.(SGHT) | 164,806 | 0 | -164,806 | $850.4K | $0 | — | -$850.4K |
| Springworks Therapeutics Inc | 625,000 | 0 | -625,000 | $22.81M | $0 | — | -$22.81M |
| Tango Therapeutics, Inc.(TNGX) | 1,966,752 | 0 | -1,966,752 | $19.47M | $0 | — | -$19.47M |