Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2024 ▲▼ | Q1 2025 ▲▼ | Change ▲▼ | Q4 2024 ▲▼ | Q1 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| AKERO THERAPEUTICS INC | 6,859,823 | 7,419,340 | +559,517 | 190,840 | 300,335 | 4.59% | +109,495 |
| INTUITIVE SURGICAL INC | 0 | 202,456 | +202,456 | 0 | 100,270 | 1.53% | +100,270 |
| VERONA PHARMA PLC | 1,821,019 | 2,848,800 | +1,027,781 | 84,568 | 180,870 | 2.77% | +96,302 |
| PROTAGONIST THERAPEUTICS INC | 5,498,545 | 5,719,415 | +220,870 | 212,244 | 276,591 | 4.23% | +64,347 |
| ZAI LAB LTD(ZLAB) | 2,509,119 | 3,136,680 | +627,561 | 65,714 | 113,360 | 1.73% | +47,646 |
| PTC THERAPEUTICS INC(PTCT) | 7,393,127 | 7,483,127 | +90,000 | 333,726 | 381,340 | 5.83% | +47,614 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 1,993,687 | 1,993,687 | 0 | 615,192 | 660,369 | 10.10% | +45,177 |
| GE HEALTHCARE TECHNOLOGIES I(GEHC) | 0 | 520,000 | +520,000 | 0 | 41,969 | 0.64% | +41,969 |
| BETA BIONICS INC | 0 | 3,299,870 | +3,299,870 | 0 | 40,390 | 0.62% | +40,390 |
| GH RESEARCH PLC(GHRS) | 3,327,129 | 5,499,769 | +2,172,640 | 23,290 | 60,662 | 0.93% | +37,373 |
| UNIQURE NV(QURE) | 903,625 | 4,265,428 | +3,361,803 | 15,958 | 45,214 | 0.69% | +29,256 |
| AVIDITY BIOSCIENCES INC | 7,932,870 | 8,746,926 | +814,056 | 230,688 | 258,209 | 3.95% | +27,521 |
| PENUMBRA INC(PEN) | 862,450 | 862,770 | +320 | 204,815 | 230,713 | 3.53% | +25,899 |
| VERASTEM INC | 0 | 4,245,476 | +4,245,476 | 0 | 25,600 | 0.39% | +25,600 |
| INSMED INC(INSM) | 3,014,558 | 3,014,558 | 0 | 208,125 | 229,981 | 3.52% | +21,856 |
| TEMPUS AI INC(TEM) | 0 | 400,000 | +400,000 | 0 | 19,296 | 0.30% | +19,296 |
| GLAUKOS CORP(GKOS) | 0 | 190,000 | +190,000 | 0 | 18,700 | 0.29% | +18,700 |
| QUEST DIAGNOSTICS INC(DGX) | 0 | 98,997 | +98,997 | 0 | 16,750 | 0.26% | +16,750 |
| TAYSHA GENE THERAPIES INC(TSHA) | 8,672,630 | 18,787,866 | +10,115,236 | 15,004 | 26,115 | 0.40% | +11,111 |
| ALKERMES PLC(ALKS) | 7,557,835 | 6,884,698 | -673,137 | 217,363 | 227,333 | 3.48% | +9,969 |
| BEAM THERAPEUTICS INC(BEAM) | 0 | 438,659 | +438,659 | 0 | 8,567 | 0.13% | +8,567 |
| STRYKER CORPORATION(SYK) | 590,221 | 590,221 | 0 | 212,509 | 219,710 | 3.36% | +7,201 |
| KESTRA MED TECHNOLOGIES LTD SHS | 0 | 200,000 | +200,000 | 0 | 4,984 | 0.08% | +4,984 |
| COMPASS PATHWAYS PLC(CMPS) | 3,098,987 | 5,538,168 | +2,439,181 | 11,714 | 15,839 | 0.24% | +4,125 |
| ALLURION TECHNOLOGIES INC | 0 | 1,050,063 | +1,050,063 | 0 | 3,371 | 0.05% | +3,371 |
| TENAX THERAPEUTICS INC | 0 | 378,346 | +378,346 | 0 | 2,478 | 0.04% | +2,478 |
| ORCHESTRA BIOMED HLDGS INC | 8,206,162 | 8,206,162 | 0 | 32,825 | 35,122 | 0.54% | +2,298 |
| GLOBUS MED INC(GMED) | 972,000 | 1,125,000 | +153,000 | 80,394 | 82,350 | 1.26% | +1,956 |
| UROGEN PHARMA LTD(URGN) | 3,834,794 | 3,834,794 | 0 | 40,841 | 42,413 | 0.65% | +1,572 |
| MASIMO CORP | 683,294 | 683,294 | 0 | 112,948 | 113,837 | 1.74% | +888 |
| IMMUNOCORE HLDGS PLC(IMCR) | 4,869,798 | 4,869,798 | 0 | 143,659 | 144,487 | 2.21% | +828 |
| MERUS N V | 4,169,393 | 4,169,393 | 0 | 175,323 | 175,490 | 2.68% | +167 |
| PERCEPTIVE CAP SOLUTIONS COR CL A ORD SHS | 742,500 | 742,500 | 0 | 7,559 | 7,648 | 0.12% | +89 |
| ROCKET PHARMACEUTICALS INC | 350,000 | 350,000 | 0 | 12 | 16 | 0.00% | +4 |
| ADAGIO MED HLDGS INC | 209,361 | 209,361 | 0 | 220 | 169 | 0.00% | -51 |
| CENTESSA PHARMACEUTICALS PLC | 50,000 | 50,000 | 0 | 838 | 719 | 0.01% | -118 |
| EXAGEN INC | 1,511,866 | 1,511,866 | 0 | 6,199 | 5,428 | 0.08% | -771 |
| CERIBELL INC | 150,000 | 150,000 | 0 | 3,882 | 2,882 | 0.04% | -1,000 |
| ALLURION TECHNOLOGIES INC | 2,947,551 | 0 | -2,947,551 | 1,267 | 0 | — | -1,267 |
| ARTIVA BIOTHERAPEUTICS INC | 148,844 | 0 | -148,844 | 1,500 | 0 | — | -1,500 |
| BIOAGE LABS INC | 786,353 | 786,353 | 0 | 4,553 | 2,957 | 0.05% | -1,596 |
| AXSOME THERAPEUTICS INC(AXSM) | 4,051,365 | 2,922,729 | -1,128,636 | 342,786 | 340,878 | 5.21% | -1,908 |
| ESSA PHARMA INC | 1,113,002 | 0 | -1,113,002 | 1,992 | 0 | — | -1,992 |
| REGENXBIO INC | 350,000 | 0 | -350,000 | 2,706 | 0 | — | -2,705 |
| LENZ THERAPEUTICS INC | 863,389 | 863,389 | 0 | 24,926 | 22,198 | 0.34% | -2,728 |
| ACELYRIN INC | 978,310 | 0 | -978,310 | 3,072 | 0 | — | -3,072 |
| STRUCTURE THERAPEUTICS INC | 125,000 | 0 | -125,000 | 3,390 | 0 | — | -3,390 |
| WAVE LIFE SCIENCES LTD(WVE) | 900,000 | 900,000 | 0 | 11,133 | 7,272 | 0.11% | -3,861 |
| MILESTONE PHARMACEUTICALS IN | 2,506,102 | 2,506,102 | 0 | 5,914 | 2,005 | 0.03% | -3,909 |
| RAPT THERAPEUTICS INC | 11,764,000 | 11,764,000 | 0 | 18,587 | 14,352 | 0.22% | -4,235 |
| IMMUNIC INC | 4,567,717 | 0 | -4,567,717 | 4,568 | 0 | — | -4,568 |
| REPLIMUNE GROUP INC(REPL) | 2,065,010 | 2,065,010 | 0 | 25,007 | 20,134 | 0.31% | -4,873 |
| IDEAYA BIOSCIENCES INC(IDYA) | 200,000 | 0 | -200,000 | 5,140 | 0 | — | -5,140 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 2,679,479 | 2,679,479 | 0 | 14,335 | 8,521 | 0.13% | -5,814 |
| CG ONCOLOGY INC(CGON) | 1,701,216 | 1,701,216 | 0 | 48,791 | 41,663 | 0.64% | -7,128 |
| CULLINAN THERAPEUTICS INC(CGEM) | 1,705,960 | 1,705,960 | 0 | 20,779 | 12,914 | 0.20% | -7,864 |
| TARSUS PHARMACEUTICALS INC(TARS) | 3,236,549 | 3,316,032 | +79,483 | 179,208 | 170,345 | 2.61% | -8,863 |
| PEPGEN INC | 3,193,097 | 0 | -3,193,097 | 12,102 | 0 | — | -12,102 |
| ESTABLISHMENT LABS HLDGS INC(ESTA) | 2,569,687 | 2,583,887 | +14,200 | 118,385 | 105,436 | 1.61% | -12,950 |
| IMMUNOVANT INC(IMVT) | 530,614 | 0 | -530,614 | 13,143 | 0 | — | -13,143 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 666,667 | 0 | -666,667 | 14,533 | 0 | — | -14,533 |
| TOURMALINE BIO INC | 736,681 | 0 | -736,681 | 14,940 | 0 | — | -14,940 |
| NEUROGENE INC | 1,350,256 | 1,348,656 | -1,600 | 30,867 | 15,793 | 0.24% | -15,074 |
| IMMATICS N.V(IMTX) | 6,540,540 | 6,909,510 | +368,970 | 46,503 | 31,162 | 0.48% | -15,341 |
| ARGENX SE(ARGX) | 673,497 | 673,497 | 0 | 414,201 | 398,619 | 6.10% | -15,581 |
| SAGE THERAPEUTICS INC | 3,002,370 | 0 | -3,002,370 | 16,303 | 0 | — | -16,303 |
| ROIVANT SCIENCES LTD(ROIV) | 1,454,273 | 0 | -1,454,273 | 17,204 | 0 | — | -17,204 |
| ORUKA THERAPEUTICS INC(ORKA) | 1,945,649 | 1,945,649 | 0 | 37,726 | 19,962 | 0.31% | -17,764 |
| ACADIA PHARMACEUTICALS INC | 8,705,501 | 8,540,117 | -165,384 | 159,746 | 141,851 | 2.17% | -17,895 |
| CYTOKINETICS INC(CYTK) | 2,721,158 | 2,721,158 | 0 | 128,003 | 109,363 | 1.67% | -18,640 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 1,968,002 | 1,707,402 | -260,600 | 82,794 | 61,825 | 0.95% | -20,969 |
| APOGEE THERAPEUTICS INC(APGE) | 2,712,097 | 2,712,097 | 0 | 122,858 | 101,324 | 1.55% | -21,534 |
| STOKE THERAPEUTICS INC(STOK) | 5,123,525 | 5,123,525 | 0 | 56,512 | 34,071 | 0.52% | -22,441 |
| RADNET INC(RDNT) | 1,978,582 | 2,317,582 | +339,000 | 138,184 | 115,230 | 1.76% | -22,954 |
| SPYRE THERAPEUTICS INC(SYRE) | 3,621,996 | 3,621,996 | 0 | 84,320 | 58,441 | 0.89% | -25,879 |
| XENCOR INC(XNCR) | 2,402,883 | 2,402,883 | 0 | 55,218 | 25,567 | 0.39% | -29,652 |
| ARVINAS INC | 3,334,308 | 3,334,308 | 0 | 63,919 | 23,407 | 0.36% | -40,512 |
| CARGO THERAPEUTICS INC | 4,124,859 | 4,124,859 | 0 | 59,480 | 16,788 | 0.26% | -42,692 |
| NATERA INC(NTRA) | 2,593,323 | 2,593,546 | +223 | 410,523 | 366,753 | 5.61% | -43,770 |
| 89BIO INC | 7,478,061 | 1,967,527 | -5,510,534 | 58,478 | 14,304 | 0.22% | -44,175 |
| ROCKET PHARMACEUTICALS INC | 17,687,772 | 17,687,772 | 0 | 222,335 | 117,977 | 1.80% | -104,358 |
| DYNE THERAPEUTICS INC(DYN) | 5,218,641 | 1,690,567 | -3,528,074 | 122,951 | 17,683 | 0.27% | -105,268 |
| BRUKER CORP(BRKR) | 2,481,119 | 0 | -2,481,119 | 145,443 | 0 | — | -145,443 |