Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 1,993,687 | 1,993,687 | 0 | $1.16B | $1.04B | 10.38% | -$117.37M |
| Insmed Incorporated(INSM) | 4,842,879 | 4,842,880 | +1 | $842.85M | $791.91M | 7.88% | -$50.95M |
| Protagonist Therapeutics Inc | 5,059,053 | 5,059,053 | 0 | $441.86M | $533.22M | 5.31% | +$91.37M |
| PTC Therapeutics, Inc.(PTCT) | 7,746,415 | 7,746,415 | 0 | $588.42M | $527.76M | 5.25% | -$60.65M |
| argenx SEADR(ARGX) | 673,497 | 709,446 | +35,949 | $566.38M | $518.07M | 5.16% | -$48.30M |
| CG Oncology, Inc.(CGON) | 2,012,127 | 6,984,808 | +4,972,681 | $83.54M | $472.73M | 4.70% | +$389.19M |
| Celcuity Inc.(CELC) | 550,160 | 3,039,621 | +2,489,461 | $54.87M | $346.94M | 3.45% | +$292.07M |
| Tango Therapeutics, Inc.(TNGX) | 1,491,228 | 13,300,620 | +11,809,392 | $13.21M | $278.25M | 2.77% | +$265.04M |
| Erasca, Inc.(ERAS) | 146,651 | 16,157,175 | +16,010,524 | $545.5K | $261.42M | 2.60% | +$260.88M |
| Natera, Inc.(NTRA) | 1,500,000 | 1,250,000 | -250,000 | $343.63M | $249.99M | 2.49% | -$93.65M |
| RadNet, Inc.(RDNT) | 3,938,500 | 4,285,000 | +346,500 | $281.01M | $239.49M | 2.38% | -$41.52M |
| Tarsus Pharmaceuticals, Inc.(TARS) | 3,335,320 | 3,346,025 | +10,705 | $273.10M | $234.72M | 2.34% | -$38.37M |
| Apogee Therapeutics Inc | 2,712,097 | 2,782,097 | +70,000 | $204.71M | $234.17M | 2.33% | +$29.46M |
| Spyre Therapeutics, Inc.(SYRE) | 4,171,996 | 4,171,996 | 0 | $136.67M | $210.44M | 2.09% | +$73.76M |
| Cogent Biosciences, Inc.(COGT) | 7,592,241 | 5,458,675 | -2,133,566 | $269.68M | $210.10M | 2.09% | -$59.57M |
| iRhythm Holdings, Inc.(IRTC) | 1,181,990 | 1,668,500 | +486,510 | $209.73M | $196.92M | 1.96% | -$12.82M |
| Stoke Therapeutics, Inc.(STOK) | 5,546,856 | 5,623,525 | +76,669 | $176.06M | $183.10M | 1.82% | +$7.04M |
| Cytokinetics, Incorporated(CYTK) | 2,721,158 | 2,721,158 | 0 | $172.90M | $179.35M | 1.78% | +$6.45M |
| Acadia Pharmaceuticals Inc | 7,144,524 | 7,144,524 | 0 | $190.83M | $159.04M | 1.58% | -$31.79M |
| Establishment Labs Holdings Inc.(ESTA) | 2,588,831 | 2,655,695 | +66,864 | $188.67M | $150.79M | 1.50% | -$37.88M |
| Apellis Pharmaceuticals Inc COM | 7,666,764 | 3,685,045 | -3,981,719 | $192.59M | $148.25M | 1.48% | -$44.34M |
| Immunocore Holdings plcADS(IMCR) | 4,869,798 | 4,869,798 | 0 | $169.03M | $146.82M | 1.46% | -$22.21M |
| Repligen Corporation(RGEN) | 1,064,000 | 1,206,000 | +142,000 | $174.35M | $142.09M | 1.41% | -$32.26M |
| Neurocrine Biosciences, Inc.(NBIX) | 1,062,072 | 1,062,072 | 0 | $150.63M | $139.92M | 1.39% | -$10.72M |
| Guardant Health, Inc.(GH) | 1,481,033 | 1,481,033 | 0 | $151.27M | $136.80M | 1.36% | -$14.47M |
| Immatics N.V.SHS(IMTX) | 11,433,354 | 12,869,340 | +1,435,986 | $120.05M | $126.63M | 1.26% | +$6.58M |
| Zai Lab LimitedADR(ZLAB) | 6,959,032 | 6,574,032 | -385,000 | $122.76M | $123.66M | 1.23% | +$900.2K |
| Belite Bio, IncADS(BLTE) | 715,332 | 715,332 | 0 | $114.42M | $114.05M | 1.13% | -$372.0K |
| Intuitive Surgical, Inc.(ISRG) | 101,228 | 220,000 | +118,772 | $57.33M | $101.42M | 1.01% | +$44.09M |
| Oruka Therapeutics, Inc.(ORKA) | 2,058,148 | 2,058,148 | 0 | $62.38M | $100.95M | 1.00% | +$38.57M |
| GH Research PLC(GHRS) | 5,933,815 | 5,933,815 | 0 | $75.36M | $83.43M | 0.83% | +$8.07M |
| Xencor, Inc.(XNCR) | 6,777,461 | 6,777,461 | 0 | $103.76M | $81.74M | 0.81% | -$22.03M |
| UroGen Pharma Ltd.(URGN) | 4,543,895 | 4,543,895 | 0 | $106.42M | $81.70M | 0.81% | -$24.72M |
| Centessa Pharmaceuticals PlcADS | 1,790,837 | 2,054,175 | +263,338 | $44.79M | $81.59M | 0.81% | +$36.80M |
| Immunovant, Inc.(IMVT) | 3,177,850 | 3,177,849 | -1 | $80.78M | $78.94M | 0.79% | -$1.84M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 3,000,139 | 3,648,795 | +648,656 | $69.00M | $76.44M | 0.76% | +$7.44M |
| Hinge Health, Inc.CL A(HNGE) | 353,500 | 1,930,000 | +1,576,500 | $16.42M | $74.42M | 0.74% | +$58.00M |
| Castle Biosciences, Inc.(CSTL) | 2,115,237 | 2,758,335 | +643,098 | $82.28M | $67.72M | 0.67% | -$14.57M |
| Rocket Pharmaceuticals, Inc.(RCKT) | 17,687,772 | 17,687,772 | 0 | $62.08M | $63.32M | 0.63% | +$1.24M |
| Taysha Gene Therapies, Inc.(TSHA) | 16,398,297 | 13,680,248 | -2,718,049 | $90.19M | $61.15M | 0.61% | -$29.04M |
| Alkermes plcSHS(ALKS) | 1,672,356 | 1,672,356 | 0 | $46.79M | $59.13M | 0.59% | +$12.34M |
| COMPASS Pathways plcADS(CMPS) | 8,757,390 | 10,632,390 | +1,875,000 | $60.43M | $58.80M | 0.59% | -$1.63M |
| Kodiak Sciences Inc.(KOD) | 1,487,933 | 1,487,934 | +1 | $41.60M | $56.72M | 0.56% | +$15.12M |
| Replimune Group, Inc.(REPL) | 7,140,352 | 7,356,916 | +216,564 | $69.40M | $56.28M | 0.56% | -$13.12M |
| Crinetics Pharmaceuticals In | 1,351,326 | 1,451,326 | +100,000 | $62.90M | $52.71M | 0.52% | -$10.19M |
| uniQure N.V.SHS(QURE) | 3,711,462 | 2,586,356 | -1,125,106 | $88.82M | $42.29M | 0.42% | -$46.53M |
| Waystar Holding Corp.(WAY) | 0 | 1,630,000 | +1,630,000 | $0 | $39.30M | 0.39% | +$39.30M |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | 584,716 | 585,682 | +966 | $38.82M | $36.72M | 0.37% | -$2.10M |
| Orchestra BioMed Holdings, Inc.(OBIO) | 8,306,063 | 8,306,063 | 0 | $34.47M | $35.30M | 0.35% | +$830.6K |
| Verastem, Inc.(VSTM) | 6,576,306 | 6,576,306 | 0 | $50.77M | $34.85M | 0.35% | -$15.91M |
| Evommune, Inc.(EVMN) | 1,283,671 | 1,502,235 | +218,564 | $21.98M | $34.54M | 0.34% | +$12.56M |
| Stryker Corporation(SYK) | 245,000 | 100,000 | -145,000 | $86.11M | $32.86M | 0.33% | -$53.25M |
| Savara Inc.(SVRA) | 5,952,380 | 5,952,380 | 0 | $35.89M | $32.50M | 0.32% | -$3.39M |
| Candel Therapeutics, Inc.(CADL) | 0 | 6,422,018 | +6,422,018 | $0 | $31.47M | 0.31% | +$31.47M |
| Aquestive Therapeutics Inc | 6,250,000 | 7,426,471 | +1,176,471 | $40.38M | $30.82M | 0.31% | -$9.56M |
| Aktis Oncology, Inc.(AKTS) | 0 | 1,592,043 | +1,592,043 | $0 | $28.48M | 0.28% | +$28.48M |
| Neurogene Inc.(NGNE) | 1,362,456 | 1,362,456 | 0 | $28.07M | $27.47M | 0.27% | -$599.5K |
| Cullinan Therapeutics, Inc.(CGEM) | 1,705,960 | 1,705,960 | 0 | $17.66M | $24.24M | 0.24% | +$6.59M |
| Compass Therapeutics, Inc.(CMPX) | 2,500,000 | 4,186,599 | +1,686,599 | $13.43M | $22.15M | 0.22% | +$8.72M |
| Dianthus Therapeutics, Inc.(DNTH) | 0 | 248,063 | +248,063 | $0 | $20.82M | 0.21% | +$20.82M |
| Fulgent Genetics, Inc.(FLGT) | 705,027 | 1,289,000 | +583,973 | $18.52M | $20.50M | 0.20% | +$1.97M |
| Beta Bionics, Inc.(BBNX) | 2,500,000 | 2,000,000 | -500,000 | $76.17M | $20.04M | 0.20% | -$56.13M |
| Kymera Therapeutics, Inc.(KYMR) | 240,000 | 240,000 | 0 | $18.67M | $19.99M | 0.20% | +$1.32M |
| Century Therapeutics, Inc.(IPSC) | 0 | 8,695,652 | +8,695,652 | $0 | $19.65M | 0.20% | +$19.65M |
| Beam Therapeutics Inc.(BEAM) | 570,394 | 570,394 | 0 | $15.81M | $13.59M | 0.14% | -$2.22M |
| Avalo Therapeutics, Inc.(AVTX) | 0 | 856,962 | +856,962 | $0 | $12.79M | 0.13% | +$12.79M |
| Ocugen, Inc.(OCGN) | 0 | 6,666,666 | +6,666,666 | $0 | $12.07M | 0.12% | +$12.07M |
| Heartflow, Inc.(HTFL) | 495,000 | 495,000 | 0 | $14.43M | $12.04M | 0.12% | -$2.39M |
| Wave Life Sciences, Inc.SHS(WVE) | 1,350,000 | 1,350,000 | 0 | $22.95M | $9.79M | 0.10% | -$13.16M |
| Perceptive Cap Solutions CorCL A CL A ORD SHS | 742,500 | 742,500 | 0 | $9.67M | $8.15M | 0.08% | -$1.53M |
| Jade Biosciences Inc | 1,449,273 | 573,205 | -876,068 | $22.36M | $8.05M | 0.08% | -$14.31M |
| Capricor Therapeutics, Inc.(CAPR) | 250,000 | 250,000 | 0 | $7.21M | $7.60M | 0.08% | +$385.0K |
| Milestone Pharmaceuticals Inc.(MIST) | 2,506,102 | 6,331,001 | +3,824,899 | $5.06M | $7.53M | 0.07% | +$2.47M |
| Kalaris Therapeutics, Inc.(KLRS) | 1,300,000 | 1,300,000 | 0 | $10.97M | $7.50M | 0.07% | -$3.47M |
| Inventiva S.A.ADS(IVA) | 1,298,701 | 1,298,702 | +1 | $6.04M | $7.21M | 0.07% | +$1.17M |
| Ataibeckley Inc | 0 | 2,000,000 | +2,000,000 | $0 | $7.08M | 0.07% | +$7.08M |
| Crescent Biopharma, Inc.(CBIO) | 372,856 | 372,856 | 0 | $4.42M | $6.85M | 0.07% | +$2.43M |
| Larimar Therapeutics, Inc.(LRMR) | 3,125,000 | 1,500,000 | -1,625,000 | $11.91M | $6.75M | 0.07% | -$5.16M |
| Tenax Therapeutics, Inc.(TENX) | 378,346 | 370,246 | -8,100 | $4.61M | $5.92M | 0.06% | +$1.31M |
| Definium Therapeutics, Inc.(DFTX) | 0 | 300,000 | +300,000 | $0 | $5.67M | 0.06% | +$5.67M |
| Lumexa Imaging Holdings, Inc.(LMRI) | 650,000 | 650,000 | 0 | $12.03M | $5.59M | 0.06% | -$6.43M |
| 4d Molecular Therapeutics In | 475,737 | 475,737 | 0 | $3.57M | $4.43M | 0.04% | +$861.1K |
| Medline Inc.CL A(MDLN) | 70,000 | 70,000 | 0 | $2.94M | $3.12M | 0.03% | +$175.0K |
| Omada Health, Inc.(OMDA) | 200,000 | 200,000 | 0 | $3.16M | $2.51M | 0.03% | -$642.0K |
| Disc Medicine, Inc.(IRON) | 30,000 | 30,000 | 0 | $2.38M | $1.92M | 0.02% | -$464.1K |
| ImageneBio, Inc.(IMA) | 334,445 | 334,445 | 0 | $2.31M | $1.67M | 0.02% | -$635.4K |
| Exagen Inc.(XGN) | 790,462 | 395,231 | -395,231 | $4.81M | $1.19M | 0.01% | -$3.62M |
| Rocket Pharmaceuticals, Inc.W EXP 09 02 202(RCKT) | 350,000 | 350,000 | 0 | $8.5K | $7.2K | 0.00% | -$1.3K |
| Allurion Technologies Inc.(ALUR) | 5,891,430 | 0 | -5,891,430 | $7.25M | $0 | — | -$7.25M |
| Atai Beckley NvSHS | 2,000,000 | 0 | -2,000,000 | $8.18M | $0 | — | -$8.18M |
| Axsome Therapeutics, Inc.(AXSM) | 888,001 | 0 | -888,001 | $162.18M | $0 | — | -$162.18M |
| Corvus Pharmaceuticals, Inc.(CRVS) | 447,607 | 0 | -447,607 | $3.45M | $0 | — | -$3.45M |
| Insulet Corporation(PODD) | 324,600 | 0 | -324,600 | $92.26M | $0 | — | -$92.26M |
| IQVIA Holdings Inc.(IQV) | 46,000 | 0 | -46,000 | $10.37M | $0 | — | -$10.37M |
| Masimo Corp | 683,294 | 0 | -683,294 | $88.87M | $0 | — | -$88.87M |
| Mind Medicine Mindmed Inc | 300,000 | 0 | -300,000 | $4.02M | $0 | — | -$4.02M |
| Penumbra, Inc.(PEN) | 866,499 | 0 | -866,499 | $269.40M | $0 | — | -$269.40M |
| Rapt Therapeutics Inc | 1,637,165 | 0 | -1,637,165 | $55.45M | $0 | — | -$55.45M |
| Structure Therapeutics IncADS | 100,000 | 0 | -100,000 | $6.96M | $0 | — | -$6.96M |
| Tempus AI, Inc.CL A(TEM) | 200,000 | 0 | -200,000 | $11.81M | $0 | — | -$11.81M |